Details for: TRAV38 2DV8

Gene ID: 28643

Symbol: TRAV38 2DV8

Ensembl ID: ENSG00000211817

Description: T cell receptor alpha variable 38-2/delta variable 8

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 15.99
    Marker Score: 162,089
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 6.83
    Marker Score: 44,015
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 3.76
    Marker Score: 6,848
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.16
    Marker Score: 3,180
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 874
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.05
    Marker Score: 800
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,838
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,063
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 398
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.76
    Marker Score: 503
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.64
    Marker Score: 388
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.56
    Marker Score: 233
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 477
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 278
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.45
    Marker Score: 436
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 373
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.37
    Marker Score: 212
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.28
    Marker Score: 127
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.28
    Marker Score: 244
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.25
    Marker Score: 435
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.25
    Marker Score: 191
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.23
    Marker Score: 204
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.21
    Marker Score: 56
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.16
    Marker Score: 132
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.15
    Marker Score: 110
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.15
    Marker Score: 289
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.14
    Marker Score: 112
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.14
    Marker Score: 441
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.14
    Marker Score: 330
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.13
    Marker Score: 545
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.12
    Marker Score: 168
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.12
    Marker Score: 79
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.11
    Marker Score: 61
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.11
    Marker Score: 5,926
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.11
    Marker Score: 198
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.11
    Marker Score: 121
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.11
    Marker Score: 46
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.1
    Marker Score: 68
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.1
    Marker Score: 108
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.1
    Marker Score: 160
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.1
    Marker Score: 956
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.1
    Marker Score: 1,113
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.1
    Marker Score: 69
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.09
    Marker Score: 56
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.09
    Marker Score: 204
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.09
    Marker Score: 111
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.09
    Marker Score: 251
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.09
    Marker Score: 64
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.08
    Marker Score: 46
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.08
    Marker Score: 117
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.07
    Marker Score: 66
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.07
    Marker Score: 32
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.07
    Marker Score: 134
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.07
    Marker Score: 272
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.06
    Marker Score: 35
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.06
    Marker Score: 37
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.06
    Marker Score: 59
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.06
    Marker Score: 52
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.06
    Marker Score: 46
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.06
    Marker Score: 54
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.06
    Marker Score: 33
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.06
    Marker Score: 62
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.06
    Marker Score: 17
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 0.05
    Marker Score: 12
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.05
    Marker Score: 19
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 0.05
    Marker Score: 34
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.05
    Marker Score: 68
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.05
    Marker Score: 12
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.04
    Marker Score: 49
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.04
    Marker Score: 37
  • Cell Name: bronchial smooth muscle cell (CL0002598)
    Fold Change: 0.04
    Marker Score: 12
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.04
    Marker Score: 101
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.04
    Marker Score: 24
  • Cell Name: type II NK T cell (CL0000922)
    Fold Change: 0.04
    Marker Score: 12
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.04
    Marker Score: 28
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.04
    Marker Score: 13
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.04
    Marker Score: 25
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.03
    Marker Score: 36
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.03
    Marker Score: 10
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.03
    Marker Score: 12
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.03
    Marker Score: 43
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.03
    Marker Score: 21
  • Cell Name: T-helper 1 cell (CL0000545)
    Fold Change: 0.03
    Marker Score: 12
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.03
    Marker Score: 42
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.03
    Marker Score: 27
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.03
    Marker Score: 20
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 0.03
    Marker Score: 12
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.03
    Marker Score: 9
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.02
    Marker Score: 38
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 0.02
    Marker Score: 8
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.02
    Marker Score: 38
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.02
    Marker Score: 25
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.02
    Marker Score: 67
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.02
    Marker Score: 51
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.02
    Marker Score: 17

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern**: TRAV38 2DV8 is expressed in a diverse range of cell types, including glutamatergic neurons, progenitor cells, microglial cells, blood vessel endothelial cells, granulocyte monocyte progenitor cells, and early T lineage precursors. 2. **T Cell Receptor Alpha Chain**: The variable region of TRAV38 2DV8 is part of the T cell receptor alpha chain, which is essential for recognizing and binding to specific antigens. 3. **Delta Variable Region**: The delta variable region of TRAV38 2DV8 is unique and has not been previously described in the context of T cell receptors. **Pathways and Functions:** 1. **Adaptive Immune Response**: TRAV38 2DV8 plays a critical role in the adaptive immune response by influencing the diversity and functionality of T cells. The variable region of the T cell receptor alpha chain recognizes and binds to specific antigens, while the delta variable region may contribute to the regulation of T cell activation and proliferation. 2. **T Cell Receptor Complex**: The T cell receptor complex, which includes TRAV38 2DV8, is essential for the recognition and binding of antigens. The complex is composed of the T cell receptor alpha chain, beta chain, gamma chain, and delta chain. 3. **Immune Response Regulation**: TRAV38 2DV8 may regulate the immune response by influencing the activation, proliferation, and differentiation of T cells. **Clinical Significance:** 1. **Autoimmune Diseases**: Dysregulation of TRAV38 2DV8 expression or function may contribute to the development of autoimmune diseases, such as multiple sclerosis or type 1 diabetes. 2. **Cancer Immunotherapy**: TRAV38 2DV8 may play a role in cancer immunotherapy by influencing the recognition and binding of tumor antigens by T cells. 3. **Neurological Disorders**: The expression of TRAV38 2DV8 in neurons and glial cells may contribute to the development of neurological disorders, such as Alzheimer's disease or Parkinson's disease. 4. **Immunodeficiency Disorders**: TRAV38 2DV8 may be involved in the regulation of the immune response in immunodeficiency disorders, such as severe combined immunodeficiency (SCID). In conclusion, TRAV38 2DV8 is a unique gene variant that plays a critical role in the adaptive immune response, influencing the diversity and functionality of T cells. Further research is needed to elucidate the clinical significance of TRAV38 2DV8 and its potential applications in immunotherapy and disease prevention.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.