Details for: LIM2

Gene ID: 3982

Symbol: LIM2

Ensembl ID: ENSG00000105370

Description: lens intrinsic membrane protein 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 1.9854
    Cell Significance Index: 62.8000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 1.3351
    Cell Significance Index: -0.5500
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.2880
    Cell Significance Index: 14.4000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.2367
    Cell Significance Index: 29.9600
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.5979
    Cell Significance Index: 8.6800
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.5000
    Cell Significance Index: 6.4600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.4993
    Cell Significance Index: 678.9000
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.4803
    Cell Significance Index: 5.1100
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.4051
    Cell Significance Index: 5.6900
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.3384
    Cell Significance Index: 4.6400
  • Cell Name: epithelial cell of lacrimal sac (CL1000436)
    Fold Change: 0.3182
    Cell Significance Index: 2.2900
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.3095
    Cell Significance Index: 4.9100
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.2024
    Cell Significance Index: 2.5600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.1348
    Cell Significance Index: 1.9300
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.1258
    Cell Significance Index: 0.9500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1148
    Cell Significance Index: 3.9900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0902
    Cell Significance Index: 138.8300
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.0806
    Cell Significance Index: 1.0200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0725
    Cell Significance Index: 4.5700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0567
    Cell Significance Index: 104.5700
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.0518
    Cell Significance Index: 0.6700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0492
    Cell Significance Index: 1.3200
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.0443
    Cell Significance Index: 0.7300
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.0181
    Cell Significance Index: 0.1200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0148
    Cell Significance Index: 0.3700
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.0057
    Cell Significance Index: 0.0400
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: 0.0055
    Cell Significance Index: 0.0800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0047
    Cell Significance Index: 0.1300
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0033
    Cell Significance Index: 0.0400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0022
    Cell Significance Index: 0.1100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0014
    Cell Significance Index: 0.0300
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.0011
    Cell Significance Index: 0.0100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0002
    Cell Significance Index: -0.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0002
    Cell Significance Index: -0.3600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0002
    Cell Significance Index: -0.0400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0002
    Cell Significance Index: -0.0100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0008
    Cell Significance Index: -0.1600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0011
    Cell Significance Index: -0.8600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0013
    Cell Significance Index: -0.4700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0014
    Cell Significance Index: -1.0200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0015
    Cell Significance Index: -0.8400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0017
    Cell Significance Index: -1.0700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0018
    Cell Significance Index: -1.0200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0021
    Cell Significance Index: -0.9600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0027
    Cell Significance Index: -0.4600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0030
    Cell Significance Index: -0.5400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0041
    Cell Significance Index: -0.1200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0052
    Cell Significance Index: -0.1300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0058
    Cell Significance Index: -0.8400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0063
    Cell Significance Index: -0.8600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0073
    Cell Significance Index: -0.1000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0073
    Cell Significance Index: -0.8400
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0073
    Cell Significance Index: -0.0800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0082
    Cell Significance Index: -0.8600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0085
    Cell Significance Index: -1.0500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0099
    Cell Significance Index: -0.2800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0102
    Cell Significance Index: -0.4200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0106
    Cell Significance Index: -1.0800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0114
    Cell Significance Index: -0.4200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0117
    Cell Significance Index: -0.5900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0126
    Cell Significance Index: -0.3200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0143
    Cell Significance Index: -0.9600
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0155
    Cell Significance Index: -0.1600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0160
    Cell Significance Index: -0.4600
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0165
    Cell Significance Index: -0.1100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0169
    Cell Significance Index: -1.0400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0175
    Cell Significance Index: -0.9800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0176
    Cell Significance Index: -0.8000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0201
    Cell Significance Index: -0.8900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0228
    Cell Significance Index: -0.8000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0235
    Cell Significance Index: -0.8900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0243
    Cell Significance Index: -0.8000
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0245
    Cell Significance Index: -0.2900
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0248
    Cell Significance Index: -0.3100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0251
    Cell Significance Index: -0.8000
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.0255
    Cell Significance Index: -0.3000
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -0.0262
    Cell Significance Index: -0.0600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0265
    Cell Significance Index: -0.9300
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.0267
    Cell Significance Index: -0.2300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0270
    Cell Significance Index: -0.2800
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0318
    Cell Significance Index: -0.5200
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: -0.0318
    Cell Significance Index: -0.2600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0325
    Cell Significance Index: -0.8100
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: -0.0333
    Cell Significance Index: -0.3900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0338
    Cell Significance Index: -0.8900
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0342
    Cell Significance Index: -0.5000
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0344
    Cell Significance Index: -0.4300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0354
    Cell Significance Index: -1.0100
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0361
    Cell Significance Index: -0.2800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0368
    Cell Significance Index: -0.7800
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0370
    Cell Significance Index: -0.4100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0370
    Cell Significance Index: -0.8000
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0380
    Cell Significance Index: -0.6100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0381
    Cell Significance Index: -1.1200
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.0382
    Cell Significance Index: -0.4800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0386
    Cell Significance Index: -0.8000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0400
    Cell Significance Index: -0.7900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0401
    Cell Significance Index: -0.8400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0403
    Cell Significance Index: -0.8100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0404
    Cell Significance Index: -1.0800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** LIM2 is a type II transmembrane protein, characterized by its unique structure and localization to the lens intrinsic membrane. It is highly expressed in lens epithelial cells, secondary lens fibers, and other cell types, including endothelial cells of blood vessels and intestinal crypt stem cells. The protein's expression pattern and localization suggest a specialized role in maintaining lens structure and function. **Pathways and Functions:** LIM2 plays a critical role in the assembly of cell-cell junctions, a process essential for maintaining tissue integrity and function. The protein is involved in the formation of tight junctions, adherens junctions, and desmosomes, which are critical for maintaining the lens's transparency and structural integrity. Beyond its role in cell-cell junction assembly, LIM2 has been implicated in immune responses, particularly in the context of lens development and disease. The protein's expression in conventional dendritic cells and plasma cells suggests a role in antigen presentation and immune regulation. In addition to its role in cell-cell junction assembly and immune responses, LIM2 has been shown to play a critical role in lens development, particularly in the formation of the lens intrinsic membrane. The protein's expression in lens epithelial cells and secondary lens fibers suggests a role in regulating lens growth and differentiation. **Clinical Significance:** Dysregulation of LIM2 has been implicated in various ocular and systemic diseases, including cataracts, glaucoma, and multiple sclerosis. The protein's role in immune responses and cell-cell junction assembly suggests a potential link between LIM2 dysfunction and autoimmune diseases. Furthermore, the protein's expression in other cell types, including endothelial cells and intestinal crypt stem cells, highlights its potential role in maintaining tissue homeostasis and preventing disease. In conclusion, LIM2 is a complex and multifunctional protein with critical roles in lens development, cell-cell junction assembly, and immune responses. Further research is needed to fully elucidate the protein's functions and implications in human disease. However, the current understanding of LIM2's role in maintaining lens integrity and function has significant implications for the development of novel therapeutic strategies for ocular and systemic diseases.

Genular Protein ID: 1662463278

Symbol: LMIP_HUMAN

Name: Lens fiber membrane intrinsic protein

UniProtKB Accession Codes:

P55344 Q6B083 Q9BXD0 Q9HAR5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 2 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 2 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8137630

Title: The human lens fiber-cell intrinsic membrane protein MP19 gene: isolation and sequence analysis.

PubMed ID: 8137630

DOI: 10.3109/02713689309033503

PubMed ID: 12107413

Title: Expressed sequence tag analysis of adult human lens for the NEIBank project: over 2000 non-redundant transcripts, novel genes and splice variants.

PubMed ID: 12107413

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2584203

Title: Identification of an 18,000-dalton protein in mammalian lens fiber cell membranes.

PubMed ID: 2584203

DOI: 10.1016/s0021-9258(19)47205-0

PubMed ID: 11917274

Title: A missense mutation in the LIM2 gene is associated with autosomal recessive presenile cataract in an inbred Iraqi Jewish family.

PubMed ID: 11917274

DOI: 10.1086/340318

Sequence Information:

  • Length: 173
  • Mass: 19674
  • Checksum: 07DBA77184DA84AD
  • Sequence:
    • MYSFMGGGLF CAWVGTILLV VAMATDHWMQ YRLSGSFAHQ GLWRYCLGNK CYLQTDSIAY 
WNATRAFMIL SALCAISGII MGIMAFAHQP TFSRISRPFS AGIMFFSSTL FVVLALAIYT 
GVTVSFLGRR FGDWRFSWSY ILGWVAVLMT FFAGIFYMCA YRVHECRRLS TPR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.