Details for: FOXA2

Gene ID: 3170

Symbol: FOXA2

Ensembl ID: ENSG00000125798

Description: forkhead box A2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 50.2637
    Cell Significance Index: -20.4200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 21.3461
    Cell Significance Index: -20.3800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.8559
    Cell Significance Index: 84.1200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9303
    Cell Significance Index: 101.1900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8956
    Cell Significance Index: 145.6600
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.8953
    Cell Significance Index: 5.3700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.8636
    Cell Significance Index: 18.7100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7854
    Cell Significance Index: 47.1500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5332
    Cell Significance Index: 36.8700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5206
    Cell Significance Index: 284.3200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.4444
    Cell Significance Index: 75.8900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4299
    Cell Significance Index: 388.1700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.3751
    Cell Significance Index: 9.0900
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.3543
    Cell Significance Index: 3.8400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2860
    Cell Significance Index: 10.0500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1688
    Cell Significance Index: 32.1300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1524
    Cell Significance Index: 15.0800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0986
    Cell Significance Index: 2.8400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0852
    Cell Significance Index: 9.7300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0119
    Cell Significance Index: 9.0300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: 0.0007
    Cell Significance Index: 0.0300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0055
    Cell Significance Index: -4.0800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0121
    Cell Significance Index: -7.5300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0141
    Cell Significance Index: -26.5300
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0183
    Cell Significance Index: -0.3200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0254
    Cell Significance Index: -14.3000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0262
    Cell Significance Index: -0.8400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0304
    Cell Significance Index: -22.3000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0352
    Cell Significance Index: -0.7500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0366
    Cell Significance Index: -4.1900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0432
    Cell Significance Index: -9.0900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0453
    Cell Significance Index: -0.9400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0634
    Cell Significance Index: -18.2400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0915
    Cell Significance Index: -18.1500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0965
    Cell Significance Index: -11.2500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1147
    Cell Significance Index: -20.6800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1474
    Cell Significance Index: -29.5700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1688
    Cell Significance Index: -20.7600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1731
    Cell Significance Index: -23.7700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2476
    Cell Significance Index: -15.1800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2548
    Cell Significance Index: -26.5300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2569
    Cell Significance Index: -26.2400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.3096
    Cell Significance Index: -4.7900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3208
    Cell Significance Index: -16.7100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3489
    Cell Significance Index: -5.2600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.3990
    Cell Significance Index: -17.3500
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.5023
    Cell Significance Index: -4.9700
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.6687
    Cell Significance Index: -11.0200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.7715
    Cell Significance Index: -28.3200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.7741
    Cell Significance Index: -19.3500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.7827
    Cell Significance Index: -13.1900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.8046
    Cell Significance Index: -21.5600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.8219
    Cell Significance Index: -28.5600
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.8563
    Cell Significance Index: -10.3500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.8589
    Cell Significance Index: -22.5900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.8632
    Cell Significance Index: -25.3500
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.8717
    Cell Significance Index: -9.2000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.8801
    Cell Significance Index: -23.5000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.9507
    Cell Significance Index: -30.2800
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.9622
    Cell Significance Index: -13.3500
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.9911
    Cell Significance Index: -24.7200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.9976
    Cell Significance Index: -29.3900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -1.0134
    Cell Significance Index: -22.1900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -1.0707
    Cell Significance Index: -55.6200
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -1.0773
    Cell Significance Index: -18.1200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -1.0879
    Cell Significance Index: -16.0600
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -1.1423
    Cell Significance Index: -28.5300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -1.1430
    Cell Significance Index: -53.7200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -1.2061
    Cell Significance Index: -12.4900
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -1.2125
    Cell Significance Index: -7.9100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -1.2214
    Cell Significance Index: -23.8800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -1.2615
    Cell Significance Index: -32.1400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -1.2638
    Cell Significance Index: -30.3100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -1.2720
    Cell Significance Index: -23.5100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -1.2834
    Cell Significance Index: -19.2300
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -1.3089
    Cell Significance Index: -26.1000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -1.3103
    Cell Significance Index: -28.3100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -1.3106
    Cell Significance Index: -30.2800
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -1.3355
    Cell Significance Index: -14.1900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -1.3438
    Cell Significance Index: -62.6600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -1.3548
    Cell Significance Index: -38.8400
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -1.3607
    Cell Significance Index: -23.2600
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -1.3969
    Cell Significance Index: -22.6300
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -1.4084
    Cell Significance Index: -17.6900
  • Cell Name: monocyte (CL0000576)
    Fold Change: -1.4166
    Cell Significance Index: -16.3000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.4239
    Cell Significance Index: -23.8300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -1.4257
    Cell Significance Index: -30.2600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -1.4520
    Cell Significance Index: -28.7100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -1.4734
    Cell Significance Index: -29.5800
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -1.5453
    Cell Significance Index: -15.9400
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -1.5646
    Cell Significance Index: -21.7000
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -1.6070
    Cell Significance Index: -20.3100
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -1.6327
    Cell Significance Index: -22.3900
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -1.6540
    Cell Significance Index: -13.1600
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -1.6599
    Cell Significance Index: -28.1900
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -1.6993
    Cell Significance Index: -20.6700
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -1.7325
    Cell Significance Index: -15.6700
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -1.7399
    Cell Significance Index: -19.3500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -1.7520
    Cell Significance Index: -25.0900
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -1.7530
    Cell Significance Index: -30.3100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Transcriptional Regulatory Function**: FOXA2 acts as a transcription factor, binding to specific DNA sequences to regulate the expression of target genes involved in various biological processes. 2. **Cell Type-Specific Expression**: FOXA2 is highly expressed in endocrine cells, epithelial cells, and blood cells, indicating its role in tissue-specific development and function. 3. **Diverse Biological Pathways**: FOXA2 is involved in multiple biological pathways, including cell differentiation, cell fate specification, and gene regulation, highlighting its broad functional scope. 4. **DNA-Binding Specificity**: FOXA2 has a high degree of specificity for binding to DNA sequences, allowing it to regulate the expression of target genes with precision. **Pathways and Functions** 1. **Developmental Biology**: FOXA2 plays a crucial role in the development of various tissues, including the endocrine system, epithelial tissues, and blood cells. 2. **Cell Differentiation**: FOXA2 regulates the expression of genes involved in cell differentiation, ensuring the proper development of specific cell types. 3. **Gene Regulation**: FOXA2 regulates the expression of target genes involved in various biological processes, including cell fate specification, cell junction formation, and gene expression in response to glucose. 4. **Endocrine Function**: FOXA2 is essential for the development and function of endocrine cells, including pancreatic beta cells, insulin-producing cells, and other hormone-producing cells. **Clinical Significance** 1. **Diabetes and Insulin Resistance**: FOXA2 has been implicated in the regulation of pancreatic beta-cell function and insulin secretion, making it a potential target for the treatment of diabetes and insulin resistance. 2. **Cancer**: FOXA2 has been shown to be overexpressed in various types of cancer, including breast, lung, and liver cancer, suggesting its potential role as a tumor suppressor gene. 3. **Neurological Disorders**: FOXA2 has been implicated in the regulation of dopaminergic neuron differentiation and function, making it a potential target for the treatment of neurological disorders, such as Parkinson's disease. 4. **Epithelial Tissue Development**: FOXA2 plays a crucial role in the development of epithelial tissues, including the lung, stomach, and pancreas, highlighting its importance in tissue-specific development and function. In conclusion, FOXA2 is a multifunctional transcription factor that plays a crucial role in various biological processes, including development, differentiation, and gene regulation. Its expression is highly restricted to specific cell types, and its dysregulation has been implicated in various diseases, including diabetes, cancer, and neurological disorders. Further research is needed to fully elucidate the functional scope of FOXA2 and its potential therapeutic applications.

Genular Protein ID: 2627416070

Symbol: FOXA2_HUMAN

Name: Hepatocyte nuclear factor 3-beta

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10672453

Title: Cloning of cDNA and the gene encoding human hepatocyte nuclear factor (HNF)-3 beta and mutation screening in Japanese subjects with maturity-onset diabetes of the young.

PubMed ID: 10672453

DOI: 10.1007/s001250050016

PubMed ID: 10899756

Title: The human HNF-3 genes: cloning, partial sequence and mutation screening in patients with impaired glucose homeostasis.

PubMed ID: 10899756

DOI: 10.1159/000022943

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14500912

Title: Insulin regulates the activity of forkhead transcription factor Hnf-3beta/Foxa-2 by Akt-mediated phosphorylation and nuclear/cytosolic localization.

PubMed ID: 14500912

DOI: 10.1073/pnas.1931483100

PubMed ID: 15737987

Title: A hepatocyte nuclear factor-3 site in the fibrinogen beta promoter is important for interleukin 6-induced expression, and its activity is influenced by the adjacent -148C/T polymorphism.

PubMed ID: 15737987

DOI: 10.1074/jbc.m501973200

PubMed ID: 19919681

Title: Differential binding and co-binding pattern of FOXA1 and FOXA3 and their relation to H3K4me3 in HepG2 cells revealed by ChIP-seq.

PubMed ID: 19919681

DOI: 10.1186/gb-2009-10-11-r129

PubMed ID: 19478084

Title: Identification of DNA-dependent protein kinase as a cofactor for the forkhead transcription factor FoxA2.

PubMed ID: 19478084

DOI: 10.1074/jbc.m109.016295

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 35798741

Title: TET1 dioxygenase is required for FOXA2-associated chromatin remodeling in pancreatic beta-cell differentiation.

PubMed ID: 35798741

DOI: 10.1038/s41467-022-31611-x

Sequence Information:

  • Length: 457
  • Mass: 48306
  • Checksum: 61DDE4C75C70680A
  • Sequence:
  • MLGAVKMEGH EPSDWSSYYA EPEGYSSVSN MNAGLGMNGM NTYMSMSAAA MGSGSGNMSA 
    GSMNMSSYVG AGMSPSLAGM SPGAGAMAGM GGSAGAAGVA GMGPHLSPSL SPLGGQAAGA 
    MGGLAPYANM NSMSPMYGQA GLSRARDPKT YRRSYTHAKP PYSYISLITM AIQQSPNKML 
    TLSEIYQWIM DLFPFYRQNQ QRWQNSIRHS LSFNDCFLKV PRSPDKPGKG SFWTLHPDSG 
    NMFENGCYLR RQKRFKCEKQ LALKEAAGAA GSGKKAAAGA QASQAQLGEA AGPASETPAG 
    TESPHSSASP CQEHKRGGLG ELKGTPAAAL SPPEPAPSPG QQQQAAAHLL GPPHHPGLPP 
    EAHLKPEHHY AFNHPFSINN LMSSEQQHHH SHHHHQPHKM DLKAYEQVMH YPGYGSPMPG 
    SLAMGPVTNK TGLDASPLAA DTSYYQGVYS RPIMNSS

Genular Protein ID: 4068019112

Symbol: B0ZTD4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 463
  • Mass: 48907
  • Checksum: 726495A18CAE1677
  • Sequence:
  • MHSASSMLGA VKMEGHEPSD WSSYYAEPEG YSSVSNMNAG LGMNGMNTYM SMSAAAMGSG 
    SGNMSAGSMN MSSYVGAGMS PSLAGMSPGA GAMAGMGGSA GAAGVAGMGP HLSPSLSPLG 
    GQAAGAMGGL APYANMNSMS PMYGQAGLSR ARDPKTYRRS YTHAKPPYSY ISLITMAIQQ 
    SPNKMLTLSE IYQWIMDLFP FYRQNQQRWQ NSIRHSLSFN DCFLKVPRSP DKPGKGSFWT 
    LHPDSGNMFE NGCYLRRQKR FKCEKQLALK EAAGAAGSGK KAAAGAQASQ AQLGEAAGPA 
    SETPAGTESP HSSASPCQEH KRGGLGELKG TPAAALSPPE PAPSPGQQQQ AAAHLLGPPH 
    HPGLPPEAHL KPEHHYAFNH PFSINNLMSS EQQHHHSHHH HQPHKMDLKA YEQVMHYPGY 
    GSPMPGSLAM GPVTNKTGLD ASPLAADTSY YQGVYSRPIM NSS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.