Details for: MPL

Gene ID: 4352

Symbol: MPL

Ensembl ID: ENSG00000117400

Description: MPL proto-oncogene, thrombopoietin receptor

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 2.41
    Marker Score: 7134
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.15
    Marker Score: 2166
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 2.11
    Marker Score: 4374.5
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.62
    Marker Score: 1174
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.34
    Marker Score: 2535
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 858
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 1.23
    Marker Score: 10360
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.18
    Marker Score: 489
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4819
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.14
    Marker Score: 7549
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.1
    Marker Score: 505
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 1.09
    Marker Score: 1518
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.03
    Marker Score: 16165
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71832
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48057
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 511
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.99
    Marker Score: 312
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 464
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.97
    Marker Score: 510.5
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.95
    Marker Score: 2729.5
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 376
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5352
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 328
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5289
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.81
    Marker Score: 618
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.8
    Marker Score: 615
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.79
    Marker Score: 2244
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 710
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1263
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 399
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.76
    Marker Score: 504
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.75
    Marker Score: 270.5
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 0.73
    Marker Score: 583
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 464
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 180
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.69
    Marker Score: 1617
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.64
    Marker Score: 337
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.6
    Marker Score: 1759.5
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 0.58
    Marker Score: 1864
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 175
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.48
    Marker Score: 201
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 279
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.43
    Marker Score: 173
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.42
    Marker Score: 148
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.41
    Marker Score: 299
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: 0.4
    Marker Score: 112.5
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.4
    Marker Score: 443
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.38
    Marker Score: 187
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.35
    Marker Score: 160
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.34
    Marker Score: 108
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.33
    Marker Score: 371
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.32
    Marker Score: 653
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.32
    Marker Score: 99
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.29
    Marker Score: 129
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.27
    Marker Score: 165
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.27
    Marker Score: 72
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.24
    Marker Score: 389
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.24
    Marker Score: 115
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.24
    Marker Score: 61
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.23
    Marker Score: 134.5
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 75
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.21
    Marker Score: 136
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.21
    Marker Score: 120
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.2
    Marker Score: 121
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.19
    Marker Score: 74
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.18
    Marker Score: 101.5
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 43
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.16
    Marker Score: 2193
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.16
    Marker Score: 90
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.15
    Marker Score: 76
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.14
    Marker Score: 53.5
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.14
    Marker Score: 63
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.13
    Marker Score: 125
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.13
    Marker Score: 123
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.12
    Marker Score: 109
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.11
    Marker Score: 37
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.11
    Marker Score: 51
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.11
    Marker Score: 60.5
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.1
    Marker Score: 103.5
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.09
    Marker Score: 42
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.09
    Marker Score: 97
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.09
    Marker Score: 32
  • Cell Name: basophil mast progenitor cell (CL0002028)
    Fold Change: 0.09
    Marker Score: 28
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.09
    Marker Score: 303.5
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.09
    Marker Score: 22
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.09
    Marker Score: 84
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.08
    Marker Score: 41
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.08
    Marker Score: 139
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.07
    Marker Score: 72
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.07
    Marker Score: 29
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.07
    Marker Score: 369
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.07
    Marker Score: 162
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.07
    Marker Score: 18

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Other Information

**Key characteristics:** - The MPL proto-oncogene is located on chromosome 1. - It is a single exon gene that encodes a protein of 140 amino acids. - The protein is a receptor for thrombopoietin. - It is expressed in a variety of cell types, including endothelial cells, kidney cells, and intestinal cells. **Pathways and functions:** - MPL is a key regulator of platelet formation. - It is expressed in endothelial cells of blood vessels, which are responsible for the formation of blood clots. - When MPL is bound by thrombopoietin, it triggers a signaling cascade that leads to the activation of platelets. - Activated platelets can then aggregate to form blood clots. **Clinical significance:** - MPL mutations are associated with a number of human diseases, including asthma, rheumatoid arthritis, and cancer. - In some cases, MPL mutations can be treated with drugs that block the effects of thrombopoietin. - Understanding the role of MPL in platelet formation and inflammation is important for the development of new treatments for human diseases. **Additional notes:** - MPL is a highly conserved gene, with a similar gene found in other mammals. - The MPL proto-oncogene is also known as ITGA2. - MPL is a promising target for the development of new drugs for cancer and other diseases that are characterized by abnormal platelet function.

Genular Protein ID: 1654288033

Symbol: TPOR_HUMAN

Name: Thrombopoietin receptor

UniProtKB Accession Codes:

P40238 Q5JUZ0

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 6 DrugCentral 1 ELM 1 EMBL 12 EMDB 1 Ensembl 1 ExpressionAtlas 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 7 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 6 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1608974

Title: Molecular cloning and characterization of MPL, the human homolog of the v-mpl oncogene: identification of a member of the hematopoietic growth factor receptor superfamily.

PubMed ID: 1608974

DOI: 10.1073/pnas.89.12.5640

PubMed ID: 8020956

Title: Structure and transcription of the human c-mpl gene (MPL).

PubMed ID: 8020956

DOI: 10.1006/geno.1994.1120

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 19880496

Title: Ubiquitination and degradation of the thrombopoietin receptor c-Mpl.

PubMed ID: 19880496

DOI: 10.1182/blood-2009-06-227033

PubMed ID: 10391209

Title: Characterization of single-nucleotide polymorphisms in coding regions of human genes.

PubMed ID: 10391209

DOI: 10.1038/10290

PubMed ID: 11784712

Title: Cloning and characterization of a family of proteins associated with Mpl.

PubMed ID: 11784712

DOI: 10.1074/jbc.m105970200

PubMed ID: 14764528

Title: Familial essential thrombocythemia associated with a dominant-positive activating mutation of the c-MPL gene, which encodes for the receptor for thrombopoietin.

PubMed ID: 14764528

DOI: 10.1182/blood-2003-10-3471

PubMed ID: 15269348

Title: Mpl Baltimore: a thrombopoietin receptor polymorphism associated with thrombocytosis.

PubMed ID: 15269348

DOI: 10.1073/pnas.0404241101

PubMed ID: 16868251

Title: MPL515 mutations in myeloproliferative and other myeloid disorders: a study of 1182 patients.

PubMed ID: 16868251

DOI: 10.1182/blood-2006-04-018879

PubMed ID: 16470591

Title: MPL mutations in 23 patients suffering from congenital amegakaryocytic thrombocytopenia: the type of mutation predicts the course of the disease.

PubMed ID: 16470591

DOI: 10.1002/humu.9415

PubMed ID: 16834459

Title: MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia.

PubMed ID: 16834459

DOI: 10.1371/journal.pmed.0030270

PubMed ID: 19483125

Title: The Asn505 mutation of the c-MPL gene, which causes familial essential thrombocythemia, induces autonomous homodimerization of the c-Mpl protein due to strong amino acid polarity.

PubMed ID: 19483125

DOI: 10.1182/blood-2008-04-149047

PubMed ID: 23441089

Title: MPL W515L mutation in pediatric essential thrombocythemia.

PubMed ID: 23441089

DOI: 10.1002/pbc.24500

PubMed ID: 25538044

Title: The thrombopoietin receptor P106L mutation functionally separates receptor signaling activity from thrombopoietin homeostasis.

PubMed ID: 25538044

DOI: 10.1182/blood-2014-07-587170

Sequence Information:

  • Length: 635
  • Mass: 71245
  • Checksum: D25D8D8959359DDC
  • Sequence:
    • MPSWALFMVT SCLLLAPQNL AQVSSQDVSL LASDSEPLKC FSRTFEDLTC FWDEEEAAPS 
GTYQLLYAYP REKPRACPLS SQSMPHFGTR YVCQFPDQEE VRLFFPLHLW VKNVFLNQTR 
TQRVLFVDSV GLPAPPSIIK AMGGSQPGEL QISWEEPAPE ISDFLRYELR YGPRDPKNST 
GPTVIQLIAT ETCCPALQRP HSASALDQSP CAQPTMPWQD GPKQTSPSRE ASALTAEGGS 
CLISGLQPGN SYWLQLRSEP DGISLGGSWG SWSLPVTVDL PGDAVALGLQ CFTLDLKNVT 
CQWQQQDHAS SQGFFYHSRA RCCPRDRYPI WENCEEEEKT NPGLQTPQFS RCHFKSRNDS 
IIHILVEVTT APGTVHSYLG SPFWIHQAVR LPTPNLHWRE ISSGHLELEW QHPSSWAAQE 
TCYQLRYTGE GHQDWKVLEP PLGARGGTLE LRPRSRYRLQ LRARLNGPTY QGPWSSWSDP 
TRVETATETA WISLVTALHL VLGLSAVLGL LLLRWQFPAH YRRLRHALWP SLPDLHRVLG 
QYLRDTAALS PPKATVSDTC EEVEPSLLEI LPKSSERTPL PLCSSQAQMD YRRLQPSCLG 
TMPLSVCPPM AESGSCCTTH IANHSYLPLS YWQQP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.