Details for: TRAV38 2DV8

Gene ID: 28643

Symbol: TRAV38 2DV8

Ensembl ID: ENSG00000211817

Description: T cell receptor alpha variable 38-2/delta variable 8

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.5478
    Cell Significance Index: 4.5400
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.4676
    Cell Significance Index: 2.5500
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.0689
    Cell Significance Index: 0.2100
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.0139
    Cell Significance Index: 0.1600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: 0.0002
    Cell Significance Index: 0.0100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0020
    Cell Significance Index: -1.5300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0023
    Cell Significance Index: -0.1000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0057
    Cell Significance Index: -1.6500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0068
    Cell Significance Index: -0.3200
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: -0.0086
    Cell Significance Index: -0.0900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0094
    Cell Significance Index: -1.9000
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: -0.0095
    Cell Significance Index: -0.0900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0112
    Cell Significance Index: -0.3000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0151
    Cell Significance Index: -2.0700
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0188
    Cell Significance Index: -0.1900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0189
    Cell Significance Index: -0.6200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0211
    Cell Significance Index: -2.1600
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0216
    Cell Significance Index: -0.2000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0239
    Cell Significance Index: -0.5800
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.0239
    Cell Significance Index: -0.2400
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0279
    Cell Significance Index: -0.3800
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0318
    Cell Significance Index: -0.5400
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0347
    Cell Significance Index: -0.4100
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0366
    Cell Significance Index: -0.3800
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0376
    Cell Significance Index: -0.5500
  • Cell Name: immature alpha-beta T cell (CL0000790)
    Fold Change: -0.0404
    Cell Significance Index: -0.3000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0444
    Cell Significance Index: -1.4200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0445
    Cell Significance Index: -1.1900
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0458
    Cell Significance Index: -0.3900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0469
    Cell Significance Index: -0.7900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0491
    Cell Significance Index: -1.4000
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.0523
    Cell Significance Index: -0.4500
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0542
    Cell Significance Index: -0.5500
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0542
    Cell Significance Index: -0.6400
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.0567
    Cell Significance Index: -0.3900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0568
    Cell Significance Index: -0.9800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0578
    Cell Significance Index: -1.6700
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0580
    Cell Significance Index: -0.9400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0617
    Cell Significance Index: -1.5800
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0641
    Cell Significance Index: -0.6000
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0641
    Cell Significance Index: -0.6800
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.0657
    Cell Significance Index: -0.5600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0659
    Cell Significance Index: -1.9400
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.0717
    Cell Significance Index: -0.7400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0731
    Cell Significance Index: -1.8600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0759
    Cell Significance Index: -1.6100
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0809
    Cell Significance Index: -1.1100
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0817
    Cell Significance Index: -0.7900
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0846
    Cell Significance Index: -0.7300
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0855
    Cell Significance Index: -1.0800
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0875
    Cell Significance Index: -0.8300
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: -0.0878
    Cell Significance Index: -0.8600
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: -0.0881
    Cell Significance Index: -1.0200
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.0882
    Cell Significance Index: -0.5400
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0886
    Cell Significance Index: -1.0700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0886
    Cell Significance Index: -2.5400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0892
    Cell Significance Index: -2.0600
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0897
    Cell Significance Index: -1.1100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0920
    Cell Significance Index: -1.0000
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.0929
    Cell Significance Index: -0.8500
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0935
    Cell Significance Index: -0.7600
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.0951
    Cell Significance Index: -0.6200
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: -0.0955
    Cell Significance Index: -1.0100
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0968
    Cell Significance Index: -0.9800
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0996
    Cell Significance Index: -0.7800
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.1001
    Cell Significance Index: -1.6100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1002
    Cell Significance Index: -1.9600
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1029
    Cell Significance Index: -1.5000
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.1030
    Cell Significance Index: -1.3000
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1039
    Cell Significance Index: -1.3500
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.1043
    Cell Significance Index: -1.3200
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1082
    Cell Significance Index: -1.8500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1099
    Cell Significance Index: -1.8400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1104
    Cell Significance Index: -2.0400
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.1118
    Cell Significance Index: -1.0900
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -0.1133
    Cell Significance Index: -1.2100
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: -0.1146
    Cell Significance Index: -1.1200
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.1147
    Cell Significance Index: -1.3500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1175
    Cell Significance Index: -2.9300
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.1180
    Cell Significance Index: -1.5400
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.1188
    Cell Significance Index: -1.3000
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.1196
    Cell Significance Index: -0.8900
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.1199
    Cell Significance Index: -1.3000
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.1208
    Cell Significance Index: -1.5800
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.1209
    Cell Significance Index: -1.6300
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.1222
    Cell Significance Index: -1.4200
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.1223
    Cell Significance Index: -1.4000
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.1233
    Cell Significance Index: -1.4300
  • Cell Name: podocyte (CL0000653)
    Fold Change: -0.1238
    Cell Significance Index: -1.4200
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.1240
    Cell Significance Index: -1.7200
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.1243
    Cell Significance Index: -1.3100
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.1280
    Cell Significance Index: -1.0700
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.1289
    Cell Significance Index: -1.6100
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.1322
    Cell Significance Index: -1.7400
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.1331
    Cell Significance Index: -1.5000
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.1337
    Cell Significance Index: -1.4200
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: -0.1342
    Cell Significance Index: -1.3900
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.1343
    Cell Significance Index: -1.5500
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.1345
    Cell Significance Index: -1.4500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1375
    Cell Significance Index: -2.0300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern**: TRAV38 2DV8 is expressed in a diverse range of cell types, including glutamatergic neurons, progenitor cells, microglial cells, blood vessel endothelial cells, granulocyte monocyte progenitor cells, and early T lineage precursors. 2. **T Cell Receptor Alpha Chain**: The variable region of TRAV38 2DV8 is part of the T cell receptor alpha chain, which is essential for recognizing and binding to specific antigens. 3. **Delta Variable Region**: The delta variable region of TRAV38 2DV8 is unique and has not been previously described in the context of T cell receptors. **Pathways and Functions:** 1. **Adaptive Immune Response**: TRAV38 2DV8 plays a critical role in the adaptive immune response by influencing the diversity and functionality of T cells. The variable region of the T cell receptor alpha chain recognizes and binds to specific antigens, while the delta variable region may contribute to the regulation of T cell activation and proliferation. 2. **T Cell Receptor Complex**: The T cell receptor complex, which includes TRAV38 2DV8, is essential for the recognition and binding of antigens. The complex is composed of the T cell receptor alpha chain, beta chain, gamma chain, and delta chain. 3. **Immune Response Regulation**: TRAV38 2DV8 may regulate the immune response by influencing the activation, proliferation, and differentiation of T cells. **Clinical Significance:** 1. **Autoimmune Diseases**: Dysregulation of TRAV38 2DV8 expression or function may contribute to the development of autoimmune diseases, such as multiple sclerosis or type 1 diabetes. 2. **Cancer Immunotherapy**: TRAV38 2DV8 may play a role in cancer immunotherapy by influencing the recognition and binding of tumor antigens by T cells. 3. **Neurological Disorders**: The expression of TRAV38 2DV8 in neurons and glial cells may contribute to the development of neurological disorders, such as Alzheimer's disease or Parkinson's disease. 4. **Immunodeficiency Disorders**: TRAV38 2DV8 may be involved in the regulation of the immune response in immunodeficiency disorders, such as severe combined immunodeficiency (SCID). In conclusion, TRAV38 2DV8 is a unique gene variant that plays a critical role in the adaptive immune response, influencing the diversity and functionality of T cells. Further research is needed to elucidate the clinical significance of TRAV38 2DV8 and its potential applications in immunotherapy and disease prevention.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.