Details for: DROSHA
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 194.3486
Cell Significance Index: -30.2300 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 117.2315
Cell Significance Index: -29.7400 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 60.4543
Cell Significance Index: -24.5600 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 25.8394
Cell Significance Index: -24.6700 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 25.0536
Cell Significance Index: -30.8900 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 10.9786
Cell Significance Index: -29.4100 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 8.4390
Cell Significance Index: -25.9200 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 7.8762
Cell Significance Index: -31.0800 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 7.3426
Cell Significance Index: -16.0700 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.5420
Cell Significance Index: 309.3200 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.2018
Cell Significance Index: 238.5000 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 1.0936
Cell Significance Index: 61.3700 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1.0253
Cell Significance Index: 925.7300 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.9791
Cell Significance Index: 351.1900 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.9273
Cell Significance Index: 41.0200 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.9150
Cell Significance Index: 34.6500 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.7344
Cell Significance Index: 10.0200 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.7343
Cell Significance Index: 79.8700 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.7079
Cell Significance Index: 115.1300 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.6688
Cell Significance Index: 18.6900 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.6204
Cell Significance Index: 38.1300 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.6198
Cell Significance Index: 37.2100 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.6133
Cell Significance Index: 424.1700 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.4887
Cell Significance Index: 10.7000 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.4687
Cell Significance Index: 35.9700 - Cell Name: cortical interneuron (CL0008031)
Fold Change: 0.4418
Cell Significance Index: 10.6000 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.4078
Cell Significance Index: 8.8400 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.3893
Cell Significance Index: 45.3700 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.3810
Cell Significance Index: 17.2700 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.3505
Cell Significance Index: 9.0100 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.3228
Cell Significance Index: 22.3200 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.2737
Cell Significance Index: 5.8500 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.2692
Cell Significance Index: 18.1000 - Cell Name: preadipocyte (CL0002334)
Fold Change: 0.2613
Cell Significance Index: 5.1000 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.2428
Cell Significance Index: 7.0000 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.1953
Cell Significance Index: 35.2100 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1921
Cell Significance Index: 19.0000 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.1712
Cell Significance Index: 8.9200 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 0.1665
Cell Significance Index: 2.0700 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.1575
Cell Significance Index: 19.3700 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.1494
Cell Significance Index: 2.5600 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.1243
Cell Significance Index: 233.9900 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.1212
Cell Significance Index: 66.1800 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.1115
Cell Significance Index: 5.7900 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.0855
Cell Significance Index: 5.3900 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.0790
Cell Significance Index: 15.0300 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0753
Cell Significance Index: 47.8400 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0718
Cell Significance Index: 132.3500 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0709
Cell Significance Index: 31.3500 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0679
Cell Significance Index: 30.8000 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0639
Cell Significance Index: 98.4200 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0538
Cell Significance Index: 1.8900 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.0521
Cell Significance Index: 2.4300 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.0347
Cell Significance Index: 4.7700 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0344
Cell Significance Index: 46.7800 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0010
Cell Significance Index: -0.1200 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0182
Cell Significance Index: -2.6500 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0211
Cell Significance Index: -15.4500 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0360
Cell Significance Index: -26.6700 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0374
Cell Significance Index: -28.3400 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0434
Cell Significance Index: -1.1600 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0486
Cell Significance Index: -8.3000 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.0491
Cell Significance Index: -1.4000 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0510
Cell Significance Index: -28.7600 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0559
Cell Significance Index: -34.8800 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.0850
Cell Significance Index: -10.9000 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0900
Cell Significance Index: -25.9000 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.0953
Cell Significance Index: -2.5500 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0982
Cell Significance Index: -10.0300 - Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.1351
Cell Significance Index: -1.6100 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.1476
Cell Significance Index: -3.6900 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.1528
Cell Significance Index: -9.8600 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1627
Cell Significance Index: -34.2700 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.1762
Cell Significance Index: -22.7700 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1816
Cell Significance Index: -8.5400 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1965
Cell Significance Index: -22.5200 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2108
Cell Significance Index: -21.9500 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.2357
Cell Significance Index: -16.6700 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.2423
Cell Significance Index: -7.7600 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.3044
Cell Significance Index: -15.9800 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.3091
Cell Significance Index: -6.5600 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.3181
Cell Significance Index: -25.1900 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.3209
Cell Significance Index: -23.9200 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.3715
Cell Significance Index: -22.7800 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.4123
Cell Significance Index: -13.5000 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.4149
Cell Significance Index: -10.9100 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.4184
Cell Significance Index: -8.9100 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.4207
Cell Significance Index: -13.4000 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.4273
Cell Significance Index: -8.4500 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.4368
Cell Significance Index: -15.1800 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.4748
Cell Significance Index: -12.9300 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -0.4812
Cell Significance Index: -6.9100 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.5046
Cell Significance Index: -10.1300 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.5690
Cell Significance Index: -8.4000 - Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: -0.5702
Cell Significance Index: -7.1100 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.5721
Cell Significance Index: -12.3600 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.5733
Cell Significance Index: -9.6000 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.6000
Cell Significance Index: -21.0200 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.6278
Cell Significance Index: -15.6600 - Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: -0.6330
Cell Significance Index: -5.3800
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3609086998
Symbol: RNC_HUMAN
Name: Ribonuclease 3
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10948199
Title: Human RNase III is a 160-kDa protein involved in preribosomal RNA processing.
PubMed ID: 10948199
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 15372022
Title: The DNA sequence and comparative analysis of human chromosome 5.
PubMed ID: 15372022
DOI: 10.1038/nature02919
PubMed ID: 10976766
Title: A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening.
PubMed ID: 10976766
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 14508493
Title: The nuclear RNase III Drosha initiates microRNA processing.
PubMed ID: 14508493
DOI: 10.1038/nature01957
PubMed ID: 15589161
Title: The human DiGeorge syndrome critical region gene 8 and its D. melanogaster homolog are required for miRNA biogenesis.
PubMed ID: 15589161
PubMed ID: 15574589
Title: The Drosha-DGCR8 complex in primary microRNA processing.
PubMed ID: 15574589
DOI: 10.1101/gad.1262504
PubMed ID: 15531877
Title: The microprocessor complex mediates the genesis of microRNAs.
PubMed ID: 15531877
DOI: 10.1038/nature03120
PubMed ID: 15565168
Title: Recognition and cleavage of primary microRNA precursors by the nuclear processing enzyme Drosha.
PubMed ID: 15565168
PubMed ID: 16751099
Title: Molecular basis for the recognition of primary microRNAs by the Drosha-DGCR8 complex.
PubMed ID: 16751099
PubMed ID: 16906129
Title: Formation of GW bodies is a consequence of microRNA genesis.
PubMed ID: 16906129
PubMed ID: 17159994
PubMed ID: 18632581
Title: The FHA domain proteins DAWDLE in Arabidopsis and SNIP1 in humans act in small RNA biogenesis.
PubMed ID: 18632581
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22118463
Title: Lin28A and Lin28B inhibit let-7 microRNA biogenesis by distinct mechanisms.
PubMed ID: 22118463
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 26027739
Title: Functional anatomy of the human microprocessor.
PubMed ID: 26027739
PubMed ID: 31819270
Title: Differential roles of human PUS10 in miRNA processing and tRNA pseudouridylation.
PubMed ID: 31819270
PubMed ID: 20226070
Title: Solution structure of the Drosha double-stranded RNA-binding domain.
PubMed ID: 20226070
PubMed ID: 26748718
Sequence Information:
- Length: 1374
- Mass: 159316
- Checksum: ED6FDEA09F3B8092
- Sequence:
MMQGNTCHRM SFHPGRGCPR GRGGHGARPS APSFRPQNLR LLHPQQPPVQ YQYEPPSAPS TTFSNSPAPN FLPPRPDFVP FPPPMPPSAQ GPLPPCPIRP PFPNHQMRHP FPVPPCFPPM PPPMPCPNNP PVPGAPPGQG TFPFMMPPPS MPHPPPPPVM PQQVNYQYPP GYSHHNFPPP SFNSFQNNPS SFLPSANNSS SPHFRHLPPY PLPKAPSERR SPERLKHYDD HRHRDHSHGR GERHRSLDRR ERGRSPDRRR QDSRYRSDYD RGRTPSRHRS YERSRERERE RHRHRDNRRS PSLERSYKKE YKRSGRSYGL SVVPEPAGCT PELPGEIIKN TDSWAPPLEI VNHRSPSREK KRARWEEEKD RWSDNQSSGK DKNYTSIKEK EPEETMPDKN EEEEEELLKP VWIRCTHSEN YYSSDPMDQV GDSTVVGTSR LRDLYDKFEE ELGSRQEKAK AARPPWEPPK TKLDEDLESS SESECESDED STCSSSSDSE VFDVIAEIKR KKAHPDRLHD ELWYNDPGQM NDGPLCKCSA KARRTGIRHS IYPGEEAIKP CRPMTNNAGR LFHYRITVSP PTNFLTDRPT VIEYDDHEYI FEGFSMFAHA PLTNIPLCKV IRFNIDYTIH FIEEMMPENF CVKGLELFSL FLFRDILELY DWNLKGPLFE DSPPCCPRFH FMPRFVRFLP DGGKEVLSMH QILLYLLRCS KALVPEEEIA NMLQWEELEW QKYAEECKGM IVTNPGTKPS SVRIDQLDRE QFNPDVITFP IIVHFGIRPA QLSYAGDPQY QKLWKSYVKL RHLLANSPKV KQTDKQKLAQ REEALQKIRQ KNTMRREVTV ELSSQGFWKT GIRSDVCQHA MMLPVLTHHI RYHQCLMHLD KLIGYTFQDR CLLQLAMTHP SHHLNFGMNP DHARNSLSNC GIRQPKYGDR KVHHMHMRKK GINTLINIMS RLGQDDPTPS RINHNERLEF LGDAVVEFLT SVHLYYLFPS LEEGGLATYR TAIVQNQHLA MLAKKLELDR FMLYAHGPDL CRESDLRHAM ANCFEALIGA VYLEGSLEEA KQLFGRLLFN DPDLREVWLN YPLHPLQLQE PNTDRQLIET SPVLQKLTEF EEAIGVIFTH VRLLARAFTL RTVGFNHLTL GHNQRMEFLG DSIMQLVATE YLFIHFPDHH EGHLTLLRSS LVNNRTQAKV AEELGMQEYA ITNDKTKRPV ALRTKTLADL LESFIAALYI DKDLEYVHTF MNVCFFPRLK EFILNQDWND PKSQLQQCCL TLRTEGKEPD IPLYKTLQTV GPSHARTYTV AVYFKGERIG CGKGPSIQQA EMGAAMDALE KYNFPQMAHQ KRFIERKYRQ ELKEMRWERE HQEREPDETE DIKK
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.