Associated with
Cells (max top 100)
(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: enterocyte of colon (CL1000347)
Fold Change: 9.67
Marker Score: 14,896 - Cell Name: hepatoblast (CL0005026)
Fold Change: 3.98
Marker Score: 13,029 - Cell Name: acinar cell (CL0000622)
Fold Change: 2.64
Marker Score: 1,864 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 2.48
Marker Score: 13,322 - Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 2.23
Marker Score: 2,361 - Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 2.16
Marker Score: 7,674 - Cell Name: retina horizontal cell (CL0000745)
Fold Change: 2.13
Marker Score: 2,042 - Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 2.12
Marker Score: 5,688 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.99
Marker Score: 1,986 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 1.99
Marker Score: 12,798 - Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 1.93
Marker Score: 8,331 - Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 1.51
Marker Score: 1,532 - Cell Name: nephron tubule epithelial cell (CL1000494)
Fold Change: 1.43
Marker Score: 335 - Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 1.37
Marker Score: 3,224 - Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.36
Marker Score: 865 - Cell Name: A2 amacrine cell (CL0004219)
Fold Change: 1.28
Marker Score: 406 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.23
Marker Score: 894 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 1.22
Marker Score: 2,582 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 1.2
Marker Score: 496 - Cell Name: kidney cell (CL1000497)
Fold Change: 1.19
Marker Score: 796 - Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 1.19
Marker Score: 1,275 - Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 1.19
Marker Score: 1,973 - Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 1.16
Marker Score: 641 - Cell Name: hepatocyte (CL0000182)
Fold Change: 1.15
Marker Score: 784 - Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 1.15
Marker Score: 2,894 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.15
Marker Score: 4,804 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 1.11
Marker Score: 509 - Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 1.09
Marker Score: 574 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 1.08
Marker Score: 2,695 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 1.04
Marker Score: 251,792 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71,811 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48,035 - Cell Name: endocrine cell (CL0000163)
Fold Change: 0.99
Marker Score: 513 - Cell Name: peptic cell (CL0000155)
Fold Change: 0.99
Marker Score: 415 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.98
Marker Score: 506 - Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,407 - Cell Name: P/D1 enteroendocrine cell (CL0002268)
Fold Change: 0.98
Marker Score: 365 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.97
Marker Score: 15,256 - Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 0.97
Marker Score: 1,377 - Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.97
Marker Score: 459 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.95
Marker Score: 1,548 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2,412 - Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.93
Marker Score: 5,325 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.93
Marker Score: 1,759 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.93
Marker Score: 371 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.92
Marker Score: 2,743 - Cell Name: type II pneumocyte (CL0002063)
Fold Change: 0.91
Marker Score: 5,946 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9
Marker Score: 324 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5,296 - Cell Name: renal principal cell (CL0005009)
Fold Change: 0.87
Marker Score: 673 - Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: 0.86
Marker Score: 3,601 - Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 0.82
Marker Score: 2,009 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: 0.82
Marker Score: 799 - Cell Name: hepatic stellate cell (CL0000632)
Fold Change: 0.79
Marker Score: 299 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.78
Marker Score: 597 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.78
Marker Score: 12,470 - Cell Name: brush cell (CL0002204)
Fold Change: 0.77
Marker Score: 699 - Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.76
Marker Score: 394 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.73
Marker Score: 470 - Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 0.73
Marker Score: 788 - Cell Name: ionocyte (CL0005006)
Fold Change: 0.72
Marker Score: 220 - Cell Name: inflammatory macrophage (CL0000863)
Fold Change: 0.71
Marker Score: 219 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.69
Marker Score: 178 - Cell Name: progenitor cell of endocrine pancreas (CL0002351)
Fold Change: 0.68
Marker Score: 148 - Cell Name: pneumocyte (CL0000322)
Fold Change: 0.64
Marker Score: 1,028 - Cell Name: epithelial cell (CL0000066)
Fold Change: 0.63
Marker Score: 1,007 - Cell Name: cholangiocyte (CL1000488)
Fold Change: 0.62
Marker Score: 232 - Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.61
Marker Score: 190 - Cell Name: epithelial cell of exocrine pancreas (CL1001433)
Fold Change: 0.59
Marker Score: 332 - Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 0.58
Marker Score: 3,049 - Cell Name: type A enteroendocrine cell (CL0002067)
Fold Change: 0.58
Marker Score: 233 - Cell Name: Kupffer cell (CL0000091)
Fold Change: 0.58
Marker Score: 576 - Cell Name: CD34-positive, CD56-positive, CD117-positive common innate lymphoid precursor, human (CL0001074)
Fold Change: 0.57
Marker Score: 157 - Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.56
Marker Score: 148 - Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.55
Marker Score: 442 - Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.55
Marker Score: 177 - Cell Name: oligodendrocyte (CL0000128)
Fold Change: 0.54
Marker Score: 1,298 - Cell Name: precursor B cell (CL0000817)
Fold Change: 0.54
Marker Score: 358 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 0.53
Marker Score: 565 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: 0.52
Marker Score: 226 - Cell Name: colon epithelial cell (CL0011108)
Fold Change: 0.51
Marker Score: 1,607 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.51
Marker Score: 530 - Cell Name: M cell of gut (CL0000682)
Fold Change: 0.51
Marker Score: 132 - Cell Name: mucous neck cell (CL0000651)
Fold Change: 0.5
Marker Score: 1,141 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 0.49
Marker Score: 10,355 - Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 0.45
Marker Score: 262 - Cell Name: enteroendocrine cell (CL0000164)
Fold Change: 0.45
Marker Score: 232 - Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
Fold Change: 0.43
Marker Score: 120 - Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 0.43
Marker Score: 414 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.43
Marker Score: 976 - Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 0.42
Marker Score: 812 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.42
Marker Score: 132 - Cell Name: kidney collecting duct cell (CL1001225)
Fold Change: 0.41
Marker Score: 81 - Cell Name: taste receptor cell (CL0000209)
Fold Change: 0.41
Marker Score: 357 - Cell Name: epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.41
Marker Score: 183 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 0.41
Marker Score: 402 - Cell Name: pro-B cell (CL0000826)
Fold Change: 0.4
Marker Score: 389 - Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.39
Marker Score: 102 - Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 0.39
Marker Score: 142 - Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.38
Marker Score: 121
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 584236979
Symbol: HEPS_HUMAN
Name: Serine protease hepsin
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2835076
Title: A novel trypsin-like serine protease (hepsin) with a putative transmembrane domain expressed by human liver and hepatoma cells.
PubMed ID: 2835076
DOI: 10.1021/bi00403a032
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 1885621
Title: Hepsin, a cell membrane-associated protease. Characterization, tissue distribution, and gene localization.
PubMed ID: 1885621
PubMed ID: 8346233
Title: Hepsin, a putative cell-surface serine protease, is required for mammalian cell growth.
PubMed ID: 8346233
PubMed ID: 19159218
Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
PubMed ID: 19159218
DOI: 10.1021/pr8008012
PubMed ID: 21875933
Title: Proteolytic activation of pro-macrophage-stimulating protein by hepsin.
PubMed ID: 21875933
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 24227843
Title: TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry driven by the severe acute respiratory syndrome coronavirus spike protein.
PubMed ID: 24227843
DOI: 10.1128/jvi.02202-13
PubMed ID: 26673890
Title: The serine protease hepsin mediates urinary secretion and polymerisation of Zona Pellucida domain protein uromodulin.
PubMed ID: 26673890
DOI: 10.7554/elife.08887
PubMed ID: 12962630
Title: The structure of the extracellular region of human hepsin reveals a serine protease domain and a novel scavenger receptor cysteine-rich (SRCR) domain.
PubMed ID: 12962630
PubMed ID: 15839837
Title: Hepatocyte growth factor is a preferred in vitro substrate for human hepsin, a membrane-anchored serine protease implicated in prostate and ovarian cancers.
PubMed ID: 15839837
DOI: 10.1042/bj20041955
Sequence Information:
- Length: 417
- Mass: 45011
- Checksum: B2086FF661E551D7
- Sequence:
MAQKEGGRTV PCCSRPKVAA LTAGTLLLLT AIGAASWAIV AVLLRSDQEP LYPVQVSSAD ARLMVFDKTE GTWRLLCSSR SNARVAGLSC EEMGFLRALT HSELDVRTAG ANGTSGFFCV DEGRLPHTQR LLEVISVCDC PRGRFLAAIC QDCGRRKLPV DRIVGGRDTS LGRWPWQVSL RYDGAHLCGG SLLSGDWVLT AAHCFPERNR VLSRWRVFAG AVAQASPHGL QLGVQAVVYH GGYLPFRDPN SEENSNDIAL VHLSSPLPLT EYIQPVCLPA AGQALVDGKI CTVTGWGNTQ YYGQQAGVLQ EARVPIISND VCNGADFYGN QIKPKMFCAG YPEGGIDACQ GDSGGPFVCE DSISRTPRWR LCGIVSWGTG CALAQKPGVY TKVSDFREWI FQAIKTHSEA SGMVTQL
Genular Protein ID: 3982014081
Symbol: B7Z1L4_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 393
- Mass: 42897
- Checksum: C229C9E6C6AA3077
- Sequence:
MCKMRTREDM QLGNEGPGTA LRLIHLQVSS ADARLMVFDK TEGTWRLLCS SRSNARVAGL SCEEMGFLRA LTHSELDVRT AGANGTSGFF CVDEGRLPHT QRLLEVISVC DCPRGRFLAA ICQDCGRRKL PVDRIVGGRD TSLGRWPWQV SLRYDGAHLC GGSLLSGDWV LTAAHCFPER NRVLSRWRVF AGAVAQASPH GLQLGVQAVV YHGGYLPFRD PNSEENSNDI ALVHLSSPLP LTEYIQPVCL PAAGQALVDG KICTVTGWGN TQYYGQQAGV LQEARVPIIS NDVCNGADFY GNQIKPKMFC AGYPEGGIDA CQGDSGGPFV CEDSISRTPR WRLCGIVSWG TGCALAQKPG VYTKVSDFRE WIFQAIKVKV GSRWEPGWGR LGV
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.