Details for: MLN

Gene ID: 4295

Symbol: MLN

Ensembl ID: ENSG00000096395

Description: motilin

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 5.3380
    Cell Significance Index: 58.8100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.6242
    Cell Significance Index: 46.8000
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 1.4945
    Cell Significance Index: 11.3300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5923
    Cell Significance Index: 26.8500
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.4879
    Cell Significance Index: 3.9500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4494
    Cell Significance Index: 85.5300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3569
    Cell Significance Index: 35.3100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.3254
    Cell Significance Index: 6.7500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3111
    Cell Significance Index: 6.7400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2644
    Cell Significance Index: 5.6300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2607
    Cell Significance Index: 235.4300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.2090
    Cell Significance Index: 6.7000
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.2082
    Cell Significance Index: 1.8500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1727
    Cell Significance Index: 28.1000
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.1195
    Cell Significance Index: 1.5100
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.1170
    Cell Significance Index: 1.1800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1012
    Cell Significance Index: 11.0100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0717
    Cell Significance Index: 4.9600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0569
    Cell Significance Index: 2.0000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0391
    Cell Significance Index: 2.3500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0280
    Cell Significance Index: 0.2900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0121
    Cell Significance Index: 1.3900
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0033
    Cell Significance Index: 0.0400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0013
    Cell Significance Index: 1.9900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0000
    Cell Significance Index: -0.0500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0011
    Cell Significance Index: -2.0100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0012
    Cell Significance Index: -0.0300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0016
    Cell Significance Index: -2.1100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0027
    Cell Significance Index: -1.9700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0028
    Cell Significance Index: -0.0700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0029
    Cell Significance Index: -1.6300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0036
    Cell Significance Index: -0.2200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0044
    Cell Significance Index: -0.1100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0049
    Cell Significance Index: -2.2400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0056
    Cell Significance Index: -2.0000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0063
    Cell Significance Index: -1.2600
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: -0.0072
    Cell Significance Index: -0.0800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0082
    Cell Significance Index: -0.3500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0096
    Cell Significance Index: -1.9300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0109
    Cell Significance Index: -2.3000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0112
    Cell Significance Index: -1.3100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0113
    Cell Significance Index: -2.0400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0129
    Cell Significance Index: -2.2100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0129
    Cell Significance Index: -3.7300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0133
    Cell Significance Index: -1.8300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0141
    Cell Significance Index: -2.0500
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: -0.0151
    Cell Significance Index: -0.1600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0167
    Cell Significance Index: -0.8400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0189
    Cell Significance Index: -2.3300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0226
    Cell Significance Index: -1.2700
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.0252
    Cell Significance Index: -0.3300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0277
    Cell Significance Index: -0.6700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0279
    Cell Significance Index: -2.9000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0283
    Cell Significance Index: -1.1600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0302
    Cell Significance Index: -0.5900
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0335
    Cell Significance Index: -0.4600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0363
    Cell Significance Index: -2.4400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0389
    Cell Significance Index: -2.3900
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0389
    Cell Significance Index: -0.4700
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0408
    Cell Significance Index: -0.4500
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0440
    Cell Significance Index: -0.4600
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.0442
    Cell Significance Index: -0.5100
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.0457
    Cell Significance Index: -0.6500
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.0500
    Cell Significance Index: -0.4300
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: -0.0507
    Cell Significance Index: -0.5100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0508
    Cell Significance Index: -3.9000
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.0528
    Cell Significance Index: -0.4700
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0531
    Cell Significance Index: -0.5600
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: -0.0531
    Cell Significance Index: -0.5600
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.0531
    Cell Significance Index: -0.5300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0557
    Cell Significance Index: -0.8400
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: -0.0569
    Cell Significance Index: -0.4500
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0583
    Cell Significance Index: -0.6700
  • Cell Name: immature NK T cell (CL0000914)
    Fold Change: -0.0602
    Cell Significance Index: -0.7700
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.0628
    Cell Significance Index: -0.5700
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.0637
    Cell Significance Index: -0.4200
  • Cell Name: muscle cell (CL0000187)
    Fold Change: -0.0638
    Cell Significance Index: -0.6100
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: -0.0648
    Cell Significance Index: -0.5400
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0653
    Cell Significance Index: -0.6200
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0656
    Cell Significance Index: -0.5100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0676
    Cell Significance Index: -2.3500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0698
    Cell Significance Index: -1.8700
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0706
    Cell Significance Index: -0.7100
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0715
    Cell Significance Index: -2.2600
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0716
    Cell Significance Index: -0.6300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0723
    Cell Significance Index: -1.2100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0751
    Cell Significance Index: -2.6300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0752
    Cell Significance Index: -2.2200
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.0752
    Cell Significance Index: -0.4800
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.0754
    Cell Significance Index: -0.5000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0758
    Cell Significance Index: -1.0900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0828
    Cell Significance Index: -2.2100
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0847
    Cell Significance Index: -0.9000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0876
    Cell Significance Index: -2.5000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0885
    Cell Significance Index: -2.2100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0894
    Cell Significance Index: -2.9300
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.0898
    Cell Significance Index: -0.5500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0907
    Cell Significance Index: -2.8900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0922
    Cell Significance Index: -2.3500
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0922
    Cell Significance Index: -2.2500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** Motilin is a peptide hormone that is primarily expressed in the gastrointestinal tract, where it influences motility and secretion. However, its expression extends to other tissues, including immune cells, suggesting a broader role in immune regulation. The promotilin protein is characterized by its ability to interact with G-protein coupled receptors, which are essential for signal transduction and downstream signaling events. This interaction is critical for the regulation of immune responses, including the modulation of inflammatory processes. **Pathways and Functions:** The Motilin gene is involved in several key signaling pathways, including: 1. **G alpha (q) signaling events:** Motilin interacts with G-protein coupled receptors, which activate the G alpha (q) subunit, leading to the activation of downstream signaling pathways. This pathway is essential for the regulation of immune responses, including the modulation of inflammatory processes. 2. **Gpcr downstream signaling:** The interaction between promotilin and G-protein coupled receptors triggers a cascade of downstream signaling events, including the activation of protein kinase C and the regulation of gene expression. 3. **Hormone activity:** Motilin has been shown to regulate hormone secretion and motility in the gastrointestinal tract, highlighting its role in maintaining homeostasis. 4. **Gpcr ligand binding:** Promotilin interacts with G-protein coupled receptors, which are essential for ligand binding and signal transduction. 5. **Signaling by gpcr:** The interaction between promotilin and G-protein coupled receptors triggers a signaling cascade that regulates immune responses and modulates physiological processes. **Clinical Significance:** The Motilin gene has significant implications in various clinical contexts, including: 1. **Immune regulation:** Dysregulation of Motilin expression has been linked to immune disorders, such as inflammatory bowel disease and autoimmune diseases. 2. **Gastrointestinal disorders:** Motilin plays a critical role in regulating gastrointestinal motility and secretion, making it a potential target for the treatment of gastrointestinal disorders, such as irritable bowel syndrome. 3. **Neurological disorders:** The expression of Motilin in the brain suggests a role in neurological disorders, such as Parkinson's disease and Alzheimer's disease. 4. **Cancer:** Motilin has been shown to regulate cell growth and proliferation, making it a potential target for cancer therapy. In conclusion, the Motilin gene plays a critical role in regulating immune responses and modulating various physiological processes. Further research is necessary to fully elucidate the mechanisms by which Motilin regulates immune function and to explore its therapeutic potential in various clinical contexts.

Genular Protein ID: 35229154

Symbol: MOTI_HUMAN

Name: Promotilin

UniProtKB Accession Codes:

P12872 B7ZLR7 E9PDN2 J3KN51 Q2M1L2 Q5T975 Q6NSY7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 16 Ensembl 3 EvolutionaryTrace 1 GO 3 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 2 RefSeq 3 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 3666144

Title: Sequence of an intestinal cDNA encoding human motilin precursor.

PubMed ID: 3666144

DOI: 10.1016/0014-5793(87)80512-4

PubMed ID: 2737284

Title: Exon-intron organization, expression, and chromosomal localization of the human motilin gene.

PubMed ID: 2737284

DOI: 10.1016/0014-5793(89)80633-7

PubMed ID: 2574660

Title: Structure and expression of the human motilin gene.

PubMed ID: 2574660

DOI: 10.1089/dna.1989.8.615

PubMed ID: 2914635

Title: Molecular heterogeneity of human motilin-like immunoreactivity explained by the processing of prepromotilin.

PubMed ID: 2914635

DOI: 10.1016/0016-5085(89)90892-5

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 12495026

Title: NMR solution structure and dynamics of motilin in isotropic phospholipid bicellar solution.

PubMed ID: 12495026

DOI: 10.1023/a:1020902915969

Sequence Information:

  • Length: 115
  • Mass: 12920
  • Checksum: 30D4BB59B2F42783
  • Sequence:
    • MVSRKAVAAL LVVHVAAMLA SQTEAFVPIF TYGELQRMQE KERNKGQKKS LSVWQRSGEE 
GPVDPAEPIR EEENEMIKLT APLEIGMRMN SRQLEKYPAT LEGLLSEMLP QHAAK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.