Details for: HPN

Gene ID: 3249

Symbol: HPN

Ensembl ID: ENSG00000105707

Description: hepsin

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 42.6583
    Cell Significance Index: -10.8200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 29.0456
    Cell Significance Index: -11.8000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 12.3803
    Cell Significance Index: -11.8200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 9.3624
    Cell Significance Index: 157.7100
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 4.6850
    Cell Significance Index: 39.8200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 3.4681
    Cell Significance Index: 27.6900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 3.1221
    Cell Significance Index: 619.6000
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 2.9565
    Cell Significance Index: 11.1400
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.8216
    Cell Significance Index: 10.4900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.9607
    Cell Significance Index: 14.1800
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 0.6969
    Cell Significance Index: 0.3500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.5785
    Cell Significance Index: 98.7900
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.4221
    Cell Significance Index: 7.1000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.3952
    Cell Significance Index: 9.5700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.2459
    Cell Significance Index: 7.8800
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.2225
    Cell Significance Index: 2.0400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.2131
    Cell Significance Index: 5.2000
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.1479
    Cell Significance Index: 1.9100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1287
    Cell Significance Index: 9.8800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0953
    Cell Significance Index: 7.1000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0943
    Cell Significance Index: 69.1300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0649
    Cell Significance Index: 8.3800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0494
    Cell Significance Index: 9.9100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0420
    Cell Significance Index: 1.9600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0252
    Cell Significance Index: 11.1200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0195
    Cell Significance Index: 0.8500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0178
    Cell Significance Index: 2.9000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0173
    Cell Significance Index: 1.9700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0153
    Cell Significance Index: 11.5500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0146
    Cell Significance Index: 2.1300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0136
    Cell Significance Index: 25.5300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0095
    Cell Significance Index: 1.8100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0068
    Cell Significance Index: 3.7200
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.0065
    Cell Significance Index: 0.0500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0029
    Cell Significance Index: 2.0000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0013
    Cell Significance Index: 0.8400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0002
    Cell Significance Index: 0.1500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0054
    Cell Significance Index: -8.3200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0058
    Cell Significance Index: -7.8900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0061
    Cell Significance Index: -11.3300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0080
    Cell Significance Index: -2.8900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0086
    Cell Significance Index: -0.8800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0098
    Cell Significance Index: -5.5500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0107
    Cell Significance Index: -2.2500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0190
    Cell Significance Index: -12.0600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0212
    Cell Significance Index: -2.4300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0257
    Cell Significance Index: -11.6800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0278
    Cell Significance Index: -5.0200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0296
    Cell Significance Index: -8.5300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0337
    Cell Significance Index: -2.6700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0381
    Cell Significance Index: -0.8800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0509
    Cell Significance Index: -5.0400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0563
    Cell Significance Index: -6.5600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0594
    Cell Significance Index: -2.7900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0670
    Cell Significance Index: -4.7400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0671
    Cell Significance Index: -9.2100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0711
    Cell Significance Index: -3.5900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0787
    Cell Significance Index: -9.6800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0830
    Cell Significance Index: -4.9800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0866
    Cell Significance Index: -1.3400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0963
    Cell Significance Index: -1.6500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1003
    Cell Significance Index: -10.4400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.1014
    Cell Significance Index: -11.0300
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.1039
    Cell Significance Index: -1.2600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1067
    Cell Significance Index: -1.1100
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.1071
    Cell Significance Index: -0.9700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1073
    Cell Significance Index: -12.6500
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.1088
    Cell Significance Index: -1.5100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1093
    Cell Significance Index: -3.1500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1095
    Cell Significance Index: -7.3600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1138
    Cell Significance Index: -3.1800
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.1237
    Cell Significance Index: -1.2800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.1255
    Cell Significance Index: -8.6800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1260
    Cell Significance Index: -3.2400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1344
    Cell Significance Index: -7.0000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1379
    Cell Significance Index: -2.8600
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.1510
    Cell Significance Index: -1.3400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1534
    Cell Significance Index: -6.2800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1770
    Cell Significance Index: -7.8300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1837
    Cell Significance Index: -5.0000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1871
    Cell Significance Index: -5.5100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1900
    Cell Significance Index: -11.6800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1905
    Cell Significance Index: -11.6800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1970
    Cell Significance Index: -6.9000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1976
    Cell Significance Index: -11.0900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2029
    Cell Significance Index: -13.0900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2070
    Cell Significance Index: -10.8700
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: -0.2086
    Cell Significance Index: -1.2500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2095
    Cell Significance Index: -7.3600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2122
    Cell Significance Index: -1.7300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2160
    Cell Significance Index: -8.1800
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: -0.2382
    Cell Significance Index: -2.3500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2398
    Cell Significance Index: -5.0200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2399
    Cell Significance Index: -10.8800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.2446
    Cell Significance Index: -4.2300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2630
    Cell Significance Index: -8.6100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2637
    Cell Significance Index: -8.4000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2659
    Cell Significance Index: -3.9300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2696
    Cell Significance Index: -5.8400
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.2733
    Cell Significance Index: -2.9300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Serine Protease Activity**: Hepsin belongs to the serine protease family, which is characterized by its ability to hydrolyze peptide bonds using a serine residue as a nucleophile. 2. **Broad Tissue Expression**: Hepsin is expressed in various epithelial cells, including enterocytes, hepatocytes, and renal epithelial cells, suggesting its involvement in maintaining tissue homeostasis. 3. **Regulation of Signaling Pathways**: Hepsin interacts with multiple signaling molecules, including receptors, kinases, and transcription factors, to modulate cellular responses to external stimuli. 4. **Peptidase Activity**: Hepsin possesses various peptidase activities, including serine-type endopeptidase, exopeptidase, and peptidase activity, which enable it to regulate protein processing and degradation. **Pathways and Functions** 1. **Apoptosis Regulation**: Hepsin negatively regulates apoptosis by interacting with pro-apoptotic proteins and modulating signaling pathways that promote cell survival. 2. **Cell Proliferation and Differentiation**: Hepsin regulates cell growth and differentiation by interacting with growth factors, cytokines, and transcription factors that control epithelial cell behavior. 3. **Metabolic Regulation**: Hepsin participates in metabolic processes, including the regulation of thyroid hormone generation, plasminogen activation, and potassium ion transport. 4. **Immune Response**: Hepsin may play a role in regulating immune responses by interacting with immune cells and modulating signaling pathways that control inflammation and immune cell activation. **Clinical Significance** 1. **Cancer**: Abnormal expression or activity of hepsin has been implicated in various cancers, including colorectal, liver, and renal cancers, suggesting its potential as a biomarker or therapeutic target. 2. **Cardiovascular Disorders**: Hepsin dysregulation has been linked to cardiovascular diseases, including atherosclerosis and hypertension, highlighting its potential role in cardiovascular disease prevention and treatment. 3. **Neurological Conditions**: Hepsin may play a role in neurological disorders, such as Alzheimer's disease and Parkinson's disease, by regulating signaling pathways that control neuronal function and survival. 4. **Thyroid Hormone Regulation**: Hepsin negatively regulates thyroid hormone generation, suggesting its potential role in thyroid hormone-related disorders, such as hypothyroidism. In conclusion, hepsin is a multifunctional serine protease that plays a critical role in regulating various cellular processes, including apoptosis, cell proliferation, and metabolic regulation. Its dysregulation has been implicated in various diseases, highlighting the need for further research into its mechanisms of action and potential therapeutic applications.

Genular Protein ID: 584236979

Symbol: HEPS_HUMAN

Name: Serine protease hepsin

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2835076

Title: A novel trypsin-like serine protease (hepsin) with a putative transmembrane domain expressed by human liver and hepatoma cells.

PubMed ID: 2835076

DOI: 10.1021/bi00403a032

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1885621

Title: Hepsin, a cell membrane-associated protease. Characterization, tissue distribution, and gene localization.

PubMed ID: 1885621

DOI: 10.1016/s0021-9258(18)55395-3

PubMed ID: 8346233

Title: Hepsin, a putative cell-surface serine protease, is required for mammalian cell growth.

PubMed ID: 8346233

DOI: 10.1073/pnas.90.15.7181

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 21875933

Title: Proteolytic activation of pro-macrophage-stimulating protein by hepsin.

PubMed ID: 21875933

DOI: 10.1158/1541-7786.mcr-11-0004

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24227843

Title: TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry driven by the severe acute respiratory syndrome coronavirus spike protein.

PubMed ID: 24227843

DOI: 10.1128/jvi.02202-13

PubMed ID: 26673890

Title: The serine protease hepsin mediates urinary secretion and polymerisation of Zona Pellucida domain protein uromodulin.

PubMed ID: 26673890

DOI: 10.7554/elife.08887

PubMed ID: 12962630

Title: The structure of the extracellular region of human hepsin reveals a serine protease domain and a novel scavenger receptor cysteine-rich (SRCR) domain.

PubMed ID: 12962630

DOI: 10.1016/s0969-2126(03)00148-5

PubMed ID: 15839837

Title: Hepatocyte growth factor is a preferred in vitro substrate for human hepsin, a membrane-anchored serine protease implicated in prostate and ovarian cancers.

PubMed ID: 15839837

DOI: 10.1042/bj20041955

Sequence Information:

  • Length: 417
  • Mass: 45011
  • Checksum: B2086FF661E551D7
  • Sequence:
  • MAQKEGGRTV PCCSRPKVAA LTAGTLLLLT AIGAASWAIV AVLLRSDQEP LYPVQVSSAD 
    ARLMVFDKTE GTWRLLCSSR SNARVAGLSC EEMGFLRALT HSELDVRTAG ANGTSGFFCV 
    DEGRLPHTQR LLEVISVCDC PRGRFLAAIC QDCGRRKLPV DRIVGGRDTS LGRWPWQVSL 
    RYDGAHLCGG SLLSGDWVLT AAHCFPERNR VLSRWRVFAG AVAQASPHGL QLGVQAVVYH 
    GGYLPFRDPN SEENSNDIAL VHLSSPLPLT EYIQPVCLPA AGQALVDGKI CTVTGWGNTQ 
    YYGQQAGVLQ EARVPIISND VCNGADFYGN QIKPKMFCAG YPEGGIDACQ GDSGGPFVCE 
    DSISRTPRWR LCGIVSWGTG CALAQKPGVY TKVSDFREWI FQAIKTHSEA SGMVTQL

Genular Protein ID: 3982014081

Symbol: B7Z1L4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 393
  • Mass: 42897
  • Checksum: C229C9E6C6AA3077
  • Sequence:
  • MCKMRTREDM QLGNEGPGTA LRLIHLQVSS ADARLMVFDK TEGTWRLLCS SRSNARVAGL 
    SCEEMGFLRA LTHSELDVRT AGANGTSGFF CVDEGRLPHT QRLLEVISVC DCPRGRFLAA 
    ICQDCGRRKL PVDRIVGGRD TSLGRWPWQV SLRYDGAHLC GGSLLSGDWV LTAAHCFPER 
    NRVLSRWRVF AGAVAQASPH GLQLGVQAVV YHGGYLPFRD PNSEENSNDI ALVHLSSPLP 
    LTEYIQPVCL PAAGQALVDG KICTVTGWGN TQYYGQQAGV LQEARVPIIS NDVCNGADFY 
    GNQIKPKMFC AGYPEGGIDA CQGDSGGPFV CEDSISRTPR WRLCGIVSWG TGCALAQKPG 
    VYTKVSDFRE WIFQAIKVKV GSRWEPGWGR LGV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.