Details for: FOXA2
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 50.2637
Cell Significance Index: -20.4200 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 21.3461
Cell Significance Index: -20.3800 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.8559
Cell Significance Index: 84.1200 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.9303
Cell Significance Index: 101.1900 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.8956
Cell Significance Index: 145.6600 - Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 0.8953
Cell Significance Index: 5.3700 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.8636
Cell Significance Index: 18.7100 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.7854
Cell Significance Index: 47.1500 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.5332
Cell Significance Index: 36.8700 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.5206
Cell Significance Index: 284.3200 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.4444
Cell Significance Index: 75.8900 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.4299
Cell Significance Index: 388.1700 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 0.3751
Cell Significance Index: 9.0900 - Cell Name: large intestine goblet cell (CL1000320)
Fold Change: 0.3543
Cell Significance Index: 3.8400 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.2860
Cell Significance Index: 10.0500 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1688
Cell Significance Index: 32.1300 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1524
Cell Significance Index: 15.0800 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.0986
Cell Significance Index: 2.8400 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: 0.0852
Cell Significance Index: 9.7300 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0119
Cell Significance Index: 9.0300 - Cell Name: neuron associated cell (CL0000095)
Fold Change: 0.0007
Cell Significance Index: 0.0300 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0055
Cell Significance Index: -4.0800 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0121
Cell Significance Index: -7.5300 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0141
Cell Significance Index: -26.5300 - Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -0.0183
Cell Significance Index: -0.3200 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0254
Cell Significance Index: -14.3000 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.0262
Cell Significance Index: -0.8400 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0304
Cell Significance Index: -22.3000 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.0352
Cell Significance Index: -0.7500 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0366
Cell Significance Index: -4.1900 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0432
Cell Significance Index: -9.0900 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.0453
Cell Significance Index: -0.9400 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0634
Cell Significance Index: -18.2400 - Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0915
Cell Significance Index: -18.1500 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0965
Cell Significance Index: -11.2500 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.1147
Cell Significance Index: -20.6800 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.1474
Cell Significance Index: -29.5700 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.1688
Cell Significance Index: -20.7600 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.1731
Cell Significance Index: -23.7700 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.2476
Cell Significance Index: -15.1800 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2548
Cell Significance Index: -26.5300 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.2569
Cell Significance Index: -26.2400 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: -0.3096
Cell Significance Index: -4.7900 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.3208
Cell Significance Index: -16.7100 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.3489
Cell Significance Index: -5.2600 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.3990
Cell Significance Index: -17.3500 - Cell Name: neural progenitor cell (CL0011020)
Fold Change: -0.5023
Cell Significance Index: -4.9700 - Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: -0.6687
Cell Significance Index: -11.0200 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.7715
Cell Significance Index: -28.3200 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.7741
Cell Significance Index: -19.3500 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.7827
Cell Significance Index: -13.1900 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.8046
Cell Significance Index: -21.5600 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.8219
Cell Significance Index: -28.5600 - Cell Name: endocrine cell (CL0000163)
Fold Change: -0.8563
Cell Significance Index: -10.3500 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.8589
Cell Significance Index: -22.5900 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.8632
Cell Significance Index: -25.3500 - Cell Name: epithelial cell (CL0000066)
Fold Change: -0.8717
Cell Significance Index: -9.2000 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.8801
Cell Significance Index: -23.5000 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.9507
Cell Significance Index: -30.2800 - Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: -0.9622
Cell Significance Index: -13.3500 - Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.9911
Cell Significance Index: -24.7200 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.9976
Cell Significance Index: -29.3900 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -1.0134
Cell Significance Index: -22.1900 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -1.0707
Cell Significance Index: -55.6200 - Cell Name: hepatoblast (CL0005026)
Fold Change: -1.0773
Cell Significance Index: -18.1200 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -1.0879
Cell Significance Index: -16.0600 - Cell Name: keratinocyte (CL0000312)
Fold Change: -1.1423
Cell Significance Index: -28.5300 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -1.1430
Cell Significance Index: -53.7200 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -1.2061
Cell Significance Index: -12.4900 - Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: -1.2125
Cell Significance Index: -7.9100 - Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -1.2214
Cell Significance Index: -23.8800 - Cell Name: erythrocyte (CL0000232)
Fold Change: -1.2615
Cell Significance Index: -32.1400 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -1.2638
Cell Significance Index: -30.3100 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -1.2720
Cell Significance Index: -23.5100 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: -1.2834
Cell Significance Index: -19.2300 - Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
Fold Change: -1.3089
Cell Significance Index: -26.1000 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -1.3103
Cell Significance Index: -28.3100 - Cell Name: peg cell (CL4033014)
Fold Change: -1.3106
Cell Significance Index: -30.2800 - Cell Name: thyroid follicular cell (CL0002258)
Fold Change: -1.3355
Cell Significance Index: -14.1900 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -1.3438
Cell Significance Index: -62.6600 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -1.3548
Cell Significance Index: -38.8400 - Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: -1.3607
Cell Significance Index: -23.2600 - Cell Name: megakaryocyte (CL0000556)
Fold Change: -1.3969
Cell Significance Index: -22.6300 - Cell Name: acinar cell (CL0000622)
Fold Change: -1.4084
Cell Significance Index: -17.6900 - Cell Name: monocyte (CL0000576)
Fold Change: -1.4166
Cell Significance Index: -16.3000 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -1.4239
Cell Significance Index: -23.8300 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -1.4257
Cell Significance Index: -30.2600 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -1.4520
Cell Significance Index: -28.7100 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -1.4734
Cell Significance Index: -29.5800 - Cell Name: respiratory goblet cell (CL0002370)
Fold Change: -1.5453
Cell Significance Index: -15.9400 - Cell Name: hepatocyte (CL0000182)
Fold Change: -1.5646
Cell Significance Index: -21.7000 - Cell Name: thymocyte (CL0000893)
Fold Change: -1.6070
Cell Significance Index: -20.3100 - Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: -1.6327
Cell Significance Index: -22.3900 - Cell Name: glandular epithelial cell (CL0000150)
Fold Change: -1.6540
Cell Significance Index: -13.1600 - Cell Name: leukocyte (CL0000738)
Fold Change: -1.6599
Cell Significance Index: -28.1900 - Cell Name: squamous epithelial cell (CL0000076)
Fold Change: -1.6993
Cell Significance Index: -20.6700 - Cell Name: goblet cell (CL0000160)
Fold Change: -1.7325
Cell Significance Index: -15.6700 - Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: -1.7399
Cell Significance Index: -19.3500 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -1.7520
Cell Significance Index: -25.0900 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -1.7530
Cell Significance Index: -30.3100
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2627416070
Symbol: FOXA2_HUMAN
Name: Hepatocyte nuclear factor 3-beta
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10672453
Title: Cloning of cDNA and the gene encoding human hepatocyte nuclear factor (HNF)-3 beta and mutation screening in Japanese subjects with maturity-onset diabetes of the young.
PubMed ID: 10672453
PubMed ID: 10899756
Title: The human HNF-3 genes: cloning, partial sequence and mutation screening in patients with impaired glucose homeostasis.
PubMed ID: 10899756
DOI: 10.1159/000022943
PubMed ID: 11780052
Title: The DNA sequence and comparative analysis of human chromosome 20.
PubMed ID: 11780052
DOI: 10.1038/414865a
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 14500912
Title: Insulin regulates the activity of forkhead transcription factor Hnf-3beta/Foxa-2 by Akt-mediated phosphorylation and nuclear/cytosolic localization.
PubMed ID: 14500912
PubMed ID: 15737987
Title: A hepatocyte nuclear factor-3 site in the fibrinogen beta promoter is important for interleukin 6-induced expression, and its activity is influenced by the adjacent -148C/T polymorphism.
PubMed ID: 15737987
PubMed ID: 19919681
Title: Differential binding and co-binding pattern of FOXA1 and FOXA3 and their relation to H3K4me3 in HepG2 cells revealed by ChIP-seq.
PubMed ID: 19919681
PubMed ID: 19478084
Title: Identification of DNA-dependent protein kinase as a cofactor for the forkhead transcription factor FoxA2.
PubMed ID: 19478084
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 35798741
Title: TET1 dioxygenase is required for FOXA2-associated chromatin remodeling in pancreatic beta-cell differentiation.
PubMed ID: 35798741
Sequence Information:
- Length: 457
- Mass: 48306
- Checksum: 61DDE4C75C70680A
- Sequence:
MLGAVKMEGH EPSDWSSYYA EPEGYSSVSN MNAGLGMNGM NTYMSMSAAA MGSGSGNMSA GSMNMSSYVG AGMSPSLAGM SPGAGAMAGM GGSAGAAGVA GMGPHLSPSL SPLGGQAAGA MGGLAPYANM NSMSPMYGQA GLSRARDPKT YRRSYTHAKP PYSYISLITM AIQQSPNKML TLSEIYQWIM DLFPFYRQNQ QRWQNSIRHS LSFNDCFLKV PRSPDKPGKG SFWTLHPDSG NMFENGCYLR RQKRFKCEKQ LALKEAAGAA GSGKKAAAGA QASQAQLGEA AGPASETPAG TESPHSSASP CQEHKRGGLG ELKGTPAAAL SPPEPAPSPG QQQQAAAHLL GPPHHPGLPP EAHLKPEHHY AFNHPFSINN LMSSEQQHHH SHHHHQPHKM DLKAYEQVMH YPGYGSPMPG SLAMGPVTNK TGLDASPLAA DTSYYQGVYS RPIMNSS
Genular Protein ID: 4068019112
Symbol: B0ZTD4_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11181995
Sequence Information:
- Length: 463
- Mass: 48907
- Checksum: 726495A18CAE1677
- Sequence:
MHSASSMLGA VKMEGHEPSD WSSYYAEPEG YSSVSNMNAG LGMNGMNTYM SMSAAAMGSG SGNMSAGSMN MSSYVGAGMS PSLAGMSPGA GAMAGMGGSA GAAGVAGMGP HLSPSLSPLG GQAAGAMGGL APYANMNSMS PMYGQAGLSR ARDPKTYRRS YTHAKPPYSY ISLITMAIQQ SPNKMLTLSE IYQWIMDLFP FYRQNQQRWQ NSIRHSLSFN DCFLKVPRSP DKPGKGSFWT LHPDSGNMFE NGCYLRRQKR FKCEKQLALK EAAGAAGSGK KAAAGAQASQ AQLGEAAGPA SETPAGTESP HSSASPCQEH KRGGLGELKG TPAAALSPPE PAPSPGQQQQ AAAHLLGPPH HPGLPPEAHL KPEHHYAFNH PFSINNLMSS EQQHHHSHHH HQPHKMDLKA YEQVMHYPGY GSPMPGSLAM GPVTNKTGLD ASPLAADTSY YQGVYSRPIM NSS
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.