PIK3R4 | ENSG00000196455 | NCBI 30849

Details for: PIK3R4

Gene ID: 30849

Symbol: PIK3R4

Ensembl ID: ENSG00000196455

Description: phosphoinositide-3-kinase regulatory subunit 4

Associated with

Adaptive immune system
(R-HSA-1280218)
Antigen presentation: folding, assembly and peptide loading of class i mhc
(R-HSA-983170)
Autophagy
(R-HSA-9612973)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Disease
(R-HSA-1643685)
Early sars-cov-2 infection events
(R-HSA-9772572)
Igf1r signaling cascade
(R-HSA-2428924)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Insulin receptor signalling cascade
(R-HSA-74751)
Irs-mediated signalling
(R-HSA-112399)
Irs-related events triggered by igf1r
(R-HSA-2428928)
Metabolism
(R-HSA-1430728)
Metabolism of lipids
(R-HSA-556833)
Phospholipid metabolism
(R-HSA-1483257)
Pi3k cascade
(R-HSA-109704)
Pi metabolism
(R-HSA-1483255)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate nadph oxidases
(R-HSA-5668599)
Sars-cov-1 infection
(R-HSA-9678108)
Sars-cov-2 activates/modulates innate and adaptive immune responses
(R-HSA-9705671)
Sars-cov-2 infection
(R-HSA-9694516)
Sars-cov-2-host interactions
(R-HSA-9705683)
Sars-cov infections
(R-HSA-9679506)
Signaling by insulin receptor
(R-HSA-74752)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by type 1 insulin-like growth factor 1 receptor (igf1r)
(R-HSA-2404192)
Signal transduction
(R-HSA-162582)
Synthesis of pips at the early endosome membrane
(R-HSA-1660516)
Synthesis of pips at the golgi membrane
(R-HSA-1660514)
Synthesis of pips at the late endosome membrane
(R-HSA-1660517)
Toll-like receptor cascades
(R-HSA-168898)
Toll like receptor 9 (tlr9) cascade
(R-HSA-168138)
Translation of replicase and assembly of the replication transcription complex
(R-HSA-9694676)
Viral infection pathways
(R-HSA-9824446)
Atp binding
(GO:0005524)
Autophagosome
(GO:0005776)
Autophagosome maturation
(GO:0097352)
Autophagy of peroxisome
(GO:0030242)
Axoneme
(GO:0005930)
Cellular response to glucose starvation
(GO:0042149)
Cytosol
(GO:0005829)
Early endosome to late endosome transport
(GO:0045022)
Intracellular membrane-bounded organelle
(GO:0043231)
Late endosome
(GO:0005770)
Late endosome to vacuole transport
(GO:0045324)
Macroautophagy
(GO:0016236)
Membrane
(GO:0016020)
Microtubule cytoskeleton
(GO:0015630)
Nucleus-vacuole junction
(GO:0071561)
Phagocytic vesicle membrane
(GO:0030670)
Phosphatidylinositol-3-phosphate biosynthetic process
(GO:0036092)
Phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0043491)
Phosphatidylinositol 3-kinase complex, class iii
(GO:0035032)
Phosphatidylinositol 3-kinase complex, class iii, type i
(GO:0034271)
Phosphatidylinositol 3-kinase complex, class iii, type ii
(GO:0034272)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Protein serine kinase activity
(GO:0106310)
Protein targeting to lysosome
(GO:0006622)
Protein targeting to vacuole
(GO:0006623)
Receptor catabolic process
(GO:0032801)
Regulation of autophagy
(GO:0010506)
Regulation of cytokinesis
(GO:0032465)
Regulation of macroautophagy
(GO:0016241)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: germ cell (CL0000586)
Fold Change: 1.57
Marker Score: 2,745
Cell Name: mural cell (CL0008034)
Fold Change: 1.47
Marker Score: 168,848
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.31
Marker Score: 11,277
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.26
Marker Score: 11,935
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.25
Marker Score: 76,882
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.17
Marker Score: 1,808
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 1.16
Marker Score: 10,882
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 1.08
Marker Score: 39,868
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.05
Marker Score: 16,402
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71,762
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 47,987
Cell Name: neuron (CL0000540)
Fold Change: 0.99
Marker Score: 4,015
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,402
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.97
Marker Score: 10,016
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2,407
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.94
Marker Score: 487
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.93
Marker Score: 441
Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 0.92
Marker Score: 735
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2,724
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 0.88
Marker Score: 17,503
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.88
Marker Score: 4,998
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5,295
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 0.87
Marker Score: 962
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 0.87
Marker Score: 6,641
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.86
Marker Score: 311
Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 0.85
Marker Score: 32,170
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.83
Marker Score: 1,814
Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.81
Marker Score: 3,128
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 0.79
Marker Score: 11,806
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.77
Marker Score: 1,252
Cell Name: oogonial cell (CL0000024)
Fold Change: 0.76
Marker Score: 1,099
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.75
Marker Score: 301
Cell Name: male germ cell (CL0000015)
Fold Change: 0.75
Marker Score: 215
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.74
Marker Score: 1,499
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.73
Marker Score: 560
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.73
Marker Score: 378
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.73
Marker Score: 3,047
Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 0.72
Marker Score: 3,106
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 0.72
Marker Score: 2,982
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 0.71
Marker Score: 4,553
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 0.7
Marker Score: 14,860
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.68
Marker Score: 4,111
Cell Name: brush cell (CL0002204)
Fold Change: 0.68
Marker Score: 618
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.67
Marker Score: 172
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.64
Marker Score: 187
Cell Name: interneuron (CL0000099)
Fold Change: 0.63
Marker Score: 289
Cell Name: type A enteroendocrine cell (CL0002067)
Fold Change: 0.63
Marker Score: 255
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.63
Marker Score: 380
Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 0.62
Marker Score: 709
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.61
Marker Score: 2,538
Cell Name: primordial germ cell (CL0000670)
Fold Change: 0.6
Marker Score: 758
Cell Name: fat cell (CL0000136)
Fold Change: 0.6
Marker Score: 334
Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 0.6
Marker Score: 643
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 0.58
Marker Score: 3,143
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.58
Marker Score: 340
Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 0.56
Marker Score: 1,084
Cell Name: pyramidal neuron (CL0000598)
Fold Change: 0.56
Marker Score: 946
Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 0.56
Marker Score: 328
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.55
Marker Score: 329
Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 0.55
Marker Score: 266
Cell Name: primitive red blood cell (CL0002355)
Fold Change: 0.55
Marker Score: 410
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.54
Marker Score: 434
Cell Name: cholangiocyte (CL1000488)
Fold Change: 0.54
Marker Score: 203
Cell Name: ependymal cell (CL0000065)
Fold Change: 0.54
Marker Score: 187
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.53
Marker Score: 1,255
Cell Name: renal principal cell (CL0005009)
Fold Change: 0.53
Marker Score: 410
Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 0.53
Marker Score: 221
Cell Name: astrocyte (CL0000127)
Fold Change: 0.52
Marker Score: 453
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.51
Marker Score: 340
Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 0.51
Marker Score: 2,377
Cell Name: lens fiber cell (CL0011004)
Fold Change: 0.51
Marker Score: 162
Cell Name: cardiac neuron (CL0010022)
Fold Change: 0.51
Marker Score: 630
Cell Name: melanocyte (CL0000148)
Fold Change: 0.49
Marker Score: 197
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 0.49
Marker Score: 481
Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 0.48
Marker Score: 255
Cell Name: podocyte (CL0000653)
Fold Change: 0.48
Marker Score: 179
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 0.48
Marker Score: 679
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.48
Marker Score: 154
Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 0.47
Marker Score: 128
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.47
Marker Score: 223
Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.46
Marker Score: 15,584
Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 0.46
Marker Score: 418
Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 0.45
Marker Score: 10,120
Cell Name: Unknown (CL0002371)
Fold Change: 0.45
Marker Score: 481
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.45
Marker Score: 154
Cell Name: proerythroblast (CL0000547)
Fold Change: 0.45
Marker Score: 302
Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 0.44
Marker Score: 308
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.44
Marker Score: 138
Cell Name: hepatocyte (CL0000182)
Fold Change: 0.44
Marker Score: 299
Cell Name: cerebellar granule cell precursor (CL0002362)
Fold Change: 0.44
Marker Score: 245
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 0.43
Marker Score: 137
Cell Name: Leydig cell (CL0000178)
Fold Change: 0.43
Marker Score: 462
Cell Name: Schwann cell (CL0002573)
Fold Change: 0.43
Marker Score: 148
Cell Name: mesangial cell (CL0000650)
Fold Change: 0.43
Marker Score: 514
Cell Name: taste receptor cell (CL0000209)
Fold Change: 0.42
Marker Score: 367
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.42
Marker Score: 510
Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: 0.42
Marker Score: 1,495
Cell Name: ciliated cell (CL0000064)
Fold Change: 0.42
Marker Score: 1,430
Cell Name: erythroblast (CL0000765)
Fold Change: 0.41
Marker Score: 259
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 0.41
Marker Score: 440

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

**Key Characteristics:** 1. **Regulatory Subunit of PI3K Complex:** PIK3R4 is a regulatory subunit that interacts with the p110 catalytic subunit of PI3K to form the PI3K complex. 2. **Signaling Pathways:** PIK3R4 is involved in various signaling pathways, including insulin signaling, cell growth, and survival. 3. **Cellular Processes:** PIK3R4 regulates cellular processes such as autophagy, cytokinesis, and protein synthesis. 4. **Expression in Significantly Expressed Cells:** PIK3R4 is significantly expressed in germ cells, mural cells, cardiac muscle myoblasts, and various types of neurons. **Pathways and Functions:** 1. **Autophagy:** PIK3R4 regulates autophagy by interacting with the PI3K complex, which is involved in the regulation of autophagy-related genes. 2. **Cytokinesis:** PIK3R4 regulates cytokinesis by interacting with the PI3K complex, which is involved in the regulation of cell division. 3. **Protein Synthesis:** PIK3R4 regulates protein synthesis by interacting with the PI3K complex, which is involved in the regulation of protein translation. 4. **Insulin Signaling:** PIK3R4 is involved in insulin signaling by interacting with the PI3K complex, which is involved in the regulation of glucose metabolism. 5. **Cell Growth and Survival:** PIK3R4 regulates cell growth and survival by interacting with the PI3K complex, which is involved in the regulation of cell proliferation and apoptosis. **Clinical Significance:** 1. **Cancer:** Abnormal expression of PIK3R4 has been implicated in various types of cancer, including breast, lung, and colon cancer. 2. **Diabetes:** PIK3R4 is involved in insulin signaling, and abnormal expression of PIK3R4 has been implicated in the development of type 2 diabetes. 3. **Infectious Diseases:** PIK3R4 is involved in the regulation of immune responses, and abnormal expression of PIK3R4 has been implicated in the development of infectious diseases such as SARS-CoV-2. 4. **Neurological Disorders:** PIK3R4 is involved in the regulation of neuronal function, and abnormal expression of PIK3R4 has been implicated in the development of neurological disorders such as Alzheimer's disease and Parkinson's disease. In conclusion, PIK3R4 is a regulatory subunit of the PI3K complex that plays a crucial role in regulating various cellular processes through its interaction with the PI3K complex. Abnormal expression of PIK3R4 has been implicated in various diseases, including cancer, diabetes, and infectious diseases. Further research is needed to fully understand the role of PIK3R4 in human disease and to develop therapeutic strategies to target PIK3R4 in the treatment of these diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Phosphoinositide 3-kinase regulatory subunit 4

Genular Protein ID: 1206229614

Symbol: PI3R4_HUMAN

Name: Phosphoinositide 3-kinase regulatory subunit 4

UniProtKB Accession Codes:

Q99570 Q2TBF4

Database IDs:

Citations:

PubMed ID: 8999962

Title: Characterization of p150, an adaptor protein for the human phosphatidylinositol (PtdIns) 3-kinase. Substrate presentation by phosphatidylinositol transfer protein to the p150.PtdIns 3-kinase complex.

PubMed ID: 8999962

DOI: 10.1074/jbc.272.4.2477

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14617358

Title: Human VPS34 and p150 are Rab7 interacting partners.

PubMed ID: 14617358

DOI: 10.1034/j.1600-0854.2003.00133.x

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 20643123

Title: A phosphatidylinositol 3-kinase class III sub-complex containing VPS15, VPS34, Beclin 1, UVRAG and BIF-1 regulates cytokinesis and degradative endocytic traffic.

PubMed ID: 20643123

DOI: 10.1016/j.yexcr.2010.07.008

PubMed ID: 19270696

Title: Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages.

PubMed ID: 19270696

DOI: 10.1038/ncb1846

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23878393

Title: Role of membrane association and Atg14-dependent phosphorylation in beclin-1-mediated autophagy.

PubMed ID: 23878393

DOI: 10.1128/mcb.00079-13

PubMed ID: 24785657

Title: NRBF2 regulates macroautophagy as a component of Vps34 Complex I.

PubMed ID: 24785657

DOI: 10.1042/bj20140515

PubMed ID: 25490155

Title: Architecture and dynamics of the autophagic phosphatidylinositol 3-kinase complex.

PubMed ID: 25490155

DOI: 10.7554/elife.05115

PubMed ID: 25255805

Title: Global profiling of co- and post-translationally N-myristoylated proteomes in human cells.

PubMed ID: 25255805

DOI: 10.1038/ncomms5919

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

Length: 1358
Mass: 153103
Checksum: 5B402175265B21F7
Sequence:

MGNQLAGIAP SQILSVESYF SDIHDFEYDK SLGSTRFFKV ARAKHREGLV VVKVFAIQDP 
TLPLTSYKQE LEELKIRLNS AQNCLPFQKA SEKASEKAAM LFRQYVRDNL YDRISTRPFL 
NNIEKRWIAF QILTAVDQAH KSGVRHGDIK TENVMVTSWN WVLLTDFASF KPTYLPEDNP 
ADFNYFFDTS RRRTCYIAPE RFVDGGMFAT ELEYMRDPST PLVDLNSNQR TRGELKRAMD 
IFSAGCVIAE LFTEGVPLFD LSQLLAYRNG HFFPEQVLNK IEDHSIRELV TQMIHREPDK 
RLEAEDYLKQ QRGNAFPEIF YTFLQPYMAQ FAKETFLSAD ERILVIRKDL GNIIHNLCGH 
DLPEKAEGEP KENGLVILVS VITSCLQTLK YCDSKLAALE LILHLAPRLS VEILLDRITP 
YLLHFSNDSV PRVRAEALRT LTKVLALVKE VPRNDINIYP EYILPGIAHL AQDDATIVRL 
AYAENIALLA ETALRFLELV QLKNLNMEND PNNEEIDEVT HPNGNYDTEL QALHEMVQQK 
VVTLLSDPEN IVKQTLMENG ITRLCVFFGR QKANDVLLSH MITFLNDKND WHLRGAFFDS 
IVGVAAYVGW QSSSILKPLL QQGLSDAEEF VIVKALYALT CMCQLGLLQK PHVYEFASDI 
APFLCHPNLW IRYGAVGFIT VVARQISTAD VYCKLMPYLD PYITQPIIQI ERKLVLLSVL 
KEPVSRSIFD YALRSKDITS LFRHLHMRQK KRNGSLPDCP PPEDPAIAQL LKKLLSQGMT 
EEEEDKLLAL KDFMMKSNKA KANIVDQSHL HDSSQKGVID LAALGITGRQ VDLVKTKQEP 
DDKRARKHVK QDSNVNEEWK SMFGSLDPPN MPQALPKGSD QEVIQTGKPP RSESSAGICV 
PLSTSSQVPE VTTVQNKKPV IPVLSSTILP STYQIRITTC KTELQQLIQQ KREQCNAERI 
AKQMMENAEW ESKPPPPGWR PKGLLVAHLH EHKSAVNRIR VSDEHSLFAT CSNDGTVKIW 
NSQKMEGKTT TTRSILTYSR IGGRVKTLTF CQGSHYLAIA SDNGAVQLLG IEASKLPKSP 
KIHPLQSRIL DQKEDGCVVD MHHFNSGAQS VLAYATVNGS LVGWDLRSSS NAWTLKHDLK 
SGLITSFAVD IHQCWLCIGT SSGTMACWDM RFQLPISSHC HPSRARIRRL SMHPLYQSWV 
IAAVQGNNEV SMWDMETGDR RFTLWASSAP PLSELQPSPH SVHGIYCSPA DGNPILLTAG 
SDMKIRFWDL AYPERSYVVA GSTSSPSVSY YRKIIEGTEV VQEIQNKQKV GPSDDTPRRG 
PESLPVGHHD IITDVATFQT TQGFIVTASR DGIVKVWK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PIK3R4

Associated with

Cells (max top 100)

Other Information

Characterization of p150, an adaptor protein for the human phosphatidylinositol (PtdIns) 3-kinase. Substrate presentation by phosphatidylinositol transfer protein to the p150.PtdIns 3-kinase complex. PubMed ID: 8999962

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Human VPS34 and p150 are Rab7 interacting partners. PubMed ID: 14617358

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Large-scale proteomics analysis of the human kinome. PubMed ID: 19369195

A phosphatidylinositol 3-kinase class III sub-complex containing VPS15, VPS34, Beclin 1, UVRAG and BIF-1 regulates cytokinesis and degradative endocytic traffic. PubMed ID: 20643123

Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages. PubMed ID: 19270696

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Role of membrane association and Atg14-dependent phosphorylation in beclin-1-mediated autophagy. PubMed ID: 23878393

NRBF2 regulates macroautophagy as a component of Vps34 Complex I. PubMed ID: 24785657

Architecture and dynamics of the autophagic phosphatidylinositol 3-kinase complex. PubMed ID: 25490155

Global profiling of co- and post-translationally N-myristoylated proteomes in human cells. PubMed ID: 25255805

The consensus coding sequences of human breast and colorectal cancers. PubMed ID: 16959974

Patterns of somatic mutation in human cancer genomes. PubMed ID: 17344846