Details for: PIK3R4
Associated with
Cells (max top 100)
(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: germ cell (CL0000586)
Fold Change: 1.57
Marker Score: 2,745 - Cell Name: mural cell (CL0008034)
Fold Change: 1.47
Marker Score: 168,848 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.31
Marker Score: 11,277 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.26
Marker Score: 11,935 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.25
Marker Score: 76,882 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.17
Marker Score: 1,808 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 1.16
Marker Score: 10,882 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 1.08
Marker Score: 39,868 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.05
Marker Score: 16,402 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71,762 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 47,987 - Cell Name: neuron (CL0000540)
Fold Change: 0.99
Marker Score: 4,015 - Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,402 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.97
Marker Score: 10,016 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2,407 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.94
Marker Score: 487 - Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.93
Marker Score: 441 - Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 0.92
Marker Score: 735 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2,724 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 0.88
Marker Score: 17,503 - Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.88
Marker Score: 4,998 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5,295 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 0.87
Marker Score: 962 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 0.87
Marker Score: 6,641 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.86
Marker Score: 311 - Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 0.85
Marker Score: 32,170 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.83
Marker Score: 1,814 - Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.81
Marker Score: 3,128 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 0.79
Marker Score: 11,806 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.77
Marker Score: 1,252 - Cell Name: oogonial cell (CL0000024)
Fold Change: 0.76
Marker Score: 1,099 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.75
Marker Score: 301 - Cell Name: male germ cell (CL0000015)
Fold Change: 0.75
Marker Score: 215 - Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.74
Marker Score: 1,499 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.73
Marker Score: 560 - Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.73
Marker Score: 378 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.73
Marker Score: 3,047 - Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 0.72
Marker Score: 3,106 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 0.72
Marker Score: 2,982 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 0.71
Marker Score: 4,553 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 0.7
Marker Score: 14,860 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.68
Marker Score: 4,111 - Cell Name: brush cell (CL0002204)
Fold Change: 0.68
Marker Score: 618 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.67
Marker Score: 172 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.64
Marker Score: 187 - Cell Name: interneuron (CL0000099)
Fold Change: 0.63
Marker Score: 289 - Cell Name: type A enteroendocrine cell (CL0002067)
Fold Change: 0.63
Marker Score: 255 - Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.63
Marker Score: 380 - Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 0.62
Marker Score: 709 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.61
Marker Score: 2,538 - Cell Name: primordial germ cell (CL0000670)
Fold Change: 0.6
Marker Score: 758 - Cell Name: fat cell (CL0000136)
Fold Change: 0.6
Marker Score: 334 - Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 0.6
Marker Score: 643 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 0.58
Marker Score: 3,143 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.58
Marker Score: 340 - Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 0.56
Marker Score: 1,084 - Cell Name: pyramidal neuron (CL0000598)
Fold Change: 0.56
Marker Score: 946 - Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 0.56
Marker Score: 328 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.55
Marker Score: 329 - Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 0.55
Marker Score: 266 - Cell Name: primitive red blood cell (CL0002355)
Fold Change: 0.55
Marker Score: 410 - Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.54
Marker Score: 434 - Cell Name: cholangiocyte (CL1000488)
Fold Change: 0.54
Marker Score: 203 - Cell Name: ependymal cell (CL0000065)
Fold Change: 0.54
Marker Score: 187 - Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.53
Marker Score: 1,255 - Cell Name: renal principal cell (CL0005009)
Fold Change: 0.53
Marker Score: 410 - Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 0.53
Marker Score: 221 - Cell Name: astrocyte (CL0000127)
Fold Change: 0.52
Marker Score: 453 - Cell Name: precursor B cell (CL0000817)
Fold Change: 0.51
Marker Score: 340 - Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 0.51
Marker Score: 2,377 - Cell Name: lens fiber cell (CL0011004)
Fold Change: 0.51
Marker Score: 162 - Cell Name: cardiac neuron (CL0010022)
Fold Change: 0.51
Marker Score: 630 - Cell Name: melanocyte (CL0000148)
Fold Change: 0.49
Marker Score: 197 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 0.49
Marker Score: 481 - Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 0.48
Marker Score: 255 - Cell Name: podocyte (CL0000653)
Fold Change: 0.48
Marker Score: 179 - Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 0.48
Marker Score: 679 - Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.48
Marker Score: 154 - Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 0.47
Marker Score: 128 - Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.47
Marker Score: 223 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.46
Marker Score: 15,584 - Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 0.46
Marker Score: 418 - Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 0.45
Marker Score: 10,120 - Cell Name: Unknown (CL0002371)
Fold Change: 0.45
Marker Score: 481 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.45
Marker Score: 154 - Cell Name: proerythroblast (CL0000547)
Fold Change: 0.45
Marker Score: 302 - Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 0.44
Marker Score: 308 - Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.44
Marker Score: 138 - Cell Name: hepatocyte (CL0000182)
Fold Change: 0.44
Marker Score: 299 - Cell Name: cerebellar granule cell precursor (CL0002362)
Fold Change: 0.44
Marker Score: 245 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 0.43
Marker Score: 137 - Cell Name: Leydig cell (CL0000178)
Fold Change: 0.43
Marker Score: 462 - Cell Name: Schwann cell (CL0002573)
Fold Change: 0.43
Marker Score: 148 - Cell Name: mesangial cell (CL0000650)
Fold Change: 0.43
Marker Score: 514 - Cell Name: taste receptor cell (CL0000209)
Fold Change: 0.42
Marker Score: 367 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.42
Marker Score: 510 - Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: 0.42
Marker Score: 1,495 - Cell Name: ciliated cell (CL0000064)
Fold Change: 0.42
Marker Score: 1,430 - Cell Name: erythroblast (CL0000765)
Fold Change: 0.41
Marker Score: 259 - Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 0.41
Marker Score: 440
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1206229614
Symbol: PI3R4_HUMAN
Name: Phosphoinositide 3-kinase regulatory subunit 4
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8999962
Title: Characterization of p150, an adaptor protein for the human phosphatidylinositol (PtdIns) 3-kinase. Substrate presentation by phosphatidylinositol transfer protein to the p150.PtdIns 3-kinase complex.
PubMed ID: 8999962
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 14617358
Title: Human VPS34 and p150 are Rab7 interacting partners.
PubMed ID: 14617358
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19369195
Title: Large-scale proteomics analysis of the human kinome.
PubMed ID: 19369195
PubMed ID: 20643123
Title: A phosphatidylinositol 3-kinase class III sub-complex containing VPS15, VPS34, Beclin 1, UVRAG and BIF-1 regulates cytokinesis and degradative endocytic traffic.
PubMed ID: 20643123
PubMed ID: 19270696
Title: Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages.
PubMed ID: 19270696
DOI: 10.1038/ncb1846
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 23878393
Title: Role of membrane association and Atg14-dependent phosphorylation in beclin-1-mediated autophagy.
PubMed ID: 23878393
DOI: 10.1128/mcb.00079-13
PubMed ID: 24785657
Title: NRBF2 regulates macroautophagy as a component of Vps34 Complex I.
PubMed ID: 24785657
DOI: 10.1042/bj20140515
PubMed ID: 25490155
Title: Architecture and dynamics of the autophagic phosphatidylinositol 3-kinase complex.
PubMed ID: 25490155
DOI: 10.7554/elife.05115
PubMed ID: 25255805
Title: Global profiling of co- and post-translationally N-myristoylated proteomes in human cells.
PubMed ID: 25255805
DOI: 10.1038/ncomms5919
PubMed ID: 16959974
Title: The consensus coding sequences of human breast and colorectal cancers.
PubMed ID: 16959974
PubMed ID: 17344846
Title: Patterns of somatic mutation in human cancer genomes.
PubMed ID: 17344846
DOI: 10.1038/nature05610
Sequence Information:
- Length: 1358
- Mass: 153103
- Checksum: 5B402175265B21F7
- Sequence:
MGNQLAGIAP SQILSVESYF SDIHDFEYDK SLGSTRFFKV ARAKHREGLV VVKVFAIQDP TLPLTSYKQE LEELKIRLNS AQNCLPFQKA SEKASEKAAM LFRQYVRDNL YDRISTRPFL NNIEKRWIAF QILTAVDQAH KSGVRHGDIK TENVMVTSWN WVLLTDFASF KPTYLPEDNP ADFNYFFDTS RRRTCYIAPE RFVDGGMFAT ELEYMRDPST PLVDLNSNQR TRGELKRAMD IFSAGCVIAE LFTEGVPLFD LSQLLAYRNG HFFPEQVLNK IEDHSIRELV TQMIHREPDK RLEAEDYLKQ QRGNAFPEIF YTFLQPYMAQ FAKETFLSAD ERILVIRKDL GNIIHNLCGH DLPEKAEGEP KENGLVILVS VITSCLQTLK YCDSKLAALE LILHLAPRLS VEILLDRITP YLLHFSNDSV PRVRAEALRT LTKVLALVKE VPRNDINIYP EYILPGIAHL AQDDATIVRL AYAENIALLA ETALRFLELV QLKNLNMEND PNNEEIDEVT HPNGNYDTEL QALHEMVQQK VVTLLSDPEN IVKQTLMENG ITRLCVFFGR QKANDVLLSH MITFLNDKND WHLRGAFFDS IVGVAAYVGW QSSSILKPLL QQGLSDAEEF VIVKALYALT CMCQLGLLQK PHVYEFASDI APFLCHPNLW IRYGAVGFIT VVARQISTAD VYCKLMPYLD PYITQPIIQI ERKLVLLSVL KEPVSRSIFD YALRSKDITS LFRHLHMRQK KRNGSLPDCP PPEDPAIAQL LKKLLSQGMT EEEEDKLLAL KDFMMKSNKA KANIVDQSHL HDSSQKGVID LAALGITGRQ VDLVKTKQEP DDKRARKHVK QDSNVNEEWK SMFGSLDPPN MPQALPKGSD QEVIQTGKPP RSESSAGICV PLSTSSQVPE VTTVQNKKPV IPVLSSTILP STYQIRITTC KTELQQLIQQ KREQCNAERI AKQMMENAEW ESKPPPPGWR PKGLLVAHLH EHKSAVNRIR VSDEHSLFAT CSNDGTVKIW NSQKMEGKTT TTRSILTYSR IGGRVKTLTF CQGSHYLAIA SDNGAVQLLG IEASKLPKSP KIHPLQSRIL DQKEDGCVVD MHHFNSGAQS VLAYATVNGS LVGWDLRSSS NAWTLKHDLK SGLITSFAVD IHQCWLCIGT SSGTMACWDM RFQLPISSHC HPSRARIRRL SMHPLYQSWV IAAVQGNNEV SMWDMETGDR RFTLWASSAP PLSELQPSPH SVHGIYCSPA DGNPILLTAG SDMKIRFWDL AYPERSYVVA GSTSSPSVSY YRKIIEGTEV VQEIQNKQKV GPSDDTPRRG PESLPVGHHD IITDVATFQT TQGFIVTASR DGIVKVWK
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.