Details for: ITGAD

Gene ID: 3681

Symbol: ITGAD

Ensembl ID: ENSG00000156886

Description: integrin subunit alpha D

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.17
    Marker Score: 5996
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.47
    Marker Score: 3685
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.14
    Marker Score: 7570
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.01
    Marker Score: 2570
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71830
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48055
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.99
    Marker Score: 625
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5357
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.9
    Marker Score: 273
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5292
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.85
    Marker Score: 13227
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1268
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 709
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.73
    Marker Score: 554
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.71
    Marker Score: 1444
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.56
    Marker Score: 236
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.54
    Marker Score: 322
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.52
    Marker Score: 343
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 277
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 0.46
    Marker Score: 150
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.45
    Marker Score: 356
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.45
    Marker Score: 855
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.43
    Marker Score: 5689
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.4
    Marker Score: 404
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.32
    Marker Score: 102
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.31
    Marker Score: 82
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.3
    Marker Score: 154
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.29
    Marker Score: 129
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.28
    Marker Score: 589.5
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.23
    Marker Score: 235
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.19
    Marker Score: 110
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.19
    Marker Score: 92
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.19
    Marker Score: 76
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.17
    Marker Score: 216
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.16
    Marker Score: 86
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.16
    Marker Score: 77
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.15
    Marker Score: 174
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.15
    Marker Score: 85
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.14
    Marker Score: 3220
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.14
    Marker Score: 109
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.14
    Marker Score: 251
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.13
    Marker Score: 129
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.12
    Marker Score: 69
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.12
    Marker Score: 52
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.11
    Marker Score: 62
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: 0.1
    Marker Score: 34
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.1
    Marker Score: 32
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.1
    Marker Score: 101
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.1
    Marker Score: 33
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.09
    Marker Score: 150
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.09
    Marker Score: 160
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.09
    Marker Score: 47
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.09
    Marker Score: 76
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 0.09
    Marker Score: 28
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.08
    Marker Score: 122
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.08
    Marker Score: 50
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.08
    Marker Score: 146
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.08
    Marker Score: 56
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.08
    Marker Score: 62
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.08
    Marker Score: 70
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.08
    Marker Score: 20
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.08
    Marker Score: 181
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.08
    Marker Score: 41
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.08
    Marker Score: 73
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.08
    Marker Score: 44
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.07
    Marker Score: 19
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.07
    Marker Score: 82
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.07
    Marker Score: 62.5
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.07
    Marker Score: 20
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.07
    Marker Score: 95
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.07
    Marker Score: 63
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.07
    Marker Score: 252
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.07
    Marker Score: 22
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.07
    Marker Score: 75
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.07
    Marker Score: 24
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.06
    Marker Score: 17
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.06
    Marker Score: 183
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.06
    Marker Score: 90
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.06
    Marker Score: 20
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.06
    Marker Score: 51
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.06
    Marker Score: 19
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.06
    Marker Score: 22
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.06
    Marker Score: 13
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.06
    Marker Score: 27
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 0.06
    Marker Score: 14
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.06
    Marker Score: 18
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.06
    Marker Score: 39
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.06
    Marker Score: 35
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.06
    Marker Score: 19
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.05
    Marker Score: 16
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.05
    Marker Score: 20
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.05
    Marker Score: 88
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.05
    Marker Score: 52

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Other Information

**Key characteristics:** - ITGAD is a single-pass transmembrane protein with a molecular weight of approximately 120 kDa. - It is a member of the immunoglobulin superfamily and belongs to the integrin family of cell adhesion molecules. - ITGAD is a key molecule in cell adhesion, mediating cell-cell interactions through its interaction with other integrins, cadherins, and other extracellular matrix proteins. - It is also involved in cell migration, cell signaling, and immune responses. **Pathways and functions:** - ITGAD is primarily expressed on the cell surface and is involved in cell-cell adhesion. - It forms homodimers to form the ITGA1-ITGA1 complex, which is crucial for cell adhesion and migration. - ITGAD also interacts with other integrins, such as ITGA2 and ITGA5, to form higher-order complexes that stabilize cell-cell adhesion junctions. - In addition to its role in cell adhesion, ITGAD is also involved in cell migration, cell signaling, and immune responses. - ITGAD is expressed in various cell types, including epithelial cells, immune cells, and cancer cells. - In epithelial cells, ITGAD is involved in cell-cell adhesion, epithelial cell migration, and tissue morphogenesis. - In immune cells, ITGAD is expressed on lymphocytes and is involved in cell adhesion, migration, and immune responses. - In cancer cells, ITGAD is often overexpressed and is a key molecule in cancer cell migration, invasion, and metastasis. **Clinical significance:** - Mutations in the ITGAD gene have been linked to several human diseases, including cancer, autoimmune disorders, and developmental disorders. - ITGAD inhibitors are being investigated as potential treatments for cancer and autoimmune disorders. - Understanding the role of ITGAD in cell adhesion and signaling pathways is important for developing new therapeutic strategies for cancer and other diseases that are characterized by abnormal cell adhesion.

Genular Protein ID: 920222534

Symbol: ITAD_HUMAN

Name: Integrin alpha-D

UniProtKB Accession Codes:

Q13349 Q15575 Q15576

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 11 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 1 GO 12 Gene3D 6 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 3 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 6 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 2 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8777714

Title: A novel leukointegrin, alpha d beta 2, binds preferentially to ICAM-3.

PubMed ID: 8777714

DOI: 10.1016/1074-7613(95)90058-6

PubMed ID: 10722744

Title: Structural and functional characterization of the leukocyte integrin gene CD11d. Essential role of Sp1 and Sp3.

PubMed ID: 10722744

DOI: 10.1074/jbc.275.12.8959

PubMed ID: 8666289

Title: Cloning and chromosomal localization of a novel gene-encoding a human beta 2-integrin alpha subunit.

PubMed ID: 8666289

DOI: 10.1016/0378-1119(95)00869-1

PubMed ID: 9841932

Title: Alphadbeta2 integrin is expressed on human eosinophils and functions as an alternative ligand for vascular cell adhesion molecule 1 (VCAM-1).

PubMed ID: 9841932

DOI: 10.1084/jem.188.11.2187

PubMed ID: 10438935

Title: The leukocyte integrin alpha D beta 2 binds VCAM-1: evidence for a binding interface between I domain and VCAM-1.

PubMed ID: 10438935

Sequence Information:

  • Length: 1161
  • Mass: 126758
  • Checksum: 769D658010CE5823
  • Sequence:
    • MTFGTVLLLS VLASYHGFNL DVEEPTIFQE DAGGFGQSVV QFGGSRLVVG APLEVVAANQ 
TGRLYDCAAA TGMCQPIPLH IRPEAVNMSL GLTLAASTNG SRLLACGPTL HRVCGENSYS 
KGSCLLLGSR WEIIQTVPDA TPECPHQEMD IVFLIDGSGS IDQNDFNQMK GFVQAVMGQF 
EGTDTLFALM QYSNLLKIHF TFTQFRTSPS QQSLVDPIVQ LKGLTFTATG ILTVVTQLFH 
HKNGARKSAK KILIVITDGQ KYKDPLEYSD VIPQAEKAGI IRYAIGVGHA FQGPTARQEL 
NTISSAPPQD HVFKVDNFAA LGSIQKQLQE KIYAVEGTQS RASSSFQHEM SQEGFSTALT 
MDGLFLGAVG SFSWSGGAFL YPPNMSPTFI NMSQENVDMR DSYLGYSTEL ALWKGVQNLV 
LGAPRYQHTG KAVIFTQVSR QWRKKAEVTG TQIGSYFGAS LCSVDVDSDG STDLILIGAP 
HYYEQTRGGQ VSVCPLPRGR VQWQCDAVLR GEQGHPWGRF GAALTVLGDV NEDKLIDVAI 
GAPGEQENRG AVYLFHGASE SGISPSHSQR IASSQLSPRL QYFGQALSGG QDLTQDGLMD 
LAVGARGQVL LLRSLPVLKV GVAMRFSPVE VAKAVYRCWE EKPSALEAGD ATVCLTIQKS 
SLDQLGDIQS SVRFDLALDP GRLTSRAIFN ETKNPTLTRR KTLGLGIHCE TLKLLLPDCV 
EDVVSPIILH LNFSLVREPI PSPQNLRPVL AVGSQDLFTA SLPFEKNCGQ DGLCEGDLGV 
TLSFSGLQTL TVGSSLELNV IVTVWNAGED SYGTVVSLYY PAGLSHRRVS GAQKQPHQSA 
LRLACETVPT EDEGLRSSRC SVNHPIFHEG SNGTFIVTFD VSYKATLGDR MLMRASASSE 
NNKASSSKAT FQLELPVKYA VYTMISRQEE STKYFNFATS DEKKMKEAEH RYRVNNLSQR 
DLAISINFWV PVLLNGVAVW DVVMEAPSQS LPCVSERKPP QHSDFLTQIS RSPMLDCSIA 
DCLQFRCDVP SFSVQEELDF TLKGNLSFGW VRETLQKKVL VVSVAEITFD TSVYSQLPGQ 
EAFMRAQMEM VLEEDEVYNA IPIIMGSSVG ALLLLALITA TLYKLGFFKR HYKEMLEDKP 
EDTATFSGDD FSCVAPNVPL S

Genular Protein ID: 1221976221

Symbol: Q59H14_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59H14

Database IDs:

ARBA 14 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 4 Gene3D 6 Genevisible 1 GenomeRNAi 1 InterPro 11 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 4 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 6 PharmGKB 1 PhylomeDB 1 RefSeq 2 RuleBase 1 SMART 2 SUPFAM 3

Sequence Information:

  • Length: 1177
  • Mass: 128451
  • Checksum: A7BBC68CE26B49C3
  • Sequence:
    • CALSPTFHFP STRCSGMTFG TVLLLSVLAS YHGFNLDVEE PTIFQEDAGG FGQSVVQFGG 
SRLVVGAPLE VVAANQTGRL YDCAAATGMC QPIPLHIRPE AVNMSLGLTL AASTNGSRLL 
ACGPTLHRVC GENSYSKGSC LLLGSRWEII QTVPDATPEC PHQEMDIVFL IDGSGSIDQN 
DFNQMKGFVQ AVMGQFEGTD TLFALMQYSN LLKIHFTFTQ FRTSPSQQSL VDPIVQLKGL 
TFTATGILTV VTQLFHHKNG ARKSAKKILI VITDGQKYKD PLEYSDVIPQ AEKAGIIRYA 
IGVGHAFQGP TARQELNTIS SAPPQDHVFK VDNFAALGSI QKQLQEKIYA VEGTQSRASS 
SFQHEMSQEG FSTALTMDGL FLGAVGSFSW SGGAFLYPPN MSPTFINMSQ ENVDMRDSYL 
GYSTELALWK GVQNLVLGAP RYQHTGKAVI FTQVSRQWRK KAEVTGTQIG SYFGASLCSV 
DVDSDGSTDL ILIGAPHYYE QTRGGQVSVC PLPRGRVQWQ CDAVLRGEQG HPWGRFGAAL 
TVLGDVNEDK LIDVAIGAPG EQENRGAVYL FHGASESGIS PSHSQRIASS QLSPRLQYFG 
QALSGGQDLT QDGLMDLAVG ARGQVLLLRS LPVLKVGVAM RFSPVEVAKA VYRCWEEKPS 
ALEAGDATVC LTIQKSSLDQ LGDIQSSVRF DLALDPGRLT SRAIFNETKN PTLTRRKTLG 
LGIHCETLKL LLPDCVEDVV SPIILHLNFS LVREPIPSPQ NLRPVLAVGS QDLFTASLPF 
EKNCGQDGLC EGDLGVTLSF SGLQTLTVGS SLELNVIVTV WNAGEDSYGT VVSLYYPAGL 
SHRRVSGAQK QPHQSALRLA CETVPTEDEG LRSSRCSVNH PIFHEGSNGT FIVTFDVSYK 
ATLGDRMLMR ASASSENNKA SSSKATFQLE LPVKYAVYTM ISRQEESTKY FNFATSDEKK 
MKEAEHRYRV NNLSQRDLAI SINFWVPVLL NGVAVWDVVM EAPSQSLPCV SERKPPQHSD 
FLTQISRSPM LDCSIADCLQ FRCDVPSFSV QEELDFTLKG NLSFGWVRET LQKKVLVVSV 
AEITFDTSVY SQLPGQEAFM RAQMEMVLEE DEVYNAIPII MGSSVGALLL LALITATLYK 
LGFFKRHYKE MLEDKPEDTA TFSGDDFSCV APNVPLS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.