Details for: TLX2

Gene ID: 3196

Symbol: TLX2

Ensembl ID: ENSG00000115297

Description: T cell leukemia homeobox 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: thymocyte (CL0000893)
    Fold Change: 5.0921
    Cell Significance Index: 64.3400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 5.0859
    Cell Significance Index: -1.2900
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 1.3666
    Cell Significance Index: 9.8900
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.9594
    Cell Significance Index: 10.5700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.7735
    Cell Significance Index: 48.7500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.7147
    Cell Significance Index: 8.5200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.4851
    Cell Significance Index: 11.7500
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 0.4275
    Cell Significance Index: 2.4300
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.3914
    Cell Significance Index: 2.9600
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.3092
    Cell Significance Index: 3.1900
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.2117
    Cell Significance Index: 1.6500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.1816
    Cell Significance Index: 2.6000
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.1754
    Cell Significance Index: 3.5700
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.1280
    Cell Significance Index: 1.5200
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.1188
    Cell Significance Index: 1.7300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1147
    Cell Significance Index: 1.5700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.0994
    Cell Significance Index: 2.5400
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 0.0521
    Cell Significance Index: 0.4600
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.0378
    Cell Significance Index: 0.5300
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.0285
    Cell Significance Index: 0.2200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0194
    Cell Significance Index: 0.5700
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.0182
    Cell Significance Index: 0.2300
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.0140
    Cell Significance Index: 0.1800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0126
    Cell Significance Index: 1.4900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0125
    Cell Significance Index: 0.6500
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.0110
    Cell Significance Index: 0.1400
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.0104
    Cell Significance Index: 0.1300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0081
    Cell Significance Index: 1.6300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0046
    Cell Significance Index: 0.9100
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 0.0010
    Cell Significance Index: 0.0100
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.0009
    Cell Significance Index: 0.0100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0002
    Cell Significance Index: 0.0100
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0002
    Cell Significance Index: -0.0100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0006
    Cell Significance Index: -0.1100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0008
    Cell Significance Index: -0.6000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0012
    Cell Significance Index: -0.6400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0017
    Cell Significance Index: -1.1100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0017
    Cell Significance Index: -1.2600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0020
    Cell Significance Index: -0.7100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0022
    Cell Significance Index: -0.6400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0022
    Cell Significance Index: -1.2500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0025
    Cell Significance Index: -1.1500
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0031
    Cell Significance Index: -0.0400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0034
    Cell Significance Index: -0.0700
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0049
    Cell Significance Index: -0.0600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0062
    Cell Significance Index: -0.1700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0063
    Cell Significance Index: -1.1300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0076
    Cell Significance Index: -0.7900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0083
    Cell Significance Index: -1.2000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0084
    Cell Significance Index: -1.1500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0088
    Cell Significance Index: -1.0800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0089
    Cell Significance Index: -1.0400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0105
    Cell Significance Index: -1.2000
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: -0.0120
    Cell Significance Index: -0.1300
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0168
    Cell Significance Index: -0.2900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0177
    Cell Significance Index: -0.8300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0183
    Cell Significance Index: -0.9600
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0200
    Cell Significance Index: -0.5000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0201
    Cell Significance Index: -0.5800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0205
    Cell Significance Index: -1.3800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0210
    Cell Significance Index: -1.1800
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.0223
    Cell Significance Index: -0.3100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0232
    Cell Significance Index: -0.8500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0250
    Cell Significance Index: -0.8800
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0256
    Cell Significance Index: -0.2900
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0286
    Cell Significance Index: -0.3700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0288
    Cell Significance Index: -0.7700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0306
    Cell Significance Index: -1.1600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0323
    Cell Significance Index: -1.1300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0323
    Cell Significance Index: -0.8300
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0333
    Cell Significance Index: -0.4300
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0338
    Cell Significance Index: -0.3200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0338
    Cell Significance Index: -0.9700
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0344
    Cell Significance Index: -0.4900
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0349
    Cell Significance Index: -0.5300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0352
    Cell Significance Index: -1.1200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0357
    Cell Significance Index: -1.1700
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0370
    Cell Significance Index: -0.5300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0376
    Cell Significance Index: -0.9400
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: -0.0380
    Cell Significance Index: -0.2900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0382
    Cell Significance Index: -0.8000
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: -0.0384
    Cell Significance Index: -0.3900
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.0390
    Cell Significance Index: -0.4700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0394
    Cell Significance Index: -0.9100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0406
    Cell Significance Index: -1.0400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0413
    Cell Significance Index: -1.0900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0418
    Cell Significance Index: -1.2300
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0425
    Cell Significance Index: -0.6200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0445
    Cell Significance Index: -1.1100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0447
    Cell Significance Index: -1.1200
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0465
    Cell Significance Index: -0.5000
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0465
    Cell Significance Index: -0.5800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0466
    Cell Significance Index: -1.3300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0469
    Cell Significance Index: -0.4900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0494
    Cell Significance Index: -1.3200
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0495
    Cell Significance Index: -0.6600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0496
    Cell Significance Index: -0.9800
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.0496
    Cell Significance Index: -0.6200
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0507
    Cell Significance Index: -0.7200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** TLX2 is a transcription factor that belongs to the homeobox family of genes. It is characterized by its ability to regulate the expression of target genes through the recruitment of coactivators and the activation of transcriptional machinery. TLX2 has been shown to interact with other transcription factors, such as NF-κB and AP-1, to regulate the expression of immune-related genes. Its expression is tightly regulated by various cellular mechanisms, including epigenetic modifications and post-translational modifications. **Pathways and Functions** TLX2 is involved in several cellular pathways, including: 1. **Animal Organ Development**: TLX2 plays a crucial role in the development of various organs, including the thymus, where it regulates the expression of genes involved in T cell development and maturation. 2. **Cellular Component**: TLX2 is involved in the regulation of cellular processes, including cellular differentiation, proliferation, and survival. 3. **Chromatin**: TLX2 interacts with chromatin to regulate the expression of target genes. 4. **Cytoplasm**: TLX2 has been shown to regulate the expression of genes involved in immune cell function, including cytokines and chemokines. **Functions** TLX2 has several functions, including: 1. **Regulation of T Cell Development**: TLX2 regulates the expression of genes involved in T cell development and maturation. 2. **Regulation of Immune Cell Function**: TLX2 regulates the expression of genes involved in immune cell function, including cytokines, chemokines, and other immune-related genes. 3. **Regulation of Epithelial Cell Function**: TLX2 regulates the expression of genes involved in epithelial cell function, including goblet cell differentiation and intestinal crypt stem cell maintenance. **Clinical Significance** TLX2 has been implicated in various diseases, including: 1. **Immunodeficiency Disorders**: TLX2 mutations have been associated with immunodeficiency disorders, including severe combined immunodeficiency (SCID) and T cell leukemia. 2. **Inflammatory Diseases**: TLX2 has been implicated in the regulation of inflammatory responses, including the expression of cytokines and chemokines. 3. **Cancer**: TLX2 has been shown to be overexpressed in various types of cancer, including T cell leukemia and lymphoma. In conclusion, TLX2 is a critical regulator of T cell development and immune cell function. Its dysregulation has been implicated in various diseases, including immunodeficiency disorders, inflammatory diseases, and cancer. Further studies are needed to fully understand the mechanisms of TLX2 regulation and its implications for human health and disease.

Genular Protein ID: 2371100496

Symbol: TLX2_HUMAN

Name: T-cell leukemia homeobox protein 2

UniProtKB Accession Codes:

O43763 Q9UD56 Q9UQ48

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 6 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10446220

Title: An enhancer element for expression of the Ncx (Enx, Hox11L1) gene in neural crest-derived cells.

PubMed ID: 10446220

DOI: 10.1074/jbc.274.34.24401

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7518789

Title: Identification of homeobox genes expressed in human haemopoietic progenitor cells.

PubMed ID: 7518789

DOI: 10.1016/0378-1119(94)90380-8

PubMed ID: 20389279

Title: Cooperative DNA-binding and sequence-recognition mechanism of aristaless and clawless.

PubMed ID: 20389279

DOI: 10.1038/emboj.2010.53

Sequence Information:

  • Length: 284
  • Mass: 30251
  • Checksum: 794B07A9E7817939
  • Sequence:
    • MEPGMLGPHN LPHHEPISFG IDQILSGPET PGGGLGLGRG GQGHGENGAF SGGYHGASGY 
GPAGSLAPLP GSSGVGPGGV IRVPAHRPLP VPPPAGGAPA VPGPSGLGGA GGLAGLTFPW 
MDSGRRFAKD RLTAALSPFS GTRRIGHPYQ NRTPPKRKKP RTSFSRSQVL ELERRFLRQK 
YLASAERAAL AKALRMTDAQ VKTWFQNRRT KWRRQTAEER EAERHRAGRL LLHLQQDALP 
RPLRPPLPPD PLCLHNSSLF ALQNLQPWAE DNKVASVSGL ASVV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.