Gene TLX2 - ENSG00000115297 | NCBI Gene ID: 3196

Details for: TLX2

Gene ID: 3196

Symbol: TLX2

Ensembl ID: ENSG00000115297

Description: T cell leukemia homeobox 2

Associated with

Animal organ development
(GO:0048513)
Cellular_component
(GO:0005575)
Chromatin
(GO:0000785)
Cytoplasm
(GO:0005737)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Enteric nervous system development
(GO:0048484)
Mesoderm formation
(GO:0001707)
Negative regulation of dendrite morphogenesis
(GO:0050774)
Nucleus
(GO:0005634)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Sequence-specific dna binding
(GO:0043565)
Sequence-specific double-stranded dna binding
(GO:1990837)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: thymocyte (CL0000893)
Fold Change: 5.36
Marker Score: 5616
Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: 2.22
Marker Score: 2230
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 1.9
Marker Score: 2137
Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
Fold Change: 1.8
Marker Score: 605
Cell Name: inhibitory motor neuron (CL0008015)
Fold Change: 1.74
Marker Score: 822
Cell Name: motor neuron (CL0000100)
Fold Change: 1.73
Marker Score: 1027
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.62
Marker Score: 1178
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.5
Marker Score: 1500
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.27
Marker Score: 862
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 1.19
Marker Score: 492
Cell Name: germ cell (CL0000586)
Fold Change: 1.16
Marker Score: 2029
Cell Name: goblet cell (CL0000160)
Fold Change: 1.16
Marker Score: 7693
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.15
Marker Score: 4824
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 1.14
Marker Score: 2164
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.12
Marker Score: 708
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 1.05
Marker Score: 803
Cell Name: neural cell (CL0002319)
Fold Change: 1.03
Marker Score: 496
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71837
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48062
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1
Marker Score: 514
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.99
Marker Score: 456
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.99
Marker Score: 467
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30409
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2413
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.95
Marker Score: 379
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.94
Marker Score: 5353
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.92
Marker Score: 330
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.92
Marker Score: 2743
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5291
Cell Name: mast cell (CL0000097)
Fold Change: 0.85
Marker Score: 491
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 0.81
Marker Score: 506
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1268
Cell Name: brush cell (CL0002204)
Fold Change: 0.78
Marker Score: 712
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.78
Marker Score: 402
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.73
Marker Score: 467
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.71
Marker Score: 1453
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.71
Marker Score: 182
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.69
Marker Score: 10789
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.69
Marker Score: 1103
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.69
Marker Score: 454
Cell Name: oogonial cell (CL0000024)
Fold Change: 0.64
Marker Score: 925
Cell Name: neutrophil (CL0000775)
Fold Change: 0.64
Marker Score: 392
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.62
Marker Score: 497
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.57
Marker Score: 151
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.56
Marker Score: 177
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.53
Marker Score: 221
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.52
Marker Score: 312
Cell Name: T-helper 17 cell (CL0000899)
Fold Change: 0.52
Marker Score: 339
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.47
Marker Score: 281
Cell Name: double negative thymocyte (CL0002489)
Fold Change: 0.47
Marker Score: 645
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 0.47
Marker Score: 493.5
Cell Name: pericyte (CL0000669)
Fold Change: 0.46
Marker Score: 270
Cell Name: fibroblast (CL0000057)
Fold Change: 0.45
Marker Score: 437
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.45
Marker Score: 432
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.43
Marker Score: 2594
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.41
Marker Score: 195
Cell Name: retinal ganglion cell (CL0000740)
Fold Change: 0.41
Marker Score: 509
Cell Name: primordial germ cell (CL0000670)
Fold Change: 0.36
Marker Score: 454
Cell Name: endothelial cell (CL0000115)
Fold Change: 0.35
Marker Score: 312
Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 0.35
Marker Score: 716.5
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.34
Marker Score: 343.5
Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.31
Marker Score: 139
Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 0.29
Marker Score: 153
Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.27
Marker Score: 85
Cell Name: enteric neuron (CL0007011)
Fold Change: 0.26
Marker Score: 139
Cell Name: neuroendocrine cell (CL0000165)
Fold Change: 0.26
Marker Score: 100
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.24
Marker Score: 71
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.23
Marker Score: 66
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.22
Marker Score: 76
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: 0.22
Marker Score: 119
Cell Name: smooth muscle cell (CL0000192)
Fold Change: 0.22
Marker Score: 144
Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.2
Marker Score: 565
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 0.2
Marker Score: 524.5
Cell Name: interneuron (CL0000099)
Fold Change: 0.18
Marker Score: 83
Cell Name: migratory enteric neural crest cell (CL0002607)
Fold Change: 0.18
Marker Score: 165
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.17
Marker Score: 43
Cell Name: neural crest cell (CL0011012)
Fold Change: 0.16
Marker Score: 173
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.16
Marker Score: 50
Cell Name: male germ cell (CL0000015)
Fold Change: 0.15
Marker Score: 44
Cell Name: chromaffin cell (CL0000166)
Fold Change: 0.14
Marker Score: 195
Cell Name: renal principal cell (CL0005009)
Fold Change: 0.13
Marker Score: 99
Cell Name: podocyte (CL0000653)
Fold Change: 0.12
Marker Score: 46
Cell Name: retinal cone cell (CL0000573)
Fold Change: 0.12
Marker Score: 345.5
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 0.12
Marker Score: 121
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 0.1
Marker Score: 56
Cell Name: endothelial cell of lymphatic vessel (CL0002138)
Fold Change: 0.09
Marker Score: 56
Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 0.09
Marker Score: 31
Cell Name: exhausted T cell (CL0011025)
Fold Change: 0.09
Marker Score: 49
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.08
Marker Score: 198
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.08
Marker Score: 26
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.08
Marker Score: 47
Cell Name: pro-T cell (CL0000827)
Fold Change: 0.08
Marker Score: 335
Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.08
Marker Score: 20
Cell Name: sympathetic neuron (CL0011103)
Fold Change: 0.08
Marker Score: 25
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: 0.08
Marker Score: 147
Cell Name: ciliated epithelial cell (CL0000067)
Fold Change: 0.07
Marker Score: 33
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.06
Marker Score: 15
Cell Name: visceromotor neuron (CL0005025)
Fold Change: 0.06
Marker Score: 18
Cell Name: erythrocyte (CL0000232)
Fold Change: 0.06
Marker Score: 34
Cell Name: oocyte (CL0000023)
Fold Change: 0.06
Marker Score: 15

Hover over a box to see details here...

**Key characteristics:** * TLX2 is a transcription factor that belongs to the T-cell leukemia homeobox (TLX) family of proteins. * It is a key regulator of enteric neuron development, as it is highly expressed in neural cells of the enteric nervous system. * TLX2 is a positive regulator of transcription, as it binds to specific DNA sequences and promotes the transcription of downstream genes. * It is also a negative regulator of dendrite morphogenesis, as it inhibits the expression of genes involved in this process. **Pathways and functions:** * TLX2 is involved in the regulation of epithelial-mesenchymal transition (EMT), which is a process by which epithelial cells lose their epithelial characteristics and acquire mesenchymal characteristics. * It also plays a role in the specification of the enteric nervous system, as it is expressed in neural cells that give rise to the enteric nervous system. * TLX2 is also involved in the regulation of angiogenesis, as it is expressed in blood vessel endothelial cells and is required for the formation of new blood vessels. **Clinical significance:** * Mutations in the TLX2 gene have been linked to a number of human diseases, including Hirschsprung's disease, an intestinal disorder characterized by the absence of gut motility. * Targeting TLX2 has been explored as a potential treatment for these diseases, as it could be used to stimulate the development of enteric neurons and correct the intestinal abnormalities that are characteristic of Hirschsprung's disease. TLX2 is a key transcription factor that plays a crucial role in the development and function of the enteric nervous system. Its dysregulation has been linked to a number of human diseases, making it a promising target for therapeutic intervention.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

T-cell leukemia homeobox protein 2

Genular Protein ID: 2371100496

Symbol: TLX2_HUMAN

Name: T-cell leukemia homeobox protein 2

UniProtKB Accession Codes:

O43763 Q9UD56 Q9UQ48

Database IDs:

Citations:

PubMed ID: 10446220

Title: An enhancer element for expression of the Ncx (Enx, Hox11L1) gene in neural crest-derived cells.

PubMed ID: 10446220

DOI: 10.1074/jbc.274.34.24401

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7518789

Title: Identification of homeobox genes expressed in human haemopoietic progenitor cells.

PubMed ID: 7518789

DOI: 10.1016/0378-1119(94)90380-8

PubMed ID: 20389279

Title: Cooperative DNA-binding and sequence-recognition mechanism of aristaless and clawless.

PubMed ID: 20389279

DOI: 10.1038/emboj.2010.53

Sequence Information:

Length: 284
Mass: 30251
Checksum: 794B07A9E7817939
Sequence:

MEPGMLGPHN LPHHEPISFG IDQILSGPET PGGGLGLGRG GQGHGENGAF SGGYHGASGY 
GPAGSLAPLP GSSGVGPGGV IRVPAHRPLP VPPPAGGAPA VPGPSGLGGA GGLAGLTFPW 
MDSGRRFAKD RLTAALSPFS GTRRIGHPYQ NRTPPKRKKP RTSFSRSQVL ELERRFLRQK 
YLASAERAAL AKALRMTDAQ VKTWFQNRRT KWRRQTAEER EAERHRAGRL LLHLQQDALP 
RPLRPPLPPD PLCLHNSSLF ALQNLQPWAE DNKVASVSGL ASVV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: TLX2

Associated with

Cells (max top 100)

Other Information

An enhancer element for expression of the Ncx (Enx, Hox11L1) gene in neural crest-derived cells. PubMed ID: 10446220

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334