Details for: KCNA7

Gene ID: 3743

Symbol: KCNA7

Ensembl ID: ENSG00000104848

Description: potassium voltage-gated channel subfamily A member 7

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 2.8543
    Cell Significance Index: 28.1600
  • Cell Name: pancreatic epsilon cell (CL0005019)
    Fold Change: 1.4970
    Cell Significance Index: 13.8700
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.6168
    Cell Significance Index: 8.9900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 0.3484
    Cell Significance Index: -1.0700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.2896
    Cell Significance Index: 180.8500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.2181
    Cell Significance Index: 13.3700
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 0.1556
    Cell Significance Index: 2.5100
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.1485
    Cell Significance Index: 1.7100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.1393
    Cell Significance Index: 3.5800
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.1311
    Cell Significance Index: 2.0800
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.1037
    Cell Significance Index: 1.3400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.1009
    Cell Significance Index: 11.5200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0947
    Cell Significance Index: 4.9200
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.0932
    Cell Significance Index: 1.0000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.0926
    Cell Significance Index: 2.2600
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.0853
    Cell Significance Index: 0.9000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0688
    Cell Significance Index: 6.8100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0525
    Cell Significance Index: 10.0000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0482
    Cell Significance Index: 3.0400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0461
    Cell Significance Index: 2.0900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0432
    Cell Significance Index: 39.0200
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.0414
    Cell Significance Index: 0.5300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0399
    Cell Significance Index: 1.1500
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.0335
    Cell Significance Index: 0.3100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0316
    Cell Significance Index: 5.1400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0263
    Cell Significance Index: 2.0200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0227
    Cell Significance Index: 0.3100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0222
    Cell Significance Index: 0.4800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0112
    Cell Significance Index: 0.2800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0107
    Cell Significance Index: 1.9300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0081
    Cell Significance Index: 1.0400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0071
    Cell Significance Index: 0.7800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0067
    Cell Significance Index: 0.1400
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.0047
    Cell Significance Index: 0.0500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0039
    Cell Significance Index: 6.0100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0030
    Cell Significance Index: 1.0700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0023
    Cell Significance Index: 4.3900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0022
    Cell Significance Index: 0.4500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0013
    Cell Significance Index: 0.0400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0004
    Cell Significance Index: 0.8200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0002
    Cell Significance Index: 0.0200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0004
    Cell Significance Index: -0.5400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0006
    Cell Significance Index: -0.0200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0006
    Cell Significance Index: -0.4200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0007
    Cell Significance Index: -0.3700
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.0008
    Cell Significance Index: -0.0100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0010
    Cell Significance Index: -0.1200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0010
    Cell Significance Index: -0.0500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0016
    Cell Significance Index: -0.3400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0020
    Cell Significance Index: -1.2400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0020
    Cell Significance Index: -1.5400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0021
    Cell Significance Index: -1.5400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0022
    Cell Significance Index: -0.3700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0022
    Cell Significance Index: -1.1900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0025
    Cell Significance Index: -0.7300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0034
    Cell Significance Index: -1.5400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0043
    Cell Significance Index: -0.8500
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.0043
    Cell Significance Index: -0.0600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0047
    Cell Significance Index: -0.6800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0056
    Cell Significance Index: -0.2500
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.0059
    Cell Significance Index: -0.0500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0062
    Cell Significance Index: -0.2000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0066
    Cell Significance Index: -0.8100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0067
    Cell Significance Index: -0.4600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0071
    Cell Significance Index: -0.1900
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0073
    Cell Significance Index: -0.0400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0079
    Cell Significance Index: -0.3700
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0087
    Cell Significance Index: -0.1300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0094
    Cell Significance Index: -0.9700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0094
    Cell Significance Index: -1.2100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0100
    Cell Significance Index: -1.3700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0108
    Cell Significance Index: -0.2700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0158
    Cell Significance Index: -1.0200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0159
    Cell Significance Index: -1.6600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0159
    Cell Significance Index: -1.8700
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.0165
    Cell Significance Index: -0.1300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0172
    Cell Significance Index: -0.2900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0184
    Cell Significance Index: -1.3700
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0185
    Cell Significance Index: -0.2600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0219
    Cell Significance Index: -1.4700
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0220
    Cell Significance Index: -0.3800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0225
    Cell Significance Index: -1.1800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0225
    Cell Significance Index: -0.6300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0234
    Cell Significance Index: -1.4400
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.0259
    Cell Significance Index: -0.1600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0262
    Cell Significance Index: -1.2300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0275
    Cell Significance Index: -1.6500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0286
    Cell Significance Index: -0.4100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0299
    Cell Significance Index: -0.8000
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0300
    Cell Significance Index: -0.4600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0328
    Cell Significance Index: -1.3500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0339
    Cell Significance Index: -1.9000
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0366
    Cell Significance Index: -0.7500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0385
    Cell Significance Index: -1.3500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0390
    Cell Significance Index: -1.1500
  • Cell Name: eosinophil (CL0000771)
    Fold Change: -0.0395
    Cell Significance Index: -0.3500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0397
    Cell Significance Index: -1.3800
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0398
    Cell Significance Index: -0.5200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0406
    Cell Significance Index: -1.3300
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0406
    Cell Significance Index: -0.5900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Channel Subunit:** KCNA7 is a pore-forming subunit of the voltage-gated potassium channel, which assembles with other subunits to form functional channels. 2. **Delayed Rectifier Potassium Channel:** KCNA7 is a key component of delayed rectifier potassium channels, which are responsible for regulating the resting membrane potential and repolarizing the action potential. 3. **High Expression in Neuronal and Intestinal Cells:** KCNA7 is highly expressed in various cell types, including cerebral cortex GABAergic interneurons, forebrain radial glial cells, and intestinal epithelial cells, highlighting its widespread importance in cellular function. 4. **Protein Homooligomerization:** KCNA7 can form homooligomers with itself, which is essential for the assembly and function of voltage-gated potassium channels. **Pathways and Functions:** 1. **Voltage-Gated Potassium Channel Activity:** KCNA7 is involved in the assembly and function of voltage-gated potassium channels, which regulate membrane excitability and maintain proper ion balance across cell membranes. 2. **Neuronal System:** KCNA7 plays a crucial role in the development and function of the nervous system, particularly in regulating the excitability of GABAergic interneurons. 3. **Intestinal Epithelium:** KCNA7 is highly expressed in intestinal epithelial cells, where it regulates the secretion of potassium ions and maintains proper ion balance across the epithelium. 4. **Immune Cell Development:** KCNA7 is also involved in the development and function of immune cells, including granulocyte monocyte progenitor cells and early T lineage precursors. **Clinical Significance:** 1. **Neurological Disorders:** Mutations in KCNA7 have been linked to various neurological disorders, including epilepsy, ataxia, and schizophrenia. 2. **Intestinal Diseases:** KCNA7 dysfunction has been implicated in intestinal diseases, such as inflammatory bowel disease and irritable bowel syndrome. 3. **Immune System Dysregulation:** KCNA7 plays a crucial role in the development and function of immune cells, and its dysfunction has been linked to immune system dysregulation and autoimmune diseases. 4. **Cancer:** KCNA7 has been implicated in the development and progression of various cancers, including colorectal cancer, where it regulates cell growth and proliferation. In conclusion, KCNA7 is a critical component of voltage-gated potassium channels, playing a pivotal role in regulating membrane excitability, maintaining proper ion balance, and developing and functioning various tissues. Its dysfunction has been linked to various diseases, highlighting the importance of understanding the molecular mechanisms underlying KCNA7 function and its clinical significance.

Genular Protein ID: 4268812416

Symbol: KCNA7_HUMAN

Name: Potassium voltage-gated channel subfamily A member 7

UniProtKB Accession Codes:

Q96RP8 A1KYX7 Q9BYS4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EMBL 3 Ensembl 1 GO 7 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 3 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 11368907

Title: Initial isolation and analysis of the human Kv1.7 (KCNA7) gene, a member of the voltage-gated potassium channel gene family.

PubMed ID: 11368907

DOI: 10.1016/s0378-1119(01)00423-1

PubMed ID: 11896454

Title: Characterisation of the human voltage-gated potassium channel gene, KCNA7, a candidate gene for inherited cardiac disorders, and its exclusion as cause of progressive familial heart block I (PFHBI).

PubMed ID: 11896454

DOI: 10.1038/sj.ejhg.5200739

Sequence Information:

  • Length: 456
  • Mass: 50559
  • Checksum: EF9980CF54D52FB8
  • Sequence:
    • MEPRCPPPCG CCERLVLNVA GLRFETRART LGRFPDTLLG DPARRGRFYD DARREYFFDR 
HRPSFDAVLY YYQSGGRLRR PAHVPLDVFL EEVAFYGLGA AALARLREDE GCPVPPERPL 
PRRAFARQLW LLFEFPESSQ AARVLAVVSV LVILVSIVVF CLETLPDFRD DRDGTGLAAA 
AAAGPFPAPL NGSSQMPGNP PRLPFNDPFF VVETLCICWF SFELLVRLLV CPSKAIFFKN 
VMNLIDFVAI LPYFVALGTE LARQRGVGQQ AMSLAILRVI RLVRVFRIFK LSRHSKGLQI 
LGQTLRASMR ELGLLIFFLF IGVVLFSSAV YFAEVDRVDS HFTSIPESFW WAVVTMTTVG 
YGDMAPVTVG GKIVGSLCAI AGVLTISLPV PVIVSNFSYF YHRETEGEEA GMFSHVDMQP 
CGPLEGKANG GLVDGEVPEL PPPLWAPPGK HLVTEV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.