Details for: FOXA1

Gene ID: 3169

Symbol: FOXA1

Ensembl ID: ENSG00000129514

Description: forkhead box A1

Associated with

  • Developmental biology
    (R-HSA-1266738)
  • Esr-mediated signaling
    (R-HSA-8939211)
  • Estrogen-dependent gene expression
    (R-HSA-9018519)
  • Formation of axial mesoderm
    (R-HSA-9796292)
  • Gastrulation
    (R-HSA-9758941)
  • Signaling by nuclear receptors
    (R-HSA-9006931)
  • Signal transduction
    (R-HSA-162582)
  • Alveolar secondary septum development
    (GO:0061144)
  • Anatomical structure formation involved in morphogenesis
    (GO:0048646)
  • Anatomical structure morphogenesis
    (GO:0009653)
  • Cell differentiation
    (GO:0030154)
  • Chromatin
    (GO:0000785)
  • Chromatin binding
    (GO:0003682)
  • Chromatin remodeling
    (GO:0006338)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna binding
    (GO:0003677)
  • Dopaminergic neuron differentiation
    (GO:0071542)
  • Dorsal/ventral neural tube patterning
    (GO:0021904)
  • Epithelial cell maturation involved in prostate gland development
    (GO:0060743)
  • Epithelial tube branching involved in lung morphogenesis
    (GO:0060441)
  • Fibrillar center
    (GO:0001650)
  • Glucose homeostasis
    (GO:0042593)
  • Hormone metabolic process
    (GO:0042445)
  • Lung epithelial cell differentiation
    (GO:0060487)
  • Mesenchymal-epithelial cell signaling involved in prostate gland development
    (GO:0060739)
  • Microvillus
    (GO:0005902)
  • Negative regulation of epithelial to mesenchymal transition
    (GO:0010719)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Neuron fate specification
    (GO:0048665)
  • Notch signaling pathway
    (GO:0007219)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Positive regulation of apoptotic process
    (GO:0043065)
  • Positive regulation of cell-cell adhesion mediated by cadherin
    (GO:2000049)
  • Positive regulation of dna-binding transcription factor activity
    (GO:0051091)
  • Positive regulation of dopaminergic neuron differentiation
    (GO:1904340)
  • Positive regulation of intracellular estrogen receptor signaling pathway
    (GO:0033148)
  • Positive regulation of mirna transcription
    (GO:1902895)
  • Positive regulation of mitotic cell cycle
    (GO:0045931)
  • Positive regulation of smoothened signaling pathway
    (GO:0045880)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Prostate gland epithelium morphogenesis
    (GO:0060740)
  • Prostate gland stromal morphogenesis
    (GO:0060741)
  • Protein binding
    (GO:0005515)
  • Protein domain specific binding
    (GO:0019904)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Respiratory basal cell differentiation
    (GO:1902691)
  • Response to estradiol
    (GO:0032355)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development
    (GO:0060528)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Smoothened signaling pathway
    (GO:0007224)
  • Transcription cis-regulatory region binding
    (GO:0000976)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 5.7337
    Cell Significance Index: 297.8500
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 5.1753
    Cell Significance Index: 31.8500
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 2.0601
    Cell Significance Index: 21.2500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 2.0583
    Cell Significance Index: 334.7600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.8166
    Cell Significance Index: 223.3700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.7918
    Cell Significance Index: 323.0100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.7198
    Cell Significance Index: 25.7700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.6598
    Cell Significance Index: 15.2900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.4043
    Cell Significance Index: 63.6500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.3352
    Cell Significance Index: 38.4700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.0852
    Cell Significance Index: 80.8800
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.8262
    Cell Significance Index: 8.5500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.6402
    Cell Significance Index: 29.8500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5660
    Cell Significance Index: 39.1400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.5544
    Cell Significance Index: 13.4300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.5390
    Cell Significance Index: 155.0900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.4832
    Cell Significance Index: 16.9800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4451
    Cell Significance Index: 9.4800
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 0.3842
    Cell Significance Index: 0.2700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3581
    Cell Significance Index: 68.1500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2776
    Cell Significance Index: 250.6300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.2704
    Cell Significance Index: 5.6100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2652
    Cell Significance Index: 52.6300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2367
    Cell Significance Index: 23.4100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1416
    Cell Significance Index: 3.9600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0778
    Cell Significance Index: 1.6900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0044
    Cell Significance Index: 0.1400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0023
    Cell Significance Index: 0.1000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0037
    Cell Significance Index: -0.1500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0037
    Cell Significance Index: -0.1900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0093
    Cell Significance Index: -7.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0136
    Cell Significance Index: -25.6000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0197
    Cell Significance Index: -36.2600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0237
    Cell Significance Index: -36.4100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0267
    Cell Significance Index: -36.3400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0325
    Cell Significance Index: -24.0500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0329
    Cell Significance Index: -20.9000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0434
    Cell Significance Index: -24.4700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0449
    Cell Significance Index: -24.5000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0487
    Cell Significance Index: -5.6700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0553
    Cell Significance Index: -34.5100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0589
    Cell Significance Index: -0.6100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0663
    Cell Significance Index: -0.7500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0778
    Cell Significance Index: -35.3200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0781
    Cell Significance Index: -2.1300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0850
    Cell Significance Index: -1.1600
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.1113
    Cell Significance Index: -1.0300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1172
    Cell Significance Index: -15.1400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.1302
    Cell Significance Index: -57.5500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1329
    Cell Significance Index: -27.9900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1411
    Cell Significance Index: -28.3100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1413
    Cell Significance Index: -24.1300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1438
    Cell Significance Index: -20.9000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1635
    Cell Significance Index: -18.7300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1960
    Cell Significance Index: -20.0200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1969
    Cell Significance Index: -27.0400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2774
    Cell Significance Index: -17.0100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2912
    Cell Significance Index: -7.2800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2996
    Cell Significance Index: -14.0800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3227
    Cell Significance Index: -20.3400
  • Cell Name: precursor cell (CL0011115)
    Fold Change: -0.3264
    Cell Significance Index: -2.4800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3305
    Cell Significance Index: -22.2200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3590
    Cell Significance Index: -23.1600
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.4216
    Cell Significance Index: -5.4300
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.5166
    Cell Significance Index: -6.0100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5237
    Cell Significance Index: -19.2300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.5241
    Cell Significance Index: -29.4100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.5735
    Cell Significance Index: -9.6600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.6089
    Cell Significance Index: -21.1600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6149
    Cell Significance Index: -18.1100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.6256
    Cell Significance Index: -27.6700
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.6290
    Cell Significance Index: -6.6400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.6738
    Cell Significance Index: -9.9500
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.6933
    Cell Significance Index: -11.4300
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.6971
    Cell Significance Index: -9.9100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.7299
    Cell Significance Index: -27.6400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.7357
    Cell Significance Index: -21.0900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.7710
    Cell Significance Index: -20.6600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.7790
    Cell Significance Index: -22.2300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.7857
    Cell Significance Index: -20.9800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.7938
    Cell Significance Index: -20.2800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.8068
    Cell Significance Index: -20.1200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.8085
    Cell Significance Index: -57.1800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.8107
    Cell Significance Index: -21.6900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.8215
    Cell Significance Index: -28.7800
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.8424
    Cell Significance Index: -21.0400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.8456
    Cell Significance Index: -22.2400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.8598
    Cell Significance Index: -28.1500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.8804
    Cell Significance Index: -28.0400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.8983
    Cell Significance Index: -19.6700
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.9191
    Cell Significance Index: -6.6800
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: -0.9319
    Cell Significance Index: -10.1000
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.9811
    Cell Significance Index: -16.7700
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -1.0110
    Cell Significance Index: -10.7400
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -1.0428
    Cell Significance Index: -17.5400
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -1.0441
    Cell Significance Index: -9.5900
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -1.0761
    Cell Significance Index: -6.6600
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -1.0765
    Cell Significance Index: -17.4400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -1.0802
    Cell Significance Index: -27.5200
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -1.1076
    Cell Significance Index: -21.6600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** FOXA1 is a transcription factor that exhibits the following key characteristics: 1. **DNA-binding specificity**: FOXA1 binds to specific DNA sequences, including those containing the consensus forkhead box (FOX) motif. 2. **Transcriptional regulation**: FOXA1 regulates the expression of target genes involved in various biological processes, including cell differentiation, development, and gene regulation. 3. **Cell-type specificity**: FOXA1 is expressed in a wide range of cell types, including epithelial cells, neural cells, and mesenchymal cells. 4. **Heterodimerization**: FOXA1 can form heterodimers with other transcription factors, such as estrogen receptor (ER) and nuclear receptor (NR) proteins, to regulate gene expression. 5. **Chromatin remodeling**: FOXA1 is involved in chromatin remodeling, which allows it to regulate gene expression by modifying chromatin structure. **Pathways and Functions** FOXA1 is involved in numerous biological pathways, including: 1. **Developmental biology**: FOXA1 plays a crucial role in the development of various tissues, including the prostate, lung, and neural system. 2. **Cell differentiation**: FOXA1 regulates the expression of genes involved in cell differentiation, including the differentiation of epithelial cells and neural cells. 3. **Gene regulation**: FOXA1 regulates the expression of target genes involved in various biological processes, including hormone metabolism, glucose homeostasis, and apoptosis. 4. **Chromatin remodeling**: FOXA1 is involved in chromatin remodeling, which allows it to regulate gene expression by modifying chromatin structure. FOXA1's functions include: 1. **Transcriptional activation**: FOXA1 activates the expression of target genes involved in various biological processes. 2. **Transcriptional repression**: FOXA1 represses the expression of target genes involved in various biological processes. 3. **Chromatin modification**: FOXA1 modifies chromatin structure to regulate gene expression. 4. **Hormone regulation**: FOXA1 regulates hormone-dependent gene expression, including estrogen-dependent gene expression. **Clinical Significance** FOXA1's dysregulation has been implicated in various diseases, including: 1. **Cancer**: FOXA1 is frequently overexpressed in various types of cancer, including prostate cancer, lung cancer, and breast cancer. 2. **Neurological disorders**: FOXA1 is involved in the regulation of neural development and function, and its dysregulation has been implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease. 3. **Metabolic disorders**: FOXA1 regulates glucose homeostasis and hormone metabolism, and its dysregulation has been implicated in metabolic disorders, including diabetes and obesity. In conclusion, FOXA1 is a highly conserved transcription factor that plays a critical role in various cellular processes, including development, differentiation, and gene regulation. Its dysregulation has been implicated in various diseases, highlighting the importance of FOXA1 in maintaining normal cellular function and preventing disease.

Genular Protein ID: 452441095

Symbol: FOXA1_HUMAN

Name: Hepatocyte nuclear factor 3-alpha

UniProtKB Accession Codes:

P55317 B2R9H6 B7ZAP5 Q9H2A0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 10 Ensembl 1 ExpressionAtlas 1 GO 47 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8652662

Title: Molecular cloning of the forkhead transcription factor HNF-3 alpha from a human pulmonary adenocarcinoma cell line.

PubMed ID: 8652662

DOI: 10.1016/0167-4781(96)00058-9

PubMed ID: 10899756

Title: The human HNF-3 genes: cloning, partial sequence and mutation screening in patients with impaired glucose homeostasis.

PubMed ID: 10899756

DOI: 10.1159/000022943

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12234996

Title: The hepatocyte nuclear factor 3 alpha gene, HNF3alpha (FOXA1), on chromosome band 14q13 is amplified and overexpressed in esophageal and lung adenocarcinomas.

PubMed ID: 12234996

PubMed ID: 15987773

Title: Forkhead box A1 regulates prostate ductal morphogenesis and promotes epithelial cell maturation.

PubMed ID: 15987773

DOI: 10.1242/dev.01917

PubMed ID: 16087863

Title: Location analysis of estrogen receptor alpha target promoters reveals that FOXA1 defines a domain of the estrogen response.

PubMed ID: 16087863

DOI: 10.1073/pnas.0505575102

PubMed ID: 16331276

Title: BRCA1 and FOXA1 proteins coregulate the expression of the cell cycle-dependent kinase inhibitor p27(Kip1).

PubMed ID: 16331276

DOI: 10.1038/sj.onc.1209170

PubMed ID: 17220277

Title: Physical and functional interactions between homeodomain NKX2.1 and winged helix/forkhead FOXA1 in lung epithelial cells.

PubMed ID: 17220277

DOI: 10.1128/mcb.01133-06

PubMed ID: 18358809

Title: FoxA1 translates epigenetic signatures into enhancer-driven lineage-specific transcription.

PubMed ID: 18358809

DOI: 10.1016/j.cell.2008.01.018

PubMed ID: 19127412

Title: Role of Foxa1 in regulation of bcl2 expression during oxidative-stress-induced apoptosis in A549 type II pneumocytes.

PubMed ID: 19127412

DOI: 10.1007/s12192-008-0095-4

PubMed ID: 19919681

Title: Differential binding and co-binding pattern of FOXA1 and FOXA3 and their relation to H3K4me3 in HepG2 cells revealed by ChIP-seq.

PubMed ID: 19919681

DOI: 10.1186/gb-2009-10-11-r129

PubMed ID: 19917725

Title: Histone deacetylase 7 and FoxA1 in estrogen-mediated repression of RPRM.

PubMed ID: 19917725

DOI: 10.1128/mcb.00907-09

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 472
  • Mass: 49148
  • Checksum: B2489523459EEB4C
  • Sequence:
    • MLGTVKMEGH ETSDWNSYYA DTQEAYSSVP VSNMNSGLGS MNSMNTYMTM NTMTTSGNMT 
PASFNMSYAN PGLGAGLSPG AVAGMPGGSA GAMNSMTAAG VTAMGTALSP SGMGAMGAQQ 
AASMNGLGPY AAAMNPCMSP MAYAPSNLGR SRAGGGGDAK TFKRSYPHAK PPYSYISLIT 
MAIQQAPSKM LTLSEIYQWI MDLFPYYRQN QQRWQNSIRH SLSFNDCFVK VARSPDKPGK 
GSYWTLHPDS GNMFENGCYL RRQKRFKCEK QPGAGGGGGS GSGGSGAKGG PESRKDPSGA 
SNPSADSPLH RGVHGKTGQL EGAPAPGPAA SPQTLDHSGA TATGGASELK TPASSTAPPI 
SSGPGALASV PASHPAHGLA PHESQLHLKG DPHYSFNHPF SINNLMSSSE QQHKLDFKAY 
EQALQYSPYG STLPASLPLG SASVTTRSPI EPSALEPAYY QGVYSRPVLN TS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.