Details for: PALD1

Gene ID: 27143

Symbol: PALD1

Ensembl ID: ENSG00000107719

Description: phosphatase domain containing paladin 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 45.1421
    Cell Significance Index: -11.4500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 9.6232
    Cell Significance Index: -11.8700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.4001
    Cell Significance Index: -9.6300
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.6464
    Cell Significance Index: 23.6800
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.7859
    Cell Significance Index: 8.1400
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.6611
    Cell Significance Index: 7.2200
  • Cell Name: endothelial stalk cell (CL0002671)
    Fold Change: 0.6234
    Cell Significance Index: 6.9900
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.5554
    Cell Significance Index: 6.8700
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.5287
    Cell Significance Index: 6.3500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3264
    Cell Significance Index: 25.0500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.3186
    Cell Significance Index: 6.8100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2830
    Cell Significance Index: 56.7600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1959
    Cell Significance Index: 13.1700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1853
    Cell Significance Index: 36.7700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1256
    Cell Significance Index: 14.8100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0977
    Cell Significance Index: 0.5900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0692
    Cell Significance Index: 2.6200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0629
    Cell Significance Index: 39.9500
  • Cell Name: surface ectodermal cell (CL0000114)
    Fold Change: 0.0545
    Cell Significance Index: 0.4300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0430
    Cell Significance Index: 15.4100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0314
    Cell Significance Index: 14.2600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0271
    Cell Significance Index: 51.1000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0224
    Cell Significance Index: 34.5200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0116
    Cell Significance Index: 6.3600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0021
    Cell Significance Index: -0.1200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0028
    Cell Significance Index: -5.1800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0048
    Cell Significance Index: -0.0800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0049
    Cell Significance Index: -6.7000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0065
    Cell Significance Index: -1.1100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0074
    Cell Significance Index: -1.0800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0093
    Cell Significance Index: -0.1600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0147
    Cell Significance Index: -10.7800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0154
    Cell Significance Index: -11.6500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0164
    Cell Significance Index: -12.1200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0176
    Cell Significance Index: -7.8000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0196
    Cell Significance Index: -12.2200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0200
    Cell Significance Index: -2.2900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0212
    Cell Significance Index: -11.9500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0270
    Cell Significance Index: -7.7600
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0278
    Cell Significance Index: -0.3900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0358
    Cell Significance Index: -3.6600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0389
    Cell Significance Index: -1.7200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0400
    Cell Significance Index: -7.2100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0410
    Cell Significance Index: -5.2600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0516
    Cell Significance Index: -7.0800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0583
    Cell Significance Index: -12.2700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0641
    Cell Significance Index: -7.4700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0687
    Cell Significance Index: -4.2200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0736
    Cell Significance Index: -9.0500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0741
    Cell Significance Index: -2.0700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0748
    Cell Significance Index: -2.0000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0756
    Cell Significance Index: -9.7700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0862
    Cell Significance Index: -8.9800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1006
    Cell Significance Index: -4.7300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1223
    Cell Significance Index: -4.2500
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.1336
    Cell Significance Index: -1.0600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1442
    Cell Significance Index: -2.0700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1458
    Cell Significance Index: -10.8700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1536
    Cell Significance Index: -9.9100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1749
    Cell Significance Index: -4.6000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1991
    Cell Significance Index: -2.9400
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: -0.2037
    Cell Significance Index: -1.2600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2041
    Cell Significance Index: -7.1500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2118
    Cell Significance Index: -11.1200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2171
    Cell Significance Index: -11.2800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2180
    Cell Significance Index: -5.2800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2314
    Cell Significance Index: -10.4900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2374
    Cell Significance Index: -5.9200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2421
    Cell Significance Index: -7.7100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2518
    Cell Significance Index: -11.7400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2614
    Cell Significance Index: -7.4600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2633
    Cell Significance Index: -8.6200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2834
    Cell Significance Index: -5.6900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2928
    Cell Significance Index: -7.4800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2946
    Cell Significance Index: -12.8100
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.2990
    Cell Significance Index: -3.5200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3110
    Cell Significance Index: -9.1600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3149
    Cell Significance Index: -11.5600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3423
    Cell Significance Index: -8.2100
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.3506
    Cell Significance Index: -11.0900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3507
    Cell Significance Index: -7.6800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3523
    Cell Significance Index: -10.1000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.3603
    Cell Significance Index: -12.6600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3606
    Cell Significance Index: -9.2700
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.3691
    Cell Significance Index: -7.5100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3717
    Cell Significance Index: -9.9600
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.3729
    Cell Significance Index: -4.6500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3739
    Cell Significance Index: -10.9800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3784
    Cell Significance Index: -9.4400
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.3969
    Cell Significance Index: -5.0900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.4057
    Cell Significance Index: -9.9000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.4059
    Cell Significance Index: -6.2800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.4093
    Cell Significance Index: -10.9300
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.4247
    Cell Significance Index: -5.3600
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.4248
    Cell Significance Index: -7.3500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.4304
    Cell Significance Index: -12.4000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4335
    Cell Significance Index: -9.2000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.4504
    Cell Significance Index: -9.7300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.4517
    Cell Significance Index: -22.8300
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.4523
    Cell Significance Index: -4.3000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Phosphatase Domain Containing**: PALD1 encodes for a protein that possesses a phosphatase domain, a characteristic shared by several enzymes involved in protein dephosphorylation. 2. **Paladin Protein**: The protein product of PALD1, Paladin, is a multifunctional protein that interacts with various signaling molecules and receptors. 3. **Tyrosine Phosphatase Activity**: Paladin exhibits significant tyrosine phosphatase activity, which is essential for regulating protein-protein interactions and signal transduction pathways. 4. **Tissue-Specific Expression**: PALD1 is significantly expressed in various cell types, including mature microglial cells, central nervous system macrophages, and endothelial cells, highlighting its role in immune regulation and vascular function. **Pathways and Functions:** 1. **Immune Cell Signaling**: PALD1 regulates immune cell signaling by modulating protein-protein interactions and tyrosine phosphorylation events. This affects the function of immune cells, such as microglial cells and macrophages, and influences the development of immune-related disorders. 2. **Cytoskeletal Dynamics**: Paladin's phosphatase activity regulates cytoskeletal dynamics, which is essential for cell migration, adhesion, and morphology. 3. **Endothelial Function**: PALD1 is expressed in endothelial cells, where it regulates vascular permeability, angiogenesis, and inflammation. 4. **Cell Proliferation and Survival**: PALD1's tyrosine phosphatase activity also regulates cell proliferation and survival pathways, influencing the development of various diseases. **Clinical Significance:** 1. **Neurological Disorders**: PALD1's role in regulating immune cell function and microglial activity makes it a potential therapeutic target for neurodegenerative diseases, such as Alzheimer's and Parkinson's. 2. **Vascular Diseases**: The gene's expression in endothelial cells and its involvement in vascular permeability and angiogenesis suggest its potential role in cardiovascular diseases, such as atherosclerosis and hypertension. 3. **Cancer**: PALD1's tyrosine phosphatase activity may also contribute to cancer development and progression, particularly in immune-related cancers, such as melanoma and ovarian cancer. 4. **Inflammatory Disorders**: The gene's expression in mononuclear cells and its involvement in immune cell signaling make it a potential therapeutic target for inflammatory disorders, such as rheumatoid arthritis and multiple sclerosis. In conclusion, PALD1 is a multifaceted gene that plays a critical role in regulating immune cell function, endothelial biology, and cellular signaling pathways. Further research is necessary to elucidate the intricate mechanisms underlying PALD1's functions and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 2098795933

Symbol: PALD_HUMAN

Name: Paladin

UniProtKB Accession Codes:

Q9ULE6 B2RMS1 B9EGC6 Q5JTK7 Q5JTK8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DEPOD 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 3 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 4 SMART 2 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10574462

Title: Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10574462

DOI: 10.1093/dnares/6.5.337

PubMed ID: 12168954

Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

PubMed ID: 12168954

DOI: 10.1093/dnares/9.3.99

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 20213681

Title: Strategy for comprehensive identification of human N-myristoylated proteins using an insect cell-free protein synthesis system.

PubMed ID: 20213681

DOI: 10.1002/pmic.200900783

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22354871

Title: Paladin (X99384) is expressed in the vasculature and shifts from endothelial to vascular smooth muscle cells during mouse development.

PubMed ID: 22354871

DOI: 10.1002/dvdy.23753

Sequence Information:

  • Length: 856
  • Mass: 96754
  • Checksum: BFCDD78DB2D4BE3B
  • Sequence:
    • MGTTASTAQQ TVSAGTPFEG LQGSGTMDSR HSVSIHSFQS TSLHNSKAKS IIPNKVAPVV 
ITYNCKEEFQ IHDELLKAHY TLGRLSDNTP EHYLVQGRYF LVRDVTEKMD VLGTVGSCGA 
PNFRQVQGGL TVFGMGQPSL SGFRRVLQKL QKDGHRECVI FCVREEPVLF LRADEDFVSY 
TPRDKQNLHE NLQGLGPGVR VESLELAIRK EIHDFAQLSE NTYHVYHNTE DLWGEPHAVA 
IHGEDDLHVT EEVYKRPLFL QPTYRYHRLP LPEQGSPLEA QLDAFVSVLR ETPSLLQLRD 
AHGPPPALVF SCQMGVGRTN LGMVLGTLIL LHRSGTTSQP EAAPTQAKPL PMEQFQVIQS 
FLRMVPQGRR MVEEVDRAIT ACAELHDLKE VVLENQKKLE GIRPESPAQG SGSRHSVWQR 
ALWSLERYFY LILFNYYLHE QYPLAFALSF SRWLCAHPEL YRLPVTLSSA GPVAPRDLIA 
RGSLREDDLV SPDALSTVRE MDVANFRRVP RMPIYGTAQP SAKALGSILA YLTDAKRRLR 
KVVWVSLREE AVLECDGHTY SLRWPGPPVA PDQLETLEAQ LKAHLSEPPP GKEGPLTYRF 
QTCLTMQEVF SQHRRACPGL TYHRIPMPDF CAPREEDFDQ LLEALRAALS KDPGTGFVFS 
CLSGQGRTTT AMVVAVLAFW HIQGFPEVGE EELVSVPDAK FTKGEFQVVM KVVQLLPDGH 
RVKKEVDAAL DTVSETMTPM HYHLREIIIC TYRQAKAAKE AQEMRRLQLR SLQYLERYVC 
LILFNAYLHL EKADSWQRPF STWMQEVASK AGIYEILNEL GFPELESGED QPFSRLRYRW 
QEQSCSLEPS APEDLL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.