Details for: ROR1

Gene ID: 4919

Symbol: ROR1

Ensembl ID: ENSG00000185483

Description: receptor tyrosine kinase like orphan receptor 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 135.5446
    Cell Significance Index: -34.3800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 70.5218
    Cell Significance Index: -28.6500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 14.5939
    Cell Significance Index: -31.9400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 6.4526
    Cell Significance Index: 495.1700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 5.0414
    Cell Significance Index: 140.8900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 4.0984
    Cell Significance Index: 79.9900
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 2.6640
    Cell Significance Index: 38.2600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 2.3001
    Cell Significance Index: 3540.9500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 2.1514
    Cell Significance Index: 53.7800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 2.1363
    Cell Significance Index: 36.6100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.1153
    Cell Significance Index: 118.7000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.0466
    Cell Significance Index: 2782.8600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.0455
    Cell Significance Index: 733.7000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.6549
    Cell Significance Index: 3051.9800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.5174
    Cell Significance Index: 2857.0100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 1.0970
    Cell Significance Index: 55.4400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.0733
    Cell Significance Index: 27.5900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.0188
    Cell Significance Index: 462.4100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.9571
    Cell Significance Index: 14.1300
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.9060
    Cell Significance Index: 5.6100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7917
    Cell Significance Index: 157.1200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.5887
    Cell Significance Index: 373.9000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5705
    Cell Significance Index: 12.3600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.4691
    Cell Significance Index: 54.6700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.4185
    Cell Significance Index: 8.7600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3882
    Cell Significance Index: 23.3100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3669
    Cell Significance Index: 36.3000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3634
    Cell Significance Index: 251.3100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3391
    Cell Significance Index: 9.7700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3345
    Cell Significance Index: 302.0700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.2934
    Cell Significance Index: 19.7300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.2902
    Cell Significance Index: 181.2400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2860
    Cell Significance Index: 31.1100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2442
    Cell Significance Index: 39.7100
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.1864
    Cell Significance Index: 1.8800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1710
    Cell Significance Index: 10.5100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1494
    Cell Significance Index: 66.0500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0938
    Cell Significance Index: 18.8200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0448
    Cell Significance Index: 8.5200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0438
    Cell Significance Index: 3.0300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0375
    Cell Significance Index: 6.7600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0221
    Cell Significance Index: 2.7200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0080
    Cell Significance Index: -4.3800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0093
    Cell Significance Index: -1.3500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0138
    Cell Significance Index: -10.2000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0287
    Cell Significance Index: -16.1700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0312
    Cell Significance Index: -5.3200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0393
    Cell Significance Index: -29.7200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0410
    Cell Significance Index: -30.0400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0442
    Cell Significance Index: -6.0700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0496
    Cell Significance Index: -1.0600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0616
    Cell Significance Index: -6.4100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0962
    Cell Significance Index: -3.0800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0996
    Cell Significance Index: -28.6500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1012
    Cell Significance Index: -21.3200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1368
    Cell Significance Index: -6.2000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1640
    Cell Significance Index: -21.0300
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.1816
    Cell Significance Index: -2.5400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1843
    Cell Significance Index: -21.0400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1853
    Cell Significance Index: -6.5100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1934
    Cell Significance Index: -22.1600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2339
    Cell Significance Index: -3.3500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2410
    Cell Significance Index: -31.1300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2477
    Cell Significance Index: -5.9400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2598
    Cell Significance Index: -26.5400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2637
    Cell Significance Index: -16.1700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2789
    Cell Significance Index: -5.9200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2930
    Cell Significance Index: -34.5500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2981
    Cell Significance Index: -14.0100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3382
    Cell Significance Index: -5.6600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3693
    Cell Significance Index: -26.1200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.3716
    Cell Significance Index: -5.7500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.3863
    Cell Significance Index: -3.1500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4033
    Cell Significance Index: -31.9400
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.4578
    Cell Significance Index: -5.8700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4657
    Cell Significance Index: -34.7100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.5024
    Cell Significance Index: -32.4100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.5111
    Cell Significance Index: -26.6200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.5448
    Cell Significance Index: -8.2100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.5899
    Cell Significance Index: -14.2900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.6154
    Cell Significance Index: -32.3100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.6239
    Cell Significance Index: -39.3200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.6285
    Cell Significance Index: -32.6500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.6984
    Cell Significance Index: -22.0900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.7062
    Cell Significance Index: -15.0400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.7106
    Cell Significance Index: -20.3700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.7303
    Cell Significance Index: -32.3100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.7745
    Cell Significance Index: -36.1100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.7788
    Cell Significance Index: -16.1600
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.7982
    Cell Significance Index: -9.9000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.8150
    Cell Significance Index: -28.3200
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.8177
    Cell Significance Index: -10.1200
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.8311
    Cell Significance Index: -14.3700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.8378
    Cell Significance Index: -22.4100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.8431
    Cell Significance Index: -21.0300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.8451
    Cell Significance Index: -27.6700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.8627
    Cell Significance Index: -32.6700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.8998
    Cell Significance Index: -39.1300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.8998
    Cell Significance Index: -31.5200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.9024
    Cell Significance Index: -19.7600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ROR1 is a transmembrane receptor tyrosine kinase with a unique structure, comprising an extracellular domain, a transmembrane domain, and an intracellular tyrosine kinase domain. Its expression is widespread, with significant levels detected in epithelial cells of the lower respiratory tract, lens epithelial cells, cardiac neurons, and neuronal brush cells. Notably, ROR1 exhibits a high degree of specificity, with its ligands remaining unknown, leaving its precise mechanism of action shrouded in mystery. **Pathways and Functions:** ROR1 is implicated in various signaling pathways, including: 1. **Wnt Signaling:** ROR1 interacts with Wnt proteins, modulating their activity and influencing cellular processes such as development, cell fate determination, and tissue homeostasis. 2. **Neurotrophic Signaling:** ROR1 is expressed in neuronal cells and has been shown to regulate neurotrophic factor signaling, influencing neuronal development, survival, and function. 3. **Canonical NF-κB Signaling:** ROR1 positively regulates NF-κB transcription factor activity, which plays a crucial role in immune responses, inflammation, and cell survival. 4. **ERK1/2 Cascade:** ROR1 also activates the ERK1/2 cascade, a key signaling pathway involved in cell proliferation, differentiation, and survival. These pathways highlight ROR1's far-reaching implications in development, signaling, and disease. **Clinical Significance:** ROR1's involvement in various diseases underscores its clinical significance: 1. **Cancer:** ROR1 has been implicated in several types of cancer, including leukemia, lymphoma, and solid tumors, where it may contribute to tumorigenesis and metastasis. 2. **Neurological Disorders:** ROR1's role in neurotrophic signaling and Wnt signaling pathways makes it a potential target for treating neurological disorders, such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. 3. **Immunological Diseases:** ROR1's involvement in canonical NF-κB signaling and ERK1/2 cascade suggests its potential as a therapeutic target for immunological diseases, such as autoimmune disorders and inflammatory conditions. In conclusion, ROR1 is a complex receptor tyrosine kinase with multifaceted roles in development, signaling, and disease. Further research is necessary to elucidate its precise mechanism of action and to explore its therapeutic potential in various diseases. As an expert immunologist, I emphasize the importance of continued investigation into ROR1's intricacies, with the ultimate goal of harnessing its therapeutic potential to improve human health.

Genular Protein ID: 2958037626

Symbol: ROR1_HUMAN

Name: Neurotrophic tyrosine kinase, receptor-related 1

UniProtKB Accession Codes:

Q01973 Q5VVX6 Q66K77 Q92776

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 3 CTD 1 ChEBI 2 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 11 Ensembl 2 ExpressionAtlas 1 GO 19 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 18 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PIR 1 PIRSF 1 PRINTS 2 PRO 1 PROSITE 6 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1334494

Title: A novel family of cell surface receptors with tyrosine kinase-like domain.

PubMed ID: 1334494

DOI: 10.1016/s0021-9258(18)35733-8

PubMed ID: 8875995

Title: Human neural tissues express a truncated Ror1 receptor tyrosine kinase, lacking both extracellular and transmembrane domains.

PubMed ID: 8875995

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 25029443

Title: Evolutionary divergence in the catalytic activity of the CAM-1, ROR1 and ROR2 kinase domains.

PubMed ID: 25029443

DOI: 10.1371/journal.pone.0102695

PubMed ID: 36949068

Title: IGFBP5 is an ROR1 ligand promoting glioblastoma invasion via ROR1/HER2-CREB signaling axis.

PubMed ID: 36949068

DOI: 10.1038/s41467-023-37306-1

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 27162350

Title: ROR1 is essential for proper innervation of auditory hair cells and hearing in humans and mice.

PubMed ID: 27162350

DOI: 10.1073/pnas.1522512113

Sequence Information:

  • Length: 937
  • Mass: 104283
  • Checksum: 0EC0E4762A90C6C7
  • Sequence:
    • MHRPRRRGTR PPLLALLAAL LLAARGAAAQ ETELSVSAEL VPTSSWNISS ELNKDSYLTL 
DEPMNNITTS LGQTAELHCK VSGNPPPTIR WFKNDAPVVQ EPRRLSFRST IYGSRLRIRN 
LDTTDTGYFQ CVATNGKEVV SSTGVLFVKF GPPPTASPGY SDEYEEDGFC QPYRGIACAR 
FIGNRTVYME SLHMQGEIEN QITAAFTMIG TSSHLSDKCS QFAIPSLCHY AFPYCDETSS 
VPKPRDLCRD ECEILENVLC QTEYIFARSN PMILMRLKLP NCEDLPQPES PEAANCIRIG 
IPMADPINKN HKCYNSTGVD YRGTVSVTKS GRQCQPWNSQ YPHTHTFTAL RFPELNGGHS 
YCRNPGNQKE APWCFTLDEN FKSDLCDIPA CDSKDSKEKN KMEILYILVP SVAIPLAIAL 
LFFFICVCRN NQKSSSAPVQ RQPKHVRGQN VEMSMLNAYK PKSKAKELPL SAVRFMEELG 
ECAFGKIYKG HLYLPGMDHA QLVAIKTLKD YNNPQQWTEF QQEASLMAEL HHPNIVCLLG 
AVTQEQPVCM LFEYINQGDL HEFLIMRSPH SDVGCSSDED GTVKSSLDHG DFLHIAIQIA 
AGMEYLSSHF FVHKDLAARN ILIGEQLHVK ISDLGLSREI YSADYYRVQS KSLLPIRWMP 
PEAIMYGKFS SDSDIWSFGV VLWEIFSFGL QPYYGFSNQE VIEMVRKRQL LPCSEDCPPR 
MYSLMTECWN EIPSRRPRFK DIHVRLRSWE GLSSHTSSTT PSGGNATTQT TSLSASPVSN 
LSNPRYPNYM FPSQGITPQG QIAGFIGPPI PQNQRFIPIN GYPIPPGYAA FPAAHYQPTG 
PPRVIQHCPP PKSRSPSSAS GSTSTGHVTS LPSSGSNQEA NIPLLPHMSI PNHPGGMGIT 
VFGNKSQKPY KIDSKQASLL GDANIHGHTE SMISAEL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.