IGHA2 | ENSG00000211890 | NCBI 3494

Details for: IGHA2

Gene ID: 3494

Symbol: IGHA2

Ensembl ID: ENSG00000211890

Description: immunoglobulin heavy constant alpha 2 (A2m marker)

Associated with

Binding and uptake of ligands by scavenger receptors
(R-HSA-2173782)
Cell surface interactions at the vascular wall
(R-HSA-202733)
Hemostasis
(R-HSA-109582)
Scavenging of heme from plasma
(R-HSA-2168880)
Vesicle-mediated transport
(R-HSA-5653656)
Adaptive immune response
(GO:0002250)
Antibacterial humoral response
(GO:0019731)
Antigen binding
(GO:0003823)
B cell receptor signaling pathway
(GO:0050853)
Blood microparticle
(GO:0072562)
Complement activation, classical pathway
(GO:0006958)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Glomerular filtration
(GO:0003094)
Iga immunoglobulin complex
(GO:0071745)
Immune response
(GO:0006955)
Immunoglobulin complex, circulating
(GO:0042571)
Immunoglobulin receptor binding
(GO:0034987)
Monomeric iga immunoglobulin complex
(GO:0071748)
Plasma membrane
(GO:0005886)
Positive regulation of respiratory burst
(GO:0060267)
Secretory dimeric iga immunoglobulin complex
(GO:0071752)
Secretory iga immunoglobulin complex
(GO:0071751)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 77.9370
Cell Significance Index: 1585.8500
Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 49.5323
Cell Significance Index: 741.0400
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 24.5275
Cell Significance Index: -11.5800
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 8.4327
Cell Significance Index: -22.5900
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 6.4888
Cell Significance Index: 206.6600
Cell Name: glandular cell of esophagus (CL0002657)
Fold Change: 6.2631
Cell Significance Index: 67.0800
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 5.6443
Cell Significance Index: 184.8000
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 4.9394
Cell Significance Index: 123.2100
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 4.8205
Cell Significance Index: 168.8700
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 4.6078
Cell Significance Index: 79.6700
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 4.1926
Cell Significance Index: 82.9000
Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
Fold Change: 4.0341
Cell Significance Index: 80.4500
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 3.7979
Cell Significance Index: 74.7500
Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: 3.3851
Cell Significance Index: 67.9600
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 3.0978
Cell Significance Index: 66.9300
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 2.2658
Cell Significance Index: 48.0900
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 2.2283
Cell Significance Index: 33.5800
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 1.6116
Cell Significance Index: -4.9500
Cell Name: IgA plasmablast (CL0000984)
Fold Change: 1.5218
Cell Significance Index: 12.2300
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 0.5299
Cell Significance Index: 11.0600
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.4559
Cell Significance Index: 9.7100
Cell Name: odontoblast (CL0000060)
Fold Change: 0.4454
Cell Significance Index: 57.1000
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.3829
Cell Significance Index: 37.8800
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.3662
Cell Significance Index: 330.6300
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.3388
Cell Significance Index: 20.3400
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.3193
Cell Significance Index: 60.7600
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.2971
Cell Significance Index: 32.3200
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.2895
Cell Significance Index: 8.3400
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.2511
Cell Significance Index: 40.8400
Cell Name: suprabasal keratinocyte (CL4033013)
Fold Change: 0.1872
Cell Significance Index: 3.0100
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.1677
Cell Significance Index: 11.6000
Cell Name: duct epithelial cell (CL0000068)
Fold Change: 0.1403
Cell Significance Index: 1.9400
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.1006
Cell Significance Index: 4.5600
Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: 0.0455
Cell Significance Index: 0.3200
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0111
Cell Significance Index: 0.3900
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0.0065
Cell Significance Index: 0.1000
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0153
Cell Significance Index: -1.7600
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0154
Cell Significance Index: -11.6800
Cell Name: keratinocyte (CL0000312)
Fold Change: -0.0204
Cell Significance Index: -0.5100
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.0340
Cell Significance Index: -0.8500
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0360
Cell Significance Index: -7.2300
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0371
Cell Significance Index: -20.9200
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0388
Cell Significance Index: -1.8100
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0496
Cell Significance Index: -6.4100
Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0625
Cell Significance Index: -12.4000
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.0709
Cell Significance Index: -1.4700
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0808
Cell Significance Index: -14.5600
Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.0835
Cell Significance Index: -3.6300
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0989
Cell Significance Index: -16.8900
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.1025
Cell Significance Index: -2.2200
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.1123
Cell Significance Index: -13.8100
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.1234
Cell Significance Index: -16.9400
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1465
Cell Significance Index: -10.9200
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.1614
Cell Significance Index: -5.1700
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.1625
Cell Significance Index: -9.9600
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.2112
Cell Significance Index: -21.5700
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.2147
Cell Significance Index: -16.4800
Cell Name: collagen secreting cell (CL0000667)
Fold Change: -0.2281
Cell Significance Index: -1.2700
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.2375
Cell Significance Index: -12.3400
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.2912
Cell Significance Index: -15.1700
Cell Name: IgA plasma cell (CL0000987)
Fold Change: -0.3033
Cell Significance Index: -2.0200
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.3060
Cell Significance Index: -19.7400
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.3236
Cell Significance Index: -11.8800
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.3477
Cell Significance Index: -3.9500
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.3981
Cell Significance Index: -10.1700
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: -0.4030
Cell Significance Index: -5.2600
Cell Name: plasma cell (CL0000786)
Fold Change: -0.4144
Cell Significance Index: -4.6300
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.4309
Cell Significance Index: -20.2500
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.4329
Cell Significance Index: -11.5800
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.4386
Cell Significance Index: -11.7100
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.4522
Cell Significance Index: -11.8900
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.4762
Cell Significance Index: -11.5400
Cell Name: microglial cell (CL0000129)
Fold Change: -0.4899
Cell Significance Index: -5.7600
Cell Name: enterocyte (CL0000584)
Fold Change: -0.5545
Cell Significance Index: -3.4400
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: -0.5915
Cell Significance Index: -7.2000
Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.6384
Cell Significance Index: -15.9200
Cell Name: lymphocyte (CL0000542)
Fold Change: -0.6417
Cell Significance Index: -8.7300
Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: -0.6779
Cell Significance Index: -6.4900
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.7424
Cell Significance Index: -18.9200
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.7471
Cell Significance Index: -21.4200
Cell Name: peg cell (CL4033014)
Fold Change: -0.7536
Cell Significance Index: -17.4100
Cell Name: early T lineage precursor (CL0002425)
Fold Change: -0.7542
Cell Significance Index: -10.9500
Cell Name: preadipocyte (CL0002334)
Fold Change: -0.7860
Cell Significance Index: -15.3400
Cell Name: oligodendrocyte (CL0000128)
Fold Change: -0.7965
Cell Significance Index: -8.5400
Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: -0.8181
Cell Significance Index: -10.5700
Cell Name: keratocyte (CL0002363)
Fold Change: -0.8207
Cell Significance Index: -13.0200
Cell Name: memory B cell (CL0000787)
Fold Change: -0.8384
Cell Significance Index: -8.9200
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.8869
Cell Significance Index: -24.1400
Cell Name: seromucus secreting cell (CL0000159)
Fold Change: -0.8885
Cell Significance Index: -18.5300
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: -0.9007
Cell Significance Index: -9.5700
Cell Name: epithelial cell (CL0000066)
Fold Change: -0.9034
Cell Significance Index: -9.5300
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.9196
Cell Significance Index: -17.9800
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: -0.9356
Cell Significance Index: -12.2400
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -0.9393
Cell Significance Index: -7.8900
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: -0.9458
Cell Significance Index: -10.5700
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.9506
Cell Significance Index: -17.5700
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: -0.9525
Cell Significance Index: -6.2100
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: -0.9549
Cell Significance Index: -11.2900
Cell Name: megakaryocyte (CL0000556)
Fold Change: -0.9697
Cell Significance Index: -15.7100
Cell Name: thymocyte (CL0000893)
Fold Change: -0.9840
Cell Significance Index: -12.4300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics** IGHA2 exhibits several key characteristics that underscore its importance in the immune system: 1. **High expression in mucosal surfaces**: IGHA2 is significantly expressed in cells involved in mucosal immunity, such as IgA plasma cells, plasmablasts, and goblet cells. 2. **Antigen binding and presentation**: The alpha 2 constant heavy chain of IgA interacts with antigens, facilitating their presentation to T cells and activation of the adaptive immune response. 3. **Complement activation**: IGHA2 is involved in the activation of the complement system, which enhances the removal of pathogens and debris from tissues. 4. **Cell surface interactions**: The alpha 2 constant heavy chain of IgA interacts with other immune cells, such as dendritic cells and neutrophils, to coordinate immune responses. **Pathways and Functions** IGHA2 is involved in several key pathways and functions that highlight its importance in the immune system: 1. **Adaptive immune response**: IGHA2 plays a crucial role in the adaptive immune response, including antigen presentation, activation of T cells, and production of cytokines. 2. **Antibacterial humoral response**: The alpha 2 constant heavy chain of IgA is essential for the production of IgA antibodies, which provide protection against bacterial infections. 3. **Antigen binding and uptake**: IGHA2 facilitates the binding of antigens to IgA molecules, which are then taken up by immune cells for processing and presentation. 4. **Scavenging of heme**: The alpha 2 constant heavy chain of IgA is involved in the scavenging of heme from plasma, which is essential for maintaining iron homeostasis. **Clinical Significance** Dysregulation of the IGHA2 gene has been implicated in various diseases, including: 1. **Immunodeficiency disorders**: IGHA2 mutations have been associated with immunodeficiency disorders, such as selective IgA deficiency. 2. **Autoimmune diseases**: Dysregulation of IgA production and function has been implicated in autoimmune diseases, such as rheumatoid arthritis and lupus. 3. **Cancer**: The alpha 2 constant heavy chain of IgA has been implicated in the development and progression of certain cancers, such as colorectal cancer. 4. **Infectious diseases**: IGHA2 is essential for the production of IgA antibodies, which provide protection against bacterial and viral infections. In conclusion, the IGHA2 gene plays a vital role in the immune system, and its dysregulation has significant clinical implications. Further research is necessary to fully understand the mechanisms by which IGHA2 influences the immune response and to develop effective therapeutic strategies for diseases associated with IGHA2 dysfunction.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.