Details for: HPN

Gene ID: 3249

Symbol: HPN

Ensembl ID: ENSG00000105707

Description: hepsin

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 9.67
    Marker Score: 14,896
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 3.98
    Marker Score: 13,029
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 2.64
    Marker Score: 1,864
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 2.48
    Marker Score: 13,322
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 2.23
    Marker Score: 2,361
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.16
    Marker Score: 7,674
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 2.13
    Marker Score: 2,042
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 2.12
    Marker Score: 5,688
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.99
    Marker Score: 1,986
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.99
    Marker Score: 12,798
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.93
    Marker Score: 8,331
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.51
    Marker Score: 1,532
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.43
    Marker Score: 335
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.37
    Marker Score: 3,224
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.36
    Marker Score: 865
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.28
    Marker Score: 406
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.23
    Marker Score: 894
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.22
    Marker Score: 2,582
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.2
    Marker Score: 496
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.19
    Marker Score: 796
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.19
    Marker Score: 1,275
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.19
    Marker Score: 1,973
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.16
    Marker Score: 641
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.15
    Marker Score: 784
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.15
    Marker Score: 2,894
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4,804
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.11
    Marker Score: 509
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.09
    Marker Score: 574
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.08
    Marker Score: 2,695
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251,792
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,811
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,035
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.99
    Marker Score: 513
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.99
    Marker Score: 415
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 506
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,407
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.98
    Marker Score: 365
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.97
    Marker Score: 15,256
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.97
    Marker Score: 1,377
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 459
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.95
    Marker Score: 1,548
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,325
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.93
    Marker Score: 1,759
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 371
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,743
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.91
    Marker Score: 5,946
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 324
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,296
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.87
    Marker Score: 673
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.86
    Marker Score: 3,601
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.82
    Marker Score: 2,009
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.82
    Marker Score: 799
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.79
    Marker Score: 299
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 597
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.78
    Marker Score: 12,470
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 699
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 394
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 470
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.73
    Marker Score: 788
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.72
    Marker Score: 220
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.71
    Marker Score: 219
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.68
    Marker Score: 148
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.64
    Marker Score: 1,028
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.63
    Marker Score: 1,007
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.62
    Marker Score: 232
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.61
    Marker Score: 190
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 0.59
    Marker Score: 332
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.58
    Marker Score: 3,049
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.58
    Marker Score: 233
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.58
    Marker Score: 576
  • Cell Name: CD34-positive, CD56-positive, CD117-positive common innate lymphoid precursor, human (CL0001074)
    Fold Change: 0.57
    Marker Score: 157
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 442
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.55
    Marker Score: 177
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.54
    Marker Score: 1,298
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.54
    Marker Score: 358
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.53
    Marker Score: 565
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.52
    Marker Score: 226
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.51
    Marker Score: 1,607
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.51
    Marker Score: 530
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.51
    Marker Score: 132
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.5
    Marker Score: 1,141
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.49
    Marker Score: 10,355
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.45
    Marker Score: 262
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.45
    Marker Score: 232
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.43
    Marker Score: 120
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.43
    Marker Score: 414
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.43
    Marker Score: 976
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.42
    Marker Score: 812
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.42
    Marker Score: 132
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.41
    Marker Score: 81
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.41
    Marker Score: 357
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.41
    Marker Score: 183
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.41
    Marker Score: 402
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.4
    Marker Score: 389
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.39
    Marker Score: 102
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.39
    Marker Score: 142
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.38
    Marker Score: 121

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Serine Protease Activity**: Hepsin belongs to the serine protease family, which is characterized by its ability to hydrolyze peptide bonds using a serine residue as a nucleophile. 2. **Broad Tissue Expression**: Hepsin is expressed in various epithelial cells, including enterocytes, hepatocytes, and renal epithelial cells, suggesting its involvement in maintaining tissue homeostasis. 3. **Regulation of Signaling Pathways**: Hepsin interacts with multiple signaling molecules, including receptors, kinases, and transcription factors, to modulate cellular responses to external stimuli. 4. **Peptidase Activity**: Hepsin possesses various peptidase activities, including serine-type endopeptidase, exopeptidase, and peptidase activity, which enable it to regulate protein processing and degradation. **Pathways and Functions** 1. **Apoptosis Regulation**: Hepsin negatively regulates apoptosis by interacting with pro-apoptotic proteins and modulating signaling pathways that promote cell survival. 2. **Cell Proliferation and Differentiation**: Hepsin regulates cell growth and differentiation by interacting with growth factors, cytokines, and transcription factors that control epithelial cell behavior. 3. **Metabolic Regulation**: Hepsin participates in metabolic processes, including the regulation of thyroid hormone generation, plasminogen activation, and potassium ion transport. 4. **Immune Response**: Hepsin may play a role in regulating immune responses by interacting with immune cells and modulating signaling pathways that control inflammation and immune cell activation. **Clinical Significance** 1. **Cancer**: Abnormal expression or activity of hepsin has been implicated in various cancers, including colorectal, liver, and renal cancers, suggesting its potential as a biomarker or therapeutic target. 2. **Cardiovascular Disorders**: Hepsin dysregulation has been linked to cardiovascular diseases, including atherosclerosis and hypertension, highlighting its potential role in cardiovascular disease prevention and treatment. 3. **Neurological Conditions**: Hepsin may play a role in neurological disorders, such as Alzheimer's disease and Parkinson's disease, by regulating signaling pathways that control neuronal function and survival. 4. **Thyroid Hormone Regulation**: Hepsin negatively regulates thyroid hormone generation, suggesting its potential role in thyroid hormone-related disorders, such as hypothyroidism. In conclusion, hepsin is a multifunctional serine protease that plays a critical role in regulating various cellular processes, including apoptosis, cell proliferation, and metabolic regulation. Its dysregulation has been implicated in various diseases, highlighting the need for further research into its mechanisms of action and potential therapeutic applications.

Genular Protein ID: 584236979

Symbol: HEPS_HUMAN

Name: Serine protease hepsin

UniProtKB Accession Codes:

P05981 B2RDS4

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 DrugCentral 1 EC 1 EMBL 5 EPD 1 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 29 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 13 PDBsum 6 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 5 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2835076

Title: A novel trypsin-like serine protease (hepsin) with a putative transmembrane domain expressed by human liver and hepatoma cells.

PubMed ID: 2835076

DOI: 10.1021/bi00403a032

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1885621

Title: Hepsin, a cell membrane-associated protease. Characterization, tissue distribution, and gene localization.

PubMed ID: 1885621

DOI: 10.1016/s0021-9258(18)55395-3

PubMed ID: 8346233

Title: Hepsin, a putative cell-surface serine protease, is required for mammalian cell growth.

PubMed ID: 8346233

DOI: 10.1073/pnas.90.15.7181

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 21875933

Title: Proteolytic activation of pro-macrophage-stimulating protein by hepsin.

PubMed ID: 21875933

DOI: 10.1158/1541-7786.mcr-11-0004

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24227843

Title: TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry driven by the severe acute respiratory syndrome coronavirus spike protein.

PubMed ID: 24227843

DOI: 10.1128/jvi.02202-13

PubMed ID: 26673890

Title: The serine protease hepsin mediates urinary secretion and polymerisation of Zona Pellucida domain protein uromodulin.

PubMed ID: 26673890

DOI: 10.7554/elife.08887

PubMed ID: 12962630

Title: The structure of the extracellular region of human hepsin reveals a serine protease domain and a novel scavenger receptor cysteine-rich (SRCR) domain.

PubMed ID: 12962630

DOI: 10.1016/s0969-2126(03)00148-5

PubMed ID: 15839837

Title: Hepatocyte growth factor is a preferred in vitro substrate for human hepsin, a membrane-anchored serine protease implicated in prostate and ovarian cancers.

PubMed ID: 15839837

DOI: 10.1042/bj20041955

Sequence Information:

  • Length: 417
  • Mass: 45011
  • Checksum: B2086FF661E551D7
  • Sequence:
    • MAQKEGGRTV PCCSRPKVAA LTAGTLLLLT AIGAASWAIV AVLLRSDQEP LYPVQVSSAD 
ARLMVFDKTE GTWRLLCSSR SNARVAGLSC EEMGFLRALT HSELDVRTAG ANGTSGFFCV 
DEGRLPHTQR LLEVISVCDC PRGRFLAAIC QDCGRRKLPV DRIVGGRDTS LGRWPWQVSL 
RYDGAHLCGG SLLSGDWVLT AAHCFPERNR VLSRWRVFAG AVAQASPHGL QLGVQAVVYH 
GGYLPFRDPN SEENSNDIAL VHLSSPLPLT EYIQPVCLPA AGQALVDGKI CTVTGWGNTQ 
YYGQQAGVLQ EARVPIISND VCNGADFYGN QIKPKMFCAG YPEGGIDACQ GDSGGPFVCE 
DSISRTPRWR LCGIVSWGTG CALAQKPGVY TKVSDFREWI FQAIKTHSEA SGMVTQL

Genular Protein ID: 3982014081

Symbol: B7Z1L4_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z1L4

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 4 Gene3D 2 GenomeRNAi 1 InterPro 10 MEROPS 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 6 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 ProteomicsDB 1 RefSeq 1 RuleBase 1 SMART 2 SUPFAM 2

Sequence Information:

  • Length: 393
  • Mass: 42897
  • Checksum: C229C9E6C6AA3077
  • Sequence:
    • MCKMRTREDM QLGNEGPGTA LRLIHLQVSS ADARLMVFDK TEGTWRLLCS SRSNARVAGL 
SCEEMGFLRA LTHSELDVRT AGANGTSGFF CVDEGRLPHT QRLLEVISVC DCPRGRFLAA 
ICQDCGRRKL PVDRIVGGRD TSLGRWPWQV SLRYDGAHLC GGSLLSGDWV LTAAHCFPER 
NRVLSRWRVF AGAVAQASPH GLQLGVQAVV YHGGYLPFRD PNSEENSNDI ALVHLSSPLP 
LTEYIQPVCL PAAGQALVDG KICTVTGWGN TQYYGQQAGV LQEARVPIIS NDVCNGADFY 
GNQIKPKMFC AGYPEGGIDA CQGDSGGPFV CEDSISRTPR WRLCGIVSWG TGCALAQKPG 
VYTKVSDFRE WIFQAIKVKV GSRWEPGWGR LGV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.