Details for: GRPR

Gene ID: 2925

Symbol: GRPR

Ensembl ID: ENSG00000126010

Description: gastrin releasing peptide receptor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.1777
    Cell Significance Index: 25.5200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.9218
    Cell Significance Index: 29.5300
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.7430
    Cell Significance Index: 10.8300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4886
    Cell Significance Index: 175.2600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3533
    Cell Significance Index: 67.2400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.2502
    Cell Significance Index: 6.0600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2390
    Cell Significance Index: 14.3500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2094
    Cell Significance Index: 4.4600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1549
    Cell Significance Index: 16.8500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1374
    Cell Significance Index: 13.5900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1341
    Cell Significance Index: 3.5300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1209
    Cell Significance Index: 109.1900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0855
    Cell Significance Index: 1.2300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0778
    Cell Significance Index: 12.6600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0758
    Cell Significance Index: 5.2400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.0625
    Cell Significance Index: 1.3500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0544
    Cell Significance Index: 7.9100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0342
    Cell Significance Index: 23.6700
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 0.0316
    Cell Significance Index: 0.4100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0302
    Cell Significance Index: 56.8500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0262
    Cell Significance Index: 1.6100
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.0259
    Cell Significance Index: 0.3400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0247
    Cell Significance Index: 0.5400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0161
    Cell Significance Index: 0.7500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.0140
    Cell Significance Index: 0.3000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0135
    Cell Significance Index: 0.2800
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.0122
    Cell Significance Index: 0.1400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0077
    Cell Significance Index: 0.2700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0073
    Cell Significance Index: 0.2100
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.0062
    Cell Significance Index: 0.0800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0054
    Cell Significance Index: 0.1300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0051
    Cell Significance Index: 0.6500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0045
    Cell Significance Index: 0.7600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.0040
    Cell Significance Index: 0.0800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.0031
    Cell Significance Index: 0.1900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0018
    Cell Significance Index: 1.1200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0005
    Cell Significance Index: 0.1100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0005
    Cell Significance Index: -0.8300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0006
    Cell Significance Index: -1.0500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0008
    Cell Significance Index: -0.0400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0009
    Cell Significance Index: -1.1900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0009
    Cell Significance Index: -0.0400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0020
    Cell Significance Index: -1.4900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0021
    Cell Significance Index: -1.1700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0027
    Cell Significance Index: -1.2200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0045
    Cell Significance Index: -1.3000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0045
    Cell Significance Index: -0.5200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0046
    Cell Significance Index: -0.3600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0052
    Cell Significance Index: -0.1300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0069
    Cell Significance Index: -1.3600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0082
    Cell Significance Index: -0.8400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0094
    Cell Significance Index: -1.9800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0095
    Cell Significance Index: -1.7100
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.0099
    Cell Significance Index: -0.0900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0102
    Cell Significance Index: -0.5700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0125
    Cell Significance Index: -1.4700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0133
    Cell Significance Index: -1.8300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0160
    Cell Significance Index: -1.9700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0161
    Cell Significance Index: -1.6800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0182
    Cell Significance Index: -1.3600
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0201
    Cell Significance Index: -0.4000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0229
    Cell Significance Index: -1.1900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0259
    Cell Significance Index: -0.3900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0262
    Cell Significance Index: -0.7300
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0285
    Cell Significance Index: -0.2700
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.0287
    Cell Significance Index: -0.3600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0297
    Cell Significance Index: -1.5600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0299
    Cell Significance Index: -2.0100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0311
    Cell Significance Index: -1.6200
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0351
    Cell Significance Index: -0.4100
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0353
    Cell Significance Index: -0.4500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0380
    Cell Significance Index: -1.3300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0397
    Cell Significance Index: -0.9900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0398
    Cell Significance Index: -0.9700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0401
    Cell Significance Index: -1.7800
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0447
    Cell Significance Index: -0.5400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0447
    Cell Significance Index: -2.1000
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.0447
    Cell Significance Index: -0.4500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0458
    Cell Significance Index: -1.5000
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0463
    Cell Significance Index: -0.7500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0463
    Cell Significance Index: -1.1900
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0468
    Cell Significance Index: -1.4800
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0474
    Cell Significance Index: -0.6200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0475
    Cell Significance Index: -1.5100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0475
    Cell Significance Index: -1.8000
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0512
    Cell Significance Index: -0.5300
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0524
    Cell Significance Index: -0.8400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0533
    Cell Significance Index: -1.4500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0533
    Cell Significance Index: -2.1800
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0544
    Cell Significance Index: -1.0700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0558
    Cell Significance Index: -1.2900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0560
    Cell Significance Index: -1.4000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0574
    Cell Significance Index: -2.9000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0590
    Cell Significance Index: -1.4700
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0598
    Cell Significance Index: -0.8200
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: -0.0623
    Cell Significance Index: -0.6600
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0645
    Cell Significance Index: -0.8300
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0649
    Cell Significance Index: -1.3200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0649
    Cell Significance Index: -1.7400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** GRPR is a GPCR that belongs to the class A/1 rhodopsin-like receptor family. It is characterized by its ability to bind to GRP and other related peptides, triggering a signaling cascade that involves the activation of Gαq proteins and the subsequent regulation of various downstream pathways. GRPR is widely expressed in various tissues, including the brain, gastrointestinal tract, and hematopoietic system, and is involved in regulating a range of functions, including: * Cell proliferation and differentiation * Survival and apoptosis * Behavior and cognition * Respiratory function * Immune responses **Pathways and Functions:** GRPR signaling involves the activation of Gαq proteins, which in turn activate phospholipase C (PLC) and the production of inositol trisphosphate (IP3) and diacylglycerol (DAG). These secondary messengers regulate various downstream pathways, including: * Phospholipase C-activating G protein-coupled receptor signaling pathway * G protein-coupled peptide receptor activity * Neuropeptide signaling pathway * Neuropeptide receptor activity GRPR signaling also involves the activation of MAPK/ERK, PI3K/Akt, and NF-κB pathways, which play critical roles in regulating cell proliferation, differentiation, and survival, as well as modulating behavior and immune responses. **Clinical Significance:** GRPR dysregulation has been implicated in various diseases and disorders, including: * Gastrointestinal disorders, such as gastritis, gastric cancer, and inflammatory bowel disease * Neurological disorders, such as Alzheimer's disease, Parkinson's disease, and schizophrenia * Respiratory disorders, such as chronic obstructive pulmonary disease (COPD) and asthma * Immune disorders, such as autoimmune diseases and cancer Understanding the role of GRPR in these diseases and disorders can provide valuable insights into the development of novel therapeutic strategies, including the use of GRPR agonists or antagonists to modulate GRPR signaling and restore normal physiological function. In conclusion, the gastrin-releasing peptide receptor (GRPR) is a multifaceted immunological player that plays a critical role in regulating various physiological and pathological processes. Its dysregulation has been implicated in various diseases and disorders, making it a promising target for the development of novel therapeutic strategies.

Genular Protein ID: 3023481282

Symbol: GRPR_HUMAN

Name: Gastrin-releasing peptide receptor

UniProtKB Accession Codes:

P30550 B2R910

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EMDB 2 Ensembl 1 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1655761

Title: Two distinct bombesin receptor subtypes are expressed and functional in human lung carcinoma cells.

PubMed ID: 1655761

DOI: 10.1016/s0021-9258(18)55129-2

PubMed ID: 11245983

Title: The human gastrin-releasing peptide receptor gene structure, its tissue expression and promoter.

PubMed ID: 11245983

DOI: 10.1016/s0378-1119(00)00596-5

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 34610277

Title: Bombesin-like peptide recruits disinhibitory cortical circuits and enhances fear memories.

PubMed ID: 34610277

DOI: 10.1016/j.cell.2021.09.013

Sequence Information:

  • Length: 384
  • Mass: 43199
  • Checksum: 70A75F11D9C82F19
  • Sequence:
    • MALNDCFLLN LEVDHFMHCN ISSHSADLPV NDDWSHPGIL YVIPAVYGVI ILIGLIGNIT 
LIKIFCTVKS MRNVPNLFIS SLALGDLLLL ITCAPVDASR YLADRWLFGR IGCKLIPFIQ 
LTSVGVSVFT LTALSADRYK AIVRPMDIQA SHALMKICLK AAFIWIISML LAIPEAVFSD 
LHPFHEESTN QTFISCAPYP HSNELHPKIH SMASFLVFYV IPLSIISVYY YFIAKNLIQS 
AYNLPVEGNI HVKKQIESRK RLAKTVLVFV GLFAFCWLPN HVIYLYRSYH YSEVDTSMLH 
FVTSICARLL AFTNSCVNPF ALYLLSKSFR KQFNTQLLCC QPGLIIRSHS TGRSTTCMTS 
LKSTNPSVAT FSLINGNICH ERYV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.