Details for: KCNA7

Gene ID: 3743

Symbol: KCNA7

Ensembl ID: ENSG00000104848

Description: potassium voltage-gated channel subfamily A member 7

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.62
    Marker Score: 1176
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 875
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 860
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.18
    Marker Score: 490
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4825
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.05
    Marker Score: 801
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71838
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48063
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 512
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 465
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 376
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5345
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 328
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5291
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.8
    Marker Score: 370
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1268
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 711
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 399
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 465
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.57
    Marker Score: 454
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 174
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.43
    Marker Score: 6658
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.3
    Marker Score: 299
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.27
    Marker Score: 515
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.27
    Marker Score: 150
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.26
    Marker Score: 90
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.22
    Marker Score: 57
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.19
    Marker Score: 383
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.17
    Marker Score: 131
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.15
    Marker Score: 170
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.15
    Marker Score: 62
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.14
    Marker Score: 288
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.14
    Marker Score: 60
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.13
    Marker Score: 74
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.13
    Marker Score: 141
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.12
    Marker Score: 63
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.12
    Marker Score: 57
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.12
    Marker Score: 789
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.11
    Marker Score: 51
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.11
    Marker Score: 68
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.1
    Marker Score: 61
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.1
    Marker Score: 61
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.1
    Marker Score: 63
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.08
    Marker Score: 164
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.08
    Marker Score: 4435
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.08
    Marker Score: 139
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.08
    Marker Score: 35
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.08
    Marker Score: 24
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.07
    Marker Score: 89
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.07
    Marker Score: 67
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.07
    Marker Score: 31
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.07
    Marker Score: 30
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.07
    Marker Score: 3555
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.07
    Marker Score: 66
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.06
    Marker Score: 22
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.06
    Marker Score: 44
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.06
    Marker Score: 77
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.06
    Marker Score: 68
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.06
    Marker Score: 12
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.06
    Marker Score: 28
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.06
    Marker Score: 59
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.06
    Marker Score: 149
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.06
    Marker Score: 12
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.06
    Marker Score: 57
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.06
    Marker Score: 14
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.06
    Marker Score: 17
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.06
    Marker Score: 72
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.06
    Marker Score: 101
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.05
    Marker Score: 41
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.05
    Marker Score: 12
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.05
    Marker Score: 222
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.05
    Marker Score: 53
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.05
    Marker Score: 28
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.05
    Marker Score: 37
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.05
    Marker Score: 54
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.05
    Marker Score: 18
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.05
    Marker Score: 12
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.05
    Marker Score: 113
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.05
    Marker Score: 65
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.05
    Marker Score: 12
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.05
    Marker Score: 12
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.05
    Marker Score: 35
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.05
    Marker Score: 65
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.04
    Marker Score: 10
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.04
    Marker Score: 10
  • Cell Name: bronchial smooth muscle cell (CL0002598)
    Fold Change: 0.04
    Marker Score: 12
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.04
    Marker Score: 38
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.04
    Marker Score: 11
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.04
    Marker Score: 10
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.04
    Marker Score: 12
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.04
    Marker Score: 28
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.04
    Marker Score: 10
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 0.04
    Marker Score: 11

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Other Information

**Key characteristics** * KCNA7 is a pore-forming protein that is expressed in the plasma membrane. * It is a member of the potassium voltage-gated channel superfamily, which is responsible for the regulation of potassium ion flow across cell membranes. * KCNA7 is a tetramer, meaning it consists of four subunits that are held together by non-covalent interactions. * Each subunit of KCNA7 contains a pore-forming domain that is responsible for the ion channel. * When the pore is open, it allows potassium ions to flow down their concentration gradient, which helps to maintain the resting membrane potential of cells. **Pathways and functions** * KCNA7 is involved in a variety of cellular processes, including epithelial barrier function, neuronal excitability, and immune responses. * In epithelial cells, KCNA7 is expressed in the tight junctions that hold cells together and helps to maintain the integrity of the epithelial barrier. * In neurons, KCNA7 is expressed in the plasma membrane of neurons and is involved in the regulation of neuronal excitability. * In immune cells, KCNA7 is expressed on the surface of immune cells, such as macrophages and dendritic cells. * KCNA7 is involved in the regulation of inflammatory responses by controlling the flow of potassium ions into immune cells. **Clinical significance** Mutations in KCNA7 have been linked to a number of human diseases, including gastrointestinal disorders, neurological disorders, and cancer. These diseases are often caused by mutations in genes that are involved in potassium ion channel function. **Additional information** * The human gene for KCNA7 is located on chromosome 19p13.2. * The protein encoded by KCNA7 is a transmembrane protein that is expressed in the plasma membrane. * The pore-forming domain of KCNA7 is a transmembrane protein that is responsible for the ion channel. * KCNA7 is a highly conserved protein, with a similar protein being found in mammals, birds, and fish.

Genular Protein ID: 4268812416

Symbol: KCNA7_HUMAN

Name: Potassium voltage-gated channel subfamily A member 7

UniProtKB Accession Codes:

Q96RP8 A1KYX7 Q9BYS4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EMBL 3 Ensembl 1 GO 5 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 3 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 11368907

Title: Initial isolation and analysis of the human Kv1.7 (KCNA7) gene, a member of the voltage-gated potassium channel gene family.

PubMed ID: 11368907

DOI: 10.1016/s0378-1119(01)00423-1

PubMed ID: 11896454

Title: Characterisation of the human voltage-gated potassium channel gene, KCNA7, a candidate gene for inherited cardiac disorders, and its exclusion as cause of progressive familial heart block I (PFHBI).

PubMed ID: 11896454

DOI: 10.1038/sj.ejhg.5200739

Sequence Information:

  • Length: 456
  • Mass: 50559
  • Checksum: EF9980CF54D52FB8
  • Sequence:
    • MEPRCPPPCG CCERLVLNVA GLRFETRART LGRFPDTLLG DPARRGRFYD DARREYFFDR 
HRPSFDAVLY YYQSGGRLRR PAHVPLDVFL EEVAFYGLGA AALARLREDE GCPVPPERPL 
PRRAFARQLW LLFEFPESSQ AARVLAVVSV LVILVSIVVF CLETLPDFRD DRDGTGLAAA 
AAAGPFPAPL NGSSQMPGNP PRLPFNDPFF VVETLCICWF SFELLVRLLV CPSKAIFFKN 
VMNLIDFVAI LPYFVALGTE LARQRGVGQQ AMSLAILRVI RLVRVFRIFK LSRHSKGLQI 
LGQTLRASMR ELGLLIFFLF IGVVLFSSAV YFAEVDRVDS HFTSIPESFW WAVVTMTTVG 
YGDMAPVTVG GKIVGSLCAI AGVLTISLPV PVIVSNFSYF YHRETEGEEA GMFSHVDMQP 
CGPLEGKANG GLVDGEVPEL PPPLWAPPGK HLVTEV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.