Details for: MPL

Gene ID: 4352

Symbol: MPL

Ensembl ID: ENSG00000117400

Description: MPL proto-oncogene, thrombopoietin receptor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 9.9971
    Cell Significance Index: -1.5600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 6.1433
    Cell Significance Index: -3.1600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 5.5984
    Cell Significance Index: -1.4200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 3.5148
    Cell Significance Index: 112.5800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.7183
    Cell Significance Index: 105.3500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4711
    Cell Significance Index: 89.6600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3221
    Cell Significance Index: 6.8600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3025
    Cell Significance Index: 29.9300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2575
    Cell Significance Index: 232.4600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.2168
    Cell Significance Index: 3.1100
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.2100
    Cell Significance Index: 2.9500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2033
    Cell Significance Index: 22.1100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1909
    Cell Significance Index: 31.0500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.1741
    Cell Significance Index: 4.4700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1471
    Cell Significance Index: 8.8300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1043
    Cell Significance Index: 7.2200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0694
    Cell Significance Index: 1.5200
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.0581
    Cell Significance Index: 0.7600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0541
    Cell Significance Index: 2.4500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0448
    Cell Significance Index: 1.2900
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.0379
    Cell Significance Index: 0.4900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0313
    Cell Significance Index: 21.6300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0198
    Cell Significance Index: 0.4300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0161
    Cell Significance Index: 3.2300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0149
    Cell Significance Index: 0.3100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0100
    Cell Significance Index: 0.3500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0055
    Cell Significance Index: 0.4200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0050
    Cell Significance Index: 1.7900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0048
    Cell Significance Index: 0.8700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0028
    Cell Significance Index: 0.0700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0011
    Cell Significance Index: 2.0100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0009
    Cell Significance Index: 1.6000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0004
    Cell Significance Index: 0.6900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0002
    Cell Significance Index: -0.0400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0003
    Cell Significance Index: -0.3900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0020
    Cell Significance Index: -1.0800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0025
    Cell Significance Index: -1.8300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0032
    Cell Significance Index: -1.8200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0037
    Cell Significance Index: -2.3700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0039
    Cell Significance Index: -1.7600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0045
    Cell Significance Index: -0.9400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0051
    Cell Significance Index: -0.7000
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0053
    Cell Significance Index: -0.0700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0056
    Cell Significance Index: -1.6100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0071
    Cell Significance Index: -1.2100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0101
    Cell Significance Index: -1.1600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0103
    Cell Significance Index: -1.4900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0129
    Cell Significance Index: -1.3400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0133
    Cell Significance Index: -1.6400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0139
    Cell Significance Index: -0.7200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0172
    Cell Significance Index: -0.8000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0173
    Cell Significance Index: -0.2600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0203
    Cell Significance Index: -0.5700
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0215
    Cell Significance Index: -0.6800
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0217
    Cell Significance Index: -0.2800
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0221
    Cell Significance Index: -0.4500
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0237
    Cell Significance Index: -0.3500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0242
    Cell Significance Index: -1.3600
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0257
    Cell Significance Index: -0.3300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0265
    Cell Significance Index: -0.7200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0275
    Cell Significance Index: -1.8500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0283
    Cell Significance Index: -2.9000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0288
    Cell Significance Index: -1.7700
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0296
    Cell Significance Index: -0.4300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0300
    Cell Significance Index: -1.0500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0321
    Cell Significance Index: -1.0500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0332
    Cell Significance Index: -0.4900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0349
    Cell Significance Index: -1.1100
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0349
    Cell Significance Index: -0.4700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0353
    Cell Significance Index: -1.5600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0356
    Cell Significance Index: -0.9600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0359
    Cell Significance Index: -0.8700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0361
    Cell Significance Index: -0.8800
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0362
    Cell Significance Index: -0.5300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0367
    Cell Significance Index: -0.9800
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0371
    Cell Significance Index: -0.4700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0374
    Cell Significance Index: -0.5100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0386
    Cell Significance Index: -0.5500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0390
    Cell Significance Index: -1.4300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0413
    Cell Significance Index: -0.6100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0419
    Cell Significance Index: -2.1800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0420
    Cell Significance Index: -0.8800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0427
    Cell Significance Index: -0.7200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0428
    Cell Significance Index: -1.6200
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0429
    Cell Significance Index: -0.4700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0441
    Cell Significance Index: -1.1800
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0443
    Cell Significance Index: -0.4200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0446
    Cell Significance Index: -2.2500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0461
    Cell Significance Index: -0.5500
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0461
    Cell Significance Index: -0.6900
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0474
    Cell Significance Index: -0.6400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0477
    Cell Significance Index: -0.9300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0480
    Cell Significance Index: -1.2000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0483
    Cell Significance Index: -0.9700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0485
    Cell Significance Index: -1.2100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0491
    Cell Significance Index: -1.0600
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.0492
    Cell Significance Index: -0.5500
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0492
    Cell Significance Index: -0.6900
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0506
    Cell Significance Index: -0.5900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0532
    Cell Significance Index: -1.2300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The MPL gene encodes a transmembrane receptor with two extracellular immunoglobulin-like domains, a transmembrane domain, and an intracellular tyrosine kinase domain. The receptor is expressed on various cell types, including platelets, basophils, eosinophils, and stem cells in the gastrointestinal tract. The MPL gene is significantly expressed in tissues involved in blood cell production, such as the bone marrow and spleen. **Pathways and Functions:** The MPL gene is involved in several signaling pathways, including: 1. **Thrombopoietin-mediated signaling pathway:** The MPL receptor binds to thrombopoietin, a cytokine produced by the liver and kidneys, to activate a signaling cascade that regulates platelet production and survival. 2. **Cell surface signaling:** The MPL receptor interacts with various ligands, including thrombopoietin, interleukin-3 (IL-3), and stem cell factor (SCF), to regulate cell surface receptor expression, migration, and adhesion. 3. **Hypoxia response:** The MPL receptor is also involved in the cellular response to hypoxia, a condition characterized by low oxygen levels, which is a common feature of many diseases, including cancer. 4. **Immune response:** The MPL receptor is expressed on immune cells, including basophils, eosinophils, and neutrophils, and plays a role in regulating immune function and response. **Clinical Significance:** Dysregulation of the MPL gene has been implicated in several clinical conditions, including: 1. **Thrombocytopenia:** A decrease in platelet production, which can lead to bleeding disorders and anemia. 2. **Immune disorders:** Mutations in the MPL gene have been associated with autoimmune diseases, such as autoimmune hemolytic anemia and thrombocytopenia. 3. **Cancer:** The MPL receptor has been found to be overexpressed in various types of cancer, including leukemia and lymphoma, where it may contribute to tumor growth and survival. 4. **Gastrointestinal disorders:** The MPL receptor is expressed in stem cells of the gastrointestinal tract, and dysregulation of this receptor may contribute to gastrointestinal disorders, such as inflammatory bowel disease. In conclusion, the MPL proto-oncogene plays a critical role in regulating cell proliferation, differentiation, and survival in various cell types, including platelets, immune cells, and stem cells. Its dysregulation has been implicated in several clinical conditions, highlighting the importance of this gene in maintaining cellular homeostasis and preventing disease.

Genular Protein ID: 1654288033

Symbol: TPOR_HUMAN

Name: Thrombopoietin receptor

UniProtKB Accession Codes:

P40238 Q5JUZ0

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 6 DrugCentral 1 ELM 1 EMBL 12 EMDB 1 Ensembl 1 ExpressionAtlas 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 7 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 6 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1608974

Title: Molecular cloning and characterization of MPL, the human homolog of the v-mpl oncogene: identification of a member of the hematopoietic growth factor receptor superfamily.

PubMed ID: 1608974

DOI: 10.1073/pnas.89.12.5640

PubMed ID: 8020956

Title: Structure and transcription of the human c-mpl gene (MPL).

PubMed ID: 8020956

DOI: 10.1006/geno.1994.1120

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 19880496

Title: Ubiquitination and degradation of the thrombopoietin receptor c-Mpl.

PubMed ID: 19880496

DOI: 10.1182/blood-2009-06-227033

PubMed ID: 10391209

Title: Characterization of single-nucleotide polymorphisms in coding regions of human genes.

PubMed ID: 10391209

DOI: 10.1038/10290

PubMed ID: 11784712

Title: Cloning and characterization of a family of proteins associated with Mpl.

PubMed ID: 11784712

DOI: 10.1074/jbc.m105970200

PubMed ID: 14764528

Title: Familial essential thrombocythemia associated with a dominant-positive activating mutation of the c-MPL gene, which encodes for the receptor for thrombopoietin.

PubMed ID: 14764528

DOI: 10.1182/blood-2003-10-3471

PubMed ID: 15269348

Title: Mpl Baltimore: a thrombopoietin receptor polymorphism associated with thrombocytosis.

PubMed ID: 15269348

DOI: 10.1073/pnas.0404241101

PubMed ID: 16868251

Title: MPL515 mutations in myeloproliferative and other myeloid disorders: a study of 1182 patients.

PubMed ID: 16868251

DOI: 10.1182/blood-2006-04-018879

PubMed ID: 16470591

Title: MPL mutations in 23 patients suffering from congenital amegakaryocytic thrombocytopenia: the type of mutation predicts the course of the disease.

PubMed ID: 16470591

DOI: 10.1002/humu.9415

PubMed ID: 16834459

Title: MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia.

PubMed ID: 16834459

DOI: 10.1371/journal.pmed.0030270

PubMed ID: 19483125

Title: The Asn505 mutation of the c-MPL gene, which causes familial essential thrombocythemia, induces autonomous homodimerization of the c-Mpl protein due to strong amino acid polarity.

PubMed ID: 19483125

DOI: 10.1182/blood-2008-04-149047

PubMed ID: 23441089

Title: MPL W515L mutation in pediatric essential thrombocythemia.

PubMed ID: 23441089

DOI: 10.1002/pbc.24500

PubMed ID: 25538044

Title: The thrombopoietin receptor P106L mutation functionally separates receptor signaling activity from thrombopoietin homeostasis.

PubMed ID: 25538044

DOI: 10.1182/blood-2014-07-587170

Sequence Information:

  • Length: 635
  • Mass: 71245
  • Checksum: D25D8D8959359DDC
  • Sequence:
    • MPSWALFMVT SCLLLAPQNL AQVSSQDVSL LASDSEPLKC FSRTFEDLTC FWDEEEAAPS 
GTYQLLYAYP REKPRACPLS SQSMPHFGTR YVCQFPDQEE VRLFFPLHLW VKNVFLNQTR 
TQRVLFVDSV GLPAPPSIIK AMGGSQPGEL QISWEEPAPE ISDFLRYELR YGPRDPKNST 
GPTVIQLIAT ETCCPALQRP HSASALDQSP CAQPTMPWQD GPKQTSPSRE ASALTAEGGS 
CLISGLQPGN SYWLQLRSEP DGISLGGSWG SWSLPVTVDL PGDAVALGLQ CFTLDLKNVT 
CQWQQQDHAS SQGFFYHSRA RCCPRDRYPI WENCEEEEKT NPGLQTPQFS RCHFKSRNDS 
IIHILVEVTT APGTVHSYLG SPFWIHQAVR LPTPNLHWRE ISSGHLELEW QHPSSWAAQE 
TCYQLRYTGE GHQDWKVLEP PLGARGGTLE LRPRSRYRLQ LRARLNGPTY QGPWSSWSDP 
TRVETATETA WISLVTALHL VLGLSAVLGL LLLRWQFPAH YRRLRHALWP SLPDLHRVLG 
QYLRDTAALS PPKATVSDTC EEVEPSLLEI LPKSSERTPL PLCSSQAQMD YRRLQPSCLG 
TMPLSVCPPM AESGSCCTTH IANHSYLPLS YWQQP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.