Details for: HOXA13

Gene ID: 3209

Symbol: HOXA13

Ensembl ID: ENSG00000106031

Description: homeobox A13

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 7.12
    Marker Score: 3944.5
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 5.33
    Marker Score: 3025
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 4.64
    Marker Score: 2444
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 4.17
    Marker Score: 5163
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 2.51
    Marker Score: 1050
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 2.26
    Marker Score: 4116
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.09
    Marker Score: 2105
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 1.4
    Marker Score: 924.5
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4803
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.1
    Marker Score: 1228
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.03
    Marker Score: 700
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71799
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48027.5
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 512.5
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.99
    Marker Score: 466
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.95
    Marker Score: 1609
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 378
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5276
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.92
    Marker Score: 330
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2740
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5285
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.86
    Marker Score: 497
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.82
    Marker Score: 782
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.8
    Marker Score: 799
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.79
    Marker Score: 5270.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1267
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 401
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 697
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.74
    Marker Score: 1190
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.74
    Marker Score: 305
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 467
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.73
    Marker Score: 424.5
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.7
    Marker Score: 1200
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.69
    Marker Score: 1418
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.63
    Marker Score: 665
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.62
    Marker Score: 1263
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.59
    Marker Score: 1122
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.55
    Marker Score: 166.5
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.55
    Marker Score: 810
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.55
    Marker Score: 1726
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.52
    Marker Score: 378.5
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.51
    Marker Score: 235
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.51
    Marker Score: 160
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 281
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.42
    Marker Score: 108
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.42
    Marker Score: 6564.5
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.41
    Marker Score: 215
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 0.41
    Marker Score: 154
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.39
    Marker Score: 1192
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.38
    Marker Score: 290
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.36
    Marker Score: 2162
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.35
    Marker Score: 111
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.35
    Marker Score: 310
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.33
    Marker Score: 387
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.31
    Marker Score: 186
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.3
    Marker Score: 210
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.3
    Marker Score: 78
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.3
    Marker Score: 702
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.28
    Marker Score: 275
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.27
    Marker Score: 131
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.27
    Marker Score: 155
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.25
    Marker Score: 73
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.25
    Marker Score: 50
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.24
    Marker Score: 130
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.24
    Marker Score: 108
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 67
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.23
    Marker Score: 614
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.23
    Marker Score: 193
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 76
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.22
    Marker Score: 214
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.21
    Marker Score: 1020
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.2
    Marker Score: 319
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.2
    Marker Score: 472
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.2
    Marker Score: 49
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.19
    Marker Score: 144.5
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.18
    Marker Score: 48
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.18
    Marker Score: 81
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.18
    Marker Score: 45
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.18
    Marker Score: 49
  • Cell Name: muscle precursor cell (CL0000680)
    Fold Change: 0.18
    Marker Score: 46
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.18
    Marker Score: 51
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.17
    Marker Score: 46
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.17
    Marker Score: 63
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.17
    Marker Score: 49
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.17
    Marker Score: 173
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.17
    Marker Score: 110
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.16
    Marker Score: 40
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.16
    Marker Score: 40
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.16
    Marker Score: 41
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.16
    Marker Score: 204
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.16
    Marker Score: 182
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: 0.15
    Marker Score: 51
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.15
    Marker Score: 79
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.15
    Marker Score: 36
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.15
    Marker Score: 48
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.15
    Marker Score: 347
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.15
    Marker Score: 129

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** * HOXA13 is a transcription factor that is highly conserved across species. * It belongs to the homeobox A13 subfamily of homeobox genes, which are characterized by their ability to bind to specific DNA sequences and regulate gene expression. * HOXA13 has been shown to play a crucial role in the development and maintenance of various tissues and organs in the human body. **Pathways and functions:** * HOXA13 is a key regulator of embryonic forelimb and hindgut morphogenesis. * It is required for the specification of the heart field and the development of the forelimb. * HOXA13 is also involved in the development of the vascular system, including the formation of blood vessels and the regulation of vascular development. * It is essential for the maintenance of tissue homeostasis and the prevention of cancer. **Clinical significance:** * HOXA13 mutations have been linked to several human diseases, including leukemia, heart defects, and vascular disorders. * Targeting HOXA13 has emerged as a promising therapeutic strategy for these diseases. * Clinical trials are currently investigating the use of HOXA13 inhibitors to treat cancer and other diseases that are characterized by abnormal cell growth. **Additional notes:** * HOXA13 is a highly versatile transcription factor that can regulate the expression of a wide range of genes involved in various cellular processes. * It is a key regulator of stem cell differentiation and proliferation. * HOXA13 is also involved in the regulation of cell cycle regulation, apoptosis, and differentiation.

Genular Protein ID: 3512434761

Symbol: HXA13_HUMAN

Name: Homeobox protein Hox-A13

UniProtKB Accession Codes:

P31271 A4D188 O43371

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 EPD 1 Ensembl 1 GO 30 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 5 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9020844

Title: Mutation of HOXA13 in hand-foot-genital syndrome.

PubMed ID: 9020844

DOI: 10.1038/ng0297-179

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 2574852

Title: The human HOX gene family.

PubMed ID: 2574852

DOI: 10.1093/nar/17.24.10385

PubMed ID: 21829694

Title: Structural basis for sequence specific DNA binding and protein dimerization of HOXA13.

PubMed ID: 21829694

DOI: 10.1371/journal.pone.0023069

PubMed ID: 10839976

Title: Novel HOXA13 mutations and the phenotypic spectrum of hand-foot-genital syndrome.

PubMed ID: 10839976

DOI: 10.1086/302961

PubMed ID: 12073020

Title: A novel stable polyalanine [poly(A)] expansion in the HOXA13 gene associated with hand-foot-genital syndrome: proper function of poly(A)-harbouring transcription factors depends on a critical repeat length?

PubMed ID: 12073020

DOI: 10.1007/s00439-002-0712-8

PubMed ID: 11968094

Title: A HOXA13 allele with a missense mutation in the homeobox and a dinucleotide deletion in the promoter underlies Guttmacher syndrome.

PubMed ID: 11968094

DOI: 10.1002/humu.9036

PubMed ID: 24934387

Title: Severe manifestations of hand-foot-genital syndrome associated with a novel HOXA13 mutation.

PubMed ID: 24934387

DOI: 10.1002/ajmg.a.36648

PubMed ID: 26590955

Title: Dual genetic diagnoses: Atypical hand-foot-genital syndrome and developmental delay due to de novo mutations in HOXA13 and NRXN1.

PubMed ID: 26590955

DOI: 10.1002/ajmg.a.37478

Sequence Information:

  • Length: 388
  • Mass: 39727
  • Checksum: 3512E7622FA931C4
  • Sequence:
    • MTASVLLHPR WIEPTVMFLY DNGGGLVADE LNKNMEGAAA AAAAAAAAAA AGAGGGGFPH 
PAAAAAGGNF SVAAAAAAAA AAAANQCRNL MAHPAPLAPG AASAYSSAPG EAPPSAAAAA 
AAAAAAAAAA AAASSSGGPG PAGPAGAEAA KQCSPCSAAA QSSSGPAALP YGYFGSGYYP 
CARMGPHPNA IKSCAQPASA AAAAAFADKY MDTAGPAAEE FSSRAKEFAF YHQGYAAGPY 
HHHQPMPGYL DMPVVPGLGG PGESRHEPLG LPMESYQPWA LPNGWNGQMY CPKEQAQPPH 
LWKSTLPDVV SHPSDASSYR RGRKKRVPYT KVQLKELERE YATNKFITKD KRRRISATTN 
LSERQVTIWF QNRRVKEKKV INKLKTTS

Genular Protein ID: 2092585226

Symbol: Q6DI00_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6DI00

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 3 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 4 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 1 RuleBase 1 SMART 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 388
  • Mass: 39769
  • Checksum: 33A33B7950F69431
  • Sequence:
    • MTASVLLHPR WIEPTVMFLY DNGGGLVADE LNKNMEGAAA AAAAAAAAAA AGAGGGGFPH 
PAAAAAGGNF SVAAAAAAAA AAAANQCRNL MAHPAPLAPV AASAYSSAPG EAPPSAAAAA 
AAAAAAAAAA AAASSSGGPG PAGPAGAEAA KQCSPCSAAA QSSSGPAALP YGYFGSGYYP 
CARMGPHPNA IKSCAQPASA AAAAAFADKY MDTAGPAAEE FSSRAKEFAF YHQGYAAGPY 
HHHQPMPGYL DMPVVPGLGG PGESRHEPLG LPMESYQPWA LPNGWNGQMY CPKEQAQPPH 
LWKSTLPDVV SHPSDASSYR RGRKKRVPYT KVQLKELERE YATNKFITKD KRRRISATTN 
LSERQVTIWF QNRRVKEKKV INKLKTTS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.