Details for: CTNNA3

Gene ID: 29119

Symbol: CTNNA3

Ensembl ID: ENSG00000183230

Description: catenin alpha 3

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 6.75
    Marker Score: 3,026
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 5.76
    Marker Score: 16,793
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 5.42
    Marker Score: 121,105
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 4.76
    Marker Score: 11,924
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 4.34
    Marker Score: 18,086
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 4.02
    Marker Score: 9,612
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 3.97
    Marker Score: 3,024
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 3.95
    Marker Score: 14,053
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 3.74
    Marker Score: 31,592
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 3.2
    Marker Score: 6,064
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 2.9
    Marker Score: 17,410
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 2.88
    Marker Score: 8,209
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.71
    Marker Score: 48,041
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 2.67
    Marker Score: 35,568
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 2.64
    Marker Score: 7,589
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 2.52
    Marker Score: 1,364
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 2.41
    Marker Score: 1,215
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 2.3
    Marker Score: 7,543
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 2.06
    Marker Score: 3,458
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.93
    Marker Score: 8,070
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.92
    Marker Score: 2,390
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.88
    Marker Score: 4,120
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.87
    Marker Score: 3,797
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.85
    Marker Score: 27,618
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.78
    Marker Score: 7,378
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.74
    Marker Score: 16,350
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.73
    Marker Score: 1,041
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.73
    Marker Score: 2,140
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.68
    Marker Score: 14,458
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.65
    Marker Score: 101,273
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.61
    Marker Score: 1,061
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6
    Marker Score: 1,162
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1.6
    Marker Score: 2,906
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.59
    Marker Score: 4,549
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.59
    Marker Score: 15,092
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.56
    Marker Score: 2,411
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.54
    Marker Score: 750
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.54
    Marker Score: 2,071
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.49
    Marker Score: 540
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.49
    Marker Score: 55,002
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.47
    Marker Score: 3,472
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167,270
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.41
    Marker Score: 10,836
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.4
    Marker Score: 53,301
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.38
    Marker Score: 431
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.37
    Marker Score: 21,441
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.35
    Marker Score: 26,778
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.33
    Marker Score: 13,764
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.32
    Marker Score: 5,356
  • Cell Name: interneuron (CL0000099)
    Fold Change: 1.3
    Marker Score: 594
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.25
    Marker Score: 5,770
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.23
    Marker Score: 1,177
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.23
    Marker Score: 4,769
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 1.23
    Marker Score: 6,610
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.23
    Marker Score: 716
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.2
    Marker Score: 7,737
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.18
    Marker Score: 346
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.16
    Marker Score: 601
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.16
    Marker Score: 365
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 1.15
    Marker Score: 6,055
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.13
    Marker Score: 459
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.13
    Marker Score: 631
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.09
    Marker Score: 5,878
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.09
    Marker Score: 4,718
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 1.08
    Marker Score: 279
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.07
    Marker Score: 1,291
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.06
    Marker Score: 918
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.06
    Marker Score: 440
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.04
    Marker Score: 905
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.04
    Marker Score: 704
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 792
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 1.03
    Marker Score: 491
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.03
    Marker Score: 380
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.02
    Marker Score: 347
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.01
    Marker Score: 587
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,776
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,001
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.99
    Marker Score: 1,286
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.99
    Marker Score: 454
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 507
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,405
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.98
    Marker Score: 572
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 461
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.97
    Marker Score: 374
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.97
    Marker Score: 336
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.96
    Marker Score: 309
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.96
    Marker Score: 1,653
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.96
    Marker Score: 303
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,412
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 373
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,297
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.92
    Marker Score: 241
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,736
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.91
    Marker Score: 509
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.91
    Marker Score: 451
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 325
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.9
    Marker Score: 270
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.89
    Marker Score: 1,030
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.89
    Marker Score: 361
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.88
    Marker Score: 512

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cell Adhesion:** CTNNA3 is a cytoplasmic component of adherens junctions, which are critical for maintaining tissue structure and function. It interacts with β-catenin, cadherins, and other proteins to form a complex that mediates cell-cell adhesion. 2. **Signaling Pathways:** CTNNA3 is involved in various signaling pathways, including the Wnt/β-catenin pathway, which regulates cell proliferation, differentiation, and survival. It also interacts with other proteins to modulate cell migration and invasion. 3. **Expression Patterns:** CTNNA3 is highly expressed in epithelial cells, cardiac myocytes, and neurons, highlighting its importance in these cell types. 4. **Alternative Splicing:** CTNNA3 undergoes alternative splicing, resulting in multiple isoforms with distinct functions and expression patterns. **Pathways and Functions:** 1. **Actin Filament Binding:** CTNNA3 interacts with actin filaments to modulate cell shape and cytoskeletal dynamics. 2. **Adherens Junction:** CTNNA3 is a key component of adherens junctions, which are essential for maintaining tissue structure and function. 3. **Beta-catenin Binding:** CTNNA3 interacts with β-catenin to regulate cell-cell adhesion and signaling pathways. 4. **Bundle of His Cell-Purkinje Myocyte Adhesion:** CTNNA3 is involved in the adhesion of cardiac myocytes to the Bundle of His, a critical structure in the heart's electrical conduction system. 5. **Regulation of Heart Rate:** CTNNA3 is involved in regulating heart rate by modulating the action potential in ventricular cardiac myocytes. 6. **Cell Migration:** CTNNA3 is involved in cell migration, particularly in the context of epithelial-to-mesenchymal transition (EMT). **Clinical Significance:** 1. **Cardiac Arrhythmias:** Alterations in CTNNA3 expression or function have been implicated in cardiac arrhythmias, including atrial fibrillation and ventricular tachycardia. 2. **Cancer:** CTNNA3 is often upregulated in various cancers, including breast, lung, and colon cancer, where it promotes cell migration and invasion. 3. **Neurological Disorders:** CTNNA3 has been implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease, where it regulates cell-cell adhesion and signaling pathways. 4. **Epithelial Dysfunctions:** CTNNA3 is involved in the regulation of epithelial function, and its dysregulation has been implicated in various epithelial disorders, including lung cancer and Barrett's esophagus. In conclusion, CTNNA3 is a multifaceted gene that plays a critical role in maintaining the integrity of various cell types, including epithelial cells, cardiac myocytes, and neurons. Its dysregulation has been implicated in various diseases, including cardiac arrhythmias, cancer, and neurological disorders. Further research is needed to fully elucidate the mechanisms by which CTNNA3 regulates cell-cell adhesion, signaling pathways, and heart function.

Genular Protein ID: 3842076129

Symbol: CTNA3_HUMAN

Name: Catenin alpha-3

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11590244

Title: AlphaT-catenin: a novel tissue-specific beta-catenin-binding protein mediating strong cell-cell adhesion.

PubMed ID: 11590244

DOI: 10.1242/jcs.114.17.3177

PubMed ID: 12596047

Title: Assessment of the CTNNA3 gene encoding human alpha T-catenin regarding its involvement in dilated cardiomyopathy.

PubMed ID: 12596047

DOI: 10.1007/s00439-002-0857-5

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17535849

Title: A unique and specific interaction between alphaT-catenin and plakophilin-2 in the area composita, the mixed-type junctional structure of cardiac intercalated discs.

PubMed ID: 17535849

DOI: 10.1242/jcs.004713

PubMed ID: 18318008

Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.

PubMed ID: 18318008

DOI: 10.1002/pmic.200700884

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 23136403

Title: Mutations in the area composita protein alphaT-catenin are associated with arrhythmogenic right ventricular cardiomyopathy.

PubMed ID: 23136403

DOI: 10.1093/eurheartj/ehs373

Sequence Information:

  • Length: 895
  • Mass: 99809
  • Checksum: 269E6DFB4956BDFE
  • Sequence:
  • MSAETPITLN IDPQDLQVQT FTVEKLLEPL IIQVTTLVNC PQNPSSRKKG RSKRASVLLA 
    SVEEATWNLL DKGEKIAQEA TVLKDELTAS LEEVRKESEA LKVSAERFTD DPCFLPKREA 
    VVQAARALLA AVTRLLILAD MIDVMCLLQH VSAFQRTFES LKNVANKSDL QKTYQKLGKE 
    LENLDYLAFK RQQDLKSPNQ RDEIAGARAS LKENSPLLHS ICSACLEHSD VASLKASKDT 
    VCEEIQNALN VISNASQGIQ NMTTPPEPQA ATLGSALDEL ENLIVLNPLT VTEEEIRPSL 
    EKRLEAIISG AALLADSSCT RDLHRERIIA ECNAIRQALQ DLLSEYMNNA GKKERSNTLN 
    IALDNMCKKT RDLRRQLRKA IIDHVSDSFL DTTVPLLVLI EAAKNGREKE IKEYAAIFHE 
    HTSRLVEVAN LACSMSTNED GIKIVKIAAN HLETLCPQII NAALALAARP KSQAVKNTME 
    MYKRTWENHI HVLTEAVDDI TSIDDFLAVS ESHILEDVNK CIIALRDQDA DNLDRAAGAI 
    RGRAARVAHI VTGEMDSYEP GAYTEGVMRN VNFLTSTVIP EFVTQVNVAL EALSKSSLNV 
    LDDNQFVDIS KKIYDTIHDI RCSVMMIRTP EELEDVSDLE EEHEVRSHTS IQTEGKTDRA 
    KMTQLPEAEK EKIAEQVADF KKVKSKLDAE IEIWDDTSND IIVLAKNMCM IMMEMTDFTR 
    GKGPLKHTTD VIYAAKMISE SGSRMDVLAR QIANQCPDPS CKQDLLAYLE QIKFYSHQLK 
    ICSQVKAEIQ NLGGELIMSA LDSVTSLIQA AKNLMNAVVQ TVKMSYIAST KIIRIQSPAG 
    PRHPVVMWRM KAPAKKPLIK REKPEETCAA VRRGSAKKKI HPLQVMSEFR GRQIY

Genular Protein ID: 2863849382

Symbol: Q8WW10_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 376
  • Mass: 41631
  • Checksum: 0656724AC2EA350B
  • Sequence:
  • MSAETPITLN IDPQDLQVQT FTVEKLLEPL IIQVTTLVNC PQNPSSRKKG RSKRASVLLA 
    SVEEATWNLL DKGEKIAQEA TVLKDELTAS LEKVRKESEA LKVSAERFTD DPCFLPKREA 
    VVQAARALLA AVTRLLILAD MIDVMCLLQH VSAFQRTFES LKNVANKSDL QKTYQKLGKE 
    LENLDYLAFK RQQDLKSPNQ RDEIAGARAS LKENSPLLHS ICSACLEHSD VASLKASKDT 
    VCEEIQNALN VISNASQGIQ NMTTPPEPQA ATLGSALDEL ENLIVLNPLT VTEEEIRPSL 
    EKRLEAIISG AALLADSSCT RDLHRERIIA ECNAIRQALQ DLLSEYMNNL CNQKSDLGLT 
    GVKIKLLEEC IIFWSL

Genular Protein ID: 4032640275

Symbol: A8K141_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 895
  • Mass: 99836
  • Checksum: 2D4509D0DE7E19EC
  • Sequence:
  • MSAETPITLN IDPQDLQVQT FTVEKLLEPL IIQVTTLVNC PQNPSSRKKG RSKRASVLLA 
    SVEEATWNLL DKGEKIAQEA TVLKDELTAS LEEVRKESEA LKVSAERFTD DPCFLPKREA 
    VVQAARALLA AVTRLLILAD MIDVMCLLQH VSAFQRTFES LKNVANKSDL QKTYQKLGKE 
    LENLDYLAFK RQQDLKSPNQ RDEIAGARAS LKENSPLLHS ICSACLEHSD VASLKASKDT 
    VCEEIQNALN VISNASQGIQ NMTTPPEPQA ATLGSALDEL ENLIVLNPLT VTEEEIRPSL 
    EKRLEAIISG AALLADSSCT RDLHRERIIA ECNAIRQALQ DLLSEYMNNA GKKERSNTLN 
    IALDNMCKKT RDLRRQLRKA IIDHVSDSFL DTTVPLLVLI EAAKNGREKE IKEYAAIFHE 
    HTSRLVEVAN LACSMSTNED GIKIVKIAAN HLETLCPQII NAALALAARP KSQAVKNTME 
    MYKRTWENHI HVLTEAVDDI TSIDDFLAVS ESHILEDVNK CIIALRDQDA DNLDRAAGAI 
    RGRAARVAHI VTGEMDSYEP GAYTEGVMRN VNFLTSTVIP EFVTQVNVAL EALSKNSLNV 
    LDDNQFVDIS KKIYDTIHDI RCSVMMIRTP EELEDVSDLE EEHEVRSHTS IQTEGKTDRA 
    KMTQLPEAEK EKIAEQVADF KKVKSKLDAE IEIWDDTSND IIVLAKNMCM IMMEMTDFTR 
    GKGPLKHTTD VIYAAKMISE SGSRMDVLAR QIANQCPDPS CKQDLLAYLE QIKFYSHQLK 
    ICSQVKAEIQ NLGGELIMSA LDSVTSLIQA AKNLMNAVVQ TVKMSYIAST KIIRIQSPAG 
    PRHPVVMWRM KAPAKKPLIK REKPEETCAA VRRGSAKKKI HPLQVMSEFR GRQIY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.