Details for: FOXA1

Gene ID: 3169

Symbol: FOXA1

Ensembl ID: ENSG00000129514

Description: forkhead box A1

Associated with

  • Developmental biology
    (R-HSA-1266738)
  • Esr-mediated signaling
    (R-HSA-8939211)
  • Estrogen-dependent gene expression
    (R-HSA-9018519)
  • Formation of axial mesoderm
    (R-HSA-9796292)
  • Gastrulation
    (R-HSA-9758941)
  • Signaling by nuclear receptors
    (R-HSA-9006931)
  • Signal transduction
    (R-HSA-162582)
  • Alveolar secondary septum development
    (GO:0061144)
  • Anatomical structure formation involved in morphogenesis
    (GO:0048646)
  • Anatomical structure morphogenesis
    (GO:0009653)
  • Cell differentiation
    (GO:0030154)
  • Chromatin
    (GO:0000785)
  • Chromatin binding
    (GO:0003682)
  • Chromatin remodeling
    (GO:0006338)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna binding
    (GO:0003677)
  • Dopaminergic neuron differentiation
    (GO:0071542)
  • Dorsal/ventral neural tube patterning
    (GO:0021904)
  • Epithelial cell maturation involved in prostate gland development
    (GO:0060743)
  • Epithelial tube branching involved in lung morphogenesis
    (GO:0060441)
  • Fibrillar center
    (GO:0001650)
  • Glucose homeostasis
    (GO:0042593)
  • Hormone metabolic process
    (GO:0042445)
  • Lung epithelial cell differentiation
    (GO:0060487)
  • Mesenchymal-epithelial cell signaling involved in prostate gland development
    (GO:0060739)
  • Microvillus
    (GO:0005902)
  • Negative regulation of epithelial to mesenchymal transition
    (GO:0010719)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Neuron fate specification
    (GO:0048665)
  • Notch signaling pathway
    (GO:0007219)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Positive regulation of apoptotic process
    (GO:0043065)
  • Positive regulation of cell-cell adhesion mediated by cadherin
    (GO:2000049)
  • Positive regulation of dna-binding transcription factor activity
    (GO:0051091)
  • Positive regulation of dopaminergic neuron differentiation
    (GO:1904340)
  • Positive regulation of intracellular estrogen receptor signaling pathway
    (GO:0033148)
  • Positive regulation of mirna transcription
    (GO:1902895)
  • Positive regulation of mitotic cell cycle
    (GO:0045931)
  • Positive regulation of smoothened signaling pathway
    (GO:0045880)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Prostate gland epithelium morphogenesis
    (GO:0060740)
  • Prostate gland stromal morphogenesis
    (GO:0060741)
  • Protein binding
    (GO:0005515)
  • Protein domain specific binding
    (GO:0019904)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Respiratory basal cell differentiation
    (GO:1902691)
  • Response to estradiol
    (GO:0032355)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development
    (GO:0060528)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Smoothened signaling pathway
    (GO:0007224)
  • Transcription cis-regulatory region binding
    (GO:0000976)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.91
    Marker Score: 2807
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.79
    Marker Score: 1414
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.79
    Marker Score: 1194
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.66
    Marker Score: 14387
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.64
    Marker Score: 474
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.63
    Marker Score: 948
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.6
    Marker Score: 5494
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.54
    Marker Score: 1049
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.53
    Marker Score: 755
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.45
    Marker Score: 606
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.43
    Marker Score: 3481
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.41
    Marker Score: 10528
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 870
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.32
    Marker Score: 5097
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.27
    Marker Score: 2418
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 1.15
    Marker Score: 15398
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.12
    Marker Score: 524
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.12
    Marker Score: 2532
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.06
    Marker Score: 581
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71808
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48034
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 510
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 464
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.96
    Marker Score: 508
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.96
    Marker Score: 1007
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5352
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2739
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 327
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.9
    Marker Score: 335
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.9
    Marker Score: 1045
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.87
    Marker Score: 415
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5287
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.87
    Marker Score: 661
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.86
    Marker Score: 5502
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.82
    Marker Score: 330
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.82
    Marker Score: 1334
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.82
    Marker Score: 813
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.81
    Marker Score: 258
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.81
    Marker Score: 8386
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.81
    Marker Score: 205
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.8
    Marker Score: 715
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.79
    Marker Score: 1887
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.79
    Marker Score: 1639
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 398
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.76
    Marker Score: 1355
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.76
    Marker Score: 188
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.74
    Marker Score: 678
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.74
    Marker Score: 471
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.73
    Marker Score: 509
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.73
    Marker Score: 376
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.72
    Marker Score: 686
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.71
    Marker Score: 297.5
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 180
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.69
    Marker Score: 2892.5
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.68
    Marker Score: 4417
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.67
    Marker Score: 3528
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.63
    Marker Score: 2607
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.62
    Marker Score: 412
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.62
    Marker Score: 659
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.62
    Marker Score: 1918
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.6
    Marker Score: 1096
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.6
    Marker Score: 515
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.59
    Marker Score: 365
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.58
    Marker Score: 1831
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.57
    Marker Score: 237
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.57
    Marker Score: 150
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.55
    Marker Score: 251
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.54
    Marker Score: 1023
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.53
    Marker Score: 848
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.53
    Marker Score: 688
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.53
    Marker Score: 1200
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.48
    Marker Score: 772
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.48
    Marker Score: 131
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.48
    Marker Score: 2285
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.47
    Marker Score: 136
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.47
    Marker Score: 95
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 279
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.46
    Marker Score: 174
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.46
    Marker Score: 320
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.46
    Marker Score: 158
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.44
    Marker Score: 392
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.44
    Marker Score: 442
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.43
    Marker Score: 912
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.43
    Marker Score: 412
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.42
    Marker Score: 102
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.42
    Marker Score: 91
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.41
    Marker Score: 217.5
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.41
    Marker Score: 80
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.4
    Marker Score: 272.5
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.4
    Marker Score: 103
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.39
    Marker Score: 3402
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.38
    Marker Score: 174
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.37
    Marker Score: 5844
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.37
    Marker Score: 1050
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 373
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.37
    Marker Score: 749
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.37
    Marker Score: 368

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Other Information

**Key characteristics:** * FOXA1 is a transcription factor belonging to the forkhead box A (FOXA) family of transcription factors. * It is highly expressed in early-stage embryos and continues to be expressed in various cell types throughout development. * FOXA1 is a key regulator of mesoderm formation, as it is required for the specification of the somite and endoderm tissues. * It is also involved in the development of the central nervous system, heart, liver, kidneys, and other organs. * FOXA1 plays a role in regulating the expression of numerous genes involved in cell proliferation, differentiation, and apoptosis. **Pathways and functions:** * FOXA1 binds to DNA sequences known as Rna polymerase II-specific DNA binding elements (RPEs) on the promoters of target genes. * It is a key regulator of the expression of genes involved in mesoderm specification, neural tube development, and the formation of the central nervous system. * FOXA1 also plays a role in regulating the differentiation of epithelial cells, promoting the development of stratified squamous and stratified columnar tissues. * It is involved in the development of various tissues and organs, including the bladder, urethra, nose, throat, lungs, prostate, skin, and teeth. **Clinical significance:** * Mutations in the FOXA1 gene have been linked to several human diseases, including liver cancer, esophageal cancer, and developmental disorders. * FOXA1 inhibitors are being investigated as potential treatments for these diseases, as they could be used to block FOXA1's activity and inhibit tumor growth. **Other important points:** * FOXA1 is a highly conserved gene, with a similar protein found in other mammals. * It is a target for a number of transcription factors and signaling pathways. * FOXA1 is a key regulator of development, and its dysregulation can lead to various diseases.

Genular Protein ID: 452441095

Symbol: FOXA1_HUMAN

Name: Hepatocyte nuclear factor 3-alpha

UniProtKB Accession Codes:

P55317 B2R9H6 B7ZAP5 Q9H2A0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 10 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 47 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8652662

Title: Molecular cloning of the forkhead transcription factor HNF-3 alpha from a human pulmonary adenocarcinoma cell line.

PubMed ID: 8652662

DOI: 10.1016/0167-4781(96)00058-9

PubMed ID: 10899756

Title: The human HNF-3 genes: cloning, partial sequence and mutation screening in patients with impaired glucose homeostasis.

PubMed ID: 10899756

DOI: 10.1159/000022943

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12234996

Title: The hepatocyte nuclear factor 3 alpha gene, HNF3alpha (FOXA1), on chromosome band 14q13 is amplified and overexpressed in esophageal and lung adenocarcinomas.

PubMed ID: 12234996

PubMed ID: 15987773

Title: Forkhead box A1 regulates prostate ductal morphogenesis and promotes epithelial cell maturation.

PubMed ID: 15987773

DOI: 10.1242/dev.01917

PubMed ID: 16087863

Title: Location analysis of estrogen receptor alpha target promoters reveals that FOXA1 defines a domain of the estrogen response.

PubMed ID: 16087863

DOI: 10.1073/pnas.0505575102

PubMed ID: 16331276

Title: BRCA1 and FOXA1 proteins coregulate the expression of the cell cycle-dependent kinase inhibitor p27(Kip1).

PubMed ID: 16331276

DOI: 10.1038/sj.onc.1209170

PubMed ID: 17220277

Title: Physical and functional interactions between homeodomain NKX2.1 and winged helix/forkhead FOXA1 in lung epithelial cells.

PubMed ID: 17220277

DOI: 10.1128/mcb.01133-06

PubMed ID: 18358809

Title: FoxA1 translates epigenetic signatures into enhancer-driven lineage-specific transcription.

PubMed ID: 18358809

DOI: 10.1016/j.cell.2008.01.018

PubMed ID: 19127412

Title: Role of Foxa1 in regulation of bcl2 expression during oxidative-stress-induced apoptosis in A549 type II pneumocytes.

PubMed ID: 19127412

DOI: 10.1007/s12192-008-0095-4

PubMed ID: 19919681

Title: Differential binding and co-binding pattern of FOXA1 and FOXA3 and their relation to H3K4me3 in HepG2 cells revealed by ChIP-seq.

PubMed ID: 19919681

DOI: 10.1186/gb-2009-10-11-r129

PubMed ID: 19917725

Title: Histone deacetylase 7 and FoxA1 in estrogen-mediated repression of RPRM.

PubMed ID: 19917725

DOI: 10.1128/mcb.00907-09

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 472
  • Mass: 49148
  • Checksum: B2489523459EEB4C
  • Sequence:
    • MLGTVKMEGH ETSDWNSYYA DTQEAYSSVP VSNMNSGLGS MNSMNTYMTM NTMTTSGNMT 
PASFNMSYAN PGLGAGLSPG AVAGMPGGSA GAMNSMTAAG VTAMGTALSP SGMGAMGAQQ 
AASMNGLGPY AAAMNPCMSP MAYAPSNLGR SRAGGGGDAK TFKRSYPHAK PPYSYISLIT 
MAIQQAPSKM LTLSEIYQWI MDLFPYYRQN QQRWQNSIRH SLSFNDCFVK VARSPDKPGK 
GSYWTLHPDS GNMFENGCYL RRQKRFKCEK QPGAGGGGGS GSGGSGAKGG PESRKDPSGA 
SNPSADSPLH RGVHGKTGQL EGAPAPGPAA SPQTLDHSGA TATGGASELK TPASSTAPPI 
SSGPGALASV PASHPAHGLA PHESQLHLKG DPHYSFNHPF SINNLMSSSE QQHKLDFKAY 
EQALQYSPYG STLPASLPLG SASVTTRSPI EPSALEPAYY QGVYSRPVLN TS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.