Gene LAMA5 - ENSG00000130702 | NCBI Gene ID: 3911

Details for: LAMA5

Gene ID: 3911

Symbol: LAMA5

Ensembl ID: ENSG00000130702

Description: laminin subunit alpha 5

Associated with

Cytokine signaling in immune system
(R-HSA-1280215)
Degradation of the extracellular matrix
(R-HSA-1474228)
Ecm proteoglycans
(R-HSA-3000178)
Extracellular matrix organization
(R-HSA-1474244)
Immune system
(R-HSA-168256)
Interleukin-4 and interleukin-13 signaling
(R-HSA-6785807)
Laminin interactions
(R-HSA-3000157)
Met activates ptk2 signaling
(R-HSA-8874081)
Met promotes cell motility
(R-HSA-8875878)
Non-integrin membrane-ecm interactions
(R-HSA-3000171)
Signaling by interleukins
(R-HSA-449147)
Signaling by met
(R-HSA-6806834)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signal transduction
(R-HSA-162582)
Basement membrane
(GO:0005604)
Branching involved in salivary gland morphogenesis
(GO:0060445)
Branching involved in ureteric bud morphogenesis
(GO:0001658)
Cell migration
(GO:0016477)
Cilium assembly
(GO:0060271)
Collagen-containing extracellular matrix
(GO:0062023)
Extracellular exosome
(GO:0070062)
Extracellular matrix of synaptic cleft
(GO:0098965)
Extracellular matrix structural constituent
(GO:0005201)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Glutamatergic synapse
(GO:0098978)
Hair follicle development
(GO:0001942)
Integrin-mediated signaling pathway
(GO:0007229)
Integrin binding
(GO:0005178)
Laminin-5 complex
(GO:0005610)
Laminin-10 complex
(GO:0043259)
Laminin-11 complex
(GO:0043260)
Lung development
(GO:0030324)
Morphogenesis of a polarized epithelium
(GO:0001738)
Morphogenesis of embryonic epithelium
(GO:0016331)
Muscle organ development
(GO:0007517)
Neuromuscular junction
(GO:0031594)
Nucleus
(GO:0005634)
Odontogenesis of dentin-containing tooth
(GO:0042475)
Postsynapse organization
(GO:0099173)
Protein localization to plasma membrane
(GO:0072659)
Regulation of cell adhesion
(GO:0030155)
Regulation of cell migration
(GO:0030334)
Regulation of embryonic development
(GO:0045995)
Regulation of epithelial cell proliferation
(GO:0050678)
Skeletal system morphogenesis
(GO:0048705)
Substrate adhesion-dependent cell spreading
(GO:0034446)
Synaptic cleft
(GO:0043083)
Trunk neural crest cell migration
(GO:0036484)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 2.34
Marker Score: 2648
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 2.24
Marker Score: 4911
Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: 1.93
Marker Score: 8035
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 1.87
Marker Score: 13949
Cell Name: cell in vitro (CL0001034)
Fold Change: 1.69
Marker Score: 58651
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 1.68
Marker Score: 4130
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 1.68
Marker Score: 982
Cell Name: type I pneumocyte (CL0002062)
Fold Change: 1.67
Marker Score: 2009
Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 1.66
Marker Score: 1587
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.66
Marker Score: 6513
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 1.65
Marker Score: 985.5
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 1.62
Marker Score: 513
Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 1.51
Marker Score: 879
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 1.48
Marker Score: 3488
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 1.48
Marker Score: 5471
Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 1.45
Marker Score: 969
Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
Fold Change: 1.43
Marker Score: 2076
Cell Name: basal cell (CL0000646)
Fold Change: 1.43
Marker Score: 1850
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 1.39
Marker Score: 2777
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 1.38
Marker Score: 3478
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 1.35
Marker Score: 1496
Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: 1.28
Marker Score: 1053
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 1.25
Marker Score: 390
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.24
Marker Score: 1307
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 1.21
Marker Score: 1466
Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
Fold Change: 1.2
Marker Score: 3060.5
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.2
Marker Score: 874
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.2
Marker Score: 1771
Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 1.2
Marker Score: 661
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.2
Marker Score: 18777.5
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 1.2
Marker Score: 1242.5
Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 1.18
Marker Score: 837
Cell Name: anterior lens cell (CL0002223)
Fold Change: 1.15
Marker Score: 1543
Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 1.11
Marker Score: 1614
Cell Name: enterocyte of colon (CL1000347)
Fold Change: 1.07
Marker Score: 1650
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 1.07
Marker Score: 2900
Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 1.04
Marker Score: 334
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 1.04
Marker Score: 251756
Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 1.03
Marker Score: 974
Cell Name: podocyte (CL0000653)
Fold Change: 1.02
Marker Score: 378
Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: 1.02
Marker Score: 245
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 1.01
Marker Score: 2385
Cell Name: taste receptor cell (CL0000209)
Fold Change: 1.01
Marker Score: 874
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71774
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 47999
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30405
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.97
Marker Score: 502
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 0.97
Marker Score: 5107
Cell Name: contractile cell (CL0000183)
Fold Change: 0.97
Marker Score: 525
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 0.97
Marker Score: 1367
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.97
Marker Score: 456
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2410
Cell Name: lactocyte (CL0002325)
Fold Change: 0.94
Marker Score: 15131
Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 0.94
Marker Score: 341
Cell Name: vein endothelial cell (CL0002543)
Fold Change: 0.94
Marker Score: 845
Cell Name: type A enteroendocrine cell (CL0002067)
Fold Change: 0.93
Marker Score: 375
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.92
Marker Score: 369
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2730
Cell Name: smooth muscle cell of large intestine (CL1000279)
Fold Change: 0.9
Marker Score: 342
Cell Name: epithelial cell of glomerular capsule (CL1000450)
Fold Change: 0.9
Marker Score: 230
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 0.9
Marker Score: 3190
Cell Name: papillary tips cell (CL1000597)
Fold Change: 0.9
Marker Score: 181
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9
Marker Score: 322
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.88
Marker Score: 4994
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5296
Cell Name: endothelial cell (CL0000115)
Fold Change: 0.87
Marker Score: 780
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.86
Marker Score: 412
Cell Name: epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.86
Marker Score: 385
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 0.85
Marker Score: 906
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 0.85
Marker Score: 18114.5
Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 0.85
Marker Score: 587
Cell Name: pulmonary artery endothelial cell (CL1001568)
Fold Change: 0.84
Marker Score: 722
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 0.83
Marker Score: 2229
Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 0.82
Marker Score: 882.5
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.81
Marker Score: 620
Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.81
Marker Score: 3115
Cell Name: lung microvascular endothelial cell (CL2000016)
Fold Change: 0.8
Marker Score: 171
Cell Name: kidney collecting duct cell (CL1001225)
Fold Change: 0.8
Marker Score: 156
Cell Name: club cell (CL0000158)
Fold Change: 0.79
Marker Score: 924.5
Cell Name: lung ciliated cell (CL1000271)
Fold Change: 0.79
Marker Score: 375.5
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1269
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 0.78
Marker Score: 792
Cell Name: secretory cell (CL0000151)
Fold Change: 0.77
Marker Score: 1411
Cell Name: brush cell (CL0002204)
Fold Change: 0.76
Marker Score: 691
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.76
Marker Score: 391
Cell Name: kidney cell (CL1000497)
Fold Change: 0.75
Marker Score: 503
Cell Name: basal cell of epidermis (CL0002187)
Fold Change: 0.75
Marker Score: 328
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.75
Marker Score: 7751.5
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.75
Marker Score: 218
Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 0.74
Marker Score: 659
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 0.72
Marker Score: 5553
Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 0.72
Marker Score: 1197
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: 0.72
Marker Score: 776
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.72
Marker Score: 3010
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.71
Marker Score: 2981.5
Cell Name: ciliated cell (CL0000064)
Fold Change: 0.71
Marker Score: 2449
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 0.71
Marker Score: 1168
Cell Name: supporting cell (CL0000630)
Fold Change: 0.71
Marker Score: 1328
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.69
Marker Score: 178
Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 0.69
Marker Score: 176

Hover over a box to see details here...

**Key characteristics:** - LAMA5 is a transmembrane protein that is highly expressed in the skin, lungs, and other tissues. - It is a type I transmembrane protein, meaning it has one extracellular domain and one transmembrane domain. - The extracellular domain of LAMA5 is responsible for binding to other ECM proteins and for forming the structural framework of the ECM. - The transmembrane domain of LAMA5 is involved in cell adhesion, migration, and signaling. **Pathways and functions:** - LAMA5 is a key component of the ECM, which is essential for the structural integrity and function of tissues. - It helps to maintain the integrity of blood vessels, skin, and other tissues by preventing the formation of gaps and holes. - It also plays a role in cell migration, adhesion, and signaling. - Mutations in the LAMA5 gene have been linked to several diseases, including psoriasis, rheumatoid arthritis, and cancer. **Clinical significance:** - LAMA5 is a promising target for the treatment of diseases that are characterized by abnormal ECM function, such as psoriasis and cancer. - By targeting LAMA5, it may be possible to inhibit cell migration, adhesion, and signaling, which could lead to the regression of these diseases. - Clinical trials are currently underway to evaluate the efficacy of LAMA5 inhibitors in treating psoriasis and other diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Laminin subunit alpha-5

Genular Protein ID: 2210038633

Symbol: LAMA5_HUMAN

Name: Laminin subunit alpha-5

UniProtKB Accession Codes:

O15230 Q5U4N9 Q8TDF8 Q8WZA7 Q9H1P1

Database IDs:

Citations:

PubMed ID: 11821406

Title: Recombinant human laminin-10 (alpha5beta1gamma1). Production, purification, and migration-promoting activity on vascular endothelial cells.

PubMed ID: 11821406

DOI: 10.1074/jbc.m111228200

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11572484

Title: Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins.

PubMed ID: 11572484

DOI: 10.1093/dnares/8.4.179

PubMed ID: 9628581

Title: Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

PubMed ID: 9628581

DOI: 10.1093/dnares/5.1.31

PubMed ID: 9271224

Title: Tissue-specific expression of the human laminin alpha5-chain, and mapping of the gene to human chromosome 20q13.2-13.3 and to distal mouse chromosome 2 near the locus for the ragged (Ra) mutation.

PubMed ID: 9271224

DOI: 10.1016/s0014-5793(97)00686-8

PubMed ID: 10964957

Title: Laminin expression in adult and developing retinae: evidence of two novel CNS laminins.

PubMed ID: 10964957

DOI: 10.1523/jneurosci.20-17-06517.2000

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 29534211

Title: Genetic variants in the LAMA5 gene in pediatric nephrotic syndrome.

PubMed ID: 29534211

DOI: 10.1093/ndt/gfy028

PubMed ID: 32439764

Title: A mutation affecting laminin alpha 5 polymerisation gives rise to a syndromic developmental disorder.

PubMed ID: 32439764

DOI: 10.1242/dev.189183

PubMed ID: 33242826

Title: Biallelic mutations in LAMA5 disrupts a skeletal noncanonical focal adhesion pathway and produces a distinct bent bone dysplasia.

PubMed ID: 33242826

DOI: 10.1016/j.ebiom.2020.103075

PubMed ID: 35419533

Title: Clear Evidence of LAMA5 Gene Biallelic Truncating Variants Causing Infantile Nephrotic Syndrome.

PubMed ID: 35419533

DOI: 10.34067/kid.0004952021

Sequence Information:

Length: 3695
Mass: 399737
Checksum: B13C479B55282E3C
Sequence:

MAKRLCAGSA LCVRGPRGPA PLLLVGLALL GAARAREEAG GGFSLHPPYF NLAEGARIAA 
SATCGEEAPA RGSPRPTEDL YCKLVGGPVA GGDPNQTIRG QYCDICTAAN SNKAHPASNA 
IDGTERWWQS PPLSRGLEYN EVNVTLDLGQ VFHVAYVLIK FANSPRPDLW VLERSMDFGR 
TYQPWQFFAS SKRDCLERFG PQTLERITRD DAAICTTEYS RIVPLENGEI VVSLVNGRPG 
AMNFSYSPLL REFTKATNVR LRFLRTNTLL GHLMGKALRD PTVTRRYYYS IKDISIGGRC 
VCHGHADACD AKDPTDPFRL QCTCQHNTCG GTCDRCCPGF NQQPWKPATA NSANECQSCN 
CYGHATDCYY DPEVDRRRAS QSLDGTYQGG GVCIDCQHHT TGVNCERCLP GFYRSPNHPL 
DSPHVCRRCN CESDFTDGTC EDLTGRCYCR PNFSGERCDV CAEGFTGFPS CYPTPSSSND 
TREQVLPAGQ IVNCDCSAAG TQGNACRKDP RVGRCLCKPN FQGTHCELCA PGFYGPGCQP 
CQCSSPGVAD DRCDPDTGQC RCRVGFEGAT CDRCAPGYFH FPLCQLCGCS PAGTLPEGCD 
EAGRCLCQPE FAGPHCDRCR PGYHGFPNCQ ACTCDPRGAL DQLCGAGGLC RCRPGYTGTA 
CQECSPGFHG FPSCVPCHCS AEGSLHAACD PRSGQCSCRP RVTGLRCDTC VPGAYNFPYC 
EAGSCHPAGL APVDPALPEA QVPCMCRAHV EGPSCDRCKP GFWGLSPSNP EGCTRCSCDL 
RGTLGGVAEC QPGTGQCFCK PHVCGQACAS CKDGFFGLDQ ADYFGCRSCR CDIGGALGQS 
CEPRTGVCRC RPNTQGPTCS EPARDHYLPD LHHLRLELEE AATPEGHAVR FGFNPLEFEN 
FSWRGYAQMA PVQPRIVARL NLTSPDLFWL VFRYVNRGAM SVSGRVSVRE EGRSATCANC 
TAQSQPVAFP PSTEPAFITV PQRGFGEPFV LNPGTWALRV EAEGVLLDYV VLLPSAYYEA 
ALLQLRVTEA CTYRPSAQQS GDNCLLYTHL PLDGFPSAAG LEALCRQDNS LPRPCPTEQL 
SPSHPPLITC TGSDVDVQLQ VAVPQPGRYA LVVEYANEDA RQEVGVAVHT PQRAPQQGLL 
SLHPCLYSTL CRGTARDTQD HLAVFHLDSE ASVRLTAEQA RFFLHGVTLV PIEEFSPEFV 
EPRVSCISSH GAFGPNSAAC LPSRFPKPPQ PIILRDCQVI PLPPGLPLTH AQDLTPAMSP 
AGPRPRPPTA VDPDAEPTLL REPQATVVFT THVPTLGRYA FLLHGYQPAH PTFPVEVLIN 
AGRVWQGHAN ASFCPHGYGC RTLVVCEGQA LLDVTHSELT VTVRVPKGRW LWLDYVLVVP 
ENVYSFGYLR EEPLDKSYDF ISHCAAQGYH ISPSSSSLFC RNAAASLSLF YNNGARPCGC 
HEVGATGPTC EPFGGQCPCH AHVIGRDCSR CATGYWGFPN CRPCDCGARL CDELTGQCIC 
PPRTIPPDCL LCQPQTFGCH PLVGCEECNC SGPGIQELTD PTCDTDSGQC KCRPNVTGRR 
CDTCSPGFHG YPRCRPCDCH EAGTAPGVCD PLTGQCYCKE NVQGPKCDQC SLGTFSLDAA 
NPKGCTRCFC FGATERCRSS SYTRQEFVDM EGWVLLSTDR QVVPHERQPG TEMLRADLRH 
VPEAVPEAFP ELYWQAPPSY LGDRVSSYGG TLRYELHSET QRGDVFVPME SRPDVVLQGN 
QMSITFLEPA YPTPGHVHRG QLQLVEGNFR HTETRNTVSR EELMMVLASL EQLQIRALFS 
QISSAVFLRR VALEVASPAG QGALASNVEL CLCPASYRGD SCQECAPGFY RDVKGLFLGR 
CVPCQCHGHS DRCLPGSGVC VDCQHNTEGA HCERCQAGFV SSRDDPSAPC VSCPCPLSVP 
SNNFAEGCVL RGGRTQCLCK PGYAGASCER CAPGFFGNPL VLGSSCQPCD CSGNGDPNLL 
FSDCDPLTGA CRGCLRHTTG PRCEICAPGF YGNALLPGNC TRCDCTPCGT EACDPHSGHC 
LCKAGVTGRR CDRCQEGHFG FDGCGGCRPC ACGPAAEGSE CHPQSGQCHC RPGTMGPQCR 
ECAPGYWGLP EQGCRRCQCP GGRCDPHTGR CNCPPGLSGE RCDTCSQQHQ VPVPGGPVGH 
SIHCEVCDHC VVLLLDDLER AGALLPAIHE QLRGINASSM AWARLHRLNA SIADLQSQLR 
SPLGPRHETA QQLEVLEQQS TSLGQDARRL GGQAVGTRDQ ASQLLAGTEA TLGHAKTLLA 
AIRAVDRTLS ELMSQTGHLG LANASAPSGE QLLRTLAEVE RLLWEMRARD LGAPQAAAEA 
ELAAAQRLLA RVQEQLSSLW EENQALATQT RDRLAQHEAG LMDLREALNR AVDATREAQE 
LNSRNQERLE EALQRKQELS RDNATLQATL HAARDTLASV FRLLHSLDQA KEELERLAAS 
LDGARTPLLQ RMQTFSPAGS KLRLVEAAEA HAQQLGQLAL NLSSIILDVN QDRLTQRAIE 
ASNAYSRILQ AVQAAEDAAG QALQQADHTW ATVVRQGLVD RAQQLLANST ALEEAMLQEQ 
QRLGLVWAAL QGARTQLRDV RAKKDQLEAH IQAAQAMLAM DTDETSKKIA HAKAVAAEAQ 
DTATRVQSQL QAMQENVERW QGQYEGLRGQ DLGQAVLDAG HSVSTLEKTL PQLLAKLSIL 
ENRGVHNASL ALSASIGRVR ELIAQARGAA SKVKVPMKFN GRSGVQLRTP RDLADLAAYT 
ALKFYLQGPE PEPGQGTEDR FVMYMGSRQA TGDYMGVSLR DKKVHWVYQL GEAGPAVLSI 
DEDIGEQFAA VSLDRTLQFG HMSVTVERQM IQETKGDTVA PGAEGLLNLR PDDFVFYVGG 
YPSTFTPPPL LRFPGYRGCI EMDTLNEEVV SLYNFERTFQ LDTAVDRPCA RSKSTGDPWL 
TDGSYLDGTG FARISFDSQI STTKRFEQEL RLVSYSGVLF FLKQQSQFLC LAVQEGSLVL 
LYDFGAGLKK AVPLQPPPPL TSASKAIQVF LLGGSRKRVL VRVERATVYS VEQDNDLELA 
DAYYLGGVPP DQLPPSLRRL FPTGGSVRGC VKGIKALGKY VDLKRLNTTG VSAGCTADLL 
VGRAMTFHGH GFLRLALSNV APLTGNVYSG FGFHSAQDSA LLYYRASPDG LCQVSLQQGR 
VSLQLLRTEV KTQAGFADGA PHYVAFYSNA TGVWLYVDDQ LQQMKPHRGP PPELQPQPEG 
PPRLLLGGLP ESGTIYNFSG CISNVFVQRL LGPQRVFDLQ QNLGSVNVST GCAPALQAQT 
PGLGPRGLQA TARKASRRSR QPARHPACML PPHLRTTRDS YQFGGSLSSH LEFVGILARH 
RNWPSLSMHV LPRSSRGLLL FTARLRPGSP SLALFLSNGH FVAQMEGLGT RLRAQSRQRS 
RPGRWHKVSV RWEKNRILLV TDGARAWSQE GPHRQHQGAE HPQPHTLFVG GLPASSHSSK 
LPVTVGFSGC VKRLRLHGRP LGAPTRMAGV TPCILGPLEA GLFFPGSGGV ITLDLPGATL 
PDVGLELEVR PLAVTGLIFH LGQARTPPYL QLQVTEKQVL LRADDGAGEF STSVTRPSVL 
CDGQWHRLAV MKSGNVLRLE VDAQSNHTVG PLLAAAAGAP APLYLGGLPE PMAVQPWPPA 
YCGCMRRLAV NRSPVAMTRS VEVHGAVGAS GCPAA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: LAMA5

Associated with

Cells (max top 100)

Other Information

Recombinant human laminin-10 (alpha5beta1gamma1). Production, purification, and migration-promoting activity on vascular endothelial cells. PubMed ID: 11821406

The DNA sequence and comparative analysis of human chromosome 20. PubMed ID: 11780052

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. PubMed ID: 11572484

Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. PubMed ID: 9628581

Tissue-specific expression of the human laminin alpha5-chain, and mapping of the gene to human chromosome 20q13.2-13.3 and to distal mouse chromosome 2 near the locus for the ragged (Ra) mutation. PubMed ID: 9271224

Laminin expression in adult and developing retinae: evidence of two novel CNS laminins. PubMed ID: 10964957

Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. PubMed ID: 19159218

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Initial characterization of the human central proteome. PubMed ID: 21269460

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Genetic variants in the LAMA5 gene in pediatric nephrotic syndrome. PubMed ID: 29534211

A mutation affecting laminin alpha 5 polymerisation gives rise to a syndromic developmental disorder. PubMed ID: 32439764

Biallelic mutations in LAMA5 disrupts a skeletal noncanonical focal adhesion pathway and produces a distinct bent bone dysplasia. PubMed ID: 33242826

Clear Evidence of LAMA5 Gene Biallelic Truncating Variants Causing Infantile Nephrotic Syndrome. PubMed ID: 35419533