Details for: DROSHA

Gene ID: 29102

Symbol: DROSHA

Ensembl ID: ENSG00000113360

Description: drosha ribonuclease III

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 194.3486
    Cell Significance Index: -30.2300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 117.2315
    Cell Significance Index: -29.7400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 60.4543
    Cell Significance Index: -24.5600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 25.8394
    Cell Significance Index: -24.6700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 25.0536
    Cell Significance Index: -30.8900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.9786
    Cell Significance Index: -29.4100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.4390
    Cell Significance Index: -25.9200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.8762
    Cell Significance Index: -31.0800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.3426
    Cell Significance Index: -16.0700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.5420
    Cell Significance Index: 309.3200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.2018
    Cell Significance Index: 238.5000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.0936
    Cell Significance Index: 61.3700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0253
    Cell Significance Index: 925.7300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.9791
    Cell Significance Index: 351.1900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.9273
    Cell Significance Index: 41.0200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.9150
    Cell Significance Index: 34.6500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.7344
    Cell Significance Index: 10.0200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7343
    Cell Significance Index: 79.8700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7079
    Cell Significance Index: 115.1300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.6688
    Cell Significance Index: 18.6900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.6204
    Cell Significance Index: 38.1300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6198
    Cell Significance Index: 37.2100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.6133
    Cell Significance Index: 424.1700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.4887
    Cell Significance Index: 10.7000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.4687
    Cell Significance Index: 35.9700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.4418
    Cell Significance Index: 10.6000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4078
    Cell Significance Index: 8.8400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.3893
    Cell Significance Index: 45.3700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3810
    Cell Significance Index: 17.2700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.3505
    Cell Significance Index: 9.0100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3228
    Cell Significance Index: 22.3200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.2737
    Cell Significance Index: 5.8500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.2692
    Cell Significance Index: 18.1000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.2613
    Cell Significance Index: 5.1000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2428
    Cell Significance Index: 7.0000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1953
    Cell Significance Index: 35.2100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1921
    Cell Significance Index: 19.0000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1712
    Cell Significance Index: 8.9200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.1665
    Cell Significance Index: 2.0700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1575
    Cell Significance Index: 19.3700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1494
    Cell Significance Index: 2.5600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1243
    Cell Significance Index: 233.9900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1212
    Cell Significance Index: 66.1800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1115
    Cell Significance Index: 5.7900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0855
    Cell Significance Index: 5.3900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0790
    Cell Significance Index: 15.0300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0753
    Cell Significance Index: 47.8400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0718
    Cell Significance Index: 132.3500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0709
    Cell Significance Index: 31.3500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0679
    Cell Significance Index: 30.8000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0639
    Cell Significance Index: 98.4200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0538
    Cell Significance Index: 1.8900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0521
    Cell Significance Index: 2.4300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0347
    Cell Significance Index: 4.7700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0344
    Cell Significance Index: 46.7800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0010
    Cell Significance Index: -0.1200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0182
    Cell Significance Index: -2.6500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0211
    Cell Significance Index: -15.4500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0360
    Cell Significance Index: -26.6700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0374
    Cell Significance Index: -28.3400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0434
    Cell Significance Index: -1.1600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0486
    Cell Significance Index: -8.3000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0491
    Cell Significance Index: -1.4000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0510
    Cell Significance Index: -28.7600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0559
    Cell Significance Index: -34.8800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0850
    Cell Significance Index: -10.9000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0900
    Cell Significance Index: -25.9000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0953
    Cell Significance Index: -2.5500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0982
    Cell Significance Index: -10.0300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1351
    Cell Significance Index: -1.6100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1476
    Cell Significance Index: -3.6900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1528
    Cell Significance Index: -9.8600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1627
    Cell Significance Index: -34.2700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1762
    Cell Significance Index: -22.7700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1816
    Cell Significance Index: -8.5400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1965
    Cell Significance Index: -22.5200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2108
    Cell Significance Index: -21.9500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2357
    Cell Significance Index: -16.6700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2423
    Cell Significance Index: -7.7600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3044
    Cell Significance Index: -15.9800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3091
    Cell Significance Index: -6.5600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3181
    Cell Significance Index: -25.1900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3209
    Cell Significance Index: -23.9200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3715
    Cell Significance Index: -22.7800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4123
    Cell Significance Index: -13.5000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4149
    Cell Significance Index: -10.9100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4184
    Cell Significance Index: -8.9100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4207
    Cell Significance Index: -13.4000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.4273
    Cell Significance Index: -8.4500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4368
    Cell Significance Index: -15.1800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.4748
    Cell Significance Index: -12.9300
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.4812
    Cell Significance Index: -6.9100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.5046
    Cell Significance Index: -10.1300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.5690
    Cell Significance Index: -8.4000
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.5702
    Cell Significance Index: -7.1100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.5721
    Cell Significance Index: -12.3600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.5733
    Cell Significance Index: -9.6000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.6000
    Cell Significance Index: -21.0200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.6278
    Cell Significance Index: -15.6600
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.6330
    Cell Significance Index: -5.3800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Function:** DROSHA is a ribonuclease III enzyme that plays a central role in the biogenesis of miRNAs. 2. **Expression:** DROSHA is highly expressed in neurons, particularly in L2/3-6 intratelencephalic projecting glutamatergic neurons, corticothalamic-projecting glutamatergic cortical neurons, and astrocytes of the cerebral cortex. 3. **Cellular localization:** DROSHA is primarily localized to the nucleus and cytosol. 4. **Protein interactions:** DROSHA interacts with DGCR8 and other RNA-binding proteins to form the microprocessor complex. **Pathways and Functions:** DROSHA is involved in several key pathways, including: 1. **MicroRNA biogenesis:** DROSHA processes precursor miRNAs into mature miRNAs, which then regulate target gene expression. 2. **Gene silencing:** Mature miRNAs bind to complementary sequences on target mRNA, leading to degradation or translational repression. 3. **Regulation of inflammatory response:** DROSHA and miRNAs play a role in regulating the inflammatory response by modulating the expression of immune-related genes. 4. **Regulation of gene expression:** DROSHA and miRNAs regulate gene expression by binding to complementary sequences on target mRNA, leading to changes in protein levels and cellular function. **Clinical Significance:** DROSHA and miRNAs have been implicated in various diseases, including: 1. **Neurological disorders:** Alterations in DROSHA and miRNA expression have been linked to neurodegenerative diseases, such as Alzheimer's and Parkinson's. 2. **Cancer:** DROSHA and miRNAs play a role in regulating cell growth and apoptosis, making them potential targets for cancer therapy. 3. **Infectious diseases:** DROSHA and miRNAs regulate the expression of immune-related genes, making them important in the response to bacterial infections. In conclusion, DROSHA is a critical gene involved in microRNA biogenesis and regulation of gene expression. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the role of DROSHA and miRNAs in human health and disease.

Genular Protein ID: 3609086998

Symbol: RNC_HUMAN

Name: Ribonuclease 3

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10948199

Title: Human RNase III is a 160-kDa protein involved in preribosomal RNA processing.

PubMed ID: 10948199

DOI: 10.1074/jbc.m005494200

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 10976766

Title: A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening.

PubMed ID: 10976766

DOI: 10.1023/a:1007177623283

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14508493

Title: The nuclear RNase III Drosha initiates microRNA processing.

PubMed ID: 14508493

DOI: 10.1038/nature01957

PubMed ID: 15589161

Title: The human DiGeorge syndrome critical region gene 8 and its D. melanogaster homolog are required for miRNA biogenesis.

PubMed ID: 15589161

DOI: 10.1016/j.cub.2004.11.001

PubMed ID: 15574589

Title: The Drosha-DGCR8 complex in primary microRNA processing.

PubMed ID: 15574589

DOI: 10.1101/gad.1262504

PubMed ID: 15531877

Title: The microprocessor complex mediates the genesis of microRNAs.

PubMed ID: 15531877

DOI: 10.1038/nature03120

PubMed ID: 15565168

Title: Recognition and cleavage of primary microRNA precursors by the nuclear processing enzyme Drosha.

PubMed ID: 15565168

DOI: 10.1038/sj.emboj.7600491

PubMed ID: 16751099

Title: Molecular basis for the recognition of primary microRNAs by the Drosha-DGCR8 complex.

PubMed ID: 16751099

DOI: 10.1016/j.cell.2006.03.043

PubMed ID: 16906129

Title: Formation of GW bodies is a consequence of microRNA genesis.

PubMed ID: 16906129

DOI: 10.1038/sj.embor.7400783

PubMed ID: 17159994

Title: Heme is involved in microRNA processing.

PubMed ID: 17159994

DOI: 10.1038/nsmb1182

PubMed ID: 18632581

Title: The FHA domain proteins DAWDLE in Arabidopsis and SNIP1 in humans act in small RNA biogenesis.

PubMed ID: 18632581

DOI: 10.1073/pnas.0804218105

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22118463

Title: Lin28A and Lin28B inhibit let-7 microRNA biogenesis by distinct mechanisms.

PubMed ID: 22118463

DOI: 10.1016/j.cell.2011.10.039

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 26027739

Title: Functional anatomy of the human microprocessor.

PubMed ID: 26027739

DOI: 10.1016/j.cell.2015.05.010

PubMed ID: 31819270

Title: Differential roles of human PUS10 in miRNA processing and tRNA pseudouridylation.

PubMed ID: 31819270

DOI: 10.1038/s41589-019-0420-5

PubMed ID: 20226070

Title: Solution structure of the Drosha double-stranded RNA-binding domain.

PubMed ID: 20226070

DOI: 10.1186/1758-907x-1-2

PubMed ID: 26748718

Title: Structure of human DROSHA.

PubMed ID: 26748718

DOI: 10.1016/j.cell.2015.12.019

Sequence Information:

  • Length: 1374
  • Mass: 159316
  • Checksum: ED6FDEA09F3B8092
  • Sequence:
  • MMQGNTCHRM SFHPGRGCPR GRGGHGARPS APSFRPQNLR LLHPQQPPVQ YQYEPPSAPS 
    TTFSNSPAPN FLPPRPDFVP FPPPMPPSAQ GPLPPCPIRP PFPNHQMRHP FPVPPCFPPM 
    PPPMPCPNNP PVPGAPPGQG TFPFMMPPPS MPHPPPPPVM PQQVNYQYPP GYSHHNFPPP 
    SFNSFQNNPS SFLPSANNSS SPHFRHLPPY PLPKAPSERR SPERLKHYDD HRHRDHSHGR 
    GERHRSLDRR ERGRSPDRRR QDSRYRSDYD RGRTPSRHRS YERSRERERE RHRHRDNRRS 
    PSLERSYKKE YKRSGRSYGL SVVPEPAGCT PELPGEIIKN TDSWAPPLEI VNHRSPSREK 
    KRARWEEEKD RWSDNQSSGK DKNYTSIKEK EPEETMPDKN EEEEEELLKP VWIRCTHSEN 
    YYSSDPMDQV GDSTVVGTSR LRDLYDKFEE ELGSRQEKAK AARPPWEPPK TKLDEDLESS 
    SESECESDED STCSSSSDSE VFDVIAEIKR KKAHPDRLHD ELWYNDPGQM NDGPLCKCSA 
    KARRTGIRHS IYPGEEAIKP CRPMTNNAGR LFHYRITVSP PTNFLTDRPT VIEYDDHEYI 
    FEGFSMFAHA PLTNIPLCKV IRFNIDYTIH FIEEMMPENF CVKGLELFSL FLFRDILELY 
    DWNLKGPLFE DSPPCCPRFH FMPRFVRFLP DGGKEVLSMH QILLYLLRCS KALVPEEEIA 
    NMLQWEELEW QKYAEECKGM IVTNPGTKPS SVRIDQLDRE QFNPDVITFP IIVHFGIRPA 
    QLSYAGDPQY QKLWKSYVKL RHLLANSPKV KQTDKQKLAQ REEALQKIRQ KNTMRREVTV 
    ELSSQGFWKT GIRSDVCQHA MMLPVLTHHI RYHQCLMHLD KLIGYTFQDR CLLQLAMTHP 
    SHHLNFGMNP DHARNSLSNC GIRQPKYGDR KVHHMHMRKK GINTLINIMS RLGQDDPTPS 
    RINHNERLEF LGDAVVEFLT SVHLYYLFPS LEEGGLATYR TAIVQNQHLA MLAKKLELDR 
    FMLYAHGPDL CRESDLRHAM ANCFEALIGA VYLEGSLEEA KQLFGRLLFN DPDLREVWLN 
    YPLHPLQLQE PNTDRQLIET SPVLQKLTEF EEAIGVIFTH VRLLARAFTL RTVGFNHLTL 
    GHNQRMEFLG DSIMQLVATE YLFIHFPDHH EGHLTLLRSS LVNNRTQAKV AEELGMQEYA 
    ITNDKTKRPV ALRTKTLADL LESFIAALYI DKDLEYVHTF MNVCFFPRLK EFILNQDWND 
    PKSQLQQCCL TLRTEGKEPD IPLYKTLQTV GPSHARTYTV AVYFKGERIG CGKGPSIQQA 
    EMGAAMDALE KYNFPQMAHQ KRFIERKYRQ ELKEMRWERE HQEREPDETE DIKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.