Details for: DKK4

Gene ID: 27121

Symbol: DKK4

Ensembl ID: ENSG00000104371

Description: dickkopf WNT signaling pathway inhibitor 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 3.1558
    Cell Significance Index: 29.6900
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.4842
    Cell Significance Index: 16.4900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 2.1058
    Cell Significance Index: 67.4500
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.0066
    Cell Significance Index: 15.0600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.8348
    Cell Significance Index: 11.3900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6414
    Cell Significance Index: 33.3200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4446
    Cell Significance Index: 26.6900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4437
    Cell Significance Index: 84.4400
  • Cell Name: epithelial cell of lacrimal sac (CL1000436)
    Fold Change: 0.4099
    Cell Significance Index: 2.9500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.4081
    Cell Significance Index: 10.7300
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.2976
    Cell Significance Index: 2.4600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2470
    Cell Significance Index: 26.8700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2367
    Cell Significance Index: 46.9700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1772
    Cell Significance Index: 17.5300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1129
    Cell Significance Index: 7.8100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0999
    Cell Significance Index: 16.2500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0981
    Cell Significance Index: 2.6700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0961
    Cell Significance Index: 86.7800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0632
    Cell Significance Index: 1.8200
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.0488
    Cell Significance Index: 0.4200
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.0386
    Cell Significance Index: 0.5500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.0158
    Cell Significance Index: 0.2800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0144
    Cell Significance Index: 2.6000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.0144
    Cell Significance Index: 0.5300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0127
    Cell Significance Index: 0.2700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0099
    Cell Significance Index: 1.1500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0083
    Cell Significance Index: 0.2900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0052
    Cell Significance Index: 0.6400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0051
    Cell Significance Index: 0.1100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0043
    Cell Significance Index: 0.0500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.0023
    Cell Significance Index: 0.1400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0002
    Cell Significance Index: 0.0100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0012
    Cell Significance Index: -2.3200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0013
    Cell Significance Index: -0.0500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0015
    Cell Significance Index: -2.1000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0015
    Cell Significance Index: -0.0700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0019
    Cell Significance Index: -0.8500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0024
    Cell Significance Index: -1.8000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0031
    Cell Significance Index: -1.7300
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0031
    Cell Significance Index: -0.0400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0038
    Cell Significance Index: -0.7600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0039
    Cell Significance Index: -2.4700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0039
    Cell Significance Index: -2.1400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0039
    Cell Significance Index: -1.7600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0057
    Cell Significance Index: -1.6500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0062
    Cell Significance Index: -1.3100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0068
    Cell Significance Index: -0.7800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0071
    Cell Significance Index: -2.5400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0087
    Cell Significance Index: -1.1100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0108
    Cell Significance Index: -1.8400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0158
    Cell Significance Index: -2.2900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0162
    Cell Significance Index: -2.2300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0175
    Cell Significance Index: -2.2600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0206
    Cell Significance Index: -0.3100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0211
    Cell Significance Index: -0.5400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0214
    Cell Significance Index: -1.5100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0239
    Cell Significance Index: -0.6700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0241
    Cell Significance Index: -2.4600
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0248
    Cell Significance Index: -0.6200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0251
    Cell Significance Index: -0.2900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0309
    Cell Significance Index: -2.0800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0310
    Cell Significance Index: -2.3100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0311
    Cell Significance Index: -1.4500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0365
    Cell Significance Index: -1.7200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0423
    Cell Significance Index: -1.1300
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0453
    Cell Significance Index: -0.4200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0486
    Cell Significance Index: -2.5300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0494
    Cell Significance Index: -2.7700
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0509
    Cell Significance Index: -0.7600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0520
    Cell Significance Index: -1.8200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0531
    Cell Significance Index: -1.7400
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0532
    Cell Significance Index: -0.7300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0537
    Cell Significance Index: -1.7100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0587
    Cell Significance Index: -0.8400
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0613
    Cell Significance Index: -0.8900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0622
    Cell Significance Index: -2.7500
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.0646
    Cell Significance Index: -0.4000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0657
    Cell Significance Index: -1.7600
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0664
    Cell Significance Index: -2.1000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0669
    Cell Significance Index: -1.4000
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0711
    Cell Significance Index: -1.0800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0729
    Cell Significance Index: -2.7600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0730
    Cell Significance Index: -1.3500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0732
    Cell Significance Index: -2.0900
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0749
    Cell Significance Index: -0.7900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0766
    Cell Significance Index: -2.0500
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.0784
    Cell Significance Index: -1.2600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0785
    Cell Significance Index: -2.2500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0790
    Cell Significance Index: -1.9700
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0818
    Cell Significance Index: -1.4100
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0835
    Cell Significance Index: -1.7000
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: -0.0838
    Cell Significance Index: -1.0400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0863
    Cell Significance Index: -2.1100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0870
    Cell Significance Index: -1.8800
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0870
    Cell Significance Index: -1.1600
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: -0.0874
    Cell Significance Index: -0.4300
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.0889
    Cell Significance Index: -0.9700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0891
    Cell Significance Index: -1.9500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0900
    Cell Significance Index: -1.9100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** DKK4 is a member of the Dickkopf family of proteins, which are known to inhibit WNT signaling pathways. DKK4 is a secreted protein that binds to WNT ligands and prevents their interaction with their receptors, thereby inhibiting the activation of the WNT signaling cascade. DKK4 is highly expressed in various tissues, including the brain, immune cells, and epithelial tissues, where it plays a crucial role in regulating cell growth, differentiation, and survival. **Pathways and Functions:** DKK4 is involved in several WNT signaling pathways, including: 1. **Negative regulation of canonical WNT signaling pathway**: DKK4 inhibits the activity of WNT ligands, which are essential for the activation of the canonical WNT signaling pathway. 2. **Negative regulation of hair follicle placode formation**: DKK4 is essential for the proper formation and maintenance of hair follicles, and its dysregulation can lead to abnormalities in hair growth. 3. **Negative regulation of tcf-dependent signaling by WNT ligand antagonists**: DKK4 inhibits the activity of tcf-dependent signaling pathways, which are essential for the regulation of WNT signaling. 4. **Negative regulation of WNT signaling pathway**: DKK4 is a negative regulator of the WNT signaling pathway, meaning it inhibits the activity of WNT ligands and their downstream effectors. 5. **Protein binding and receptor antagonist activity**: DKK4 binds to WNT ligands and prevents their interaction with their receptors, thereby inhibiting the activation of the WNT signaling cascade. **Clinical Significance:** DKK4 has been implicated in various diseases, including: 1. **Cancer**: DKK4 is often downregulated in cancer cells, leading to the activation of the WNT signaling pathway and the promotion of tumor growth and metastasis. 2. **Neurological disorders**: DKK4 has been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis. 3. **Immune system disorders**: DKK4 is essential for the regulation of the immune system, and its dysregulation can lead to abnormalities in immune cell function and disease. 4. **Gastrointestinal disorders**: DKK4 is involved in the regulation of gut homeostasis, and its dysregulation can lead to abnormalities in gut function and disease. In conclusion, DKK4 is a critical regulator of WNT signaling pathways, and its dysregulation can lead to various diseases. Further research is needed to fully understand the role of DKK4 in human diseases and to explore its potential as a therapeutic target.

Genular Protein ID: 584109189

Symbol: DKK4_HUMAN

Name: Dickkopf-related protein 4

UniProtKB Accession Codes:

Q9UBT3 Q3KNX0 Q9Y4C3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 3 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 10570958

Title: Functional and structural diversity of the human Dickkopf gene family.

PubMed ID: 10570958

DOI: 10.1016/s0378-1119(99)00365-0

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 17143291

Title: Function and biological roles of the Dickkopf family of Wnt modulators.

PubMed ID: 17143291

DOI: 10.1038/sj.onc.1210054

Sequence Information:

  • Length: 224
  • Mass: 24876
  • Checksum: 45F8EBC476961357
  • Sequence:
    • MVAAVLLGLS WLCSPLGALV LDFNNIRSSA DLHGARKGSQ CLSDTDCNTR KFCLQPRDEK 
PFCATCRGLR RRCQRDAMCC PGTLCVNDVC TTMEDATPIL ERQLDEQDGT HAEGTTGHPV 
QENQPKRKPS IKKSQGRKGQ EGESCLRTFD CGPGLCCARH FWTKICKPVL LEGQVCSRRG 
HKDTAQAPEI FQRCDCGPGL LCRSQLTSNR QHARLRVCQK IEKL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.