Details for: GH2

Gene ID: 2689

Symbol: GH2

Ensembl ID: ENSG00000136487

Description: growth hormone 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 6.69
    Marker Score: 8279
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 3.76
    Marker Score: 6845
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.74
    Marker Score: 2754
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 2.33
    Marker Score: 1291
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 1.38
    Marker Score: 786
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: 1.06
    Marker Score: 343
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71834
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48059
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 394
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.46
    Marker Score: 194
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 273
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.32
    Marker Score: 438
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.26
    Marker Score: 4063
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.23
    Marker Score: 119.5
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.23
    Marker Score: 240
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.22
    Marker Score: 128.5
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.22
    Marker Score: 128.5
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.22
    Marker Score: 410
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.19
    Marker Score: 402
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.15
    Marker Score: 270
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.14
    Marker Score: 290
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.13
    Marker Score: 158
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.12
    Marker Score: 716
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.12
    Marker Score: 103
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.09
    Marker Score: 49
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.08
    Marker Score: 48
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.08
    Marker Score: 52
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.07
    Marker Score: 199
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.07
    Marker Score: 71.5
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.06
    Marker Score: 29
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.05
    Marker Score: 17
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.05
    Marker Score: 33.5
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.05
    Marker Score: 15
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.05
    Marker Score: 13
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.04
    Marker Score: 15
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.04
    Marker Score: 34
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.04
    Marker Score: 88
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.03
    Marker Score: 45
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.03
    Marker Score: 26
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.03
    Marker Score: 25.5
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.03
    Marker Score: 10
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.03
    Marker Score: 17
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.03
    Marker Score: 16
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.03
    Marker Score: 13
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.03
    Marker Score: 10
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.03
    Marker Score: 15
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.02
    Marker Score: 24
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.02
    Marker Score: 17
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.02
    Marker Score: 86
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.02
    Marker Score: 16
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.02
    Marker Score: 37
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.02
    Marker Score: 18
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.02
    Marker Score: 22.5
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.02
    Marker Score: 17
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.02
    Marker Score: 29.5
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.02
    Marker Score: 8
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.01
    Marker Score: 24.5
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.01
    Marker Score: 14
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.01
    Marker Score: 18
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.01
    Marker Score: 17
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.01
    Marker Score: 10.5
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.01
    Marker Score: 15
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 0.01
    Marker Score: 16
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.01
    Marker Score: 18
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 0.01
    Marker Score: 15
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.01
    Marker Score: 37
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.01
    Marker Score: 76
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.01
    Marker Score: 113
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.01
    Marker Score: 18
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.01
    Marker Score: 14
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.01
    Marker Score: 16
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.01
    Marker Score: 18
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.01
    Marker Score: 24.5
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0
    Marker Score: 13
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0
    Marker Score: 17
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0
    Marker Score: 18
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0
    Marker Score: 14
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0
    Marker Score: 10
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0
    Marker Score: 9

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Other Information

**Key characteristics:** * The GH2 gene is located on chromosome 17p13.1. * It is a large gene, encoding a protein of 1333 amino acids. * The GH2 receptor is a type I receptor for growth hormone. * It is expressed in high levels in the central nervous system, where it plays a role in regulating brain development and function. **Pathways and functions:** * The GH2 receptor binds to growth hormone, which stimulates its signaling pathway. * This pathway is involved in a variety of cellular processes, including cell growth, differentiation, proliferation, and survival. * In the central nervous system, the GH2 receptor is essential for the development and maintenance of oligodendrocytes, which are a type of glial cell that is responsible for the formation of the central nervous system. * The GH2 receptor is also involved in the regulation of inflammation and apoptosis. **Clinical significance:** * Mutations in the GH2 gene have been linked to a number of human diseases, including autism, schizophrenia, and growth disorders. * These mutations can disrupt the normal signaling pathway of the GH2 receptor, leading to abnormal cell growth and development. * Therefore, GH2 is a promising target for the treatment of these disorders. **Additional notes:** * The GH2 gene is also known as SOM2. * The GH2 receptor is a member of the GH receptor family of cell surface receptors. * The GH2 signaling pathway is a complex and multifaceted pathway that involves multiple signaling molecules.

Genular Protein ID: 1881583367

Symbol: SOM2_HUMAN

Name: Growth hormone variant

UniProtKB Accession Codes:

P01242 B1A4H5 B1A4H7 O14643 O14644 P09587

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 20 Ensembl 4 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 2 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 RNAct 1 Reactome 2 RefSeq 4 SIGNOR 1 SMR 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7169009

Title: The human growth hormone gene family: nucleotide sequences show recent divergence and predict a new polypeptide hormone.

PubMed ID: 7169009

DOI: 10.1089/dna.1.1982.1.239

PubMed ID: 3379057

Title: Two distinct species of human growth hormone-variant mRNA in the human placenta predict the expression of novel growth hormone proteins.

PubMed ID: 3379057

DOI: 10.1016/s0021-9258(18)68407-8

PubMed ID: 2460050

Title: Cloning and nucleotide sequence of placental hGH-V cDNA.

PubMed ID: 2460050

DOI: 10.3109/13813458809079626

PubMed ID: 2744760

Title: The human growth hormone locus: nucleotide sequence, biology, and evolution.

PubMed ID: 2744760

DOI: 10.1016/0888-7543(89)90271-1

PubMed ID: 9709963

Title: Cloning of two novel growth hormone transcripts expressed in human placenta.

PubMed ID: 9709963

DOI: 10.1210/jcem.83.8.5017

PubMed ID: 18473352

Title: Complex signatures of locus-specific selective pressures and gene conversion on human growth hormone/chorionic somatomammotropin genes.

PubMed ID: 18473352

DOI: 10.1002/humu.20767

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2196278

Title: Identification of placental human growth hormone as the growth hormone-V gene expression product.

PubMed ID: 2196278

DOI: 10.1210/jcem-71-1-15

PubMed ID: 10393484

Title: Growth hormone heterogeneity in human pituitary and plasma.

PubMed ID: 10393484

DOI: 10.1159/000053128

Sequence Information:

  • Length: 217
  • Mass: 25000
  • Checksum: 7B9324698E822F96
  • Sequence:
    • MAAGSRTSLL LAFGLLCLSW LQEGSAFPTI PLSRLFDNAM LRARRLYQLA YDTYQEFEEA 
YILKEQKYSF LQNPQTSLCF SESIPTPSNR VKTQQKSNLE LLRISLLLIQ SWLEPVQLLR 
SVFANSLVYG ASDSNVYRHL KDLEEGIQTL MWRLEDGSPR TGQIFNQSYS KFDTKSHNDD 
ALLKNYGLLY CFRKDMDKVE TFLRIVQCRS VEGSCGF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.