Gene GRPR - ENSG00000126010 | NCBI Gene ID: 2925

Details for: GRPR

Gene ID: 2925

Symbol: GRPR

Ensembl ID: ENSG00000126010

Description: gastrin releasing peptide receptor

Associated with

Class a/1 (rhodopsin-like receptors)
(R-HSA-373076)
G alpha (q) signalling events
(R-HSA-416476)
Gpcr downstream signalling
(R-HSA-388396)
Gpcr ligand binding
(R-HSA-500792)
Peptide ligand-binding receptors
(R-HSA-375276)
Signaling by gpcr
(R-HSA-372790)
Signal transduction
(R-HSA-162582)
G protein-coupled peptide receptor activity
(GO:0008528)
G protein-coupled receptor signaling pathway
(GO:0007186)
Learning or memory
(GO:0007611)
Motor behavior
(GO:0061744)
Neuropeptide binding
(GO:0042923)
Neuropeptide receptor activity
(GO:0008188)
Neuropeptide signaling pathway
(GO:0007218)
Phospholipase c-activating g protein-coupled receptor signaling pathway
(GO:0007200)
Plasma membrane
(GO:0005886)
Positive regulation of behavioral fear response
(GO:2000987)
Positive regulation of respiratory gaseous exchange
(GO:1903942)
Psychomotor behavior
(GO:0036343)
Regulation of cell population proliferation
(GO:0042127)
Response to external biotic stimulus
(GO:0043207)
Social behavior
(GO:0035176)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: erythrocyte (CL0000232)
Fold Change: 2.91
Marker Score: 1612
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 2.01
Marker Score: 2002
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.62
Marker Score: 1177
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.27
Marker Score: 861
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 1.19
Marker Score: 492
Cell Name: goblet cell (CL0000160)
Fold Change: 1.16
Marker Score: 7693
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.15
Marker Score: 4824
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 1.11
Marker Score: 508
Cell Name: megakaryocyte (CL0000556)
Fold Change: 1.07
Marker Score: 608
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71835
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48060
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1
Marker Score: 514
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.99
Marker Score: 467
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30409
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2413
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.94
Marker Score: 378
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.94
Marker Score: 5353
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.92
Marker Score: 330
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.92
Marker Score: 2741
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5290
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.86
Marker Score: 1402
Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.85
Marker Score: 3292
Cell Name: mast cell (CL0000097)
Fold Change: 0.85
Marker Score: 491
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.83
Marker Score: 1688
Cell Name: brush cell (CL0002204)
Fold Change: 0.78
Marker Score: 711
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.77
Marker Score: 401
Cell Name: double negative thymocyte (CL0002489)
Fold Change: 0.76
Marker Score: 1049
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 0.74
Marker Score: 11037
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.73
Marker Score: 467
Cell Name: plasma cell (CL0000786)
Fold Change: 0.67
Marker Score: 744
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.66
Marker Score: 1259
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 0.66
Marker Score: 346
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.63
Marker Score: 1017
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.62
Marker Score: 495
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.59
Marker Score: 245
Cell Name: pericyte (CL0000669)
Fold Change: 0.57
Marker Score: 332
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.55
Marker Score: 175
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.43
Marker Score: 6757
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.39
Marker Score: 1643.5
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.38
Marker Score: 229
Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 0.37
Marker Score: 765
Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 0.32
Marker Score: 11965
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.28
Marker Score: 182.5
Cell Name: T cell (CL0000084)
Fold Change: 0.24
Marker Score: 422
Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.23
Marker Score: 101
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.23
Marker Score: 65
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.22
Marker Score: 75
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.19
Marker Score: 93
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.19
Marker Score: 112.5
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.17
Marker Score: 43
Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.15
Marker Score: 48
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.14
Marker Score: 1410
Cell Name: renal principal cell (CL0005009)
Fold Change: 0.14
Marker Score: 107
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.14
Marker Score: 44
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.13
Marker Score: 316
Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 0.13
Marker Score: 32
Cell Name: melanocyte (CL0000148)
Fold Change: 0.12
Marker Score: 50
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 0.11
Marker Score: 116
Cell Name: epithelial cell (CL0000066)
Fold Change: 0.11
Marker Score: 173
Cell Name: macrophage (CL0000235)
Fold Change: 0.11
Marker Score: 119
Cell Name: interstitial cell of Cajal (CL0002088)
Fold Change: 0.1
Marker Score: 35
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 0.09
Marker Score: 90
Cell Name: neuron (CL0000540)
Fold Change: 0.09
Marker Score: 365
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.09
Marker Score: 27
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.08
Marker Score: 170
Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 0.08
Marker Score: 29
Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: 0.08
Marker Score: 79
Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 0.07
Marker Score: 36
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 0.07
Marker Score: 532.5
Cell Name: astrocyte (CL0000127)
Fold Change: 0.07
Marker Score: 59
Cell Name: endothelial cell of lymphatic vessel (CL0002138)
Fold Change: 0.07
Marker Score: 42
Cell Name: endothelial tip cell (CL0000704)
Fold Change: 0.07
Marker Score: 15.5
Cell Name: B cell (CL0000236)
Fold Change: 0.07
Marker Score: 63
Cell Name: smooth muscle cell (CL0000192)
Fold Change: 0.07
Marker Score: 43
Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 0.06
Marker Score: 59
Cell Name: endothelial cell (CL0000115)
Fold Change: 0.06
Marker Score: 57
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.06
Marker Score: 15
Cell Name: fibroblast (CL0000057)
Fold Change: 0.06
Marker Score: 60
Cell Name: epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.06
Marker Score: 26
Cell Name: podocyte (CL0000653)
Fold Change: 0.06
Marker Score: 21
Cell Name: acinar cell (CL0000622)
Fold Change: 0.05
Marker Score: 38
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 0.05
Marker Score: 55
Cell Name: retinal ganglion cell (CL0000740)
Fold Change: 0.05
Marker Score: 64
Cell Name: supporting cell (CL0000630)
Fold Change: 0.05
Marker Score: 96
Cell Name: lens fiber cell (CL0011004)
Fold Change: 0.05
Marker Score: 16
Cell Name: GABAergic neuron (CL0000617)
Fold Change: 0.05
Marker Score: 210
Cell Name: ependymal cell (CL0000065)
Fold Change: 0.05
Marker Score: 17
Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.05
Marker Score: 12
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 0.05
Marker Score: 14.5
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.04
Marker Score: 13
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 0.04
Marker Score: 55
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.04
Marker Score: 15
Cell Name: retinal pigment epithelial cell (CL0002586)
Fold Change: 0.04
Marker Score: 12.5
Cell Name: oocyte (CL0000023)
Fold Change: 0.04
Marker Score: 10.5
Cell Name: stromal cell (CL0000499)
Fold Change: 0.04
Marker Score: 49
Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 0.04
Marker Score: 191.5
Cell Name: microglial cell (CL0000129)
Fold Change: 0.04
Marker Score: 74
Cell Name: gut endothelial cell (CL0000131)
Fold Change: 0.04
Marker Score: 14.5
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 0.04
Marker Score: 56
Cell Name: ciliated epithelial cell (CL0000067)
Fold Change: 0.04
Marker Score: 18

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**Key characteristics:** * GRPR is a member of the G protein-coupled receptor (GPCR) superfamily. * It is a transmembrane protein that is expressed in the plasma membrane. * It is a single-pass protein that is composed of 14 transmembrane domains. * It is a ligand-gated ion channel. * It is a key regulator of gastrointestinal function. **Pathways and functions:** * The GRPR is a key regulator of epithelial cell migration. * It is expressed in the epithelial cells of the gastrointestinal tract, where it is involved in the regulation of epithelial cell migration. * It is also expressed in the enterocytes of the small intestine, where it is involved in the regulation of cell cycle regulation and inflammation. * It is a key regulator of gastrointestinal inflammation. **Clinical significance:** * Mutations in the GRPR gene have been linked to a number of gastrointestinal diseases, including gastroesophageal reflux disease, Crohn's disease, and ulcerative colitis. * The GRPR is a potential target for the treatment of these diseases. **Other important points:** * The GRPR is a highly conserved protein, with a similar sequence in mammals and humans. * It is a member of the G protein-coupled receptor superfamily, which is a large family of proteins that are involved in a variety of cellular processes. * It is a key regulator of epithelial cell migration, cell cycle regulation, and inflammation.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Gastrin-releasing peptide receptor

Genular Protein ID: 3023481282

Symbol: GRPR_HUMAN

Name: Gastrin-releasing peptide receptor

UniProtKB Accession Codes:

P30550 B2R910

Database IDs:

Citations:

PubMed ID: 1655761

Title: Two distinct bombesin receptor subtypes are expressed and functional in human lung carcinoma cells.

PubMed ID: 1655761

DOI: 10.1016/s0021-9258(18)55129-2

PubMed ID: 11245983

Title: The human gastrin-releasing peptide receptor gene structure, its tissue expression and promoter.

PubMed ID: 11245983

DOI: 10.1016/s0378-1119(00)00596-5

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 34610277

Title: Bombesin-like peptide recruits disinhibitory cortical circuits and enhances fear memories.

PubMed ID: 34610277

DOI: 10.1016/j.cell.2021.09.013

Sequence Information:

Length: 384
Mass: 43199
Checksum: 70A75F11D9C82F19
Sequence:

MALNDCFLLN LEVDHFMHCN ISSHSADLPV NDDWSHPGIL YVIPAVYGVI ILIGLIGNIT 
LIKIFCTVKS MRNVPNLFIS SLALGDLLLL ITCAPVDASR YLADRWLFGR IGCKLIPFIQ 
LTSVGVSVFT LTALSADRYK AIVRPMDIQA SHALMKICLK AAFIWIISML LAIPEAVFSD 
LHPFHEESTN QTFISCAPYP HSNELHPKIH SMASFLVFYV IPLSIISVYY YFIAKNLIQS 
AYNLPVEGNI HVKKQIESRK RLAKTVLVFV GLFAFCWLPN HVIYLYRSYH YSEVDTSMLH 
FVTSICARLL AFTNSCVNPF ALYLLSKSFR KQFNTQLLCC QPGLIIRSHS TGRSTTCMTS 
LKSTNPSVAT FSLINGNICH ERYV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: GRPR

Associated with

Cells (max top 100)

Other Information

Two distinct bombesin receptor subtypes are expressed and functional in human lung carcinoma cells. PubMed ID: 1655761

The human gastrin-releasing peptide receptor gene structure, its tissue expression and promoter. PubMed ID: 11245983

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039