Details for: GP1BA

Gene ID: 2811

Symbol: GP1BA

Ensembl ID: ENSG00000185245

Description: glycoprotein Ib platelet subunit alpha

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1169
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.53
    Marker Score: 638
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 169894
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 854
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71831
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48056
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 506
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 459
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5338
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 371
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2739
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 323
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.9
    Marker Score: 372
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5288
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.83
    Marker Score: 381
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1261
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 708
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.77
    Marker Score: 172
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 394
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.71
    Marker Score: 2975
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.65
    Marker Score: 493
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.64
    Marker Score: 1204
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.59
    Marker Score: 390
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.59
    Marker Score: 1191
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.57
    Marker Score: 283.5
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.54
    Marker Score: 8512
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.54
    Marker Score: 348
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 170
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 274
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.45
    Marker Score: 643
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.41
    Marker Score: 856
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.35
    Marker Score: 110
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.3
    Marker Score: 1974
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.25
    Marker Score: 113
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.24
    Marker Score: 146
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: 0.23
    Marker Score: 64
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 62
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.21
    Marker Score: 71
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.21
    Marker Score: 99
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.19
    Marker Score: 50
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.18
    Marker Score: 103
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.17
    Marker Score: 129
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.16
    Marker Score: 40
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.16
    Marker Score: 54
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.15
    Marker Score: 63
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.15
    Marker Score: 44
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.14
    Marker Score: 60
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.13
    Marker Score: 314
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.13
    Marker Score: 85
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.12
    Marker Score: 124
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.11
    Marker Score: 54
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.11
    Marker Score: 60
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.11
    Marker Score: 2418
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1
    Marker Score: 285
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.1
    Marker Score: 32
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.1
    Marker Score: 95
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.1
    Marker Score: 51
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.09
    Marker Score: 18
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.09
    Marker Score: 140
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.09
    Marker Score: 24
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.09
    Marker Score: 19
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.09
    Marker Score: 157
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.08
    Marker Score: 31
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.08
    Marker Score: 65
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.08
    Marker Score: 97
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.08
    Marker Score: 57
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.08
    Marker Score: 18
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.08
    Marker Score: 25
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.08
    Marker Score: 460
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.08
    Marker Score: 19
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.08
    Marker Score: 40
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.08
    Marker Score: 37
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.08
    Marker Score: 19
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.08
    Marker Score: 27
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.07
    Marker Score: 19
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.07
    Marker Score: 628
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.07
    Marker Score: 22
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.07
    Marker Score: 19
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.07
    Marker Score: 36
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.07
    Marker Score: 32
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: follicular dendritic cell (CL0000442)
    Fold Change: 0.07
    Marker Score: 25
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.07
    Marker Score: 16
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.07
    Marker Score: 183
  • Cell Name: bronchial smooth muscle cell (CL0002598)
    Fold Change: 0.07
    Marker Score: 19
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.07
    Marker Score: 30
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.07
    Marker Score: 17
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.07
    Marker Score: 21
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.07
    Marker Score: 114
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.07
    Marker Score: 19
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.06
    Marker Score: 16
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.06
    Marker Score: 229
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.06
    Marker Score: 16

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Other Information

## Summary GP1BA is a glycoprotein expressed on platelets, which are crucial for blood clotting. It plays a significant role in the platelet aggregation cascade by binding to von Willebrand factor (VWF) and triggering the activation of factor IX. GP1BA is also involved in the intrinsic pathway of fibrin clot formation, where it forms a complex with von Willebrand factor (VWF) and activates factor IX. ## Key characteristics * GP1BA is a glycoprotein with a molecular weight of approximately 120 kDa. * It is expressed on platelets and other blood cells. * It is a key regulator of blood clotting. * It binds to von Willebrand factor (VWF) and triggers the activation of factor IX. * It also plays a role in the intrinsic pathway of fibrin clot formation. ## Pathways and functions * GP1BA is involved in the platelet aggregation cascade. * It binds to von Willebrand factor (VWF) and triggers the activation of factor IX. * Factor IX is a key protein in the coagulation cascade. * GP1BA also plays a role in the intrinsic pathway of fibrin clot formation. * It forms a complex with VWF and activates factor IX, which is necessary for the formation of a blood clot. ## Clinical significance GP1BA gene mutations can lead to hemophilia b, a genetic disorder caused by a deficiency of factor IX. Factor IX is essential for the conversion of fibrinogen into fibrin, which is a protein that is necessary for blood clotting. People with hemophilia b have a severe form of the disorder, and they often die before the age of 5. GP1BA gene variants have also been linked to other clotting disorders, such as von Willebrand disease and thrombocytopenia. These disorders are caused by mutations in genes that are involved in the coagulation cascade. GP1BA is a promising target for the treatment of clotting disorders. By inhibiting GP1BA, it is possible to prevent the formation of blood clots and save lives.

Genular Protein ID: 151557369

Symbol: GP1BA_HUMAN

Name: Platelet glycoprotein Ib alpha chain

UniProtKB Accession Codes:

P07359 E7ES66 Q14441 Q16469 Q8N1F3 Q8NG39 Q9HDC7 Q9UEK1 Q9UQS4

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChEMBL 1 ComplexPortal 2 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 EMBL 11 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 21 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 9 MINT 1 MalaCards 1 MassIVE 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 4 OrthoDB 1 PANTHER 2 PDB 28 PDBsum 19 PIR 2 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 6 RefSeq 1 SAM 1 SIGNOR 1 SMART 4 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3303030

Title: Cloning of the alpha chain of human platelet glycoprotein Ib: a transmembrane protein with homology to leucine-rich alpha 2-glycoprotein.

PubMed ID: 3303030

DOI: 10.1073/pnas.84.16.5615

PubMed ID: 2845978

Title: Structure of the human blood platelet membrane glycoprotein Ib alpha gene.

PubMed ID: 2845978

DOI: 10.1016/s0006-291x(88)80853-2

PubMed ID: 12038791

Title: A novel polymorphism, 70Leu/Phe, disrupts a consensus Leu residue within the leucine-rich repeat sequence of platelet glycoprotein Ibalpha.

PubMed ID: 12038791

PubMed ID: 14521605

Title: Identification of a novel point mutation in platelet glycoprotein Ibalpha, Gly to Ser at residue 233, in a Japanese family with platelet-type von Willebrand disease.

PubMed ID: 14521605

DOI: 10.1046/j.1538-7836.2003.00369.x

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3497398

Title: Amino acid sequence of the von Willebrand factor-binding domain of platelet membrane glycoprotein Ib.

PubMed ID: 3497398

DOI: 10.1073/pnas.84.16.5610

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 9088113

Title: StyI polymorphism at nucleotide 1610 in the human platelet glycoprotein Ib alpha gene.

PubMed ID: 9088113

DOI: 10.1007/bf01876333

PubMed ID: 2070794

Title: Identification of the disulphide bonds in human platelet glycocalicin.

PubMed ID: 2070794

DOI: 10.1111/j.1432-1033.1991.tb16135.x

PubMed ID: 9651345

Title: Human beta-filamin is a new protein that interacts with the cytoplasmic tail of glycoprotein Ibalpha.

PubMed ID: 9651345

DOI: 10.1074/jbc.273.28.17531

PubMed ID: 16263699

Title: Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach.

PubMed ID: 16263699

DOI: 10.1074/mcp.m500324-mcp200

PubMed ID: 17008541

Title: Glycoprotein Ibalpha forms disulfide bonds with 2 glycoprotein Ibbeta subunits in the resting platelet.

PubMed ID: 17008541

DOI: 10.1182/blood-2006-05-024091

PubMed ID: 17445093

Title: Controlled shedding of platelet glycoprotein (GP)VI and GPIb-IX-V by ADAM family metalloproteinases.

PubMed ID: 17445093

DOI: 10.1111/j.1538-7836.2007.02590.x

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 19828450

Title: Identification and characterization of multiple similar ligand-binding repeats in filamin: implication on filamin-mediated receptor clustering and cross-talk.

PubMed ID: 19828450

DOI: 10.1074/jbc.m109.060954

PubMed ID: 21552524

Title: GPVI and GPIbalpha mediate staphylococcal superantigen-like protein 5 (SSL5) induced platelet activation and direct toward glycans as potential inhibitors.

PubMed ID: 21552524

DOI: 10.1371/journal.pone.0019190

PubMed ID: 36740532

Title: Comprehensive analysis of platelet glycoprotein Ibalpha ectodomain glycosylation.

PubMed ID: 36740532

DOI: 10.1016/j.jtha.2023.01.009

PubMed ID: 12087105

Title: Crystal structure of the platelet glycoprotein Ibalpha N-terminal domain reveals an unmasking mechanism for receptor activation.

PubMed ID: 12087105

DOI: 10.1074/jbc.m205271200

PubMed ID: 12183630

Title: Structures of glycoprotein Ibalpha and its complex with von Willebrand factor A1 domain.

PubMed ID: 12183630

DOI: 10.1126/science.107355

PubMed ID: 11858495

Title: Molecular modeling of the seven tandem leucine-rich repeats within the ligand-binding region of platelet glycoprotein Ib alpha.

PubMed ID: 11858495

PubMed ID: 1586750

Title: Genetic and structural characterization of an amino acid dimorphism in glycoprotein Ib alpha involved in platelet transfusion refractoriness.

PubMed ID: 1586750

PubMed ID: 1730088

Title: Mutation of leucine-57 to phenylalanine in a platelet glycoprotein Ib alpha leucine tandem repeat occurring in patients with an autosomal dominant variant of Bernard-Soulier disease.

PubMed ID: 1730088

PubMed ID: 1577776

Title: Polymorphism of human glycoprotein Ib alpha results from a variable number of tandem repeats of a 13-amino acid sequence in the mucin-like macroglycopeptide region. Structure/function implications.

PubMed ID: 1577776

DOI: 10.1016/s0021-9258(19)50199-5

PubMed ID: 7690774

Title: Point mutation in a leucine-rich repeat of platelet glycoprotein Ib alpha resulting in the Bernard-Soulier syndrome.

PubMed ID: 7690774

DOI: 10.1172/jci116692

PubMed ID: 7819107

Title: Cys209 Ser mutation in the platelet membrane glycoprotein Ib alpha gene is associated with Bernard-Soulier syndrome.

PubMed ID: 7819107

DOI: 10.1111/j.1365-2141.1994.tb05125.x

PubMed ID: 2052556

Title: Mutation in the gene encoding the alpha chain of platelet glycoprotein Ib in platelet-type von Willebrand disease.

PubMed ID: 2052556

DOI: 10.1073/pnas.88.11.4761

PubMed ID: 8486780

Title: Expression of the phenotypic abnormality of platelet-type von Willebrand disease in a recombinant glycoprotein Ib alpha fragment.

PubMed ID: 8486780

DOI: 10.1172/jci116438

PubMed ID: 8384898

Title: Pseudo-von Willebrand disease: a mutation in the platelet glycoprotein Ib alpha gene associated with a hyperactive surface receptor.

PubMed ID: 8384898

PubMed ID: 7632942

Title: The largest variant of platelet glycoprotein Ib alpha has four tandem repeats of 13 amino acids in the macroglycopeptide region and a genetic linkage with methionine145.

PubMed ID: 7632942

PubMed ID: 7873390

Title: A three-base deletion removing a leucine residue in a leucine-rich repeat of platelet glycoprotein Ib alpha associated with a variant of Bernard-Soulier syndrome (Nancy I).

PubMed ID: 7873390

DOI: 10.1111/j.1365-2141.1995.tb03316.x

PubMed ID: 9639514

Title: Naturally occurring mutations in glycoprotein Ibalpha that result in defective ligand binding and synthesis of a truncated protein.

PubMed ID: 9639514

PubMed ID: 10391209

Title: Characterization of single-nucleotide polymorphisms in coding regions of human genes.

PubMed ID: 10391209

DOI: 10.1038/10290

PubMed ID: 10089893

Title: Molecular characterization of two mutations in platelet glycoprotein (GP) Ib alpha in two Finnish Bernard-Soulier syndrome families.

PubMed ID: 10089893

DOI: 10.1111/j.1600-0609.1999.tb01739.x

PubMed ID: 11222377

Title: Autosomal dominant macrothrombocytopenia in Italy is most frequently a type of heterozygous Bernard-Soulier syndrome.

PubMed ID: 11222377

DOI: 10.1182/blood.v97.5.1330

PubMed ID: 14711733

Title: Nonarteritic anterior ischemic optic neuropathy is associated with a specific platelet polymorphism located on the glycoprotein Ibalpha gene.

PubMed ID: 14711733

DOI: 10.1016/j.ophtha.2003.05.006

Sequence Information:

  • Length: 652
  • Mass: 71540
  • Checksum: 053346683AEB927E
  • Sequence:
    • MPLLLLLLLL PSPLHPHPIC EVSKVASHLE VNCDKRNLTA LPPDLPKDTT ILHLSENLLY 
TFSLATLMPY TRLTQLNLDR CELTKLQVDG TLPVLGTLDL SHNQLQSLPL LGQTLPALTV 
LDVSFNRLTS LPLGALRGLG ELQELYLKGN ELKTLPPGLL TPTPKLEKLS LANNNLTELP 
AGLLNGLENL DTLLLQENSL YTIPKGFFGS HLLPFAFLHG NPWLCNCEIL YFRRWLQDNA 
ENVYVWKQGV DVKAMTSNVA SVQCDNSDKF PVYKYPGKGC PTLGDEGDTD LYDYYPEEDT 
EGDKVRATRT VVKFPTKAHT TPWGLFYSWS TASLDSQMPS SLHPTQESTK EQTTFPPRWT 
PNFTLHMESI TFSKTPKSTT EPTPSPTTSE PVPEPAPNMT TLEPTPSPTT PEPTSEPAPS 
PTTPEPTSEP APSPTTPEPT SEPAPSPTTP EPTPIPTIAT SPTILVSATS LITPKSTFLT 
TTKPVSLLES TKKTIPELDQ PPKLRGVLQG HLESSRNDPF LHPDFCCLLP LGFYVLGLFW 
LLFASVVLIL LLSWVGHVKP QALDSGQGAA LTTATQTTHL ELQRGRQVTV PRAWLLFLRG 
SLPTFRSSLF LWVRPNGRVG PLVAGRRPSA LSQGRGQDLL STVSIRYSGH SL

Genular Protein ID: 10424423

Symbol: L7UYB8_HUMAN

Name: N/A

UniProtKB Accession Codes:

L7UYB8

Database IDs:

ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 Gene3D 1 GenomeRNAi 1 InterPro 5 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 1 PeptideAtlas 1 Pfam 2 RefSeq 1 SAM 1 SMART 6 SUPFAM 1

Citations:

PubMed ID: 23300803

Title: Abnormal whole blood thrombi in humans with inherited platelet receptor defects.

PubMed ID: 23300803

DOI: 10.1371/journal.pone.0052878

Sequence Information:

  • Length: 333
  • Mass: 36973
  • Checksum: B30AE8A23B6A9C58
  • Sequence:
    • MPLLLLLLLL PSPLHPHPIC EVSKVASHLE VNCDKRNLTA LPPDLPKDTT ILHLSENLLY 
TFSLATLMPY TRLTQLNLDR CELTKLQVDG TLPVLGTLDL SHNQLQSLPL LGQTLPALTV 
LDVSFNRLTS LPLGALRGLG ELQELYLKGN ELKTLPPGLL TPTPKLEKLS LANNNLTELP 
AGLLNGLENL DTLLLQENSL YTIPKGFFGS HLLPFAFLHG NPWLCNCEIL YFRRWLQDNA 
ENVYVWKQGV DVKAMTSNVA SVQCDNSDKF PVYKYPGKGC PTLGDEGDTD LYDYYPEEDT 
EGDKVRATRT VVKFPTKPIQ PPGVYSTHGP LLL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.