Details for: ARR3

Gene ID: 407

Symbol: ARR3

Ensembl ID: ENSG00000120500

Description: arrestin 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.22
    Marker Score: 2232
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2
    Marker Score: 1989
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.72
    Marker Score: 1916
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6
    Marker Score: 1166
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 851
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.17
    Marker Score: 485
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4808
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.09
    Marker Score: 501
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71815
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48041
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 507
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 460
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5355
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 372
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 324
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5284
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1266
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 706
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 395
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.75
    Marker Score: 2147.5
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 459.5
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.66
    Marker Score: 1908
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.58
    Marker Score: 462
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.55
    Marker Score: 3648
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 171
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.45
    Marker Score: 498
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.43
    Marker Score: 537
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.33
    Marker Score: 461
  • Cell Name: S cone cell (CL0003050)
    Fold Change: 0.33
    Marker Score: 99
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.3
    Marker Score: 156
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.27
    Marker Score: 159
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.26
    Marker Score: 155
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.23
    Marker Score: 373
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.21
    Marker Score: 205
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.21
    Marker Score: 61
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.18
    Marker Score: 75
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.18
    Marker Score: 170
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 43
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.17
    Marker Score: 51
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.14
    Marker Score: 59
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.14
    Marker Score: 44
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.14
    Marker Score: 56
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.14
    Marker Score: 278
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.14
    Marker Score: 282
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.14
    Marker Score: 258
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.13
    Marker Score: 35
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.13
    Marker Score: 33
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.13
    Marker Score: 229.5
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.13
    Marker Score: 34
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.12
    Marker Score: 34
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.12
    Marker Score: 234
  • Cell Name: starburst amacrine cell (CL0004232)
    Fold Change: 0.11
    Marker Score: 31
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.11
    Marker Score: 102
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.11
    Marker Score: 900
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.11
    Marker Score: 62
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.11
    Marker Score: 29
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.11
    Marker Score: 31
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.11
    Marker Score: 309
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.1
    Marker Score: 93
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.1
    Marker Score: 51
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1
    Marker Score: 1604
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.1
    Marker Score: 24
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.1
    Marker Score: 86
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1
    Marker Score: 118
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.1
    Marker Score: 92
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.1
    Marker Score: 104.5
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.09
    Marker Score: 148
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.09
    Marker Score: 34
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.09
    Marker Score: 105
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.09
    Marker Score: 28
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.09
    Marker Score: 33
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.09
    Marker Score: 304
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 0.09
    Marker Score: 202
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.09
    Marker Score: 28
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.09
    Marker Score: 31
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.09
    Marker Score: 29
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.08
    Marker Score: 51
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.08
    Marker Score: 20
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.08
    Marker Score: 495
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.08
    Marker Score: 26
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.08
    Marker Score: 33
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.08
    Marker Score: 33
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.08
    Marker Score: 92
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.07
    Marker Score: 26
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.07
    Marker Score: 30
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.07
    Marker Score: 34.5
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.07
    Marker Score: 99
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.07
    Marker Score: 35
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.07
    Marker Score: 49
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.07
    Marker Score: 949
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.07
    Marker Score: 41
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.07
    Marker Score: 32
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.07
    Marker Score: 24
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.07
    Marker Score: 36
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.06
    Marker Score: 29

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Other Information

**Key characteristics:** * ARRR3 is a type I transmembrane protein that is expressed in the endoplasmic reticulum. * It is a phosphatidylserine-rich protein that is involved in the regulation of protein phosphorylation. * It is a key regulator of the expression of many proteins involved in cell growth, differentiation, and survival. **Pathways and functions:** * ARRR3 is involved in the regulation of protein phosphorylation through its interaction with the Src family of phosphatases. * It is also involved in the regulation of G protein-coupled receptor internalization. * It is a key regulator of the expression of many proteins involved in cell growth, differentiation, and survival, including those involved in cell cycle regulation, transcription, and translation. **Clinical significance:** * Mutations in ARRR3 have been linked to a number of human diseases, including retinal dystrophies, cancer, and neurodegenerative disorders. * Thus, ARRR3 is an important target for the development of new therapies for these diseases. **Additional notes:** * ARRR3 is a highly conserved protein that is found in vertebrates. * It is expressed in high levels in the brain, particularly in the retina. * Mutations in ARRR3 have been shown to be associated with a number of human diseases, including retinal dystrophies, cancer, and neurodegenerative disorders.

Genular Protein ID: 2571180250

Symbol: ARRC_HUMAN

Name: Arrestin-C

UniProtKB Accession Codes:

P36575 B5B0B9 Q5JT23 Q5JT24 Q6IBF5 Q96EN2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 22 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 11 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8224247

Title: X-arrestin: a new retinal arrestin mapping to the X chromosome.

PubMed ID: 8224247

DOI: 10.1016/0014-5793(93)81712-9

PubMed ID: 8308033

Title: Cone arrestin identified by targeting expression of a functional family.

PubMed ID: 8308033

DOI: 10.1016/s0021-9258(17)41820-5

PubMed ID: 8612728

Title: Immunolocalization of X-arrestin in human cone photoreceptors.

PubMed ID: 8612728

DOI: 10.1016/0014-5793(96)00163-9

PubMed ID: 9931451

Title: Isolation and characterization of the human X-arrestin gene.

PubMed ID: 9931451

DOI: 10.1016/s0378-1119(98)00510-1

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 20048153

Title: Site-specific phosphorylation of CXCR4 is dynamically regulated by multiple kinases and results in differential modulation of CXCR4 signaling.

PubMed ID: 20048153

DOI: 10.1074/jbc.m109.091173

PubMed ID: 35427647

Title: Selective phosphorylation of threonine residues defines GPR84-arrestin interactions of biased ligands.

PubMed ID: 35427647

DOI: 10.1016/j.jbc.2022.101932

PubMed ID: 27829781

Title: cause female-limited early onset high myopia.

PubMed ID: 27829781

Sequence Information:

  • Length: 388
  • Mass: 42778
  • Checksum: 491F4EE4EE1ADA0D
  • Sequence:
    • MSKVFKKTSS NGKLSIYLGK RDFVDHVDTV EPIDGVVLVD PEYLKCRKLF VMLTCAFRYG 
RDDLEVIGLT FRKDLYVQTL QVVPAESSSP QGPLTVLQER LLHKLGDNAY PFTLQMVTNL 
PCSVTLQPGP EDAGKPCGID FEVKSFCAEN PEETVSKRDY VRLVVRKVQF APPEAGPGPS 
AQTIRRFLLS AQPLQLQAWM DREVHYHGEP ISVNVSINNC TNKVIKKIKI SVDQITDVVL 
YSLDKYTKTV FIQEFTETVA ANSSFSQSFA VTPILAASCQ KRGLALDGKL KHEDTNLASS 
TIIRPGMDKE LLGILVSYKV RVNLMVSCGG ILGDLTASDV GVELPLVLIH PKPSHEAASS 
EDIVIEEFTR KGEEESQKAV EAEGDEGS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.