PIK3R4 | ENSG00000196455 | NCBI 30849

Details for: PIK3R4

Gene ID: 30849

Symbol: PIK3R4

Ensembl ID: ENSG00000196455

Description: phosphoinositide-3-kinase regulatory subunit 4

Associated with

Adaptive immune system
(R-HSA-1280218)
Antigen presentation: folding, assembly and peptide loading of class i mhc
(R-HSA-983170)
Autophagy
(R-HSA-9612973)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Disease
(R-HSA-1643685)
Early sars-cov-2 infection events
(R-HSA-9772572)
Igf1r signaling cascade
(R-HSA-2428924)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Insulin receptor signalling cascade
(R-HSA-74751)
Irs-mediated signalling
(R-HSA-112399)
Irs-related events triggered by igf1r
(R-HSA-2428928)
Macroautophagy
(R-HSA-1632852)
Metabolism
(R-HSA-1430728)
Metabolism of lipids
(R-HSA-556833)
Phospholipid metabolism
(R-HSA-1483257)
Pi3k cascade
(R-HSA-109704)
Pi metabolism
(R-HSA-1483255)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate nadph oxidases
(R-HSA-5668599)
Sars-cov-1 infection
(R-HSA-9678108)
Sars-cov-2 activates/modulates innate and adaptive immune responses
(R-HSA-9705671)
Sars-cov-2 infection
(R-HSA-9694516)
Sars-cov-2-host interactions
(R-HSA-9705683)
Sars-cov infections
(R-HSA-9679506)
Signaling by insulin receptor
(R-HSA-74752)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by type 1 insulin-like growth factor 1 receptor (igf1r)
(R-HSA-2404192)
Signal transduction
(R-HSA-162582)
Synthesis of pips at the early endosome membrane
(R-HSA-1660516)
Synthesis of pips at the golgi membrane
(R-HSA-1660514)
Synthesis of pips at the late endosome membrane
(R-HSA-1660517)
Toll-like receptor cascades
(R-HSA-168898)
Toll like receptor 9 (tlr9) cascade
(R-HSA-168138)
Translation of replicase and assembly of the replication transcription complex
(R-HSA-9694676)
Viral infection pathways
(R-HSA-9824446)
Atp binding
(GO:0005524)
Autophagosome
(GO:0005776)
Autophagosome maturation
(GO:0097352)
Axoneme
(GO:0005930)
Cellular response to glucose starvation
(GO:0042149)
Chromatin remodeling
(GO:0006338)
Cytosol
(GO:0005829)
Early endosome to late endosome transport
(GO:0045022)
Histone h2as1 kinase activity
(GO:0044024)
Intracellular membrane-bounded organelle
(GO:0043231)
Late endosome
(GO:0005770)
Late endosome to vacuole transport
(GO:0045324)
Membrane
(GO:0016020)
Microtubule cytoskeleton
(GO:0015630)
Nucleus-vacuole junction
(GO:0071561)
Pexophagy
(GO:0000425)
Phagocytic vesicle membrane
(GO:0030670)
Phosphatidylinositol-3-phosphate biosynthetic process
(GO:0036092)
Phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0043491)
Phosphatidylinositol 3-kinase complex, class iii
(GO:0035032)
Phosphatidylinositol 3-kinase complex, class iii, type i
(GO:0034271)
Phosphatidylinositol 3-kinase complex, class iii, type ii
(GO:0034272)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Protein serine kinase activity
(GO:0106310)
Protein targeting to lysosome
(GO:0006622)
Protein targeting to vacuole
(GO:0006623)
Receptor catabolic process
(GO:0032801)
Regulation of autophagy
(GO:0010506)
Regulation of cytokinesis
(GO:0032465)
Regulation of macroautophagy
(GO:0016241)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 123.1475
Cell Significance Index: -19.1600
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 77.0373
Cell Significance Index: -19.5400
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 41.8700
Cell Significance Index: -17.0100
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 16.1320
Cell Significance Index: -19.8900
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 7.2568
Cell Significance Index: -19.4400
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 5.1038
Cell Significance Index: -20.1400
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 4.8890
Cell Significance Index: -10.7000
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 1.9492
Cell Significance Index: 370.9400
Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: 1.3326
Cell Significance Index: 21.9600
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.2392
Cell Significance Index: 201.5500
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.2350
Cell Significance Index: 122.1700
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.0089
Cell Significance Index: 202.3900
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.7183
Cell Significance Index: 9.8000
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.6974
Cell Significance Index: 75.8600
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.6848
Cell Significance Index: 135.9100
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.6565
Cell Significance Index: 39.4100
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.5875
Cell Significance Index: 32.9700
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.4056
Cell Significance Index: 15.3600
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.3978
Cell Significance Index: 17.6000
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.3811
Cell Significance Index: 24.0200
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.3797
Cell Significance Index: 10.9400
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.3716
Cell Significance Index: 133.3000
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.3711
Cell Significance Index: 8.0400
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.3683
Cell Significance Index: 28.2700
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.3569
Cell Significance Index: 24.6800
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.3342
Cell Significance Index: 38.9500
Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.3096
Cell Significance Index: 6.7800
Cell Name: preadipocyte (CL0002334)
Fold Change: 0.2003
Cell Significance Index: 3.9100
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.1940
Cell Significance Index: 10.0800
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.1918
Cell Significance Index: 5.3600
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.1869
Cell Significance Index: 22.9800
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.1803
Cell Significance Index: 124.6900
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.1726
Cell Significance Index: 31.1200
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.1541
Cell Significance Index: 3.9600
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.1357
Cell Significance Index: 6.1500
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.1015
Cell Significance Index: 44.8600
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.0864
Cell Significance Index: 5.8100
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0723
Cell Significance Index: 2.5400
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0658
Cell Significance Index: 35.9600
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0403
Cell Significance Index: 75.8200
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0382
Cell Significance Index: 24.2900
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.0373
Cell Significance Index: 1.7400
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.0332
Cell Significance Index: 4.5600
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0304
Cell Significance Index: 13.8100
Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.0277
Cell Significance Index: 0.3300
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.0208
Cell Significance Index: 1.2800
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0162
Cell Significance Index: 24.9500
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 0.0126
Cell Significance Index: 0.3600
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0118
Cell Significance Index: 21.7800
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.0099
Cell Significance Index: 0.2100
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0093
Cell Significance Index: 12.6100
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.0035
Cell Significance Index: 0.1800
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0045
Cell Significance Index: -0.1200
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.0088
Cell Significance Index: -0.1500
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.0118
Cell Significance Index: -0.3200
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0125
Cell Significance Index: -1.8200
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0134
Cell Significance Index: -9.8500
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0192
Cell Significance Index: -3.2700
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0201
Cell Significance Index: -14.9100
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0220
Cell Significance Index: -16.6900
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0322
Cell Significance Index: -18.1500
Cell Name: odontoblast (CL0000060)
Fold Change: -0.0331
Cell Significance Index: -4.2400
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0362
Cell Significance Index: -22.6300
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0382
Cell Significance Index: -4.5000
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0581
Cell Significance Index: -16.7200
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0594
Cell Significance Index: -6.0700
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0709
Cell Significance Index: -5.0200
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0835
Cell Significance Index: -3.9300
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.1000
Cell Significance Index: -2.5000
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1033
Cell Significance Index: -21.7600
Cell Name: lactocyte (CL0002325)
Fold Change: -0.1183
Cell Significance Index: -15.2800
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1217
Cell Significance Index: -13.9400
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.1220
Cell Significance Index: -2.0600
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1518
Cell Significance Index: -15.8100
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.1638
Cell Significance Index: -10.5700
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1675
Cell Significance Index: -12.4800
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.1778
Cell Significance Index: -4.8400
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.2300
Cell Significance Index: -18.2200
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.2441
Cell Significance Index: -5.1800
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: -0.2447
Cell Significance Index: -3.5200
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -0.2472
Cell Significance Index: -3.5500
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.2477
Cell Significance Index: -5.3000
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.2541
Cell Significance Index: -15.5800
Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.2594
Cell Significance Index: -6.2200
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.2879
Cell Significance Index: -15.1200
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: -0.2898
Cell Significance Index: -3.6000
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.2928
Cell Significance Index: -7.7000
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.2963
Cell Significance Index: -9.7000
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.3035
Cell Significance Index: -4.4800
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.3036
Cell Significance Index: -9.6700
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.3236
Cell Significance Index: -2.9800
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.3450
Cell Significance Index: -11.0500
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.3584
Cell Significance Index: -5.2900
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.3646
Cell Significance Index: -12.6700
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.3722
Cell Significance Index: -9.9600
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.3775
Cell Significance Index: -7.4700
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.3848
Cell Significance Index: -6.4400
Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.3945
Cell Significance Index: -7.9200
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.4202
Cell Significance Index: -12.3400
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.4208
Cell Significance Index: -14.7400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** 1. **Regulatory Subunit of PI3K Complex:** PIK3R4 is a regulatory subunit that interacts with the p110 catalytic subunit of PI3K to form the PI3K complex. 2. **Signaling Pathways:** PIK3R4 is involved in various signaling pathways, including insulin signaling, cell growth, and survival. 3. **Cellular Processes:** PIK3R4 regulates cellular processes such as autophagy, cytokinesis, and protein synthesis. 4. **Expression in Significantly Expressed Cells:** PIK3R4 is significantly expressed in germ cells, mural cells, cardiac muscle myoblasts, and various types of neurons. **Pathways and Functions:** 1. **Autophagy:** PIK3R4 regulates autophagy by interacting with the PI3K complex, which is involved in the regulation of autophagy-related genes. 2. **Cytokinesis:** PIK3R4 regulates cytokinesis by interacting with the PI3K complex, which is involved in the regulation of cell division. 3. **Protein Synthesis:** PIK3R4 regulates protein synthesis by interacting with the PI3K complex, which is involved in the regulation of protein translation. 4. **Insulin Signaling:** PIK3R4 is involved in insulin signaling by interacting with the PI3K complex, which is involved in the regulation of glucose metabolism. 5. **Cell Growth and Survival:** PIK3R4 regulates cell growth and survival by interacting with the PI3K complex, which is involved in the regulation of cell proliferation and apoptosis. **Clinical Significance:** 1. **Cancer:** Abnormal expression of PIK3R4 has been implicated in various types of cancer, including breast, lung, and colon cancer. 2. **Diabetes:** PIK3R4 is involved in insulin signaling, and abnormal expression of PIK3R4 has been implicated in the development of type 2 diabetes. 3. **Infectious Diseases:** PIK3R4 is involved in the regulation of immune responses, and abnormal expression of PIK3R4 has been implicated in the development of infectious diseases such as SARS-CoV-2. 4. **Neurological Disorders:** PIK3R4 is involved in the regulation of neuronal function, and abnormal expression of PIK3R4 has been implicated in the development of neurological disorders such as Alzheimer's disease and Parkinson's disease. In conclusion, PIK3R4 is a regulatory subunit of the PI3K complex that plays a crucial role in regulating various cellular processes through its interaction with the PI3K complex. Abnormal expression of PIK3R4 has been implicated in various diseases, including cancer, diabetes, and infectious diseases. Further research is needed to fully understand the role of PIK3R4 in human disease and to develop therapeutic strategies to target PIK3R4 in the treatment of these diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Phosphoinositide 3-kinase regulatory subunit 4

Genular Protein ID: 1206229614

Symbol: PI3R4_HUMAN

Name: Phosphoinositide 3-kinase regulatory subunit 4

UniProtKB Accession Codes:

Q99570 Q2TBF4

Database IDs:

Citations:

PubMed ID: 8999962

Title: Characterization of p150, an adaptor protein for the human phosphatidylinositol (PtdIns) 3-kinase. Substrate presentation by phosphatidylinositol transfer protein to the p150.PtdIns 3-kinase complex.

PubMed ID: 8999962

DOI: 10.1074/jbc.272.4.2477

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14617358

Title: Human VPS34 and p150 are Rab7 interacting partners.

PubMed ID: 14617358

DOI: 10.1034/j.1600-0854.2003.00133.x

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 20643123

Title: A phosphatidylinositol 3-kinase class III sub-complex containing VPS15, VPS34, Beclin 1, UVRAG and BIF-1 regulates cytokinesis and degradative endocytic traffic.

PubMed ID: 20643123

DOI: 10.1016/j.yexcr.2010.07.008

PubMed ID: 19270696

Title: Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages.

PubMed ID: 19270696

DOI: 10.1038/ncb1846

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23878393

Title: Role of membrane association and Atg14-dependent phosphorylation in beclin-1-mediated autophagy.

PubMed ID: 23878393

DOI: 10.1128/mcb.00079-13

PubMed ID: 24785657

Title: NRBF2 regulates macroautophagy as a component of Vps34 Complex I.

PubMed ID: 24785657

DOI: 10.1042/bj20140515

PubMed ID: 25490155

Title: Architecture and dynamics of the autophagic phosphatidylinositol 3-kinase complex.

PubMed ID: 25490155

DOI: 10.7554/elife.05115

PubMed ID: 25255805

Title: Global profiling of co- and post-translationally N-myristoylated proteomes in human cells.

PubMed ID: 25255805

DOI: 10.1038/ncomms5919

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

Length: 1358
Mass: 153103
Checksum: 5B402175265B21F7
Sequence:

MGNQLAGIAP SQILSVESYF SDIHDFEYDK SLGSTRFFKV ARAKHREGLV VVKVFAIQDP 
TLPLTSYKQE LEELKIRLNS AQNCLPFQKA SEKASEKAAM LFRQYVRDNL YDRISTRPFL 
NNIEKRWIAF QILTAVDQAH KSGVRHGDIK TENVMVTSWN WVLLTDFASF KPTYLPEDNP 
ADFNYFFDTS RRRTCYIAPE RFVDGGMFAT ELEYMRDPST PLVDLNSNQR TRGELKRAMD 
IFSAGCVIAE LFTEGVPLFD LSQLLAYRNG HFFPEQVLNK IEDHSIRELV TQMIHREPDK 
RLEAEDYLKQ QRGNAFPEIF YTFLQPYMAQ FAKETFLSAD ERILVIRKDL GNIIHNLCGH 
DLPEKAEGEP KENGLVILVS VITSCLQTLK YCDSKLAALE LILHLAPRLS VEILLDRITP 
YLLHFSNDSV PRVRAEALRT LTKVLALVKE VPRNDINIYP EYILPGIAHL AQDDATIVRL 
AYAENIALLA ETALRFLELV QLKNLNMEND PNNEEIDEVT HPNGNYDTEL QALHEMVQQK 
VVTLLSDPEN IVKQTLMENG ITRLCVFFGR QKANDVLLSH MITFLNDKND WHLRGAFFDS 
IVGVAAYVGW QSSSILKPLL QQGLSDAEEF VIVKALYALT CMCQLGLLQK PHVYEFASDI 
APFLCHPNLW IRYGAVGFIT VVARQISTAD VYCKLMPYLD PYITQPIIQI ERKLVLLSVL 
KEPVSRSIFD YALRSKDITS LFRHLHMRQK KRNGSLPDCP PPEDPAIAQL LKKLLSQGMT 
EEEEDKLLAL KDFMMKSNKA KANIVDQSHL HDSSQKGVID LAALGITGRQ VDLVKTKQEP 
DDKRARKHVK QDSNVNEEWK SMFGSLDPPN MPQALPKGSD QEVIQTGKPP RSESSAGICV 
PLSTSSQVPE VTTVQNKKPV IPVLSSTILP STYQIRITTC KTELQQLIQQ KREQCNAERI 
AKQMMENAEW ESKPPPPGWR PKGLLVAHLH EHKSAVNRIR VSDEHSLFAT CSNDGTVKIW 
NSQKMEGKTT TTRSILTYSR IGGRVKTLTF CQGSHYLAIA SDNGAVQLLG IEASKLPKSP 
KIHPLQSRIL DQKEDGCVVD MHHFNSGAQS VLAYATVNGS LVGWDLRSSS NAWTLKHDLK 
SGLITSFAVD IHQCWLCIGT SSGTMACWDM RFQLPISSHC HPSRARIRRL SMHPLYQSWV 
IAAVQGNNEV SMWDMETGDR RFTLWASSAP PLSELQPSPH SVHGIYCSPA DGNPILLTAG 
SDMKIRFWDL AYPERSYVVA GSTSSPSVSY YRKIIEGTEV VQEIQNKQKV GPSDDTPRRG 
PESLPVGHHD IITDVATFQT TQGFIVTASR DGIVKVWK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PIK3R4

Associated with

Cells (max top 100)

Other Information

Characterization of p150, an adaptor protein for the human phosphatidylinositol (PtdIns) 3-kinase. Substrate presentation by phosphatidylinositol transfer protein to the p150.PtdIns 3-kinase complex. PubMed ID: 8999962

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Human VPS34 and p150 are Rab7 interacting partners. PubMed ID: 14617358

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Large-scale proteomics analysis of the human kinome. PubMed ID: 19369195

A phosphatidylinositol 3-kinase class III sub-complex containing VPS15, VPS34, Beclin 1, UVRAG and BIF-1 regulates cytokinesis and degradative endocytic traffic. PubMed ID: 20643123

Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages. PubMed ID: 19270696

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Role of membrane association and Atg14-dependent phosphorylation in beclin-1-mediated autophagy. PubMed ID: 23878393

NRBF2 regulates macroautophagy as a component of Vps34 Complex I. PubMed ID: 24785657

Architecture and dynamics of the autophagic phosphatidylinositol 3-kinase complex. PubMed ID: 25490155

Global profiling of co- and post-translationally N-myristoylated proteomes in human cells. PubMed ID: 25255805

The consensus coding sequences of human breast and colorectal cancers. PubMed ID: 16959974

Patterns of somatic mutation in human cancer genomes. PubMed ID: 17344846