Details for: MCF2
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 30.0422
Cell Significance Index: -7.6200 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 4.4500
Cell Significance Index: 119.2400 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 1.9943
Cell Significance Index: 63.8800 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.7629
Cell Significance Index: 28.8900 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.7008
Cell Significance Index: 31.0000 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.5557
Cell Significance Index: 111.4700 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.4652
Cell Significance Index: 166.8700 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.4051
Cell Significance Index: 8.8700 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.3438
Cell Significance Index: 21.1300 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.3311
Cell Significance Index: 22.2600 - Cell Name: cortical interneuron (CL0008031)
Fold Change: 0.3017
Cell Significance Index: 7.2400 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 0.2403
Cell Significance Index: 2.9800 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 0.2180
Cell Significance Index: 6.2200 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.1977
Cell Significance Index: 12.1200 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.1842
Cell Significance Index: 127.4000 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.1550
Cell Significance Index: 7.0300 - Cell Name: hippocampal interneuron (CL1001569)
Fold Change: 0.0540
Cell Significance Index: 0.7000 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0527
Cell Significance Index: 9.5000 - Cell Name: retinal ganglion cell (CL0000740)
Fold Change: 0.0479
Cell Significance Index: 0.4000 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.0388
Cell Significance Index: 2.9800 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0320
Cell Significance Index: 60.1700 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.0306
Cell Significance Index: 27.6600 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 0.0283
Cell Significance Index: 0.5600 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.0241
Cell Significance Index: 0.6200 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.0222
Cell Significance Index: 0.4600 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0201
Cell Significance Index: 12.7900 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0184
Cell Significance Index: 8.3500 - Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: 0.0128
Cell Significance Index: 0.1600 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.0117
Cell Significance Index: 0.2000 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0095
Cell Significance Index: 12.9200 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.0041
Cell Significance Index: 0.6000 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0033
Cell Significance Index: 5.1300 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0000
Cell Significance Index: 0.0700 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.0019
Cell Significance Index: -0.0400 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: -0.0022
Cell Significance Index: -0.3600 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.0036
Cell Significance Index: -0.1900 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0063
Cell Significance Index: -0.7700 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0077
Cell Significance Index: -5.6600 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: -0.0103
Cell Significance Index: -1.9600 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0104
Cell Significance Index: -7.9000 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0105
Cell Significance Index: -7.7800 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.0107
Cell Significance Index: -0.4700 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0133
Cell Significance Index: -7.2400 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0139
Cell Significance Index: -7.8400 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0162
Cell Significance Index: -0.5700 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0178
Cell Significance Index: -5.1200 - Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0207
Cell Significance Index: -4.1000 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.0250
Cell Significance Index: -0.5300 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0255
Cell Significance Index: -1.1900 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0281
Cell Significance Index: -4.8000 - Cell Name: colon goblet cell (CL0009039)
Fold Change: -0.0334
Cell Significance Index: -3.3100 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0356
Cell Significance Index: -4.8900 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0376
Cell Significance Index: -7.9300 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.0392
Cell Significance Index: -1.2500 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.0402
Cell Significance Index: -0.5800 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0441
Cell Significance Index: -4.5000 - Cell Name: ON midget ganglion cell (CL4033046)
Fold Change: -0.0460
Cell Significance Index: -0.5800 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.0489
Cell Significance Index: -1.6000 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.0533
Cell Significance Index: -1.0700 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0544
Cell Significance Index: -6.3400 - Cell Name: retinal cone cell (CL0000573)
Fold Change: -0.0545
Cell Significance Index: -0.6800 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: -0.0581
Cell Significance Index: -6.3200 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0601
Cell Significance Index: -7.0900 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0618
Cell Significance Index: -6.4400 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0643
Cell Significance Index: -7.3700 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.0734
Cell Significance Index: -1.8300 - Cell Name: keratocyte (CL0002363)
Fold Change: -0.0826
Cell Significance Index: -1.3100 - Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
Fold Change: -0.0847
Cell Significance Index: -1.1300 - Cell Name: neuron (CL0000540)
Fold Change: -0.0865
Cell Significance Index: -0.8200 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.0877
Cell Significance Index: -5.5300 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.0907
Cell Significance Index: -6.2700 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.0943
Cell Significance Index: -4.9100 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.0982
Cell Significance Index: -5.1000 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.1057
Cell Significance Index: -5.9300 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: -0.1064
Cell Significance Index: -2.2200 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.1075
Cell Significance Index: -2.9300 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.1079
Cell Significance Index: -6.9600 - Cell Name: inhibitory interneuron (CL0000498)
Fold Change: -0.1112
Cell Significance Index: -1.3300 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.1125
Cell Significance Index: -3.9400 - Cell Name: neural cell (CL0002319)
Fold Change: -0.1149
Cell Significance Index: -1.3400 - Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: -0.1177
Cell Significance Index: -1.1200 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.1237
Cell Significance Index: -2.6800 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.1274
Cell Significance Index: -3.1900 - Cell Name: glutamatergic neuron (CL0000679)
Fold Change: -0.1285
Cell Significance Index: -1.4000 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1306
Cell Significance Index: -6.1400 - Cell Name: lens fiber cell (CL0011004)
Fold Change: -0.1353
Cell Significance Index: -4.2800 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.1506
Cell Significance Index: -4.2100 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.1649
Cell Significance Index: -4.7500 - Cell Name: epithelial cell of lacrimal sac (CL1000436)
Fold Change: -0.1737
Cell Significance Index: -1.2500 - Cell Name: GABAergic neuron (CL0000617)
Fold Change: -0.1807
Cell Significance Index: -2.2800 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: -0.1890
Cell Significance Index: -3.7200 - Cell Name: intratelencephalic-projecting glutamatergic cortical neuron (CL4023008)
Fold Change: -0.1906
Cell Significance Index: -1.9600 - Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
Fold Change: -0.1916
Cell Significance Index: -3.8200 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.1925
Cell Significance Index: -5.6700 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: -0.1974
Cell Significance Index: -2.8100 - Cell Name: midget ganglion cell of retina (CL4023188)
Fold Change: -0.1997
Cell Significance Index: -2.0800 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.2101
Cell Significance Index: -4.4800 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.2161
Cell Significance Index: -3.1900 - Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
Fold Change: -0.2198
Cell Significance Index: -2.9300 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.2305
Cell Significance Index: -6.0600
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 4264557341
Symbol: MCF2_HUMAN
Name: Proto-oncogene DBL
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 3056717
Title: Molecular cloning and characterization of the human dbl proto-oncogene: evidence that its overexpression is sufficient to transform NIH/3T3 cells.
PubMed ID: 3056717
PubMed ID: 12445822
Title: Alternative splicing variants of the human DBL (MCF-2) proto-oncogene.
PubMed ID: 12445822
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15772651
PubMed ID: 3281159
Title: The predicted DBL oncogene product defines a distinct class of transforming proteins.
PubMed ID: 3281159
PubMed ID: 2577874
Title: Activation of a mcf.2 oncogene by deletion of amino-terminal coding sequences.
PubMed ID: 2577874
PubMed ID: 2065022
Title: A region of proto-dbl essential for its transforming activity shows sequence similarity to a yeast cell cycle gene, CDC24, and the human breakpoint cluster gene, bcr.
PubMed ID: 2065022
PubMed ID: 8276860
Title: Cellular transformation and guanine nucleotide exchange activity are catalyzed by a common domain on the dbl oncogene product.
PubMed ID: 8276860
PubMed ID: 10652228
Title: Activation of the guanine nucleotide exchange factor Dbl following ACK1-dependent tyrosine phosphorylation.
PubMed ID: 10652228
PubMed ID: 15157669
Title: Role of the Sec14-like domain of Dbl family exchange factors in the regulation of Rho family GTPases in different subcellular sites.
PubMed ID: 15157669
PubMed ID: 17000758
Title: Ccpg1, a novel scaffold protein that regulates the activity of the Rho guanine nucleotide exchange factor Dbs.
PubMed ID: 17000758
DOI: 10.1128/mcb.00670-06
Sequence Information:
- Length: 925
- Mass: 107673
- Checksum: 96233C7AFC85D637
- Sequence:
MAEANPRRGK MRFRRNAASF PGNLHLVLVL RPTSFLQRTF TDIGFWFSQE DFMLKLPVVM LSSVSDLLTY IDDKQLTPEL GGTLQYCHSE WIIFRNAIEN FALTVKEMAQ MLQSFGTELA ETELPDDIPS IEEILAIRAE RYHLLKNDIT AVTKEGKILL TNLEVPDTEG AVSSRLECHR QISGDWQTIN KLLTQVHDME TAFDGFWEKH QLKMEQYLQL WKFEQDFQQL VTEVEFLLNQ QAELADVTGT IAQVKQKIKK LENLDENSQE LLSKAQFVIL HGHKLAANHH YALDLICQRC NELRYLSDIL VNEIKAKRIQ LSRTFKMHKL LQQARQCCDE GECLLANQEI DKFQSKEDAQ KALQDIENFL EMALPFINYE PETLQYEFDV ILSPELKVQM KTIQLKLENI RSIFENQQAG FRNLADKHVR PIQFVVPTPE NLVTSGTPFF SSKQGKKTWR QNQSNLKIEV VPDCQEKRSS GPSSSLDNGN SLDVLKNHVL NELIQTERVY VRELYTVLLG YRAEMDNPEM FDLMPPLLRN KKDILFGNMA EIYEFHNDIF LSSLENCAHA PERVGPCFLE RKDDFQMYAK YCQNKPRSET IWRKYSECAF FQECQRKLKH RLRLDSYLLK PVQRITKYQL LLKELLKYSK DCEGSALLKK ALDAMLDLLK SVNDSMHQIA INGYIGNLNE LGKMIMQGGF SVWIGHKKGA TKMKDLARFK PMQRHLFLYE KAIVFCKRRV ESGEGSDRYP SYSFKHCWKM DEVGITEYVK GDNRKFEIWY GEKEEVYIVQ ASNVDVKMTW LKEIRNILLK QQELLTVKKR KQQDQLTERD KFQISLQQND EKQQGAFIST EETELEHTST VVEVCEAIAS VQAEANTVWT EASQSAEISE EPAEWSSNYF YPTYDENEEE NRPLMRPVSE MALLY
Genular Protein ID: 624976162
Symbol: B2R9S6_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 925
- Mass: 107632
- Checksum: 823BDF6E72F367EB
- Sequence:
MAEANPRRGK MRFRRNAASF PGNLHLVLVL RPTSFLQRTF TDIGFWFSQE DFMLKLPVVM LSSVSDLLTY IDDKQLTPEL GGTLQYCHSE WIIFRNAIEN FALTVKEMAQ MLQSFGTELA ETELPDDIPS IEEILAIRAE RYHLLKNDIT AVTKEGKILL TNLEVPDTEG AVSSRLECHR QISGDWQTIN KLLTQVHDME TAFDGFWEKH QLKMEQYLQL WKFEQDFQQL VTEVEFLLNQ QAELADVTGT IAQVKQKIKK LENLDENSQE LLSKAQFVIL HGHKLAANHH YALDLICQRC NELRYLSDIL VNEIKAKRIQ LSRTFKMHKL LQQARQCCDE GECLLANQEI DKFQSKEDAQ KALQDIENFL EMALPFINYE PETLQYEFDV ILSPELKVQM KTIQLKLENI RSIFENQQAG FRNLADKHVR PIQFVVPTPE NLVTSGTPFF SSKQGKKTWR QNQSNLKIEV VPDCQEKRSS GPSSSLDNGN SLDVLKNHVL NELIQTERVY VRELYTVLLG YRAEMDNPEM FDLMPPLLRN KKDILFGNMA EIYEFHNDIF LSSLENCAHA PERVGPCFLE RKDDFQMYAK YCQNKPRSET IWRKYSECAF FQECQRKLKH RLRLDSYLLK PGQRITKYQL LLKELLKYSK DCEGSALLKK ALDAMLDLLK SVNDSMHQIA INGYIGNLNE LGKMIMQGGF SVWIGHKKGA TKMKDLARFK PMQRHLFLYE KAIVFCKRRV ESGEGSDRYP SYSFKHCWKM DEVGITEYVK GDNRKFEIWY GEKEEVYIVQ ASNVDVKMTW LKEIRNILLK QQELLTVKKR KQQDQLTERD KFQISLQQND EKQQGAFIST EETELEHTST VVEVCEAIAS VQAEANTVWT EASQSAEISE EPAEWSSNYF YPTYDEDEEE NRPLMRPVSE MALLY
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.