Details for: MMP17

Gene ID: 4326

Symbol: MMP17

Ensembl ID: ENSG00000198598

Description: matrix metallopeptidase 17

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 65.9615
    Cell Significance Index: -10.2600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 40.4111
    Cell Significance Index: -10.2500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 23.9503
    Cell Significance Index: -9.7300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 8.3580
    Cell Significance Index: -10.3100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 4.1785
    Cell Significance Index: 256.1800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.6254
    Cell Significance Index: -10.3600
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 2.3885
    Cell Significance Index: 18.3200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.9540
    Cell Significance Index: 55.7600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.6563
    Cell Significance Index: 332.2500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.4447
    Cell Significance Index: 31.3000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.1996
    Cell Significance Index: 53.0600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.1609
    Cell Significance Index: 25.4200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.1400
    Cell Significance Index: 43.1700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.1239
    Cell Significance Index: 213.8800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9164
    Cell Significance Index: 90.6600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.8599
    Cell Significance Index: 57.8200
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: 0.7641
    Cell Significance Index: 10.7100
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.7352
    Cell Significance Index: 11.8000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7135
    Cell Significance Index: 644.2600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.6999
    Cell Significance Index: 45.1600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.6850
    Cell Significance Index: 21.9400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4600
    Cell Significance Index: 164.9900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4460
    Cell Significance Index: 72.5300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3440
    Cell Significance Index: 37.4200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2042
    Cell Significance Index: 12.5500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1654
    Cell Significance Index: 11.4400
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.1094
    Cell Significance Index: 1.4600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0843
    Cell Significance Index: 11.5800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0810
    Cell Significance Index: 1.7300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0478
    Cell Significance Index: 2.8700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0425
    Cell Significance Index: 1.0200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0410
    Cell Significance Index: 28.3600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0329
    Cell Significance Index: 0.9200
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.0168
    Cell Significance Index: 0.1600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0017
    Cell Significance Index: -0.0600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0028
    Cell Significance Index: -5.2000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0038
    Cell Significance Index: -0.1100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0046
    Cell Significance Index: -0.5900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0052
    Cell Significance Index: -0.1300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0054
    Cell Significance Index: -9.9300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0067
    Cell Significance Index: -10.3000
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: -0.0069
    Cell Significance Index: -0.0300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0071
    Cell Significance Index: -4.5000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0077
    Cell Significance Index: -10.5200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0146
    Cell Significance Index: -0.6600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0148
    Cell Significance Index: -8.1000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0149
    Cell Significance Index: -11.2700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0150
    Cell Significance Index: -11.0900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0156
    Cell Significance Index: -6.8800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0191
    Cell Significance Index: -11.9000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0196
    Cell Significance Index: -11.0400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0198
    Cell Significance Index: -9.0000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0248
    Cell Significance Index: -1.3900
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.0285
    Cell Significance Index: -0.3700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0291
    Cell Significance Index: -8.3900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0358
    Cell Significance Index: -7.1000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0425
    Cell Significance Index: -7.2500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0447
    Cell Significance Index: -0.6400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0450
    Cell Significance Index: -8.1100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0535
    Cell Significance Index: -7.7800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0546
    Cell Significance Index: -1.7400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0551
    Cell Significance Index: -11.6000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0614
    Cell Significance Index: -7.9300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0769
    Cell Significance Index: -1.5200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0771
    Cell Significance Index: -9.4800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0865
    Cell Significance Index: -10.2000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0883
    Cell Significance Index: -2.8900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0956
    Cell Significance Index: -9.9500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0959
    Cell Significance Index: -10.9900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0975
    Cell Significance Index: -2.0700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1008
    Cell Significance Index: -2.0900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1030
    Cell Significance Index: -10.5200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1135
    Cell Significance Index: -1.7100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1138
    Cell Significance Index: -8.4800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1156
    Cell Significance Index: -2.3200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1194
    Cell Significance Index: -2.5800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1227
    Cell Significance Index: -9.4200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1464
    Cell Significance Index: -9.2300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1575
    Cell Significance Index: -3.9300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1615
    Cell Significance Index: -1.7600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1641
    Cell Significance Index: -5.7500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1645
    Cell Significance Index: -3.2100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1657
    Cell Significance Index: -8.7000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1709
    Cell Significance Index: -8.8800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1715
    Cell Significance Index: -8.0600
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1730
    Cell Significance Index: -1.6400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1806
    Cell Significance Index: -3.7700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1819
    Cell Significance Index: -8.4800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1839
    Cell Significance Index: -9.5800
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -0.1976
    Cell Significance Index: -2.1800
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.2151
    Cell Significance Index: -3.0200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2410
    Cell Significance Index: -10.4800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2428
    Cell Significance Index: -6.9600
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.2442
    Cell Significance Index: -3.7200
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.2589
    Cell Significance Index: -3.0200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.2592
    Cell Significance Index: -4.0100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2598
    Cell Significance Index: -6.9500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2626
    Cell Significance Index: -6.7500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2675
    Cell Significance Index: -9.8200
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.2933
    Cell Significance Index: -4.6500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MMP17 is a secreted, zinc-dependent endopeptidase that exhibits a dual specificity for prolyl and lysine residues, allowing it to cleave a wide range of ECM components, including collagens, elastins, and proteoglycans. Its enzymatic activity is essential for the remodeling of the ECM, a process that is crucial for tissue development, repair, and homeostasis. MMP17 is also capable of activating other MMPs, thereby amplifying its pro-degradative effects. **Pathways and Functions:** MMP17 plays a critical role in various cellular signaling pathways, including: 1. **Extracellular matrix degradation:** MMP17's enzymatic activity is essential for the breakdown of ECM components, allowing for tissue remodeling, cell migration, and differentiation. 2. **Cell migration and invasion:** MMP17's ability to degrade ECM components enables cells to migrate and invade surrounding tissues, a process that is crucial for development, wound healing, and cancer metastasis. 3. **Angiogenesis:** MMP17 has been implicated in the regulation of angiogenesis, the formation of new blood vessels, which is a critical process in tissue development and cancer progression. 4. **Inflammation and immune response:** MMP17 has been shown to regulate the inflammatory response by degrading pro-inflammatory cytokines and chemokines, thereby modulating immune cell activity. **Clinical Significance:** MMP17 has been implicated in various diseases and disorders, including: 1. **Cancer:** Elevated MMP17 expression has been observed in various types of cancer, including breast, lung, and colon cancer, where it contributes to tumor progression and metastasis. 2. **Neurological disorders:** MMP17 has been implicated in neurodegenerative diseases, such as Alzheimer's and Parkinson's disease, where it contributes to the degradation of the blood-brain barrier and the accumulation of amyloid-β peptides. 3. **Cardiovascular disease:** MMP17 has been shown to regulate the remodeling of the cardiovascular system, which is critical in the development of atherosclerosis and cardiac fibrosis. 4. **Developmental disorders:** MMP17 has been implicated in developmental disorders, such as congenital heart defects and cleft palate, where it contributes to the degradation of ECM components and the disruption of tissue homeostasis. In conclusion, MMP17 is a key player in the regulation of extracellular matrix degradation and cellular signaling, with significant implications for various physiological and pathological processes. Further research is necessary to fully elucidate the mechanisms by which MMP17 contributes to disease and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 938552542

Symbol: MMP17_HUMAN

Name: Matrix metalloproteinase-17

UniProtKB Accession Codes:

Q9ULZ9 Q14850

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CTD 1 ChEBI 6 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 1 EMBL 3 Ensembl 2 ExpressionAtlas 1 GO 13 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 InterPro 10 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 4 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10471807

Title: Human membrane type-4 matrix metalloproteinase (MT4-MMP) is encoded by a novel major transcript: isolation of complementary DNA clones for human and mouse mt4-mmp transcripts.

PubMed ID: 10471807

DOI: 10.1016/s0014-5793(99)01065-0

PubMed ID: 8640782

Title: Molecular cloning of a novel membrane-type matrix metalloproteinase from a human breast carcinoma.

PubMed ID: 8640782

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 10551873

Title: Catalytic activities and substrate specificity of the human membrane type 4 matrix metalloproteinase catalytic domain.

PubMed ID: 10551873

DOI: 10.1074/jbc.274.46.33043

PubMed ID: 10567400

Title: Membrane type 4 matrix metalloproteinase (MT4-MMP, MMP-17) is a glycosylphosphatidylinositol-anchored proteinase.

PubMed ID: 10567400

DOI: 10.1074/jbc.274.48.34260

PubMed ID: 10543448

Title: Biochemical characterization of the catalytic domain of membrane-type 4 matrix metalloproteinase.

PubMed ID: 10543448

DOI: 10.1515/bc.1999.137

Sequence Information:

  • Length: 603
  • Mass: 66653
  • Checksum: BB297B21973C7A0B
  • Sequence:
    • MRRRAARGPG PPPPGPGLSR LPLPLLLLLA LGTRGGCAAP APAPRAEDLS LGVEWLSRFG 
YLPPADPTTG QLQTQEELSK AITAMQQFGG LEATGILDEA TLALMKTPRC SLPDLPVLTQ 
ARRRRQAPAP TKWNKRNLSW RVRTFPRDSP LGHDTVRALM YYALKVWSDI APLNFHEVAG 
SAADIQIDFS KADHNDGYPF DGPGGTVAHA FFPGHHHTAG DTHFDDDEAW TFRSSDAHGM 
DLFAVAVHEF GHAIGLSHVA AAHSIMRPYY QGPVGDPLRY GLPYEDKVRV WQLYGVRESV 
SPTAQPEEPP LLPEPPDNRS SAPPRKDVPH RCSTHFDAVA QIRGEAFFFK GKYFWRLTRD 
RHLVSLQPAQ MHRFWRGLPL HLDSVDAVYE RTSDHKIVFF KGDRYWVFKD NNVEEGYPRP 
VSDFSLPPGG IDAAFSWAHN DRTYFFKDQL YWRYDDHTRH MDPGYPAQSP LWRGVPSTLD 
DAMRWSDGAS YFFRGQEYWK VLDGELEVAP GYPQSTARDW LVCGDSQADG SVAAGVDAAE 
GPRAPPGQHD QSRSEDGYEV CSCTSGASSP PGAPGPLVAA TMLLLLPPLS PGALWTAAQA 
LTL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.