Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 42.6583
Cell Significance Index: -10.8200 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 29.0456
Cell Significance Index: -11.8000 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 12.3803
Cell Significance Index: -11.8200 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 9.3624
Cell Significance Index: 157.7100 - Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 4.6850
Cell Significance Index: 39.8200 - Cell Name: kidney cell (CL1000497)
Fold Change: 3.4681
Cell Significance Index: 27.6900 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 3.1221
Cell Significance Index: 619.6000 - Cell Name: intrahepatic cholangiocyte (CL0002538)
Fold Change: 2.9565
Cell Significance Index: 11.1400 - Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 1.8216
Cell Significance Index: 10.4900 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 0.9607
Cell Significance Index: 14.1800 - Cell Name: epithelial cell of exocrine pancreas (CL1001433)
Fold Change: 0.6969
Cell Significance Index: 0.3500 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.5785
Cell Significance Index: 98.7900 - Cell Name: hepatoblast (CL0005026)
Fold Change: 0.4221
Cell Significance Index: 7.1000 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 0.3952
Cell Significance Index: 9.5700 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.2459
Cell Significance Index: 7.8800 - Cell Name: brush cell (CL0002204)
Fold Change: 0.2225
Cell Significance Index: 2.0400 - Cell Name: type I muscle cell (CL0002211)
Fold Change: 0.2131
Cell Significance Index: 5.2000 - Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 0.1479
Cell Significance Index: 1.9100 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.1287
Cell Significance Index: 9.8800 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.0953
Cell Significance Index: 7.1000 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.0943
Cell Significance Index: 69.1300 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.0649
Cell Significance Index: 8.3800 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0494
Cell Significance Index: 9.9100 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.0420
Cell Significance Index: 1.9600 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0252
Cell Significance Index: 11.1200 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: 0.0195
Cell Significance Index: 0.8500 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.0178
Cell Significance Index: 2.9000 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: 0.0173
Cell Significance Index: 1.9700 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0153
Cell Significance Index: 11.5500 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.0146
Cell Significance Index: 2.1300 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0136
Cell Significance Index: 25.5300 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.0095
Cell Significance Index: 1.8100 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0068
Cell Significance Index: 3.7200 - Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 0.0065
Cell Significance Index: 0.0500 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0029
Cell Significance Index: 2.0000 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.0013
Cell Significance Index: 0.8400 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: 0.0002
Cell Significance Index: 0.1500 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0054
Cell Significance Index: -8.3200 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0058
Cell Significance Index: -7.8900 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0061
Cell Significance Index: -11.3300 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0080
Cell Significance Index: -2.8900 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0086
Cell Significance Index: -0.8800 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0098
Cell Significance Index: -5.5500 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0107
Cell Significance Index: -2.2500 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0190
Cell Significance Index: -12.0600 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0212
Cell Significance Index: -2.4300 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0257
Cell Significance Index: -11.6800 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0278
Cell Significance Index: -5.0200 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0296
Cell Significance Index: -8.5300 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.0337
Cell Significance Index: -2.6700 - Cell Name: peg cell (CL4033014)
Fold Change: -0.0381
Cell Significance Index: -0.8800 - Cell Name: colon goblet cell (CL0009039)
Fold Change: -0.0509
Cell Significance Index: -5.0400 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0563
Cell Significance Index: -6.5600 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0594
Cell Significance Index: -2.7900 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0670
Cell Significance Index: -4.7400 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0671
Cell Significance Index: -9.2100 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0711
Cell Significance Index: -3.5900 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0787
Cell Significance Index: -9.6800 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: -0.0830
Cell Significance Index: -4.9800 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: -0.0866
Cell Significance Index: -1.3400 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.0963
Cell Significance Index: -1.6500 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1003
Cell Significance Index: -10.4400 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: -0.1014
Cell Significance Index: -11.0300 - Cell Name: retinal bipolar neuron (CL0000748)
Fold Change: -0.1039
Cell Significance Index: -1.2600 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.1067
Cell Significance Index: -1.1100 - Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: -0.1071
Cell Significance Index: -0.9700 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.1073
Cell Significance Index: -12.6500 - Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: -0.1088
Cell Significance Index: -1.5100 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.1093
Cell Significance Index: -3.1500 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.1095
Cell Significance Index: -7.3600 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.1138
Cell Significance Index: -3.1800 - Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: -0.1237
Cell Significance Index: -1.2800 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.1255
Cell Significance Index: -8.6800 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.1260
Cell Significance Index: -3.2400 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.1344
Cell Significance Index: -7.0000 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.1379
Cell Significance Index: -2.8600 - Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: -0.1510
Cell Significance Index: -1.3400 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.1534
Cell Significance Index: -6.2800 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.1770
Cell Significance Index: -7.8300 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.1837
Cell Significance Index: -5.0000 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.1871
Cell Significance Index: -5.5100 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.1900
Cell Significance Index: -11.6800 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.1905
Cell Significance Index: -11.6800 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.1970
Cell Significance Index: -6.9000 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.1976
Cell Significance Index: -11.0900 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.2029
Cell Significance Index: -13.0900 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.2070
Cell Significance Index: -10.8700 - Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: -0.2086
Cell Significance Index: -1.2500 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.2095
Cell Significance Index: -7.3600 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.2122
Cell Significance Index: -1.7300 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.2160
Cell Significance Index: -8.1800 - Cell Name: cholangiocyte (CL1000488)
Fold Change: -0.2382
Cell Significance Index: -2.3500 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.2398
Cell Significance Index: -5.0200 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.2399
Cell Significance Index: -10.8800 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -0.2446
Cell Significance Index: -4.2300 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.2630
Cell Significance Index: -8.6100 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.2637
Cell Significance Index: -8.4000 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.2659
Cell Significance Index: -3.9300 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.2696
Cell Significance Index: -5.8400 - Cell Name: oligodendrocyte (CL0000128)
Fold Change: -0.2733
Cell Significance Index: -2.9300
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 584236979
Symbol: HEPS_HUMAN
Name: Serine protease hepsin
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2835076
Title: A novel trypsin-like serine protease (hepsin) with a putative transmembrane domain expressed by human liver and hepatoma cells.
PubMed ID: 2835076
DOI: 10.1021/bi00403a032
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 1885621
Title: Hepsin, a cell membrane-associated protease. Characterization, tissue distribution, and gene localization.
PubMed ID: 1885621
PubMed ID: 8346233
Title: Hepsin, a putative cell-surface serine protease, is required for mammalian cell growth.
PubMed ID: 8346233
PubMed ID: 19159218
Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
PubMed ID: 19159218
DOI: 10.1021/pr8008012
PubMed ID: 21875933
Title: Proteolytic activation of pro-macrophage-stimulating protein by hepsin.
PubMed ID: 21875933
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 24227843
Title: TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry driven by the severe acute respiratory syndrome coronavirus spike protein.
PubMed ID: 24227843
DOI: 10.1128/jvi.02202-13
PubMed ID: 26673890
Title: The serine protease hepsin mediates urinary secretion and polymerisation of Zona Pellucida domain protein uromodulin.
PubMed ID: 26673890
DOI: 10.7554/elife.08887
PubMed ID: 12962630
Title: The structure of the extracellular region of human hepsin reveals a serine protease domain and a novel scavenger receptor cysteine-rich (SRCR) domain.
PubMed ID: 12962630
PubMed ID: 15839837
Title: Hepatocyte growth factor is a preferred in vitro substrate for human hepsin, a membrane-anchored serine protease implicated in prostate and ovarian cancers.
PubMed ID: 15839837
DOI: 10.1042/bj20041955
Sequence Information:
- Length: 417
- Mass: 45011
- Checksum: B2086FF661E551D7
- Sequence:
MAQKEGGRTV PCCSRPKVAA LTAGTLLLLT AIGAASWAIV AVLLRSDQEP LYPVQVSSAD ARLMVFDKTE GTWRLLCSSR SNARVAGLSC EEMGFLRALT HSELDVRTAG ANGTSGFFCV DEGRLPHTQR LLEVISVCDC PRGRFLAAIC QDCGRRKLPV DRIVGGRDTS LGRWPWQVSL RYDGAHLCGG SLLSGDWVLT AAHCFPERNR VLSRWRVFAG AVAQASPHGL QLGVQAVVYH GGYLPFRDPN SEENSNDIAL VHLSSPLPLT EYIQPVCLPA AGQALVDGKI CTVTGWGNTQ YYGQQAGVLQ EARVPIISND VCNGADFYGN QIKPKMFCAG YPEGGIDACQ GDSGGPFVCE DSISRTPRWR LCGIVSWGTG CALAQKPGVY TKVSDFREWI FQAIKTHSEA SGMVTQL
Genular Protein ID: 3982014081
Symbol: B7Z1L4_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 393
- Mass: 42897
- Checksum: C229C9E6C6AA3077
- Sequence:
MCKMRTREDM QLGNEGPGTA LRLIHLQVSS ADARLMVFDK TEGTWRLLCS SRSNARVAGL SCEEMGFLRA LTHSELDVRT AGANGTSGFF CVDEGRLPHT QRLLEVISVC DCPRGRFLAA ICQDCGRRKL PVDRIVGGRD TSLGRWPWQV SLRYDGAHLC GGSLLSGDWV LTAAHCFPER NRVLSRWRVF AGAVAQASPH GLQLGVQAVV YHGGYLPFRD PNSEENSNDI ALVHLSSPLP LTEYIQPVCL PAAGQALVDG KICTVTGWGN TQYYGQQAGV LQEARVPIIS NDVCNGADFY GNQIKPKMFC AGYPEGGIDA CQGDSGGPFV CEDSISRTPR WRLCGIVSWG TGCALAQKPG VYTKVSDFRE WIFQAIKVKV GSRWEPGWGR LGV
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.