Details for: TLX3

Gene ID: 30012

Symbol: TLX3

Ensembl ID: ENSG00000164438

Description: T cell leukemia homeobox 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 1.8296
    Cell Significance Index: 10.4000
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 1.4798
    Cell Significance Index: 16.8100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.3653
    Cell Significance Index: 33.0700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.6611
    Cell Significance Index: 14.4800
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.3671
    Cell Significance Index: 5.3500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.2260
    Cell Significance Index: 3.8700
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.1879
    Cell Significance Index: 2.0700
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.1617
    Cell Significance Index: 1.6000
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: 0.1234
    Cell Significance Index: 2.4600
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 0.1081
    Cell Significance Index: 1.2000
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.0076
    Cell Significance Index: 0.0700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0025
    Cell Significance Index: 1.1200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0028
    Cell Significance Index: -2.0500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0032
    Cell Significance Index: -2.0300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0037
    Cell Significance Index: -2.0200
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0062
    Cell Significance Index: -0.0700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0067
    Cell Significance Index: -1.9400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0098
    Cell Significance Index: -1.9400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0098
    Cell Significance Index: -0.1400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0104
    Cell Significance Index: -2.0800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0107
    Cell Significance Index: -1.9300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0137
    Cell Significance Index: -2.0000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0145
    Cell Significance Index: -1.6600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0164
    Cell Significance Index: -2.2500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0182
    Cell Significance Index: -3.1100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0183
    Cell Significance Index: -0.8500
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0227
    Cell Significance Index: -0.2700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0264
    Cell Significance Index: -1.3700
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0286
    Cell Significance Index: -0.4100
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: -0.0290
    Cell Significance Index: -0.2300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0319
    Cell Significance Index: -1.5000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0356
    Cell Significance Index: -2.0000
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0381
    Cell Significance Index: -0.3800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0416
    Cell Significance Index: -0.8700
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.0418
    Cell Significance Index: -0.2600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0427
    Cell Significance Index: -1.1400
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.0447
    Cell Significance Index: -0.6200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0575
    Cell Significance Index: -1.5400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0581
    Cell Significance Index: -2.0200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0593
    Cell Significance Index: -1.4800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0596
    Cell Significance Index: -1.9500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0722
    Cell Significance Index: -1.8400
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.0746
    Cell Significance Index: -0.8600
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0749
    Cell Significance Index: -0.7100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0753
    Cell Significance Index: -1.9800
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0773
    Cell Significance Index: -0.9400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0800
    Cell Significance Index: -0.8700
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0808
    Cell Significance Index: -1.0600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0838
    Cell Significance Index: -2.0900
  • Cell Name: brush cell of tracheobronchial tree (CL0002075)
    Fold Change: -0.0883
    Cell Significance Index: -0.8000
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: -0.0891
    Cell Significance Index: -0.6500
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0897
    Cell Significance Index: -1.2400
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0915
    Cell Significance Index: -1.2000
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0915
    Cell Significance Index: -1.8000
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.0922
    Cell Significance Index: -1.0100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0954
    Cell Significance Index: -1.9200
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0958
    Cell Significance Index: -1.2100
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0966
    Cell Significance Index: -1.5500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0980
    Cell Significance Index: -2.0800
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1008
    Cell Significance Index: -1.7000
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.1020
    Cell Significance Index: -1.2200
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.1028
    Cell Significance Index: -1.1700
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1033
    Cell Significance Index: -2.0200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1042
    Cell Significance Index: -2.0600
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1043
    Cell Significance Index: -1.3500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1055
    Cell Significance Index: -1.7700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1055
    Cell Significance Index: -2.2800
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1094
    Cell Significance Index: -1.8600
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.1163
    Cell Significance Index: -1.6700
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.1168
    Cell Significance Index: -0.7600
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.1185
    Cell Significance Index: -1.5500
  • Cell Name: neuroplacodal cell (CL0000032)
    Fold Change: -0.1210
    Cell Significance Index: -1.4900
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.1213
    Cell Significance Index: -1.6500
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.1214
    Cell Significance Index: -2.0000
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.1223
    Cell Significance Index: -1.6800
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.1261
    Cell Significance Index: -1.5000
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.1291
    Cell Significance Index: -1.4300
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: -0.1296
    Cell Significance Index: -1.5000
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.1300
    Cell Significance Index: -1.5100
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.1305
    Cell Significance Index: -1.6800
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1309
    Cell Significance Index: -1.9000
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.1311
    Cell Significance Index: -1.5000
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: -0.1313
    Cell Significance Index: -1.4300
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: -0.1327
    Cell Significance Index: -1.4400
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.1333
    Cell Significance Index: -1.5900
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1337
    Cell Significance Index: -1.4100
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.1337
    Cell Significance Index: -1.6700
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1342
    Cell Significance Index: -1.8400
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.1356
    Cell Significance Index: -1.7700
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.1356
    Cell Significance Index: -1.5400
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.1360
    Cell Significance Index: -1.9100
  • Cell Name: interneuron (CL0000099)
    Fold Change: -0.1361
    Cell Significance Index: -1.5900
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.1381
    Cell Significance Index: -1.6300
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -0.1382
    Cell Significance Index: -1.6600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1382
    Cell Significance Index: -2.0400
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.1389
    Cell Significance Index: -1.6900
  • Cell Name: differentiation-committed oligodendrocyte precursor (CL4023059)
    Fold Change: -0.1391
    Cell Significance Index: -1.6500
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.1393
    Cell Significance Index: -1.5600
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.1394
    Cell Significance Index: -1.5300
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1395
    Cell Significance Index: -2.2600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** TLX3 exhibits several key characteristics that distinguish it from other transcription factors: 1. **Cell-type specific expression**: TLX3 is specifically expressed in various cell types, suggesting its involvement in specific cellular processes. 2. **Transcriptional regulation**: TLX3 acts as a transcription factor, regulating the expression of target genes involved in cellular differentiation, migration, and survival. 3. **DNA-binding domain**: TLX3 possesses a conserved DNA-binding domain, allowing it to interact with specific DNA sequences and regulate gene expression. 4. **Multiple isoforms**: TLX3 has been shown to generate multiple isoforms, which may contribute to its diverse cellular functions. **Pathways and Functions** TLX3 is involved in several signaling pathways and cellular processes, including: 1. **Neuron fate specification**: TLX3 regulates the differentiation and migration of GABAergic interneurons, highlighting its role in the development of the central nervous system. 2. **Cell migration**: TLX3 is involved in the regulation of cell migration, which is crucial for tissue development and immune function. 3. **Apoptosis regulation**: TLX3 has been shown to regulate apoptosis, a process essential for maintaining tissue homeostasis. 4. **Immune system development**: TLX3 is expressed in immune cells and plays a role in the development and function of the immune system. 5. **Respiratory gaseous exchange**: TLX3 is involved in the regulation of respiratory gaseous exchange by the nervous system, highlighting its role in the development of the respiratory system. **Clinical Significance** The clinical significance of TLX3 is multifaceted, with potential implications for various diseases and disorders: 1. **Immune system disorders**: Abnormalities in TLX3 expression have been linked to immune system disorders, such as autoimmune diseases and cancer. 2. **Neurological disorders**: TLX3 has been implicated in the development of neurological disorders, including Alzheimer's disease and Parkinson's disease. 3. **Respiratory diseases**: TLX3 may play a role in the development of respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD). 4. **Cancer**: TLX3 has been shown to be overexpressed in certain types of cancer, suggesting its potential role as a tumor suppressor or oncogene. In conclusion, TLX3 is a complex transcription factor that plays a multifaceted role in various cellular processes, including cell differentiation, migration, and survival. Its clinical significance is substantial, with potential implications for the development of immune system disorders, neurological disorders, respiratory diseases, and cancer. Further research is necessary to fully elucidate the functions of TLX3 and its role in human disease.

Genular Protein ID: 2035008674

Symbol: TLX3_HUMAN

Name: T-cell leukemia homeobox protein 3

UniProtKB Accession Codes:

O43711 Q96AD3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 4 Ensembl 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 291
  • Mass: 31867
  • Checksum: B5E3B910393EB4F3
  • Sequence:
    • MEAPASAQTP HPHEPISFGI DQILNSPDQD SAPAPRGPDG ASYLGGPPGG RPGATYPSLP 
ASFAGLGAPF EDAGSYSVNL SLAPAGVIRV PAHRPLPGAV PPPLPSALPA MPSVPTVSSL 
GGLNFPWMES SRRFVKDRFT AAAALTPFTV TRRIGHPYQN RTPPKRKKPR TSFSRVQICE 
LEKRFHRQKY LASAERAALA KSLKMTDAQV KTWFQNRRTK WRRQTAEERE AERQQASRLM 
LQLQHDAFQK SLNDSIQPDP LCLHNSSLFA LQNLQPWEED SSKVPAVTSL V

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.