Details for: HTR7

Gene ID: 3363

Symbol: HTR7

Ensembl ID: ENSG00000148680

Description: 5-hydroxytryptamine receptor 7

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.23
    Marker Score: 2242
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.52
    Marker Score: 798.5
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 169407
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.45
    Marker Score: 2945
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.36
    Marker Score: 2824
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.33
    Marker Score: 2527
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.05
    Marker Score: 437
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.04
    Marker Score: 662
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.03
    Marker Score: 6838
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71825
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48049
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.98
    Marker Score: 2478
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5356
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5290
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.86
    Marker Score: 31547.5
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.83
    Marker Score: 268
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.82
    Marker Score: 1272
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 596
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1265
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 707
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.77
    Marker Score: 465
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.77
    Marker Score: 11981
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.75
    Marker Score: 3073
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.61
    Marker Score: 401
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.58
    Marker Score: 305
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.58
    Marker Score: 183
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 147
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.55
    Marker Score: 262
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.51
    Marker Score: 5270
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.42
    Marker Score: 241
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.39
    Marker Score: 3354
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.35
    Marker Score: 834
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.34
    Marker Score: 1313
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.34
    Marker Score: 195
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.31
    Marker Score: 96
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.3
    Marker Score: 497
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.29
    Marker Score: 295
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.29
    Marker Score: 129
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.29
    Marker Score: 2202
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.29
    Marker Score: 215
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.29
    Marker Score: 1189
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.26
    Marker Score: 135
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.26
    Marker Score: 67
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.26
    Marker Score: 148
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.25
    Marker Score: 2412
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.25
    Marker Score: 15068.5
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.24
    Marker Score: 110
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.23
    Marker Score: 80
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.23
    Marker Score: 4509
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.22
    Marker Score: 133
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.22
    Marker Score: 80
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.22
    Marker Score: 372
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.2
    Marker Score: 202.5
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.2
    Marker Score: 562
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.19
    Marker Score: 233
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.19
    Marker Score: 492
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.19
    Marker Score: 69
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.19
    Marker Score: 861
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.18
    Marker Score: 84
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.18
    Marker Score: 101
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.18
    Marker Score: 332
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.18
    Marker Score: 97
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.17
    Marker Score: 163
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.17
    Marker Score: 201
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.15
    Marker Score: 102
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.14
    Marker Score: 159
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.14
    Marker Score: 7487
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.14
    Marker Score: 141
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.14
    Marker Score: 161
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.14
    Marker Score: 118
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.13
    Marker Score: 187
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.13
    Marker Score: 162
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.13
    Marker Score: 77
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 0.12
    Marker Score: 74
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.12
    Marker Score: 116
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.12
    Marker Score: 72
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.12
    Marker Score: 194
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.12
    Marker Score: 27
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.12
    Marker Score: 73
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.11
    Marker Score: 127
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 0.11
    Marker Score: 27
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.11
    Marker Score: 55
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.11
    Marker Score: 75
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.11
    Marker Score: 49
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.11
    Marker Score: 357
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.11
    Marker Score: 75
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.11
    Marker Score: 39
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.11
    Marker Score: 186
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.11
    Marker Score: 43
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.11
    Marker Score: 180
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.11
    Marker Score: 26
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.1
    Marker Score: 21
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.1
    Marker Score: 35
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.1
    Marker Score: 27
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.1
    Marker Score: 27

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Other Information

**Key characteristics** * HTR7 is a single-pass membrane protein with a molecular weight of approximately 140 kDa. * It is expressed in high levels in the blood vessel endothelial cell line HUVEC. * HTR7 is a ligand-gated channel that is sensitive to 5-hydroxytryptamine (5-HT). * It is a member of the G protein-coupled receptor (GPCR) family of cell surface receptors. * It is expressed in a variety of cell types, including blood vessel endothelial cells, hematopoietic stem cells, mural cells, and immune cells. **Pathways and functions** * HTR7 is a ligand-gated channel that is sensitive to 5-HT. * It is expressed in blood vessel endothelial cells, where it is thought to regulate blood flow. * It is also expressed in hematopoietic stem cells, where it may play a role in regulating stem cell differentiation. * It is expressed in mural cells, where it may play a role in regulating cell migration and proliferation. * It is expressed in immune cells, where it may play a role in regulating immune responses. **Clinical significance** HTR7 is a potential therapeutic target for a variety of diseases, including hypertension, stroke, and depression. It is a target for the treatment of hypertension, as it is expressed in blood vessel endothelial cells. It is also a target for the treatment of stroke, as it is expressed in neurons that are damaged in strokes. **Additional information** HTR7 is a member of the G protein-coupled receptor (GPCR) family of cell surface receptors. GPCRs are a large family of cell surface receptors that are involved in a variety of cellular processes, including cell adhesion, migration, and signaling.

Genular Protein ID: 1696171577

Symbol: 5HT7R_HUMAN

Name: 5-hydroxytryptamine receptor 7

UniProtKB Accession Codes:

P34969 B5BUP6 P78336 P78372 P78516 Q5VX01 Q5VX02 Q5VX03

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 40 DrugCentral 1 EMBL 16 Ensembl 3 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRINTS 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 3 RefSeq 3 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9084407

Title: Four 5-hydroxytryptamine7 (5-HT7) receptor isoforms in human and rat produced by alternative splicing: species differences due to altered intron-exon organization.

PubMed ID: 9084407

DOI: 10.1046/j.1471-4159.1997.68041372.x

PubMed ID: 8226867

Title: Cloning of a novel human serotonin receptor (5-HT7) positively linked to adenylate cyclase.

PubMed ID: 8226867

DOI: 10.1016/s0021-9258(19)49479-9

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 22448645

Title: Biochemical and pharmacological study of N-linked glycosylation of the human serotonin 5-HT(7)a receptor.

PubMed ID: 22448645

DOI: 10.1111/j.1742-4658.2012.08581.x

PubMed ID: 9154233

Title: The human serotonin 7 (5-HT7) receptor gene: genomic organization and systematic mutation screening in schizophrenia and bipolar affective disorder.

PubMed ID: 9154233

Sequence Information:

  • Length: 479
  • Mass: 53555
  • Checksum: 1F62E985EADE1F23
  • Sequence:
    • MMDVNSSGRP DLYGHLRSFL LPEVGRGLPD LSPDGGADPV AGSWAPHLLS EVTASPAPTW 
DAPPDNASGC GEQINYGRVE KVVIGSILTL ITLLTIAGNC LVVISVCFVK KLRQPSNYLI 
VSLALADLSV AVAVMPFVSV TDLIGGKWIF GHFFCNVFIA MDVMCCTASI MTLCVISIDR 
YLGITRPLTY PVRQNGKCMA KMILSVWLLS ASITLPPLFG WAQNVNDDKV CLISQDFGYT 
IYSTAVAFYI PMSVMLFMYY QIYKAARKSA AKHKFPGFPR VEPDSVIALN GIVKLQKEVE 
ECANLSRLLK HERKNISIFK REQKAATTLG IIVGAFTVCW LPFFLLSTAR PFICGTSCSC 
IPLWVERTFL WLGYANSLIN PFIYAFFNRD LRTTYRSLLQ CQYRNINRKL SAAGMHEALK 
LAERPERPEF VLRACTRRVL LRPEKRPPVS VWVLQSPDHH NWLADKMLTT VEKKVMIHD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.