Details for: PACSIN1

Gene ID: 29993

Symbol: PACSIN1

Ensembl ID: ENSG00000124507

Description: protein kinase C and casein kinase substrate in neurons 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 53.3820
    Cell Significance Index: -13.5400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 25.1196
    Cell Significance Index: -10.2100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 4.9606
    Cell Significance Index: 312.6500
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 2.7894
    Cell Significance Index: 21.5000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 2.6542
    Cell Significance Index: 31.6400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 2.4689
    Cell Significance Index: 79.0800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.4316
    Cell Significance Index: 30.1600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.0382
    Cell Significance Index: 408.8700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.9453
    Cell Significance Index: 42.1500
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 1.6750
    Cell Significance Index: 23.5300
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 1.6612
    Cell Significance Index: 22.1600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.2491
    Cell Significance Index: 448.0200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.0861
    Cell Significance Index: 48.0400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.0657
    Cell Significance Index: 737.1000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.0627
    Cell Significance Index: 30.3300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.0109
    Cell Significance Index: 38.2800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.9575
    Cell Significance Index: 64.3800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.9430
    Cell Significance Index: 49.5100
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.7878
    Cell Significance Index: 9.5500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.7321
    Cell Significance Index: 139.3300
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: 0.5873
    Cell Significance Index: 6.4800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.5428
    Cell Significance Index: 11.8900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4903
    Cell Significance Index: 48.5000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4112
    Cell Significance Index: 371.2900
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 0.4056
    Cell Significance Index: 5.2600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2601
    Cell Significance Index: 42.3000
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.2282
    Cell Significance Index: 2.0100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.2112
    Cell Significance Index: 3.6200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2109
    Cell Significance Index: 22.9400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1959
    Cell Significance Index: 12.0400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.1483
    Cell Significance Index: 3.1700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1449
    Cell Significance Index: 3.0900
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: 0.0930
    Cell Significance Index: 1.1600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0696
    Cell Significance Index: 1.6700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0678
    Cell Significance Index: 4.0700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0574
    Cell Significance Index: 3.9700
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.0399
    Cell Significance Index: 0.3800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0262
    Cell Significance Index: 2.0100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.0199
    Cell Significance Index: 0.4300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0068
    Cell Significance Index: 0.2400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0064
    Cell Significance Index: 3.5200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0040
    Cell Significance Index: 0.1800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0014
    Cell Significance Index: -0.0300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0032
    Cell Significance Index: -5.9500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0037
    Cell Significance Index: -0.0400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0039
    Cell Significance Index: -6.0100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0045
    Cell Significance Index: -6.0800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0048
    Cell Significance Index: -0.2100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0049
    Cell Significance Index: -9.1700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0050
    Cell Significance Index: -0.1600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0087
    Cell Significance Index: -0.2500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0144
    Cell Significance Index: -0.3600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0160
    Cell Significance Index: -11.8200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0171
    Cell Significance Index: -10.8900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0194
    Cell Significance Index: -0.3900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0197
    Cell Significance Index: -8.9600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0202
    Cell Significance Index: -1.2400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0209
    Cell Significance Index: -11.7700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0218
    Cell Significance Index: -13.6000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0262
    Cell Significance Index: -0.3800
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0272
    Cell Significance Index: -0.3400
  • Cell Name: intratelencephalic-projecting glutamatergic cortical neuron (CL4023008)
    Fold Change: -0.0297
    Cell Significance Index: -0.3100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0318
    Cell Significance Index: -5.7300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0331
    Cell Significance Index: -9.5200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0450
    Cell Significance Index: -0.8900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0452
    Cell Significance Index: -7.7100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0526
    Cell Significance Index: -7.6400
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0570
    Cell Significance Index: -0.7200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0597
    Cell Significance Index: -12.5700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0616
    Cell Significance Index: -12.2200
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0682
    Cell Significance Index: -0.8600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0685
    Cell Significance Index: -1.4300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0716
    Cell Significance Index: -8.8100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0733
    Cell Significance Index: -2.4000
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0765
    Cell Significance Index: -1.0200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0787
    Cell Significance Index: -4.0900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0795
    Cell Significance Index: -1.6500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0795
    Cell Significance Index: -10.9200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0827
    Cell Significance Index: -2.3100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0857
    Cell Significance Index: -10.1100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0860
    Cell Significance Index: -9.8500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0994
    Cell Significance Index: -2.4800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1087
    Cell Significance Index: -14.0400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1260
    Cell Significance Index: -16.1500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1262
    Cell Significance Index: -14.7100
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.1292
    Cell Significance Index: -1.4600
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.1320
    Cell Significance Index: -1.5400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1331
    Cell Significance Index: -7.4700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1355
    Cell Significance Index: -14.1100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1370
    Cell Significance Index: -13.9900
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1382
    Cell Significance Index: -1.3100
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.1530
    Cell Significance Index: -1.8300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1547
    Cell Significance Index: -5.4200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1572
    Cell Significance Index: -12.4500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1680
    Cell Significance Index: -4.0700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1870
    Cell Significance Index: -13.9400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1964
    Cell Significance Index: -10.2300
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.2023
    Cell Significance Index: -1.6700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2087
    Cell Significance Index: -13.4700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2227
    Cell Significance Index: -10.3900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Substrate for PKC and casein kinase**: PACSIN1 is a substrate for both PKC and casein kinase, which phosphorylate and regulate its activity. 2. **Regulation of endocytosis**: PACSIN1 modulates the endocytic pathway, influencing the internalization and degradation of membrane proteins and receptors. 3. **Cytoskeleton organization**: PACSIN1 interacts with cytoskeletal proteins, maintaining the structural integrity of the cytoskeleton and regulating cell shape and movement. 4. **Synaptic transmission**: PACSIN1 is involved in the regulation of synaptic transmission, including the endocytosis of synaptic vesicles and the modulation of neurotransmitter release. **Pathways and Functions:** 1. **Endocytosis**: PACSIN1 regulates the clathrin-mediated endocytosis of membrane proteins and receptors, influencing the internalization and degradation of these molecules. 2. **Cytoskeleton organization**: PACSIN1 interacts with cytoskeletal proteins, maintaining the structural integrity of the cytoskeleton and regulating cell shape and movement. 3. **Synaptic transmission**: PACSIN1 is involved in the regulation of synaptic transmission, including the endocytosis of synaptic vesicles and the modulation of neurotransmitter release. 4. **Neuronal morphology**: PACSIN1 regulates neuronal morphology, influencing the development and maintenance of axonal and dendritic structures. **Clinical Significance:** Dysregulation of PACSIN1 has been implicated in various neurological disorders, including: 1. **Neurodegenerative diseases**: PACSIN1 has been linked to neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 2. **Neurodevelopmental disorders**: PACSIN1 has been implicated in neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia. 3. **Stroke and trauma**: PACSIN1 has been shown to play a role in the regulation of synaptic plasticity and the recovery from stroke and traumatic brain injury. In conclusion, PACSIN1 is a critical regulator of neuronal function and endocytosis, and its dysregulation has been implicated in various neurological disorders. Further research is needed to fully understand the mechanisms by which PACSIN1 regulates neuronal function and to identify potential therapeutic targets for the treatment of these disorders.

Genular Protein ID: 958693191

Symbol: PACN1_HUMAN

Name: Protein kinase C and casein kinase substrate in neurons protein 1

UniProtKB Accession Codes:

Q9BY11 Q9P2G8

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 25 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11179684

Title: PACSIN 3 is a novel SH3 domain cytoplasmic adapter protein of the pacsin-syndapin-FAP52 gene family.

PubMed ID: 11179684

DOI: 10.1016/s0378-1119(00)00531-x

PubMed ID: 10718198

Title: Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10718198

DOI: 10.1093/dnares/7.1.65

PubMed ID: 12168954

Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

PubMed ID: 12168954

DOI: 10.1093/dnares/9.3.99

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 23236520

Title: Versatile membrane deformation potential of activated pacsin.

PubMed ID: 23236520

DOI: 10.1371/journal.pone.0051628

PubMed ID: 19549836

Title: Molecular mechanism of membrane constriction and tubulation mediated by the F-BAR protein Pacsin/Syndapin.

PubMed ID: 19549836

DOI: 10.1073/pnas.0902974106

PubMed ID: 22573331

Title: Rigidity of wedge loop in PACSIN 3 protein is a key factor in dictating diameters of tubules.

PubMed ID: 22573331

DOI: 10.1074/jbc.m112.358960

Sequence Information:

  • Length: 444
  • Mass: 50966
  • Checksum: 6AAF801873770975
  • Sequence:
    • MSSSYDEASL APEETTDSFW EVGNYKRTVK RIDDGHRLCN DLMNCVQERA KIEKAYGQQL 
TDWAKRWRQL IEKGPQYGSL ERAWGAIMTE ADKVSELHQE VKNNLLNEDL EKVKNWQKDA 
YHKQIMGGFK ETKEAEDGFR KAQKPWAKKM KELEAAKKAY HLACKEEKLA MTREMNSKTE 
QSVTPEQQKK LQDKVDKCKQ DVQKTQEKYE KVLEDVGKTT PQYMENMEQV FEQCQQFEEK 
RLVFLKEVLL DIKRHLNLAE NSSYIHVYRE LEQAIRGADA QEDLRWFRST SGPGMPMNWP 
QFEEWNPDLP HTTTKKEKQP KKAEGVALTN ATGAVESTSQ AGDRGSVSSY DRGQPYATEW 
SDDESGNPFG GSETNGGANP FEDDSKGVRV RALYDYDGQE QDELSFKAGD ELTKLGEEDE 
QGWCRGRLDS GQLGLYPANY VEAI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.