Details for: LIM2

Gene ID: 3982

Symbol: LIM2

Ensembl ID: ENSG00000105370

Description: lens intrinsic membrane protein 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.16
    Marker Score: 3177
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.63
    Marker Score: 1538
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 2.17
    Marker Score: 1495
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.93
    Marker Score: 2158
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 874
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.18
    Marker Score: 1427
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.14
    Marker Score: 7601
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.05
    Marker Score: 800
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71834
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1
    Marker Score: 2537
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48059
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5356
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.9
    Marker Score: 1205
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.88
    Marker Score: 1165.5
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5293
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.84
    Marker Score: 488
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.82
    Marker Score: 443
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 712
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1265
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 399
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.76
    Marker Score: 504
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.74
    Marker Score: 2055
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 180
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.64
    Marker Score: 389
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.63
    Marker Score: 502
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.57
    Marker Score: 150
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.56
    Marker Score: 234
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.5
    Marker Score: 478
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 279
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 375
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.37
    Marker Score: 117
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.37
    Marker Score: 751
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.34
    Marker Score: 428
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.31
    Marker Score: 187
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.25
    Marker Score: 144
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.21
    Marker Score: 276
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 0.21
    Marker Score: 614
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.19
    Marker Score: 353
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.18
    Marker Score: 307
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.17
    Marker Score: 74
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.15
    Marker Score: 86
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.15
    Marker Score: 469
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.15
    Marker Score: 75
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.15
    Marker Score: 140
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.14
    Marker Score: 2238
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.14
    Marker Score: 148
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.14
    Marker Score: 93
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.13
    Marker Score: 273
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.1
    Marker Score: 50
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.1
    Marker Score: 45
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.1
    Marker Score: 116
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.1
    Marker Score: 76
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.09
    Marker Score: 67
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.09
    Marker Score: 1166
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.09
    Marker Score: 40
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.08
    Marker Score: 73
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 0.08
    Marker Score: 27
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.08
    Marker Score: 138
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.08
    Marker Score: 131
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.08
    Marker Score: 168
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.08
    Marker Score: 89
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.08
    Marker Score: 497
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 0.07
    Marker Score: 23
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.07
    Marker Score: 47
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.07
    Marker Score: 114
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.07
    Marker Score: 17
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.07
    Marker Score: 17
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.07
    Marker Score: 21
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.07
    Marker Score: 15
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.06
    Marker Score: 38
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.06
    Marker Score: 33
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.06
    Marker Score: 109
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.06
    Marker Score: 17
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.06
    Marker Score: 26
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 0.06
    Marker Score: 13
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.06
    Marker Score: 25
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.05
    Marker Score: 16
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.05
    Marker Score: 23
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.05
    Marker Score: 51
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.05
    Marker Score: 91
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.05
    Marker Score: 30
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.05
    Marker Score: 16
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.05
    Marker Score: 13
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.05
    Marker Score: 109
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.05
    Marker Score: 43
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.05
    Marker Score: 15
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.05
    Marker Score: 47
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.05
    Marker Score: 29
  • Cell Name: epithelial cell of thymus (CL0002293)
    Fold Change: 0.05
    Marker Score: 15
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.05
    Marker Score: 36
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.04
    Marker Score: 25
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 0.04
    Marker Score: 11
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.04
    Marker Score: 15
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.04
    Marker Score: 17
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.04
    Marker Score: 36
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.04
    Marker Score: 17
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.04
    Marker Score: 16

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Other Information

**Key characteristics:** * The LIM2 gene is a transmembrane protein that is expressed in the lens tissue of the eye. * It is a member of the immunoglobulin superfamily. * It is a key component of the cell-cell junctions that hold the lens tissue together. * It is also involved in the development of the lens. **Pathways and functions:** * The LIM2 gene is involved in the assembly of cell-cell junctions in the eye lens. * It is a key component of the cell junctions that hold the lens tissue together. * It is also involved in the development of the lens. **Clinical significance:** * Mutations in the LIM2 gene have been linked to a number of eye diseases, including cataracts and glaucoma. * These diseases are caused by mutations in genes that are involved in the assembly of cell-cell junctions. * By understanding the role of LIM2 in cell-cell junction assembly, we may be able to develop new treatments for eye diseases.

Genular Protein ID: 1662463278

Symbol: LMIP_HUMAN

Name: Lens fiber membrane intrinsic protein

UniProtKB Accession Codes:

P55344 Q6B083 Q9BXD0 Q9HAR5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 2 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 2 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8137630

Title: The human lens fiber-cell intrinsic membrane protein MP19 gene: isolation and sequence analysis.

PubMed ID: 8137630

DOI: 10.3109/02713689309033503

PubMed ID: 12107413

Title: Expressed sequence tag analysis of adult human lens for the NEIBank project: over 2000 non-redundant transcripts, novel genes and splice variants.

PubMed ID: 12107413

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2584203

Title: Identification of an 18,000-dalton protein in mammalian lens fiber cell membranes.

PubMed ID: 2584203

DOI: 10.1016/s0021-9258(19)47205-0

PubMed ID: 11917274

Title: A missense mutation in the LIM2 gene is associated with autosomal recessive presenile cataract in an inbred Iraqi Jewish family.

PubMed ID: 11917274

DOI: 10.1086/340318

Sequence Information:

  • Length: 173
  • Mass: 19674
  • Checksum: 07DBA77184DA84AD
  • Sequence:
    • MYSFMGGGLF CAWVGTILLV VAMATDHWMQ YRLSGSFAHQ GLWRYCLGNK CYLQTDSIAY 
WNATRAFMIL SALCAISGII MGIMAFAHQP TFSRISRPFS AGIMFFSSTL FVVLALAIYT 
GVTVSFLGRR FGDWRFSWSY ILGWVAVLMT FFAGIFYMCA YRVHECRRLS TPR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.