Gene IGHA2 - ENSG00000211890 | NCBI Gene ID: 3494

Details for: IGHA2

Gene ID: 3494

Symbol: IGHA2

Ensembl ID: ENSG00000211890

Description: immunoglobulin heavy constant alpha 2 (A2m marker)

Associated with

Binding and uptake of ligands by scavenger receptors
(R-HSA-2173782)
Cell surface interactions at the vascular wall
(R-HSA-202733)
Hemostasis
(R-HSA-109582)
Scavenging of heme from plasma
(R-HSA-2168880)
Vesicle-mediated transport
(R-HSA-5653656)
Adaptive immune response
(GO:0002250)
Antibacterial humoral response
(GO:0019731)
Antigen binding
(GO:0003823)
B cell receptor signaling pathway
(GO:0050853)
Blood microparticle
(GO:0072562)
Complement activation, classical pathway
(GO:0006958)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Glomerular filtration
(GO:0003094)
Iga immunoglobulin complex
(GO:0071745)
Immune response
(GO:0006955)
Immunoglobulin complex, circulating
(GO:0042571)
Immunoglobulin receptor binding
(GO:0034987)
Monomeric iga immunoglobulin complex
(GO:0071748)
Plasma membrane
(GO:0005886)
Positive regulation of respiratory burst
(GO:0060267)
Secretory dimeric iga immunoglobulin complex
(GO:0071752)
Secretory iga immunoglobulin complex
(GO:0071751)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: IgA plasma cell (CL0000987)
Fold Change: 5.18
Marker Score: 4413
Cell Name: IgA plasmablast (CL0000984)
Fold Change: 3.27
Marker Score: 858
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.33
Marker Score: 842
Cell Name: type G enteroendocrine cell (CL0000508)
Fold Change: 1.28
Marker Score: 440
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.22
Marker Score: 828
Cell Name: hematopoietic cell (CL0000988)
Fold Change: 1.17
Marker Score: 780
Cell Name: goblet cell (CL0000160)
Fold Change: 1.12
Marker Score: 7446
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.11
Marker Score: 806
Cell Name: plasmacytoid dendritic cell, human (CL0001058)
Fold Change: 1.08
Marker Score: 283
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 1.04
Marker Score: 6623
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 1.04
Marker Score: 251753
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 1.01
Marker Score: 771
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30404
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.96
Marker Score: 493
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2409
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.94
Marker Score: 446
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.91
Marker Score: 5211
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2735
Cell Name: T-helper 1 cell (CL0000545)
Fold Change: 0.9
Marker Score: 350
Cell Name: mucous neck cell (CL0000651)
Fold Change: 0.89
Marker Score: 2013
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.88
Marker Score: 316
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5281
Cell Name: duct epithelial cell (CL0000068)
Fold Change: 0.82
Marker Score: 384
Cell Name: memory B cell (CL0000787)
Fold Change: 0.8
Marker Score: 606
Cell Name: IgG memory B cell (CL0000979)
Fold Change: 0.79
Marker Score: 474
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1268
Cell Name: brush cell (CL0002204)
Fold Change: 0.76
Marker Score: 692
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.76
Marker Score: 303
Cell Name: enteroendocrine cell (CL0000164)
Fold Change: 0.74
Marker Score: 384
Cell Name: plasmablast (CL0000980)
Fold Change: 0.7
Marker Score: 934.5
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.69
Marker Score: 176
Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
Fold Change: 0.67
Marker Score: 151
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.66
Marker Score: 2767
Cell Name: germinal center B cell (CL0000844)
Fold Change: 0.65
Marker Score: 395
Cell Name: enterocyte (CL0000584)
Fold Change: 0.64
Marker Score: 3079
Cell Name: class switched memory B cell (CL0000972)
Fold Change: 0.61
Marker Score: 569
Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
Fold Change: 0.59
Marker Score: 457
Cell Name: IgG plasma cell (CL0000985)
Fold Change: 0.57
Marker Score: 247
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.56
Marker Score: 360.5
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.55
Marker Score: 147
Cell Name: colon macrophage (CL0009038)
Fold Change: 0.55
Marker Score: 153
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.55
Marker Score: 442
Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: 0.55
Marker Score: 207
Cell Name: memory T cell (CL0000813)
Fold Change: 0.54
Marker Score: 234
Cell Name: T-helper 17 cell (CL0000899)
Fold Change: 0.54
Marker Score: 352
Cell Name: fibroblast (CL0000057)
Fold Change: 0.5
Marker Score: 485
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.49
Marker Score: 279
Cell Name: IgM plasma cell (CL0000986)
Fold Change: 0.48
Marker Score: 167
Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: 0.47
Marker Score: 1219
Cell Name: stem cell (CL0000034)
Fold Change: 0.46
Marker Score: 1096
Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
Fold Change: 0.46
Marker Score: 331
Cell Name: follicular B cell (CL0000843)
Fold Change: 0.45
Marker Score: 493
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 0.45
Marker Score: 1273
Cell Name: innate lymphoid cell (CL0001065)
Fold Change: 0.45
Marker Score: 162
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.45
Marker Score: 1018
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.44
Marker Score: 204
Cell Name: mast cell (CL0000097)
Fold Change: 0.42
Marker Score: 246
Cell Name: plasma cell (CL0000786)
Fold Change: 0.42
Marker Score: 472
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.4
Marker Score: 167
Cell Name: peptic cell (CL0000155)
Fold Change: 0.4
Marker Score: 168
Cell Name: exhausted T cell (CL0011025)
Fold Change: 0.38
Marker Score: 221
Cell Name: B cell (CL0000236)
Fold Change: 0.38
Marker Score: 365
Cell Name: T cell (CL0000084)
Fold Change: 0.38
Marker Score: 660
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.37
Marker Score: 359
Cell Name: natural T-regulatory cell (CL0000903)
Fold Change: 0.37
Marker Score: 188
Cell Name: leukocyte (CL0000738)
Fold Change: 0.36
Marker Score: 209
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.36
Marker Score: 361
Cell Name: B-1b B cell (CL0000821)
Fold Change: 0.35
Marker Score: 80
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.35
Marker Score: 145
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.34
Marker Score: 228
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.34
Marker Score: 109
Cell Name: intestine goblet cell (CL0019031)
Fold Change: 0.34
Marker Score: 326
Cell Name: glandular cell of esophagus (CL0002657)
Fold Change: 0.33
Marker Score: 105
Cell Name: B-1a B cell (CL0000820)
Fold Change: 0.33
Marker Score: 78
Cell Name: classical monocyte (CL0000860)
Fold Change: 0.32
Marker Score: 1349
Cell Name: late promyelocyte (CL0002151)
Fold Change: 0.32
Marker Score: 80
Cell Name: keratocyte (CL0002363)
Fold Change: 0.31
Marker Score: 72
Cell Name: IgG plasmablast (CL0000982)
Fold Change: 0.31
Marker Score: 85
Cell Name: ILC1, human (CL0001077)
Fold Change: 0.31
Marker Score: 78
Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 0.31
Marker Score: 78
Cell Name: professional antigen presenting cell (CL0000145)
Fold Change: 0.3
Marker Score: 157
Cell Name: blood vessel smooth muscle cell (CL0019018)
Fold Change: 0.3
Marker Score: 79
Cell Name: oocyte (CL0000023)
Fold Change: 0.3
Marker Score: 74
Cell Name: alpha-beta T cell (CL0000789)
Fold Change: 0.3
Marker Score: 225
Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
Fold Change: 0.3
Marker Score: 217
Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
Fold Change: 0.29
Marker Score: 66
Cell Name: type L enteroendocrine cell (CL0002279)
Fold Change: 0.29
Marker Score: 79
Cell Name: large intestine goblet cell (CL1000320)
Fold Change: 0.29
Marker Score: 76
Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: 0.28
Marker Score: 68
Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
Fold Change: 0.28
Marker Score: 456
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.28
Marker Score: 69
Cell Name: gamma-delta T cell (CL0000798)
Fold Change: 0.28
Marker Score: 187
Cell Name: male germ cell (CL0000015)
Fold Change: 0.28
Marker Score: 80
Cell Name: mononuclear phagocyte (CL0000113)
Fold Change: 0.27
Marker Score: 276
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 0.27
Marker Score: 858
Cell Name: tracheobronchial smooth muscle cell (CL0019019)
Fold Change: 0.27
Marker Score: 80
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.27
Marker Score: 65
Cell Name: naive B cell (CL0000788)
Fold Change: 0.27
Marker Score: 242
Cell Name: enterocyte of colon (CL1000347)
Fold Change: 0.27
Marker Score: 413
Cell Name: endothelial cell of artery (CL1000413)
Fold Change: 0.27
Marker Score: 110

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Other Information

Description

**Key characteristics:** - The IGHA2 gene is located on chromosome 15q21.1. - It is a single copy gene. - It is expressed in a variety of cell types, including plasma cells, plasmablasts, granulocyte monocyte progenitor cells, type G enteroendocrine cells, intestinal crypt stem cells, hematopoietic cells, goblet cells, colon goblet cells, plasmacytoid dendritic cells, and human cells. - The protein encoded by IGHA2 is a transmembrane protein that is expressed on the cell surface. - The protein is a member of the immunoglobulin superfamily. - It is involved in the regulation of the immune response. **Pathways and functions:** - The IGHA2 gene is involved in the adaptive immune response. The protein encoded by IGHA2 is expressed on the surface of plasma cells, plasmablasts, and other immune cells. These cells are responsible for the recognition and binding of antigens, which triggers the adaptive immune response. - The IGHA2 gene is also involved in the antibacterial humoral response. The protein encoded by IGHA2 is expressed on the surface of plasma cells and is involved in the binding of antibodies to antigens. This binding helps to neutralize pathogens and protect the body from infection. - The IGHA2 gene is also involved in antigen binding. The protein encoded by IGHA2 is expressed on the surface of antigen-presenting cells, such as macrophages and dendritic cells. This allows these cells to recognize and bind to antigens, which then triggers the adaptive immune response. **Clinical significance:** - Mutations in the IGHA2 gene have been linked to a number of human diseases, including systemic lupus, rheumatoid arthritis, and inflammatory bowel disease. - In these diseases, the IGHA2 gene is often mutated in a way that results in the production of a non-functional protein. This leads to the activation of the immune system, which can damage tissue and organs.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.