Details for: CACNG5

Gene ID: 27091

Symbol: CACNG5

Ensembl ID: ENSG00000075429

Description: calcium voltage-gated channel auxiliary subunit gamma 5

Associated with

  • Ampa glutamate receptor complex
    (GO:0032281)
  • Calcium ion transmembrane transport
    (GO:0070588)
  • Channel regulator activity
    (GO:0016247)
  • Glutamatergic synapse
    (GO:0098978)
  • Monoatomic ion transmembrane transporter activity
    (GO:0015075)
  • Neurotransmitter receptor internalization
    (GO:0099590)
  • Neurotransmitter receptor transport, postsynaptic endosome to lysosome
    (GO:0098943)
  • Positive regulation of synaptic transmission, glutamatergic
    (GO:0051968)
  • Postsynaptic density
    (GO:0014069)
  • Postsynaptic density membrane
    (GO:0098839)
  • Postsynaptic neurotransmitter receptor diffusion trapping
    (GO:0098970)
  • Regulation of ampa receptor activity
    (GO:2000311)
  • Transmission of nerve impulse
    (GO:0019226)
  • Voltage-gated calcium channel activity
    (GO:0005245)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 2.6458
    Cell Significance Index: 37.1600
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 0.9197
    Cell Significance Index: 9.5800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.7268
    Cell Significance Index: 9.0200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.4361
    Cell Significance Index: 6.2500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.4261
    Cell Significance Index: 9.3300
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.3598
    Cell Significance Index: 2.9700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2095
    Cell Significance Index: 11.7600
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.1575
    Cell Significance Index: 2.3000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1361
    Cell Significance Index: 94.1600
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: 0.1347
    Cell Significance Index: 1.6800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.1245
    Cell Significance Index: 3.2000
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0935
    Cell Significance Index: 2.3300
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.0715
    Cell Significance Index: 0.5200
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.0326
    Cell Significance Index: 0.3500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0237
    Cell Significance Index: 4.7600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0016
    Cell Significance Index: -2.9700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0019
    Cell Significance Index: -3.5800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0034
    Cell Significance Index: -5.1600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0037
    Cell Significance Index: -5.0100
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0063
    Cell Significance Index: -0.0800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0076
    Cell Significance Index: -5.6000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0103
    Cell Significance Index: -6.5400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0107
    Cell Significance Index: -0.3000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0124
    Cell Significance Index: -6.9700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0128
    Cell Significance Index: -4.6000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0139
    Cell Significance Index: -6.3300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0204
    Cell Significance Index: -1.0700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0215
    Cell Significance Index: -6.2000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0260
    Cell Significance Index: -5.1600
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0282
    Cell Significance Index: -0.3700
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: -0.0342
    Cell Significance Index: -0.1800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0361
    Cell Significance Index: -6.5000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0367
    Cell Significance Index: -7.7400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0384
    Cell Significance Index: -6.5500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0407
    Cell Significance Index: -5.9200
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0449
    Cell Significance Index: -0.6300
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0531
    Cell Significance Index: -0.3600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0568
    Cell Significance Index: -6.9900
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.0611
    Cell Significance Index: -0.8000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0652
    Cell Significance Index: -6.7900
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0662
    Cell Significance Index: -0.9900
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0675
    Cell Significance Index: -0.6400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0717
    Cell Significance Index: -4.4100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0745
    Cell Significance Index: -1.1000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0750
    Cell Significance Index: -8.6000
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.0965
    Cell Significance Index: -0.8400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1053
    Cell Significance Index: -8.0800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1063
    Cell Significance Index: -1.7900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1102
    Cell Significance Index: -2.1500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1157
    Cell Significance Index: -4.3800
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.1181
    Cell Significance Index: -0.9400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1185
    Cell Significance Index: -7.9700
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: -0.1190
    Cell Significance Index: -1.1200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1268
    Cell Significance Index: -2.5100
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.1300
    Cell Significance Index: -1.6800
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.1303
    Cell Significance Index: -1.5800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1362
    Cell Significance Index: -2.8900
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1399
    Cell Significance Index: -2.9200
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.1413
    Cell Significance Index: -1.5300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1509
    Cell Significance Index: -4.9400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1531
    Cell Significance Index: -6.7700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1560
    Cell Significance Index: -7.3300
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.1566
    Cell Significance Index: -1.6200
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.1571
    Cell Significance Index: -2.0600
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: -0.1612
    Cell Significance Index: -1.3200
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.1621
    Cell Significance Index: -1.8500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1663
    Cell Significance Index: -2.8500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1696
    Cell Significance Index: -5.9400
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -0.1744
    Cell Significance Index: -1.6700
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.1755
    Cell Significance Index: -2.2900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1803
    Cell Significance Index: -3.6200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1805
    Cell Significance Index: -7.4000
  • Cell Name: flat midget bipolar cell (CL4033033)
    Fold Change: -0.1842
    Cell Significance Index: -2.2900
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.1937
    Cell Significance Index: -2.2600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1937
    Cell Significance Index: -6.1700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1940
    Cell Significance Index: -5.5900
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: -0.1940
    Cell Significance Index: -2.2500
  • Cell Name: immature NK T cell (CL0000914)
    Fold Change: -0.1953
    Cell Significance Index: -2.5000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2012
    Cell Significance Index: -4.8300
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.2076
    Cell Significance Index: -2.2100
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: -0.2088
    Cell Significance Index: -2.1600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2106
    Cell Significance Index: -4.5500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2132
    Cell Significance Index: -5.3300
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.2164
    Cell Significance Index: -2.0800
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.2224
    Cell Significance Index: -2.0100
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.2262
    Cell Significance Index: -2.1400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2299
    Cell Significance Index: -2.7400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.2316
    Cell Significance Index: -5.6500
  • Cell Name: group 3 innate lymphoid cell, human (CL0001078)
    Fold Change: -0.2359
    Cell Significance Index: -2.2100
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.2376
    Cell Significance Index: -2.8000
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.2382
    Cell Significance Index: -3.2200
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.2418
    Cell Significance Index: -2.6500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2419
    Cell Significance Index: -6.4600
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.2496
    Cell Significance Index: -2.2200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2504
    Cell Significance Index: -6.2500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.2552
    Cell Significance Index: -8.0700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2570
    Cell Significance Index: -6.4200
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.2571
    Cell Significance Index: -2.0300
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.2597
    Cell Significance Index: -1.3600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2618
    Cell Significance Index: -5.4300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CACNG5 is a gamma subunit of the voltage-gated calcium channel, which is a heteromeric complex composed of alpha, beta, gamma, delta, and epsilon subunits. The gamma subunit, specifically CACNG5, is involved in the modulation of calcium channel activity, influencing the influx of calcium ions into the cell. This calcium influx is essential for various cellular processes, including neurotransmitter release, muscle contraction, and cell signaling. **Pathways and Functions** CACNG5 is involved in several critical signaling pathways, including: 1. **Ampa glutamate receptor complex**: CACNG5 interacts with the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor complex, modulating the release of glutamate, the primary excitatory neurotransmitter in the brain. 2. **Calcium ion transmembrane transport**: CACNG5 regulates the influx of calcium ions into the cell, which is essential for various cellular processes, including neurotransmitter release and muscle contraction. 3. **Channel regulator activity**: CACNG5 modulates the activity of voltage-gated calcium channels, influencing the flow of calcium ions into the cell. 4. **Glutamatergic synapse**: CACNG5 plays a crucial role in the regulation of glutamatergic synapses, which are essential for learning and memory. **Clinical Significance** Dysregulation of CACNG5 has been implicated in various neurological and psychiatric disorders, including: 1. **Epilepsy**: Altered expression of CACNG5 has been observed in patients with epilepsy, suggesting its potential role in the regulation of seizure activity. 2. **Mood disorders**: CACNG5 has been linked to mood disorders, such as depression and bipolar disorder, which may be related to its role in regulating glutamatergic neurotransmission. 3. **Neurodegenerative diseases**: CACNG5 has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, which may be related to its role in regulating calcium ion flow and neurotransmitter release. In conclusion, CACNG5 is a critical gene that plays a significant role in the regulation of calcium ion flow and neurotransmitter release in the nervous system. Its dysregulation has been implicated in various neurological and psychiatric disorders, highlighting the importance of further research into its role in human health and disease.

Genular Protein ID: 1181098606

Symbol: CCG5_HUMAN

Name: Voltage-dependent calcium channel gamma-5 subunit

UniProtKB Accession Codes:

Q9UF02 A8K2A6 Q547R3 Q8WXS7 Q9UHM3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 7 EMBL 10 Ensembl 2 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10613843

Title: Identification of three novel Ca(2+) channel gamma subunit genes reveals molecular diversification by tandem and chromosome duplication.

PubMed ID: 10613843

DOI: 10.1101/gr.9.12.1204

PubMed ID: 11738816

Title: Calcium channel gamma subunits provide insights into the evolution of this gene family.

PubMed ID: 11738816

DOI: 10.1016/s0378-1119(01)00738-7

PubMed ID: 11927536

Title: The novel product of a five-exon stargazin-related gene abolishes CaV2.2 calcium channel expression.

PubMed ID: 11927536

DOI: 10.1093/emboj/21.7.1514

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 275
  • Mass: 30903
  • Checksum: 889E04DAC036C2AE
  • Sequence:
    • MSACGRKALT LLSSVFAVCG LGLLGIAVST DYWLYLEEGV IVPQNQSTEI KMSLHSGLWR 
VCFLAGEERG RCFTIEYVMP MNTQLTSEST VNVLKMIRSA TPFPLVSLFF MFIGFILNNI 
GHIRPHRTIL AFVSGIFFIL SGLSLVVGLV LYISSINDEM LNRTKDAETY FNYKYGWSFA 
FAAISFLLTE SAGVMSVYLF MKRYTAEDMY RPHPGFYRPR LSNCSDYSGQ FLHPDAWVRG 
RSPSDISSEA SLQMNSNYPA LLKCPDYDQM SSSPC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.