Details for: KRT85

Gene ID: 3891

Symbol: KRT85

Ensembl ID: ENSG00000135443

Description: keratin 85

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 6.64
    Marker Score: 8213
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 3.72
    Marker Score: 6779
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.14
    Marker Score: 3157
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.98
    Marker Score: 2215
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.25
    Marker Score: 1194.5
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.18
    Marker Score: 380
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7693
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.11
    Marker Score: 649
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71691
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47939
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30404
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.94
    Marker Score: 1940.5
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5340
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.89
    Marker Score: 231
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5285
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.86
    Marker Score: 498
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.8
    Marker Score: 1302
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.78
    Marker Score: 405
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 713
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.75
    Marker Score: 1197
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.74
    Marker Score: 424.5
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.71
    Marker Score: 690
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.67
    Marker Score: 713
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.67
    Marker Score: 536
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.66
    Marker Score: 10250
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.64
    Marker Score: 353
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.61
    Marker Score: 365
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.6
    Marker Score: 1133
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.58
    Marker Score: 167
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.53
    Marker Score: 240
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.52
    Marker Score: 437
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.51
    Marker Score: 270
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.49
    Marker Score: 154
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.49
    Marker Score: 276
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.48
    Marker Score: 285
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.47
    Marker Score: 150
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.45
    Marker Score: 165
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.45
    Marker Score: 168
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.43
    Marker Score: 743
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.43
    Marker Score: 386
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.4
    Marker Score: 819
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.38
    Marker Score: 256
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.36
    Marker Score: 212.5
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.36
    Marker Score: 167
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.36
    Marker Score: 171
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.35
    Marker Score: 142
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.33
    Marker Score: 389
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.33
    Marker Score: 218
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.32
    Marker Score: 1949
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.31
    Marker Score: 165
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.29
    Marker Score: 166
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.28
    Marker Score: 148
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.28
    Marker Score: 169
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.26
    Marker Score: 163
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.25
    Marker Score: 169
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.25
    Marker Score: 589.5
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.24
    Marker Score: 1568
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.23
    Marker Score: 170
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.23
    Marker Score: 255
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.23
    Marker Score: 606.5
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.21
    Marker Score: 94
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.21
    Marker Score: 139
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.21
    Marker Score: 159
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.21
    Marker Score: 159
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.21
    Marker Score: 86
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.2
    Marker Score: 171
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.17
    Marker Score: 305
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.16
    Marker Score: 173
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.16
    Marker Score: 208
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.15
    Marker Score: 252
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.15
    Marker Score: 256
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.13
    Marker Score: 169
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.12
    Marker Score: 170
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.12
    Marker Score: 171
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.12
    Marker Score: 361.5
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.11
    Marker Score: 256
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.11
    Marker Score: 160
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.11
    Marker Score: 109
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.1
    Marker Score: 145
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.1
    Marker Score: 171
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.09
    Marker Score: 170
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.08
    Marker Score: 138
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.08
    Marker Score: 290
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.08
    Marker Score: 171
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.07
    Marker Score: 255
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.07
    Marker Score: 165
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.07
    Marker Score: 117
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.06
    Marker Score: 642
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.06
    Marker Score: 255
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.06
    Marker Score: 167
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.05
    Marker Score: 81
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.04
    Marker Score: 119
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.04
    Marker Score: 171
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.03
    Marker Score: 167
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.03
    Marker Score: 103
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.02
    Marker Score: 107
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.01
    Marker Score: 149
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.01
    Marker Score: 170

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Other Information

**Key characteristics:** * KRT85 is a keratin protein that is involved in the formation of the cornified envelope, a protective barrier that covers the surface of mammalian cells. * It is a transmembrane protein that is expressed in the skin, hair, nails, and mucous membranes. * It is a key structural component of the skin epidermis, providing strength and integrity to the skin barrier. * It is also involved in the regulation of skin hydration and inflammation. **Pathways and functions:** * KRT85 is involved in the regulation of skin hydration and inflammation. * It is a key component of the cornified envelope, which protects the skin from environmental damage and pathogens. * It is also involved in the formation of the skin barrier, providing strength and integrity to the skin. * It is involved in the regulation of keratinization, the process by which skin cells produce keratin proteins. **Clinical significance:** Mutations in the KRT85 gene have been linked to a number of skin disorders, including ichthyosis vulgaris, a condition characterized by dry, flaky skin that is prone to cracking. KRT85 is a promising target for the treatment of skin disorders that are caused by mutations in keratin genes.

Genular Protein ID: 1098290968

Symbol: KRT85_HUMAN

Name: Keratin, type II cuticular Hb5

UniProtKB Accession Codes:

P78386 Q9NSB1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 1 ExpressionAtlas 1 GO 8 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9084137

Title: Sequences and differential expression of three novel human type-II hair keratins.

PubMed ID: 9084137

DOI: 10.1046/j.1432-0436.1997.6130187.x

PubMed ID: 10692104

Title: Characterization of a 300 kbp region of human DNA containing the type II hair keratin.

PubMed ID: 10692104

DOI: 10.1046/j.1523-1747.2000.00910.x

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 16525032

Title: A mutation in the hair matrix and cuticle keratin KRTHB5 gene causes ectodermal dysplasia of hair and nail type.

PubMed ID: 16525032

DOI: 10.1136/jmg.2005.033381

Sequence Information:

  • Length: 507
  • Mass: 55802
  • Checksum: 0A3E5ABEAAF4C04D
  • Sequence:
    • MSCRSYRISS GCGVTRNFSS CSAVAPKTGN RCCISAAPYR GVSCYRGLTG FGSRSLCNLG 
SCGPRIAVGG FRAGSCGRSF GYRSGGVCGP SPPCITTVSV NESLLTPLNL EIDPNAQCVK 
QEEKEQIKSL NSRFAAFIDK VRFLEQQNKL LETKWQFYQN QRCCESNLEP LFSGYIETLR 
REAECVEADS GRLASELNHV QEVLEGYKKK YEEEVALRAT AENEFVVLKK DVDCAYLRKS 
DLEANVEALV EESSFLRRLY EEEIRVLQAH ISDTSVIVKM DNSRDLNMDC IIAEIKAQYD 
DVASRSRAEA ESWYRSKCEE MKATVIRHGE TLRRTKEEIN ELNRMIQRLT AEIENAKCQR 
AKLEAAVAEA EQQGEAALSD ARCKLAELEG ALQKAKQDMA CLLKEYQEVM NSKLGLDIEI 
ATYRRLLEGE EHRLCEGVGS VNVCVSSSRG GVSCGGLSYS TTPGRQITSG PSAIGGSITV 
VAPDSCAPCQ PRSSSFSCGS SRSVRFA

Genular Protein ID: 626930885

Symbol: B7Z7N3_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z7N3

Database IDs:

ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GO 1 Gene3D 3 GenomeRNAi 1 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PeptideAtlas 1 Pfam 1 RefSeq 1 RuleBase 1 SAM 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 295
  • Mass: 32455
  • Checksum: 2EE2FB2A4F0D6B2E
  • Sequence:
    • MVFKVQFLSS RPSLSHTQDV DCAYLRKSDL EANVEALVEE SSFLRRLYEE EIRVLQAHIS 
DTSVIVKMDN SRDLNMDCII AEIKAQYDDV ASRSRAEAES WYRSKCEEMK ATVIRHGETL 
RRTKEEINEL NRVIQRLTAE IENAKCQRAK LEAAVAEAEQ QGEAALSDAR CKLAELEGAL 
QKAKQDMACL LKEYQEVMNS KLGLDIEIAT YRRLLEGEEH RLCEGVGSVN VCVSSSPGGV 
SCGGLSYSTT PGRQITSGPS AIGGSITVVA PDSCAPCQPR SSSFSCGSSR SVRFA

Genular Protein ID: 363730588

Symbol: F5GYI5_HUMAN

Name: N/A

UniProtKB Accession Codes:

F5GYI5

Database IDs:

ARBA 3 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 1 Gene3D 3 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 2 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 RuleBase 1 SAM 1 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

Sequence Information:

  • Length: 295
  • Mass: 32546
  • Checksum: 328F4696BD8C387E
  • Sequence:
    • MVFKVQFLSS RPSLSHTQDV DCAYLRKSDL EANVEALVEE SSFLRRLYEE EIRVLQAHIS 
DTSVIVKMDN SRDLNMDCII AEIKAQYDDV ASRSRAEAES WYRSKCEEMK ATVIRHGETL 
RRTKEEINEL NRMIQRLTAE IENAKCQRAK LEAAVAEAEQ QGEAALSDAR CKLAELEGAL 
QKAKQDMACL LKEYQEVMNS KLGLDIEIAT YRRLLEGEEH RLCEGVGSVN VCVSSSRGGV 
SCGGLSYSTT PGRQITSGPS AIGGSITVVA PDSCAPCQPR SSSFSCGSSR SVRFA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.