Details for: EHD3

Gene ID: 30845

Symbol: EHD3

Ensembl ID: ENSG00000013016

Description: EH domain containing 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 61.9755
    Cell Significance Index: -9.6400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 36.9416
    Cell Significance Index: -9.3700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 18.8769
    Cell Significance Index: -9.7100
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 15.3825
    Cell Significance Index: 57.3300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.1148
    Cell Significance Index: 15.2100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.0221
    Cell Significance Index: 205.0400
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.9005
    Cell Significance Index: 8.5600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.7716
    Cell Significance Index: 51.8800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6913
    Cell Significance Index: 35.9100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.6389
    Cell Significance Index: 9.1500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.5712
    Cell Significance Index: 18.3000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.5295
    Cell Significance Index: 15.1100
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.4528
    Cell Significance Index: 3.5800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4171
    Cell Significance Index: 79.3700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3786
    Cell Significance Index: 23.8600
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.3531
    Cell Significance Index: 4.7100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3460
    Cell Significance Index: 9.2700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3192
    Cell Significance Index: 8.9200
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.2634
    Cell Significance Index: 3.7500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2601
    Cell Significance Index: 25.7300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2291
    Cell Significance Index: 206.8800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1978
    Cell Significance Index: 70.9400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1974
    Cell Significance Index: 35.5900
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.1834
    Cell Significance Index: 1.9000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.1494
    Cell Significance Index: 3.9900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1479
    Cell Significance Index: 18.1900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1338
    Cell Significance Index: 21.7600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1337
    Cell Significance Index: 92.4700
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.1265
    Cell Significance Index: 0.8400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1101
    Cell Significance Index: 2.4100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0914
    Cell Significance Index: 9.9400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0850
    Cell Significance Index: 6.5300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0535
    Cell Significance Index: 3.4500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0337
    Cell Significance Index: 0.9700
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.0321
    Cell Significance Index: 0.2700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0268
    Cell Significance Index: 0.6700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0265
    Cell Significance Index: 3.1200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0248
    Cell Significance Index: 13.5500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0197
    Cell Significance Index: 1.3600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0159
    Cell Significance Index: 3.1600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0110
    Cell Significance Index: 0.5800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0043
    Cell Significance Index: 0.1500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0008
    Cell Significance Index: 0.0500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0004
    Cell Significance Index: -0.7300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0008
    Cell Significance Index: -0.0500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0009
    Cell Significance Index: -0.4000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0022
    Cell Significance Index: -4.1200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0038
    Cell Significance Index: -5.7800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0062
    Cell Significance Index: -8.4400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0098
    Cell Significance Index: -6.2100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0114
    Cell Significance Index: -5.1600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0119
    Cell Significance Index: -8.7000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0131
    Cell Significance Index: -9.9400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0134
    Cell Significance Index: -9.9000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0147
    Cell Significance Index: -2.1400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0165
    Cell Significance Index: -9.3200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0175
    Cell Significance Index: -0.3800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0191
    Cell Significance Index: -11.9200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0204
    Cell Significance Index: -0.4400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0239
    Cell Significance Index: -3.2800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0253
    Cell Significance Index: -7.2800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0263
    Cell Significance Index: -1.1900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0280
    Cell Significance Index: -3.5900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0340
    Cell Significance Index: -3.9700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0443
    Cell Significance Index: -0.7600
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.0447
    Cell Significance Index: -0.4300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0477
    Cell Significance Index: -2.9300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0515
    Cell Significance Index: -10.8500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0577
    Cell Significance Index: -9.8600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0609
    Cell Significance Index: -2.8400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0612
    Cell Significance Index: -1.2700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0675
    Cell Significance Index: -6.9000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0691
    Cell Significance Index: -3.6000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0714
    Cell Significance Index: -9.2200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0810
    Cell Significance Index: -9.2800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0843
    Cell Significance Index: -1.7900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0858
    Cell Significance Index: -6.0700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0928
    Cell Significance Index: -9.6600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0952
    Cell Significance Index: -4.2100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1101
    Cell Significance Index: -4.1700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1163
    Cell Significance Index: -2.3000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1167
    Cell Significance Index: -2.5000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1169
    Cell Significance Index: -9.2600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1265
    Cell Significance Index: -9.4300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1281
    Cell Significance Index: -4.0800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1318
    Cell Significance Index: -3.1600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1374
    Cell Significance Index: -4.5000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1386
    Cell Significance Index: -7.7800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1419
    Cell Significance Index: -1.7600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1575
    Cell Significance Index: -1.4500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1677
    Cell Significance Index: -7.8800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1708
    Cell Significance Index: -7.4300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1768
    Cell Significance Index: -2.6100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1819
    Cell Significance Index: -3.9300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1840
    Cell Significance Index: -4.5900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1864
    Cell Significance Index: -6.5300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1877
    Cell Significance Index: -5.5300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1973
    Cell Significance Index: -5.0400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1990
    Cell Significance Index: -3.3300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2055
    Cell Significance Index: -2.3400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** EHD3 protein exhibits a characteristic EH domain, which is a conserved motif involved in protein-protein interactions. The EH domain allows EHD3 to recognize and bind to specific phosphotyrosine motifs, thereby regulating the endocytic pathway and modulating the activity of various proteins. EHD3 also contains a PDZ domain, which enables it to interact with other proteins and regulate their localization and function. These domains confer EHD3 a diverse range of functions, including protein transport, localization, and degradation. **Pathways and Functions:** EHD3 is involved in several cellular pathways, including: 1. **Endocytic Recycling:** EHD3 regulates the endocytic pathway by interacting with clathrin and AP-2 complex, thereby controlling the internalization and degradation of membrane proteins. 2. **Cytoskeletal Dynamics:** EHD3 modulates the activity of cytoskeletal proteins, such as actin and myosin, to regulate cell shape and movement. 3. **Cell Signaling:** EHD3 interacts with signaling proteins, including receptor tyrosine kinases and G-protein coupled receptors, to regulate cell growth and differentiation. 4. **Gene Expression:** EHD3 regulates gene expression by interacting with transcription factors and chromatin-modifying enzymes, thereby controlling the expression of various genes. **Clinical Significance:** EHD3 has been implicated in several diseases, including: 1. **Cardiac Conduction Disorders:** Mutations in EHD3 have been associated with cardiac conduction disorders, including atrioventricular block and long QT syndrome. 2. **Immune Disorders:** EHD3 has been implicated in immune disorders, including autoimmune diseases and cancer. 3. **Neurological Disorders:** EHD3 has been linked to neurological disorders, including Alzheimer's disease and Parkinson's disease. 4. **Cancer:** EHD3 has been found to be overexpressed in various cancers, including breast, lung, and colon cancer. In conclusion, EHD3 is a multifaceted protein that plays a critical role in various cellular processes, including endocytic recycling, cytoskeletal dynamics, cell signaling, and gene expression. Its dysregulation has been implicated in several diseases, highlighting the importance of EHD3 in human health and disease. Further research is needed to fully elucidate the mechanisms by which EHD3 regulates cellular processes and to explore its therapeutic potential in disease treatment.

Genular Protein ID: 534405862

Symbol: EHD3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9NZN3 B4DFR5 D6W574 Q8N514 Q9NZB3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEBI 8 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 1 GO 28 Gene3D 3 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10673336

Title: EHD2, EHD3, and EHD4 encode novel members of a highly conserved family of EH domain-containing proteins.

PubMed ID: 10673336

DOI: 10.1006/geno.1999.6087

PubMed ID: 12121420

Title: EHD3: a protein that resides in recycling tubular and vesicular membrane structures and interacts with EHD1.

PubMed ID: 12121420

DOI: 10.1034/j.1600-0854.2002.30807.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 16251358

Title: Interactions between EHD proteins and Rab11-FIP2: a role for EHD3 in early endosomal transport.

PubMed ID: 16251358

DOI: 10.1091/mbc.e05-05-0466

PubMed ID: 17233914

Title: Shared as well as distinct roles of EHD proteins revealed by biochemical and functional comparisons in mammalian cells and C. elegans.

PubMed ID: 17233914

DOI: 10.1186/1471-2121-8-3

PubMed ID: 18331452

Title: A role for EHD4 in the regulation of early endosomal transport.

PubMed ID: 18331452

DOI: 10.1111/j.1600-0854.2008.00732.x

PubMed ID: 19139087

Title: EHD3 regulates early-endosome-to-Golgi transport and preserves Golgi morphology.

PubMed ID: 19139087

DOI: 10.1242/jcs.037051

PubMed ID: 19864458

Title: MICAL-L1 links EHD1 to tubular recycling endosomes and regulates receptor recycling.

PubMed ID: 19864458

DOI: 10.1091/mbc.e09-06-0535

PubMed ID: 20489164

Title: EH domain proteins regulate cardiac membrane protein targeting.

PubMed ID: 20489164

DOI: 10.1161/circresaha.110.216713

PubMed ID: 21791287

Title: Endocytosis promotes rapid dopaminergic signaling.

PubMed ID: 21791287

DOI: 10.1016/j.neuron.2011.05.036

PubMed ID: 24019528

Title: Differential roles of C-terminal Eps15 homology domain proteins as vesiculators and tubulators of recycling endosomes.

PubMed ID: 24019528

DOI: 10.1074/jbc.m113.488627

PubMed ID: 23781025

Title: Alphavbeta3-integrin-mediated adhesion is regulated through an AAK1L- and EHD3-dependent rapid-recycling pathway.

PubMed ID: 23781025

DOI: 10.1242/jcs.122465

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25686250

Title: Early steps in primary cilium assembly require EHD1/EHD3-dependent ciliary vesicle formation.

PubMed ID: 25686250

DOI: 10.1038/ncb3109

PubMed ID: 26226295

Title: SUMOylation of EHD3 Modulates Tubulation of the Endocytic Recycling Compartment.

PubMed ID: 26226295

DOI: 10.1371/journal.pone.0134053

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 23754701

Title: Chemical shift assignments of the C-terminal Eps15 homology domain-3 EH domain.

PubMed ID: 23754701

DOI: 10.1007/s12104-013-9497-z

Sequence Information:

  • Length: 535
  • Mass: 60887
  • Checksum: 0F8AE99F84B966AD
  • Sequence:
    • MFSWLGTDDR RRKDPEVFQT VSEGLKKLYK SKLLPLEEHY RFHEFHSPAL EDADFDNKPM 
VLLVGQYSTG KTTFIRYLLE QDFPGMRIGP EPTTDSFIAV MQGDMEGIIP GNALVVDPKK 
PFRKLNAFGN AFLNRFVCAQ LPNPVLESIS VIDTPGILSG EKQRISRGYD FAAVLEWFAE 
RVDRIILLFD AHKLDISDEF SEVIKALKNH EDKMRVVLNK ADQIETQQLM RVYGALMWSL 
GKIVNTPEVI RVYIGSFWSH PLLIPDNRKL FEAEEQDLFR DIQSLPRNAA LRKLNDLIKR 
ARLAKVHAYI ISSLKKEMPS VFGKDNKKKE LVNNLAEIYG RIEREHQISP GDFPNLKRMQ 
DQLQAQDFSK FQPLKSKLLE VVDDMLAHDI AQLMVLVRQE ESQRPIQMVK GGAFEGTLHG 
PFGHGYGEGA GEGIDDAEWV VARDKPMYDE IFYTLSPVDG KITGANAKKE MVRSKLPNSV 
LGKIWKLADI DKDGMLDDDE FALANHLIKV KLEGHELPNE LPAHLLPPSK RKVAE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.