Details for: HRG

Gene ID: 3273

Symbol: HRG

Ensembl ID: ENSG00000113905

Description: histidine rich glycoprotein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 12.7098
    Cell Significance Index: 213.7700
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 7.2177
    Cell Significance Index: 19.0400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 3.3627
    Cell Significance Index: 56.6500
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 1.5324
    Cell Significance Index: 4.1100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.5115
    Cell Significance Index: 22.3100
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.4986
    Cell Significance Index: 8.6300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.3972
    Cell Significance Index: 33.8500
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.8163
    Cell Significance Index: 9.0000
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.5662
    Cell Significance Index: 4.4700
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.2386
    Cell Significance Index: 0.8300
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.1593
    Cell Significance Index: 0.6000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1219
    Cell Significance Index: 24.2000
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.0878
    Cell Significance Index: 0.8400
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.0649
    Cell Significance Index: 0.7700
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.0627
    Cell Significance Index: 0.8100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0611
    Cell Significance Index: 42.2700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0456
    Cell Significance Index: 33.4600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0093
    Cell Significance Index: 0.2300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0013
    Cell Significance Index: -2.4900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0019
    Cell Significance Index: -3.4700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0023
    Cell Significance Index: -3.5400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0028
    Cell Significance Index: -3.7500
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0039
    Cell Significance Index: -0.0400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0042
    Cell Significance Index: -2.2800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0046
    Cell Significance Index: -3.4000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0061
    Cell Significance Index: -3.4300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0073
    Cell Significance Index: -3.3300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0075
    Cell Significance Index: -4.7500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0088
    Cell Significance Index: -1.7700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0092
    Cell Significance Index: -3.3000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0099
    Cell Significance Index: -2.8500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0110
    Cell Significance Index: -0.3000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0123
    Cell Significance Index: -0.3200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0144
    Cell Significance Index: -0.4000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0156
    Cell Significance Index: -0.3600
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0168
    Cell Significance Index: -0.2900
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0173
    Cell Significance Index: -0.2400
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: -0.0189
    Cell Significance Index: -0.2000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0191
    Cell Significance Index: -2.6200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0192
    Cell Significance Index: -3.2700
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0204
    Cell Significance Index: -0.1700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0221
    Cell Significance Index: -0.9100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0221
    Cell Significance Index: -1.1200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0256
    Cell Significance Index: -0.5000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0258
    Cell Significance Index: -4.6500
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: -0.0276
    Cell Significance Index: -0.3000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0280
    Cell Significance Index: -2.9200
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0289
    Cell Significance Index: -0.4100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0300
    Cell Significance Index: -3.4400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0305
    Cell Significance Index: -1.5900
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.0306
    Cell Significance Index: -0.3300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0314
    Cell Significance Index: -4.5700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0336
    Cell Significance Index: -1.5700
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0354
    Cell Significance Index: -0.3700
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: -0.0364
    Cell Significance Index: -0.3600
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0366
    Cell Significance Index: -0.4300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0379
    Cell Significance Index: -4.6600
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0399
    Cell Significance Index: -0.3700
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: -0.0415
    Cell Significance Index: -0.4500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0423
    Cell Significance Index: -3.3500
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.0433
    Cell Significance Index: -0.3800
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0435
    Cell Significance Index: -0.5800
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.0441
    Cell Significance Index: -0.2700
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.0460
    Cell Significance Index: -0.3300
  • Cell Name: paneth cell (CL0000510)
    Fold Change: -0.0522
    Cell Significance Index: -0.5400
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0523
    Cell Significance Index: -0.3500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0526
    Cell Significance Index: -1.4100
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: -0.0540
    Cell Significance Index: -0.2700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0545
    Cell Significance Index: -5.5700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0565
    Cell Significance Index: -3.8000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0574
    Cell Significance Index: -3.5300
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: -0.0574
    Cell Significance Index: -0.3500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0576
    Cell Significance Index: -3.2300
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.0668
    Cell Significance Index: -0.6200
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -0.0700
    Cell Significance Index: -0.6700
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: -0.0715
    Cell Significance Index: -0.7400
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: -0.0730
    Cell Significance Index: -0.7200
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0742
    Cell Significance Index: -0.6400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0766
    Cell Significance Index: -3.6000
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.0773
    Cell Significance Index: -0.7000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0794
    Cell Significance Index: -3.5100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0871
    Cell Significance Index: -3.0500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0883
    Cell Significance Index: -1.2700
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0890
    Cell Significance Index: -1.7400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0910
    Cell Significance Index: -2.9800
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0917
    Cell Significance Index: -2.2900
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.0921
    Cell Significance Index: -0.8300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0927
    Cell Significance Index: -3.5100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0934
    Cell Significance Index: -3.4300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0936
    Cell Significance Index: -2.9800
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.0950
    Cell Significance Index: -0.9800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1052
    Cell Significance Index: -3.0300
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: -0.1070
    Cell Significance Index: -0.6700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1073
    Cell Significance Index: -3.1600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1092
    Cell Significance Index: -2.3400
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.1129
    Cell Significance Index: -1.1900
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.1197
    Cell Significance Index: -1.3700
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.1200
    Cell Significance Index: -1.9300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1235
    Cell Significance Index: -3.0800
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: -0.1240
    Cell Significance Index: -0.6500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** HRG is characterized by its high histidine content, which is essential for its structure and function. The protein's glycoprotein nature, comprising multiple carbohydrate chains, confers it with unique properties, including binding affinity for various ligands and interactions with cell surface receptors. HRG's molecular weight is approximately 100 kDa, and it is secreted into the extracellular environment, where it can exert its biological effects. The protein's expression is widespread, with significant levels found in the liver, kidneys, and intestines. **Pathways and Functions** HRG's biological activities are mediated through its interactions with various signaling pathways and cellular processes. Some of the key pathways and functions associated with HRG include: 1. **Coagulation regulation**: HRG inhibits fibrinolysis and promotes coagulation by binding to thrombin and plasminogen, thereby regulating the fibrinolytic system. 2. **Antimicrobial response**: HRG exhibits antimicrobial properties, which are thought to be mediated by its interaction with antimicrobial peptides. 3. **Angiogenesis regulation**: HRG acts as an angiogenesis inhibitor by binding to vascular endothelial growth factor (VEGF) and negatively regulating its signaling pathway. 4. **Cell growth regulation**: HRG inhibits cell growth and proliferation by interacting with cell surface receptors and modulating signaling pathways involved in cell growth and division. 5. **Immune response modulation**: HRG modulates the immune response by interacting with immune cells, such as neutrophils and macrophages, and regulating their activation and function. **Clinical Significance** HRG's dysregulation has been implicated in various diseases, including: 1. **Thrombotic disorders**: HRG's role in regulating coagulation and fibrinolysis makes it a potential target for the treatment of thrombotic disorders, such as deep vein thrombosis and pulmonary embolism. 2. **Inflammatory diseases**: HRG's antimicrobial properties and ability to modulate the immune response make it a potential therapeutic target for inflammatory diseases, such as sepsis and rheumatoid arthritis. 3. **Cancer**: HRG's role in regulating cell growth and proliferation makes it a potential biomarker for cancer diagnosis and treatment. 4. **Neurological disorders**: HRG's involvement in angiogenesis and immune response modulation makes it a potential therapeutic target for neurological disorders, such as Alzheimer's disease and multiple sclerosis. In conclusion, HRG is a multifunctional protein that plays a critical role in various physiological and pathological processes. Its dysregulation has been implicated in various diseases, making it an important target for therapeutic intervention. Further research is needed to fully understand HRG's biological functions and its role in human disease.

Genular Protein ID: 1949269945

Symbol: HRG_HUMAN

Name: Histidine-rich glycoprotein

UniProtKB Accession Codes:

P04196 B9EK35 D3DNU7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 7 Ensembl 1 GO 43 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MEROPS 2 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRIDE 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3011081

Title: Amino acid sequence of human histidine-rich glycoprotein derived from the nucleotide sequence of its cDNA.

PubMed ID: 3011081

DOI: 10.1021/bi00356a055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8188234

Title: Evidence for the absence of intron H of the histidine-rich glycoprotein (HRG) gene: genetic mapping and in situ localization of HRG to chromosome 3q28-q29.

PubMed ID: 8188234

DOI: 10.1006/geno.1994.1046

PubMed ID: 1459097

Title: Plasma protein map: an update by microsequencing.

PubMed ID: 1459097

DOI: 10.1002/elps.11501301150

PubMed ID: 678554

Title: Human serum histidine-rich glycoprotein. I. Interactions with heme, metal ions and organic ligands.

PubMed ID: 678554

DOI: 10.1016/0005-2795(78)90098-3

PubMed ID: 10514432

Title: Differential binding of histidine-rich glycoprotein (HRG) to human IgG subclasses and IgG molecules containing kappa and lambda light chains.

PubMed ID: 10514432

DOI: 10.1074/jbc.274.42.29633

PubMed ID: 11134179

Title: Histidine-rich glycoprotein inhibits the antiangiogenic effect of thrombospondin-1.

PubMed ID: 11134179

DOI: 10.1172/jci9061

PubMed ID: 12235005

Title: Histidine-proline-rich glycoprotein has potent antiangiogenic activity mediated through the histidine-proline-rich domain.

PubMed ID: 12235005

PubMed ID: 14744774

Title: A fragment of histidine-rich glycoprotein is a potent inhibitor of tumor vascularization.

PubMed ID: 14744774

DOI: 10.1158/0008-5472.can-03-1941

PubMed ID: 15313924

Title: Peptides derived from the histidine-proline domain of the histidine-proline-rich glycoprotein bind to tropomyosin and have antiangiogenic and antitumor activities.

PubMed ID: 15313924

DOI: 10.1158/0008-5472.can-04-0440

PubMed ID: 15138272

Title: Histidine-rich glycoprotein binds to cell-surface heparan sulfate via its N-terminal domain following Zn2+ chelation.

PubMed ID: 15138272

DOI: 10.1074/jbc.m401996200

PubMed ID: 15220341

Title: Plasminogen is tethered with high affinity to the cell surface by the plasma protein, histidine-rich glycoprotein.

PubMed ID: 15220341

DOI: 10.1074/jbc.m406027200

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 16489009

Title: Minimal active domain and mechanism of action of the angiogenesis inhibitor histidine-rich glycoprotein.

PubMed ID: 16489009

DOI: 10.1158/0008-5472.can-05-2217

PubMed ID: 16436387

Title: The anti-angiogenic His/Pro-rich fragment of histidine-rich glycoprotein binds to endothelial cell heparan sulfate in a Zn2+-dependent manner.

PubMed ID: 16436387

DOI: 10.1074/jbc.m508483200

PubMed ID: 19712047

Title: Regulation of histidine-rich glycoprotein (HRG) function via plasmin-mediated proteolytic cleavage.

PubMed ID: 19712047

DOI: 10.1042/bj20090794

PubMed ID: 19285951

Title: High affinity interaction between histidine-rich glycoprotein and the cell surface type ATP synthase on T-cells.

PubMed ID: 19285951

DOI: 10.1016/j.bbamem.2009.03.005

PubMed ID: 19535045

Title: Histidine-rich glycoprotein and concanavalin A synergistically stimulate the phosphatidylinositol 3-kinase-independent signaling pathway in leukocytes leading to increased cell adhesion and changes in cell morphology.

PubMed ID: 19535045

DOI: 10.1016/j.cellimm.2009.05.001

PubMed ID: 19786305

Title: Probing the Cu(2+) and Zn(2+) binding affinity of histidine-rich glycoprotein.

PubMed ID: 19786305

DOI: 10.1016/j.jinorgbio.2009.09.002

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19903770

Title: Activated platelets provide a functional microenvironment for the antiangiogenic fragment of histidine-rich glycoprotein.

PubMed ID: 19903770

DOI: 10.1158/1541-7786.mcr-09-0094

PubMed ID: 20561914

Title: Histidine-rich glycoprotein binds heparanase and regulates its enzymatic activity and cell surface interactions.

PubMed ID: 20561914

DOI: 10.1016/j.biocel.2010.05.008

PubMed ID: 20573803

Title: Histidine-rich glycoprotein functions cooperatively with cell surface heparan sulfate on phagocytes to promote necrotic cell uptake.

PubMed ID: 20573803

DOI: 10.1189/jlb.0210087

PubMed ID: 21304106

Title: Histidine-rich glycoprotein binds factor XIIa with high affinity and inhibits contact-initiated coagulation.

PubMed ID: 21304106

DOI: 10.1182/blood-2010-07-290551

PubMed ID: 21215706

Title: HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PlGF.

PubMed ID: 21215706

DOI: 10.1016/j.ccr.2010.11.009

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 9414276

Title: HRG Tokushima: molecular and cellular characterization of histidine-rich glycoprotein (HRG) deficiency.

PubMed ID: 9414276

PubMed ID: 11057869

Title: Histidine-rich glycoprotein (HRG) Tokushima 2: novel HRG deficiency, molecular and cellular characterization.

PubMed ID: 11057869

Sequence Information:

  • Length: 525
  • Mass: 59578
  • Checksum: A2B124D6CE93114F
  • Sequence:
    • MKALIAALLL ITLQYSCAVS PTDCSAVEPE AEKALDLINK RRRDGYLFQL LRIADAHLDR 
VENTTVYYLV LDVQESDCSV LSRKYWNDCE PPDSRRPSEI VIGQCKVIAT RHSHESQDLR 
VIDFNCTTSS VSSALANTKD SPVLIDFFED TERYRKQANK ALEKYKEEND DFASFRVDRI 
ERVARVRGGE GTGYFVDFSV RNCPRHHFPR HPNVFGFCRA DLFYDVEALD LESPKNLVIN 
CEVFDPQEHE NINGVPPHLG HPFHWGGHER SSTTKPPFKP HGSRDHHHPH KPHEHGPPPP 
PDERDHSHGP PLPQGPPPLL PMSCSSCQHA TFGTNGAQRH SHNNNSSDLH PHKHHSHEQH 
PHGHHPHAHH PHEHDTHRQH PHGHHPHGHH PHGHHPHGHH PHGHHPHCHD FQDYGPCDPP 
PHNQGHCCHG HGPPPGHLRR RGPGKGPRPF HCRQIGSVYR LPPLRKGEVL PLPEANFPSF 
PLPHHKHPLK PDNQPFPQSV SESCPGKFKS GFPQVSMFFT HTFPK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.