Details for: KRT85

Gene ID: 3891

Symbol: KRT85

Ensembl ID: ENSG00000135443

Description: keratin 85

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: granular cell of epidermis (CL0002189)
    Fold Change: 14.7720
    Cell Significance Index: 17.0100
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.7862
    Cell Significance Index: 13.4400
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.7310
    Cell Significance Index: 11.8400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.6822
    Cell Significance Index: 20.1000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.5829
    Cell Significance Index: 14.8500
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.5129
    Cell Significance Index: 5.8700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4165
    Cell Significance Index: 184.1200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.2908
    Cell Significance Index: 3.0100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.1578
    Cell Significance Index: 2.2600
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: 0.1429
    Cell Significance Index: 2.8500
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.1273
    Cell Significance Index: 1.4800
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.0985
    Cell Significance Index: 2.4600
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.0896
    Cell Significance Index: 1.1600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.0854
    Cell Significance Index: 1.3700
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.0303
    Cell Significance Index: 0.3300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0114
    Cell Significance Index: 0.8100
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.0026
    Cell Significance Index: 0.0300
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.0026
    Cell Significance Index: 0.0200
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0005
    Cell Significance Index: 0.0000
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0008
    Cell Significance Index: -0.0100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0009
    Cell Significance Index: -0.0400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0014
    Cell Significance Index: -0.2700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0014
    Cell Significance Index: -0.2400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0015
    Cell Significance Index: -0.0800
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.0023
    Cell Significance Index: -0.0200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0026
    Cell Significance Index: -1.1700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0038
    Cell Significance Index: -0.1000
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0039
    Cell Significance Index: -0.0800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0041
    Cell Significance Index: -0.1100
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0051
    Cell Significance Index: -0.0700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0059
    Cell Significance Index: -1.1900
  • Cell Name: lung resident memory CD8-positive, alpha-beta T cell (CL4033039)
    Fold Change: -0.0059
    Cell Significance Index: -0.0500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0064
    Cell Significance Index: -0.6500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0064
    Cell Significance Index: -0.8800
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0083
    Cell Significance Index: -0.1100
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0096
    Cell Significance Index: -0.1400
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0101
    Cell Significance Index: -0.0900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0102
    Cell Significance Index: -0.8100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0106
    Cell Significance Index: -0.2200
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0113
    Cell Significance Index: -0.1900
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: -0.0157
    Cell Significance Index: -0.1300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0158
    Cell Significance Index: -0.1700
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0182
    Cell Significance Index: -0.2400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0254
    Cell Significance Index: -0.8300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0255
    Cell Significance Index: -0.9000
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0259
    Cell Significance Index: -0.3100
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.0265
    Cell Significance Index: -0.2900
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0272
    Cell Significance Index: -0.3500
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0282
    Cell Significance Index: -0.3000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0283
    Cell Significance Index: -1.0400
  • Cell Name: peridermal cell (CL0000078)
    Fold Change: -0.0283
    Cell Significance Index: -0.1800
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0284
    Cell Significance Index: -0.3000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0315
    Cell Significance Index: -0.6900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0322
    Cell Significance Index: -1.5200
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: -0.0326
    Cell Significance Index: -0.3700
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0332
    Cell Significance Index: -0.3600
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0334
    Cell Significance Index: -0.3600
  • Cell Name: muscle cell (CL0000187)
    Fold Change: -0.0345
    Cell Significance Index: -0.3300
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0345
    Cell Significance Index: -0.4500
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: -0.0350
    Cell Significance Index: -0.3700
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0353
    Cell Significance Index: -0.4900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0364
    Cell Significance Index: -0.6100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0367
    Cell Significance Index: -0.4000
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0370
    Cell Significance Index: -0.4900
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0378
    Cell Significance Index: -0.4500
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0379
    Cell Significance Index: -0.4500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0380
    Cell Significance Index: -0.8200
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0382
    Cell Significance Index: -0.4400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0386
    Cell Significance Index: -0.6500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0413
    Cell Significance Index: -0.8300
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.0421
    Cell Significance Index: -0.4100
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.0422
    Cell Significance Index: -0.2800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0425
    Cell Significance Index: -0.8400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.0461
    Cell Significance Index: -0.5900
  • Cell Name: epithelial cell of thymus (CL0002293)
    Fold Change: -0.0468
    Cell Significance Index: -0.3600
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0507
    Cell Significance Index: -0.6400
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.0528
    Cell Significance Index: -0.6000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0530
    Cell Significance Index: -0.9800
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.0535
    Cell Significance Index: -0.4900
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.0538
    Cell Significance Index: -0.6400
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0542
    Cell Significance Index: -0.6300
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.0552
    Cell Significance Index: -0.5400
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0555
    Cell Significance Index: -0.5900
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0568
    Cell Significance Index: -0.5800
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.0568
    Cell Significance Index: -0.6900
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.0571
    Cell Significance Index: -0.6500
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0581
    Cell Significance Index: -0.4900
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0584
    Cell Significance Index: -0.5900
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: -0.0589
    Cell Significance Index: -0.4800
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: -0.0591
    Cell Significance Index: -0.3700
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0597
    Cell Significance Index: -0.9100
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: -0.0640
    Cell Significance Index: -0.6900
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: -0.0648
    Cell Significance Index: -0.7000
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.0669
    Cell Significance Index: -0.7600
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.0669
    Cell Significance Index: -0.8400
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0675
    Cell Significance Index: -0.9000
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0680
    Cell Significance Index: -0.5200
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0684
    Cell Significance Index: -0.5900
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0685
    Cell Significance Index: -0.8100
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: -0.0693
    Cell Significance Index: -0.6600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** KRT85 is a type II keratin, which distinguishes it from type I keratins. Type II keratins are characterized by their ability to form dimers and interact with other keratin proteins to maintain the structural integrity of cells. KRT85 is significantly expressed in various cell types, including oligodendrocyte precursor cells, microglial cells, blood vessel endothelial cells, plasma cells, B cells, mononuclear cells, goblet cells, pericytes, cerebral cortex GABAergic interneurons, and forebrain radial glial cells. Its expression is also observed in the skin, where it plays a crucial role in keratinization and the formation of the cornified envelope. **Pathways and Functions:** KRT85 is involved in several cellular processes, including: 1. **Intermediate Filament Organization:** KRT85 interacts with other keratin proteins to form intermediate filaments, which provide mechanical support and stability to cells. 2. **Keratinization:** KRT85 is essential for the process of keratinization, which involves the transformation of epithelial cells into keratinized cells. 3. **Protein Binding:** KRT85 interacts with various proteins, including other keratins, to regulate cell signaling and maintain cellular homeostasis. 4. **Cytoskeleton Dynamics:** KRT85 regulates cytoskeleton dynamics, which is crucial for cell migration, division, and differentiation. **Clinical Significance:** Dysregulation of KRT85 has been implicated in various immune-related disorders, including: 1. **Autoimmune Diseases:** KRT85 has been shown to play a role in autoimmune diseases, such as rheumatoid arthritis and lupus, where it contributes to the formation of autoantibodies and immune complexes. 2. **Cancer:** Aberrant expression of KRT85 has been observed in various types of cancer, including breast, lung, and skin cancers, where it contributes to tumor progression and metastasis. 3. **Neurological Disorders:** KRT85 has been implicated in neurological disorders, such as multiple sclerosis and Alzheimer's disease, where it contributes to demyelination and neuronal degeneration. 4. **Skin Disorders:** KRT85 is essential for maintaining the integrity of the skin, and its dysregulation can lead to skin disorders, such as ichthyosis and psoriasis. In conclusion, KRT85 is a multifunctional protein that plays a crucial role in immune response, development, and disease pathogenesis. Further research is needed to fully understand the mechanisms by which KRT85 contributes to immune-related disorders and to develop therapeutic strategies for the treatment of these diseases.

Genular Protein ID: 1098290968

Symbol: KRT85_HUMAN

Name: Keratin, type II cuticular Hb5

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9084137

Title: Sequences and differential expression of three novel human type-II hair keratins.

PubMed ID: 9084137

DOI: 10.1046/j.1432-0436.1997.6130187.x

PubMed ID: 10692104

Title: Characterization of a 300 kbp region of human DNA containing the type II hair keratin.

PubMed ID: 10692104

DOI: 10.1046/j.1523-1747.2000.00910.x

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 16525032

Title: A mutation in the hair matrix and cuticle keratin KRTHB5 gene causes ectodermal dysplasia of hair and nail type.

PubMed ID: 16525032

DOI: 10.1136/jmg.2005.033381

Sequence Information:

  • Length: 507
  • Mass: 55802
  • Checksum: 0A3E5ABEAAF4C04D
  • Sequence:
  • MSCRSYRISS GCGVTRNFSS CSAVAPKTGN RCCISAAPYR GVSCYRGLTG FGSRSLCNLG 
    SCGPRIAVGG FRAGSCGRSF GYRSGGVCGP SPPCITTVSV NESLLTPLNL EIDPNAQCVK 
    QEEKEQIKSL NSRFAAFIDK VRFLEQQNKL LETKWQFYQN QRCCESNLEP LFSGYIETLR 
    REAECVEADS GRLASELNHV QEVLEGYKKK YEEEVALRAT AENEFVVLKK DVDCAYLRKS 
    DLEANVEALV EESSFLRRLY EEEIRVLQAH ISDTSVIVKM DNSRDLNMDC IIAEIKAQYD 
    DVASRSRAEA ESWYRSKCEE MKATVIRHGE TLRRTKEEIN ELNRMIQRLT AEIENAKCQR 
    AKLEAAVAEA EQQGEAALSD ARCKLAELEG ALQKAKQDMA CLLKEYQEVM NSKLGLDIEI 
    ATYRRLLEGE EHRLCEGVGS VNVCVSSSRG GVSCGGLSYS TTPGRQITSG PSAIGGSITV 
    VAPDSCAPCQ PRSSSFSCGS SRSVRFA

Genular Protein ID: 363730588

Symbol: F5GYI5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

Sequence Information:

  • Length: 295
  • Mass: 32546
  • Checksum: 328F4696BD8C387E
  • Sequence:
  • MVFKVQFLSS RPSLSHTQDV DCAYLRKSDL EANVEALVEE SSFLRRLYEE EIRVLQAHIS 
    DTSVIVKMDN SRDLNMDCII AEIKAQYDDV ASRSRAEAES WYRSKCEEMK ATVIRHGETL 
    RRTKEEINEL NRMIQRLTAE IENAKCQRAK LEAAVAEAEQ QGEAALSDAR CKLAELEGAL 
    QKAKQDMACL LKEYQEVMNS KLGLDIEIAT YRRLLEGEEH RLCEGVGSVN VCVSSSRGGV 
    SCGGLSYSTT PGRQITSGPS AIGGSITVVA PDSCAPCQPR SSSFSCGSSR SVRFA

Genular Protein ID: 626930885

Symbol: B7Z7N3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 295
  • Mass: 32455
  • Checksum: 2EE2FB2A4F0D6B2E
  • Sequence:
  • MVFKVQFLSS RPSLSHTQDV DCAYLRKSDL EANVEALVEE SSFLRRLYEE EIRVLQAHIS 
    DTSVIVKMDN SRDLNMDCII AEIKAQYDDV ASRSRAEAES WYRSKCEEMK ATVIRHGETL 
    RRTKEEINEL NRVIQRLTAE IENAKCQRAK LEAAVAEAEQ QGEAALSDAR CKLAELEGAL 
    QKAKQDMACL LKEYQEVMNS KLGLDIEIAT YRRLLEGEEH RLCEGVGSVN VCVSSSPGGV 
    SCGGLSYSTT PGRQITSGPS AIGGSITVVA PDSCAPCQPR SSSFSCGSSR SVRFA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.