Details for: FOXD3

Gene ID: 27022

Symbol: FOXD3

Ensembl ID: ENSG00000187140

Description: forkhead box D3

Associated with

  • Developmental biology
    (R-HSA-1266738)
  • Mitf-m-regulated melanocyte development
    (R-HSA-9730414)
  • Pou5f1 (oct4), sox2, nanog activate genes related to proliferation
    (R-HSA-2892247)
  • Transcriptional and post-translational regulation of mitf-m expression and activity
    (R-HSA-9856649)
  • Transcriptional regulation of pluripotent stem cells
    (R-HSA-452723)
  • Anatomical structure morphogenesis
    (GO:0009653)
  • Cell differentiation
    (GO:0030154)
  • Chromatin
    (GO:0000785)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • In utero embryonic development
    (GO:0001701)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nucleoplasm
    (GO:0005654)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.3200
    Cell Significance Index: 5.4700
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 0.1988
    Cell Significance Index: 1.1300
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.1327
    Cell Significance Index: 0.9600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0901
    Cell Significance Index: 1.2900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0421
    Cell Significance Index: 1.9100
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.0098
    Cell Significance Index: 0.1100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0004
    Cell Significance Index: -0.0200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0010
    Cell Significance Index: -0.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0019
    Cell Significance Index: -3.5800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0048
    Cell Significance Index: -3.0700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0048
    Cell Significance Index: -3.6200
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0048
    Cell Significance Index: -0.0600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0059
    Cell Significance Index: -3.3400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0061
    Cell Significance Index: -3.3400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0067
    Cell Significance Index: -0.1900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0071
    Cell Significance Index: -3.2000
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0141
    Cell Significance Index: -0.2000
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.0146
    Cell Significance Index: -0.1600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0154
    Cell Significance Index: -0.8000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0160
    Cell Significance Index: -2.8800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0161
    Cell Significance Index: -0.7500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0163
    Cell Significance Index: -2.7900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0187
    Cell Significance Index: -3.7600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0203
    Cell Significance Index: -2.9500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0248
    Cell Significance Index: -3.4000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0252
    Cell Significance Index: -3.1000
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0276
    Cell Significance Index: -0.5500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0289
    Cell Significance Index: -3.3100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0327
    Cell Significance Index: -4.2200
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0347
    Cell Significance Index: -0.2300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0359
    Cell Significance Index: -3.7400
  • Cell Name: PP cell (CL0000696)
    Fold Change: -0.0367
    Cell Significance Index: -0.3700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0454
    Cell Significance Index: -0.6200
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.0459
    Cell Significance Index: -0.3300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0463
    Cell Significance Index: -0.9700
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.0498
    Cell Significance Index: -0.8000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0562
    Cell Significance Index: -4.3100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0615
    Cell Significance Index: -1.6800
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0615
    Cell Significance Index: -0.8500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0637
    Cell Significance Index: -3.0000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0725
    Cell Significance Index: -2.3800
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.0741
    Cell Significance Index: -0.8300
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.0765
    Cell Significance Index: -1.0400
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.0794
    Cell Significance Index: -0.8700
  • Cell Name: neuroplacodal cell (CL0000032)
    Fold Change: -0.0836
    Cell Significance Index: -1.0300
  • Cell Name: melanocyte (CL0000148)
    Fold Change: -0.0875
    Cell Significance Index: -0.8200
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0906
    Cell Significance Index: -1.1700
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0910
    Cell Significance Index: -1.0300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0926
    Cell Significance Index: -2.3600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0954
    Cell Significance Index: -2.8100
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0997
    Cell Significance Index: -1.2600
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.1010
    Cell Significance Index: -0.9800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1041
    Cell Significance Index: -2.7900
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1053
    Cell Significance Index: -1.7100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1085
    Cell Significance Index: -1.1800
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1100
    Cell Significance Index: -1.6700
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.1109
    Cell Significance Index: -1.1500
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: -0.1142
    Cell Significance Index: -1.2400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1144
    Cell Significance Index: -4.2000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1146
    Cell Significance Index: -3.0700
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.1147
    Cell Significance Index: -1.5600
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.1163
    Cell Significance Index: -1.4900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1215
    Cell Significance Index: -3.0400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1236
    Cell Significance Index: -3.3000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1239
    Cell Significance Index: -3.5700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1335
    Cell Significance Index: -3.5100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1369
    Cell Significance Index: -3.3400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1388
    Cell Significance Index: -3.9800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1402
    Cell Significance Index: -3.0700
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.1404
    Cell Significance Index: -0.8600
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.1463
    Cell Significance Index: -1.7200
  • Cell Name: contractile cell (CL0000183)
    Fold Change: -0.1502
    Cell Significance Index: -0.2900
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1515
    Cell Significance Index: -2.2000
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.1608
    Cell Significance Index: -1.9400
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.1619
    Cell Significance Index: -2.1200
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.1647
    Cell Significance Index: -1.6300
  • Cell Name: peridermal cell (CL0000078)
    Fold Change: -0.1652
    Cell Significance Index: -1.0300
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1677
    Cell Significance Index: -2.1700
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.1698
    Cell Significance Index: -1.9700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1721
    Cell Significance Index: -3.5700
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.1723
    Cell Significance Index: -2.0100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1724
    Cell Significance Index: -3.6600
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.1738
    Cell Significance Index: -1.0200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1740
    Cell Significance Index: -3.7600
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.1766
    Cell Significance Index: -1.8300
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.1792
    Cell Significance Index: -1.3700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1795
    Cell Significance Index: -2.6900
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.1814
    Cell Significance Index: -2.3800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1828
    Cell Significance Index: -3.0600
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.1845
    Cell Significance Index: -2.7600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1850
    Cell Significance Index: -4.4800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1873
    Cell Significance Index: -3.7600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1891
    Cell Significance Index: -3.1800
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1915
    Cell Significance Index: -3.7500
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.1923
    Cell Significance Index: -2.4700
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1925
    Cell Significance Index: -2.6400
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.1942
    Cell Significance Index: -2.1200
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.1952
    Cell Significance Index: -2.0200
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1955
    Cell Significance Index: -3.3200
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.1965
    Cell Significance Index: -2.5700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcriptional Regulation:** FOXD3 acts as a transcriptional regulator by binding to specific DNA sequences, modulating the expression of target genes involved in cell proliferation, differentiation, and survival. 2. **Cell-Specific Expression:** FOXD3 is expressed in various cell types, including microglial cells, conventional dendritic cells, blood vessel endothelial cells, plasma cells, neural crest cells, granulocyte monocyte progenitor cells, and goblet cells. 3. **Differential Expression:** FOXD3 expression is regulated by various transcription factors, including Pou5f1 (Oct4), Sox2, and Nanog, which are essential for the maintenance of pluripotency in embryonic stem cells. **Pathways and Functions:** 1. **Developmental Biology:** FOXD3 is involved in the regulation of embryonic development, particularly in the context of neural crest cell migration and differentiation. 2. **Cell Differentiation:** FOXD3 regulates the expression of genes involved in cell differentiation, including the transition from a pluripotent state to a more differentiated state. 3. **Proliferation:** FOXD3 modulates the expression of genes involved in cell proliferation, including the regulation of the cell cycle and DNA synthesis. 4. **Immune Cell Development:** FOXD3 is essential for the development and function of various immune cells, including microglial cells, conventional dendritic cells, and plasma cells. 5. **Transcriptional Regulation:** FOXD3 acts as a transcriptional regulator by binding to specific DNA sequences, modulating the expression of target genes involved in cell proliferation, differentiation, and survival. **Clinical Significance:** 1. **Cancer:** Dysregulation of FOXD3 has been implicated in various types of cancer, including leukemia, lymphoma, and solid tumors. 2. **Autoimmune Disorders:** FOXD3 dysregulation has been linked to autoimmune disorders, including multiple sclerosis and rheumatoid arthritis. 3. **Neurological Disorders:** FOXD3 is involved in the regulation of neural crest cell migration and differentiation, and its dysregulation has been implicated in neurological disorders, including autism and schizophrenia. 4. **Regenerative Medicine:** FOXD3 is essential for the maintenance of pluripotency in embryonic stem cells, and its dysregulation has significant implications for regenerative medicine. In conclusion, FOXD3 is a crucial transcription factor involved in various cellular processes, including development, differentiation, and proliferation. Its dysregulation has significant implications for various diseases, including cancer, autoimmune disorders, and neurological disorders. Further research is necessary to fully elucidate the mechanisms by which FOXD3 regulates these processes and to explore its therapeutic potential in the treatment of these diseases.

Genular Protein ID: 3131184873

Symbol: FOXD3_HUMAN

Name: Forkhead box protein D3

UniProtKB Accession Codes:

Q9UJU5 Q9BYM2 Q9UDD1

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 8499623

Title: Drosophila forkhead homologues are expressed in a lineage-restricted manner in human hematopoietic cells.

PubMed ID: 8499623

PubMed ID: 11891324

Title: The embryonic stem cell transcription factors Oct-4 and FoxD3 interact to regulate endodermal-specific promoter expression.

PubMed ID: 11891324

DOI: 10.1073/pnas.062041099

PubMed ID: 16098053

Title: Candidate functional promoter variant in the FOXD3 melanoblast developmental regulator gene in autosomal dominant vitiligo.

PubMed ID: 16098053

DOI: 10.1111/j.0022-202x.2005.23822.x

PubMed ID: 22306510

Title: Identification of Rhit as a novel transcriptional repressor of human Mpv17-like protein with a mitigating effect on mitochondrial dysfunction, and its transcriptional regulation by FOXD3 and GABP.

PubMed ID: 22306510

DOI: 10.1016/j.freeradbiomed.2012.01.003

Sequence Information:

  • Length: 478
  • Mass: 47630
  • Checksum: 06163F6318FB13CB
  • Sequence:
    • MTLSGGGSAS DMSGQTVLTA EDVDIDVVGE GDDGLEEKDS DAGCDSPAGP PELRLDEADE 
VPPAAPHHGQ PQPPHQQPLT LPKEAAGAGA GPGGDVGAPE ADGCKGGVGG EEGGASGGGP 
GAGSGSAGGL APSKPKNSLV KPPYSYIALI TMAILQSPQK KLTLSGICEF ISNRFPYYRE 
KFPAWQNSIR HNLSLNDCFV KIPREPGNPG KGNYWTLDPQ SEDMFDNGSF LRRRKRFKRH 
QQEHLREQTA LMMQSFGAYS LAAAAGAAGP YGRPYGLHPA AAAGAYSHPA AAAAAAAAAA 
LQYPYALPPV APVLPPAVPL LPSGELGRKA AAFGSQLGPG LQLQLNSLGA AAAAAGTAGA 
AGTTASLIKS EPSARPSFSI ENIIGGGPAA PGGSAVGAGV AGGTGGSGGG STAQSFLRPP 
GTVQSAALMA THQPLSLSRT TATIAPILSV PLSGQFLQPA ASAAAAAAAA AQAKWPAQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.