Details for: FOXA2

Gene ID: 3170

Symbol: FOXA2

Ensembl ID: ENSG00000125798

Description: forkhead box A2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 2.32
    Marker Score: 1198.5
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.82
    Marker Score: 1003
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.7
    Marker Score: 634
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.51
    Marker Score: 3713
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.42
    Marker Score: 5941
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.4
    Marker Score: 1450
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.07
    Marker Score: 6845
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 1.06
    Marker Score: 1282
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251794
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.03
    Marker Score: 727
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1
    Marker Score: 2108
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71811
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48037
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1
    Marker Score: 5230
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 511
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.99
    Marker Score: 6452
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.98
    Marker Score: 942
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 464
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.97
    Marker Score: 2200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5315
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2740
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 328
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.91
    Marker Score: 205
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.89
    Marker Score: 1427
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.89
    Marker Score: 397
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.88
    Marker Score: 933
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.88
    Marker Score: 1664
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5286
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.86
    Marker Score: 29900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.84
    Marker Score: 336
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.83
    Marker Score: 287
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.83
    Marker Score: 430
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.82
    Marker Score: 357
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.82
    Marker Score: 798
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.79
    Marker Score: 331
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1267
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 399
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.77
    Marker Score: 309
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.76
    Marker Score: 527
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 684
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.71
    Marker Score: 2982.5
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.71
    Marker Score: 454
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.68
    Marker Score: 1077
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.63
    Marker Score: 137
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.63
    Marker Score: 190
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.62
    Marker Score: 623
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.62
    Marker Score: 6450
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.54
    Marker Score: 1273
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.53
    Marker Score: 137
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.5
    Marker Score: 6755
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.5
    Marker Score: 337
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.49
    Marker Score: 359
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.47
    Marker Score: 128
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 279
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.46
    Marker Score: 211
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.45
    Marker Score: 141
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.44
    Marker Score: 432
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.42
    Marker Score: 1793
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.41
    Marker Score: 190
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.39
    Marker Score: 104
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.38
    Marker Score: 6106
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.38
    Marker Score: 142
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.37
    Marker Score: 772
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.37
    Marker Score: 92
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.36
    Marker Score: 209
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.36
    Marker Score: 183
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.34
    Marker Score: 1834
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.34
    Marker Score: 86
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.34
    Marker Score: 302
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.34
    Marker Score: 2155
  • Cell Name: type I enteroendocrine cell (CL0002277)
    Fold Change: 0.33
    Marker Score: 83
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.33
    Marker Score: 155
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.31
    Marker Score: 117
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.31
    Marker Score: 1016
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.31
    Marker Score: 71
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.31
    Marker Score: 2680
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.31
    Marker Score: 92
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.31
    Marker Score: 2031
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: 0.3
    Marker Score: 85
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.28
    Marker Score: 106
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.28
    Marker Score: 220
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.27
    Marker Score: 343
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.26
    Marker Score: 886
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.25
    Marker Score: 97
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.24
    Marker Score: 129
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.24
    Marker Score: 745
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.24
    Marker Score: 69
  • Cell Name: parietal cell (CL0000162)
    Fold Change: 0.24
    Marker Score: 66
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.24
    Marker Score: 379.5
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 67
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.23
    Marker Score: 270
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.22
    Marker Score: 70
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.2
    Marker Score: 960
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.2
    Marker Score: 68
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.19
    Marker Score: 63
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.18
    Marker Score: 564
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.17
    Marker Score: 37

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Other Information

**Key characteristics:** * FOXA2 is a member of the forkhead box (FOX) family of transcription factors. * It is a highly conserved protein with important roles in vertebrates. * FOXA2 is known to be a key regulator of cell fate specification and tissue differentiation. * It is involved in the development of the thyroid, parathyroid, and kidney. * It also plays a role in the development of the cardiovascular, respiratory, and gastrointestinal systems. **Pathways and functions:** * FOXA2 is a key regulator of cell fate specification in the developing embryo. * It is required for the specification of endoderm, a group of cells that gives rise to the majority of the organs and tissues in the body. * FOXA2 is also involved in the development of the cardiovascular, respiratory, and gastrointestinal systems. * It plays a role in the regulation of epithelial cell differentiation and function. * FOXA2 is a key regulator of beta-cell development and function in the pancreas. **Clinical significance:** * Mutations in FOXA2 have been linked to a number of human diseases, including diabetes, heart disease, and cancer. * These mutations can disrupt FOXA2's function, leading to the development of these diseases. * Therefore, FOXA2 is a promising target for the treatment of cancer and other diseases that are characterized by abnormal cell growth. **Conclusion:** FOXA2 is a critical transcription factor that plays a vital role in the development and maintenance of various tissues in the body. Its mutations can lead to a number of human diseases, highlighting its importance in human health.

Genular Protein ID: 2627416070

Symbol: FOXA2_HUMAN

Name: Hepatocyte nuclear factor 3-beta

UniProtKB Accession Codes:

Q9Y261 Q8WUW4 Q96DF7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 7 Ensembl 2 ExpressionAtlas 1 GO 35 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 3 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 3 RefSeq 2 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10672453

Title: Cloning of cDNA and the gene encoding human hepatocyte nuclear factor (HNF)-3 beta and mutation screening in Japanese subjects with maturity-onset diabetes of the young.

PubMed ID: 10672453

DOI: 10.1007/s001250050016

PubMed ID: 10899756

Title: The human HNF-3 genes: cloning, partial sequence and mutation screening in patients with impaired glucose homeostasis.

PubMed ID: 10899756

DOI: 10.1159/000022943

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14500912

Title: Insulin regulates the activity of forkhead transcription factor Hnf-3beta/Foxa-2 by Akt-mediated phosphorylation and nuclear/cytosolic localization.

PubMed ID: 14500912

DOI: 10.1073/pnas.1931483100

PubMed ID: 15737987

Title: A hepatocyte nuclear factor-3 site in the fibrinogen beta promoter is important for interleukin 6-induced expression, and its activity is influenced by the adjacent -148C/T polymorphism.

PubMed ID: 15737987

DOI: 10.1074/jbc.m501973200

PubMed ID: 19919681

Title: Differential binding and co-binding pattern of FOXA1 and FOXA3 and their relation to H3K4me3 in HepG2 cells revealed by ChIP-seq.

PubMed ID: 19919681

DOI: 10.1186/gb-2009-10-11-r129

PubMed ID: 19478084

Title: Identification of DNA-dependent protein kinase as a cofactor for the forkhead transcription factor FoxA2.

PubMed ID: 19478084

DOI: 10.1074/jbc.m109.016295

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 35798741

Title: TET1 dioxygenase is required for FOXA2-associated chromatin remodeling in pancreatic beta-cell differentiation.

PubMed ID: 35798741

DOI: 10.1038/s41467-022-31611-x

Sequence Information:

  • Length: 457
  • Mass: 48306
  • Checksum: 61DDE4C75C70680A
  • Sequence:
    • MLGAVKMEGH EPSDWSSYYA EPEGYSSVSN MNAGLGMNGM NTYMSMSAAA MGSGSGNMSA 
GSMNMSSYVG AGMSPSLAGM SPGAGAMAGM GGSAGAAGVA GMGPHLSPSL SPLGGQAAGA 
MGGLAPYANM NSMSPMYGQA GLSRARDPKT YRRSYTHAKP PYSYISLITM AIQQSPNKML 
TLSEIYQWIM DLFPFYRQNQ QRWQNSIRHS LSFNDCFLKV PRSPDKPGKG SFWTLHPDSG 
NMFENGCYLR RQKRFKCEKQ LALKEAAGAA GSGKKAAAGA QASQAQLGEA AGPASETPAG 
TESPHSSASP CQEHKRGGLG ELKGTPAAAL SPPEPAPSPG QQQQAAAHLL GPPHHPGLPP 
EAHLKPEHHY AFNHPFSINN LMSSEQQHHH SHHHHQPHKM DLKAYEQVMH YPGYGSPMPG 
SLAMGPVTNK TGLDASPLAA DTSYYQGVYS RPIMNSS

Genular Protein ID: 4068019112

Symbol: B0ZTD4_HUMAN

Name: N/A

UniProtKB Accession Codes:

B0ZTD4

Database IDs:

ARBA 4 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 4 ExpressionAtlas 1 GO 6 Gene3D 1 GenomeRNAi 1 InterPro 7 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 4 PROSITE-ProRule 1 Pfam 3 PharmGKB 1 RefSeq 1 SAM 1 SMART 1 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 463
  • Mass: 48907
  • Checksum: 726495A18CAE1677
  • Sequence:
    • MHSASSMLGA VKMEGHEPSD WSSYYAEPEG YSSVSNMNAG LGMNGMNTYM SMSAAAMGSG 
SGNMSAGSMN MSSYVGAGMS PSLAGMSPGA GAMAGMGGSA GAAGVAGMGP HLSPSLSPLG 
GQAAGAMGGL APYANMNSMS PMYGQAGLSR ARDPKTYRRS YTHAKPPYSY ISLITMAIQQ 
SPNKMLTLSE IYQWIMDLFP FYRQNQQRWQ NSIRHSLSFN DCFLKVPRSP DKPGKGSFWT 
LHPDSGNMFE NGCYLRRQKR FKCEKQLALK EAAGAAGSGK KAAAGAQASQ AQLGEAAGPA 
SETPAGTESP HSSASPCQEH KRGGLGELKG TPAAALSPPE PAPSPGQQQQ AAAHLLGPPH 
HPGLPPEAHL KPEHHYAFNH PFSINNLMSS EQQHHHSHHH HQPHKMDLKA YEQVMHYPGY 
GSPMPGSLAM GPVTNKTGLD ASPLAADTSY YQGVYSRPIM NSS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.