Details for: HTR7

Gene ID: 3363

Symbol: HTR7

Ensembl ID: ENSG00000148680

Description: 5-hydroxytryptamine receptor 7

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 1.4671
    Cell Significance Index: 20.6100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.6479
    Cell Significance Index: 18.4900
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.5092
    Cell Significance Index: 8.5700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3742
    Cell Significance Index: 258.7900
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.3145
    Cell Significance Index: 3.8900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2928
    Cell Significance Index: 15.2100
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 0.2221
    Cell Significance Index: 2.8800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1957
    Cell Significance Index: 39.2500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1495
    Cell Significance Index: 26.9500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.0834
    Cell Significance Index: 0.6800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0499
    Cell Significance Index: 3.0700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0108
    Cell Significance Index: 0.2600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0089
    Cell Significance Index: 0.2300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0046
    Cell Significance Index: 0.5600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.0038
    Cell Significance Index: 0.0800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0014
    Cell Significance Index: -0.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0016
    Cell Significance Index: -2.9800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0018
    Cell Significance Index: -0.0300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0018
    Cell Significance Index: -3.3700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0021
    Cell Significance Index: -3.2200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0023
    Cell Significance Index: -0.8100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0025
    Cell Significance Index: -3.3700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0036
    Cell Significance Index: -0.2400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0060
    Cell Significance Index: -3.7900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0069
    Cell Significance Index: -5.1500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0086
    Cell Significance Index: -4.7200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0089
    Cell Significance Index: -4.0600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0092
    Cell Significance Index: -5.1700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0117
    Cell Significance Index: -3.3800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0149
    Cell Significance Index: -2.9500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0170
    Cell Significance Index: -2.1800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0208
    Cell Significance Index: -3.0300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0227
    Cell Significance Index: -0.9900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0248
    Cell Significance Index: -5.2300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0259
    Cell Significance Index: -2.6500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0268
    Cell Significance Index: -0.5300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0273
    Cell Significance Index: -4.6700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0304
    Cell Significance Index: -4.1700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0339
    Cell Significance Index: -4.3800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0344
    Cell Significance Index: -0.4700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0380
    Cell Significance Index: -0.8200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0436
    Cell Significance Index: -5.0000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0462
    Cell Significance Index: -4.8100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0488
    Cell Significance Index: -2.7400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0517
    Cell Significance Index: -1.6500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0524
    Cell Significance Index: -4.0200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0551
    Cell Significance Index: -4.1100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0565
    Cell Significance Index: -1.5800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0598
    Cell Significance Index: -1.4900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0605
    Cell Significance Index: -2.1200
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0627
    Cell Significance Index: -0.8600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0628
    Cell Significance Index: -2.9300
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0670
    Cell Significance Index: -0.8500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0698
    Cell Significance Index: -4.5000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0718
    Cell Significance Index: -2.3500
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0737
    Cell Significance Index: -0.8600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0760
    Cell Significance Index: -3.9900
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0770
    Cell Significance Index: -0.7300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0796
    Cell Significance Index: -3.7400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0835
    Cell Significance Index: -0.9100
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0853
    Cell Significance Index: -0.4700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0921
    Cell Significance Index: -3.3800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0936
    Cell Significance Index: -2.5100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1031
    Cell Significance Index: -4.5600
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.1153
    Cell Significance Index: -2.2700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1191
    Cell Significance Index: -2.9700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1204
    Cell Significance Index: -4.5600
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.1238
    Cell Significance Index: -1.6500
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.1246
    Cell Significance Index: -1.4900
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: -0.1338
    Cell Significance Index: -1.1000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1347
    Cell Significance Index: -2.8200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1353
    Cell Significance Index: -4.7600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1373
    Cell Significance Index: -3.6800
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1429
    Cell Significance Index: -4.5200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1446
    Cell Significance Index: -2.4200
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.1447
    Cell Significance Index: -1.9300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1494
    Cell Significance Index: -4.4000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1497
    Cell Significance Index: -4.2900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1509
    Cell Significance Index: -1.3900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1509
    Cell Significance Index: -3.0300
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.1527
    Cell Significance Index: -2.0000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1543
    Cell Significance Index: -3.9300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1589
    Cell Significance Index: -3.4800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1610
    Cell Significance Index: -4.3000
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1619
    Cell Significance Index: -2.3500
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.1636
    Cell Significance Index: -2.6400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1639
    Cell Significance Index: -4.4600
  • Cell Name: intratelencephalic-projecting glutamatergic cortical neuron (CL4023008)
    Fold Change: -0.1663
    Cell Significance Index: -1.7100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1664
    Cell Significance Index: -4.8000
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1672
    Cell Significance Index: -3.4900
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1702
    Cell Significance Index: -2.4800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1742
    Cell Significance Index: -3.4000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1758
    Cell Significance Index: -4.2900
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron (CL4030065)
    Fold Change: -0.1780
    Cell Significance Index: -1.8600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1799
    Cell Significance Index: -4.7300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1815
    Cell Significance Index: -3.8800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1841
    Cell Significance Index: -4.4600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1844
    Cell Significance Index: -4.7100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1882
    Cell Significance Index: -4.7000
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1941
    Cell Significance Index: -3.9500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The 5-HT7 receptor is a serotonin receptor that belongs to the class A/1 (rhodopsin-like receptors) subgroup. It is characterized by its high affinity for 5-hydroxytryptamine (5-HT) and its ability to couple with Gs proteins, leading to the activation of adenylate cyclase and the production of cyclic AMP (cAMP). The 5-HT7 receptor is also known for its unique ligand-binding properties, including its high affinity for 5-HT and its ability to bind to other ligands, such as 8-OH-DPT and 8-OH-DPTA. **Pathways and Functions:** The 5-HT7 receptor is involved in several signaling pathways, including: 1. **Cyclic nucleotide second messenger pathway:** The 5-HT7 receptor couples with Gs proteins, leading to the activation of adenylate cyclase and the production of cAMP. 2. **G alpha (s) signaling events:** The 5-HT7 receptor also couples with Gs proteins, leading to the activation of protein kinase A (PKA) and the phosphorylation of downstream targets. 3. **G protein-coupled receptor signaling pathway:** The 5-HT7 receptor is a member of the G protein-coupled receptor family and is involved in various signaling pathways, including the activation of phospholipase C (PLC) and the production of inositol trisphosphate (IP3) and diacylglycerol (DAG). 4. **Neurotransmitter receptor activity:** The 5-HT7 receptor is a serotonin receptor and is involved in the regulation of neurotransmission, including the modulation of synaptic transmission and the regulation of mood and cognition. **Clinical Significance:** The 5-HT7 receptor has been implicated in various diseases, including: 1. **Mood disorders:** The 5-HT7 receptor has been shown to play a role in the regulation of mood and cognition, and its dysfunction has been implicated in various mood disorders, including depression and anxiety. 2. **Cardiovascular disease:** The 5-HT7 receptor has been shown to play a role in the regulation of blood pressure and the modulation of cardiac function, and its dysfunction has been implicated in various cardiovascular diseases, including hypertension and heart failure. 3. **Neurodegenerative diseases:** The 5-HT7 receptor has been shown to play a role in the regulation of neurotransmission and the modulation of synaptic transmission, and its dysfunction has been implicated in various neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. 4. **Cancer:** The 5-HT7 receptor has been shown to play a role in the regulation of cell growth and the modulation of apoptosis, and its overexpression has been implicated in various types of cancer, including breast cancer and colon cancer. In conclusion, the 5-HT7 receptor is a complex receptor that plays a crucial role in various physiological processes, including blood circulation, neurotransmission, and immune responses. Its dysfunction has been implicated in various diseases, and its potential as a therapeutic target has been explored in various clinical settings. Further research is needed to fully understand the function and clinical significance of the 5-HT7 receptor.

Genular Protein ID: 1696171577

Symbol: 5HT7R_HUMAN

Name: 5-HT-X

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9084407

Title: Four 5-hydroxytryptamine7 (5-HT7) receptor isoforms in human and rat produced by alternative splicing: species differences due to altered intron-exon organization.

PubMed ID: 9084407

DOI: 10.1046/j.1471-4159.1997.68041372.x

PubMed ID: 8226867

Title: Cloning of a novel human serotonin receptor (5-HT7) positively linked to adenylate cyclase.

PubMed ID: 8226867

DOI: 10.1016/s0021-9258(19)49479-9

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 22448645

Title: Biochemical and pharmacological study of N-linked glycosylation of the human serotonin 5-HT(7)a receptor.

PubMed ID: 22448645

DOI: 10.1111/j.1742-4658.2012.08581.x

PubMed ID: 35714614

Title: GPCRs steer Gi and Gs selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors.

PubMed ID: 35714614

DOI: 10.1016/j.molcel.2022.05.031

PubMed ID: 9154233

Title: The human serotonin 7 (5-HT7) receptor gene: genomic organization and systematic mutation screening in schizophrenia and bipolar affective disorder.

PubMed ID: 9154233

Sequence Information:

  • Length: 479
  • Mass: 53555
  • Checksum: 1F62E985EADE1F23
  • Sequence:
  • MMDVNSSGRP DLYGHLRSFL LPEVGRGLPD LSPDGGADPV AGSWAPHLLS EVTASPAPTW 
    DAPPDNASGC GEQINYGRVE KVVIGSILTL ITLLTIAGNC LVVISVCFVK KLRQPSNYLI 
    VSLALADLSV AVAVMPFVSV TDLIGGKWIF GHFFCNVFIA MDVMCCTASI MTLCVISIDR 
    YLGITRPLTY PVRQNGKCMA KMILSVWLLS ASITLPPLFG WAQNVNDDKV CLISQDFGYT 
    IYSTAVAFYI PMSVMLFMYY QIYKAARKSA AKHKFPGFPR VEPDSVIALN GIVKLQKEVE 
    ECANLSRLLK HERKNISIFK REQKAATTLG IIVGAFTVCW LPFFLLSTAR PFICGTSCSC 
    IPLWVERTFL WLGYANSLIN PFIYAFFNRD LRTTYRSLLQ CQYRNINRKL SAAGMHEALK 
    LAERPERPEF VLRACTRRVL LRPEKRPPVS VWVLQSPDHH NWLADKMLTT VEKKVMIHD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.