Details for: OBP2A

Gene ID: 29991

Symbol: OBP2A

Ensembl ID: ENSG00000122136

Description: odorant binding protein 2A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 8.4342
    Cell Significance Index: 296.3700
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 7.3415
    Cell Significance Index: 5.2500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 3.7440
    Cell Significance Index: 93.5900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 3.4212
    Cell Significance Index: 98.5700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 2.4486
    Cell Significance Index: 56.5700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.3954
    Cell Significance Index: 63.2500
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 1.1882
    Cell Significance Index: 2.6800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.9662
    Cell Significance Index: 183.8800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.8583
    Cell Significance Index: 18.6000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7239
    Cell Significance Index: 71.6100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6368
    Cell Significance Index: 574.9900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.3266
    Cell Significance Index: 8.3200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.3264
    Cell Significance Index: 5.0500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3020
    Cell Significance Index: 49.1200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.2440
    Cell Significance Index: 7.8200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.2272
    Cell Significance Index: 8.3400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1579
    Cell Significance Index: 17.1800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0516
    Cell Significance Index: 6.6200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0382
    Cell Significance Index: 2.6400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0079
    Cell Significance Index: 0.3500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0012
    Cell Significance Index: -0.6800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0073
    Cell Significance Index: -13.7600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0099
    Cell Significance Index: -0.4600
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0146
    Cell Significance Index: -0.3700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0183
    Cell Significance Index: -10.0200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0217
    Cell Significance Index: -0.5400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0235
    Cell Significance Index: -0.7500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0293
    Cell Significance Index: -22.1400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0356
    Cell Significance Index: -12.7600
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0358
    Cell Significance Index: -0.3700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0369
    Cell Significance Index: -0.7300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0425
    Cell Significance Index: -0.6400
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: -0.0445
    Cell Significance Index: -0.5100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0449
    Cell Significance Index: -0.5100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0506
    Cell Significance Index: -6.5400
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: -0.0727
    Cell Significance Index: -0.4500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0743
    Cell Significance Index: -14.9000
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.0762
    Cell Significance Index: -0.7700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1080
    Cell Significance Index: -6.6200
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: -0.1093
    Cell Significance Index: -0.5800
  • Cell Name: peridermal cell (CL0000078)
    Fold Change: -0.1170
    Cell Significance Index: -0.7300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1216
    Cell Significance Index: -17.6700
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.1261
    Cell Significance Index: -0.7400
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: -0.1434
    Cell Significance Index: -0.3300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1449
    Cell Significance Index: -10.8000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1469
    Cell Significance Index: -20.1700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1514
    Cell Significance Index: -17.3500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1883
    Cell Significance Index: -19.2300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2042
    Cell Significance Index: -12.5500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2099
    Cell Significance Index: -4.4700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.2277
    Cell Significance Index: -13.6700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.2445
    Cell Significance Index: -110.9600
  • Cell Name: contractile cell (CL0000183)
    Fold Change: -0.2484
    Cell Significance Index: -0.4800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3210
    Cell Significance Index: -15.0900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3929
    Cell Significance Index: -10.3300
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.4364
    Cell Significance Index: -7.4600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4382
    Cell Significance Index: -9.3000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4580
    Cell Significance Index: -13.1300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4778
    Cell Significance Index: -25.0900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4964
    Cell Significance Index: -17.2500
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.5353
    Cell Significance Index: -9.2600
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.5468
    Cell Significance Index: -7.7700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.5741
    Cell Significance Index: -11.9100
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.5776
    Cell Significance Index: -9.8100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6179
    Cell Significance Index: -18.2000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.6762
    Cell Significance Index: -18.1200
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.6785
    Cell Significance Index: -9.2300
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.6794
    Cell Significance Index: -9.5300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.6926
    Cell Significance Index: -16.6100
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.6926
    Cell Significance Index: -7.9700
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.6979
    Cell Significance Index: -8.2400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.7330
    Cell Significance Index: -14.7200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.7423
    Cell Significance Index: -19.8200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.7505
    Cell Significance Index: -16.2200
  • Cell Name: chorionic trophoblast cell (CL0011101)
    Fold Change: -0.7592
    Cell Significance Index: -2.3600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.7606
    Cell Significance Index: -13.4400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.7806
    Cell Significance Index: -20.8800
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.7846
    Cell Significance Index: -8.3400
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.8144
    Cell Significance Index: -13.1900
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.8195
    Cell Significance Index: -16.1300
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.8269
    Cell Significance Index: -10.5900
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.9091
    Cell Significance Index: -13.8300
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.9719
    Cell Significance Index: -13.4800
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.9743
    Cell Significance Index: -13.8700
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.9762
    Cell Significance Index: -6.7700
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -1.0265
    Cell Significance Index: -15.5900
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -1.0298
    Cell Significance Index: -15.0100
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -1.0311
    Cell Significance Index: -16.5800
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -1.0481
    Cell Significance Index: -10.3700
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -1.0597
    Cell Significance Index: -10.9900
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -1.0705
    Cell Significance Index: -14.6800
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -1.0862
    Cell Significance Index: -21.6600
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -1.0931
    Cell Significance Index: -15.8700
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -1.0991
    Cell Significance Index: -13.8700
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -1.1111
    Cell Significance Index: -14.0800
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -1.1190
    Cell Significance Index: -14.4100
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -1.1223
    Cell Significance Index: -15.7300
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -1.1225
    Cell Significance Index: -13.5500
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -1.1262
    Cell Significance Index: -13.3700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -1.1483
    Cell Significance Index: -11.8900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Odorant Binding Protein Function:** OBP2A is a member of the odorant binding protein family, which is responsible for binding and transporting odorant molecules in the nasal cavity. This function is essential for the detection of chemical stimuli and the initiation of sensory perception. 2. **Immune Regulation:** OBP2A is expressed in various immune cells, including dendritic cells, T cells, and microglial cells, suggesting a role in immune regulation and modulation. 3. **Glucose Homeostasis:** Recent studies have implicated OBP2A in glucose homeostasis, highlighting its potential involvement in metabolic regulation. 4. **Small Molecule Binding:** OBP2A has been shown to bind small molecules, including odorants and other ligands, suggesting its role in sensing and responding to chemical stimuli. **Pathways and Functions:** 1. **Sensory Perception of Chemical Stimuli:** OBP2A is involved in the detection of chemical stimuli, including odorants, through its binding and transport function. 2. **Immune Regulation:** OBP2A modulates immune responses by influencing the function of immune cells, including dendritic cells, T cells, and microglial cells. 3. **Glucose Homeostasis:** OBP2A regulates glucose homeostasis by modulating the activity of glucose-sensing cells, such as pancreatic beta cells. 4. **Small Molecule Binding:** OBP2A binds small molecules, including odorants and other ligands, to initiate sensory perception and immune responses. **Clinical Significance:** 1. **Volatile Organic Compound (VOC) Detection:** OBP2A's role in detecting VOCs has significant implications for the diagnosis and treatment of diseases related to olfactory dysfunction. 2. **Immune-Mediated Disorders:** The involvement of OBP2A in immune regulation and modulation has implications for the treatment of immune-mediated disorders, such as autoimmune diseases and allergies. 3. **Metabolic Disorders:** OBP2A's role in glucose homeostasis suggests its potential involvement in metabolic disorders, such as type 2 diabetes and metabolic syndrome. 4. **Sensory Perception and Quality of Life:** The detection and regulation of chemical stimuli by OBP2A have significant implications for our understanding of sensory perception and its impact on quality of life. In conclusion, OBP2A is a multifaceted gene that plays a crucial role in sensory perception, immune regulation, and glucose homeostasis. Further research is needed to fully elucidate the molecular mechanisms underlying OBP2A's functions and its clinical significance.

Genular Protein ID: 3015731988

Symbol: OBP2A_HUMAN

Name: Odorant-binding protein 2a

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10607840

Title: A novel human odorant-binding protein gene family resulting from genomic duplicons at 9q34: differential expression in the oral and genital spheres.

PubMed ID: 10607840

DOI: 10.1093/hmg/9.2.289

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12044155

Title: Evidence of an odorant-binding protein in the human olfactory mucus: location, structural characterization, and odorant-binding properties.

PubMed ID: 12044155

DOI: 10.1021/bi015916c

PubMed ID: 16546182

Title: A single lysyl residue defines the binding specificity of a human odorant-binding protein for aldehydes.

PubMed ID: 16546182

DOI: 10.1016/j.febslet.2006.03.017

PubMed ID: 27827363

Title: Control of diabetic hyperglycaemia and insulin resistance through TSC22D4.

PubMed ID: 27827363

DOI: 10.1038/ncomms13267

PubMed ID: 25810031

Title: Crystal structure of the human odorant binding protein, OBPIIa.

PubMed ID: 25810031

DOI: 10.1002/prot.24797

Sequence Information:

  • Length: 170
  • Mass: 19318
  • Checksum: 391F55E2E3629E75
  • Sequence:
  • MKTLFLGVTL GLAAALSFTL EEEDITGTWY VKAMVVDKDF PEDRRPRKVS PVKVTALGGG 
    NLEATFTFMR EDRCIQKKIL MRKTEEPGKF SAYGGRKLIY LQELPGTDDY VFYCKDQRRG 
    GLRYMGKLVG RNPNTNLEAL EEFKKLVQHK GLSEEDIFMP LQTGSCVLEH

Genular Protein ID: 385245275

Symbol: B7ZLH4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 220
  • Mass: 24761
  • Checksum: A1876C2CA7C62672
  • Sequence:
  • MKTLFLGVTL GLAAALSFTL EEEDITGTWY VKAMVVDKDF PEDRRPRKVS PVKVTALGGG 
    NLEATFTFMR EDRCIQKKIL MRKTEEPGKF SAYGGRKLIY LQELPGTDDY VFYCKDQRRG 
    GLCHMGKLVA SAPCRAVPLS PPWLTWPPHL QLGILIPTWR PWKNLRNWCS TRDSPRRTFS 
    RPCRREAAFP NTRQPPGSAP PEPTLPPDTE PGPPGPTLQP

Genular Protein ID: 3166646309

Symbol: Q5T8A4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 147
  • Mass: 15749
  • Checksum: 8C37B238D35F34BA
  • Sequence:
  • MKTLFLGVTL GLAAALSFTL EEEDEGGSVH PEENPDAEDG GAWQIQRLWG QEAHIPAGAA 
    RDGRLRLLLQ RPAPWGPALH GKACGICSLQ GRAAVPTLAH LATSPAGRNP NTNLEALEEF 
    KKLVQHKGLS EEDIFMPLQT GSCVLEH

Genular Protein ID: 1414028209

Symbol: Q5T8A5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 228
  • Mass: 25985
  • Checksum: 7506B5D23F8C07C2
  • Sequence:
  • MKTLFLGVTL GLAAALSFTL EEEDITGTWY VKAMVVDKDF PEDRRPRKVS PVKVTALGGG 
    NLEATFTFMR EDRCIQKKIL MRKTEEPGKF SAYGGRKLIY LQELPGTDDY VFYCKDQRRG 
    GLRYMGKLVA SAPCRAVPLS PPWLTWPPHL QVGILIPTWR PWKNLRNWCS TRDSRRRTFS 
    CPCRREAAFS NTRQPPGLHL QSPPYHQTQS PDHLDLPSSH DPSLLPPT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.