Details for: ORM2

Gene ID: 5005

Symbol: ORM2

Ensembl ID: ENSG00000228278

Description: orosomucoid 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: plasmablast (CL0000980)
    Fold Change: 31.5516
    Cell Significance Index: 292.8200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 9.4364
    Cell Significance Index: 195.7500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 3.9722
    Cell Significance Index: 127.2300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 2.8773
    Cell Significance Index: 43.3600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 1.9890
    Cell Significance Index: 49.7200
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 1.5334
    Cell Significance Index: 5.7800
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.3452
    Cell Significance Index: 19.5300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.9513
    Cell Significance Index: 16.0000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.7473
    Cell Significance Index: 11.0300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6928
    Cell Significance Index: 41.5900
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.6697
    Cell Significance Index: 3.1900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6392
    Cell Significance Index: 63.2400
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.6390
    Cell Significance Index: 4.9100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.6386
    Cell Significance Index: 13.6000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5395
    Cell Significance Index: 107.0700
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.4636
    Cell Significance Index: 2.6700
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.4503
    Cell Significance Index: 7.4200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4478
    Cell Significance Index: 85.2300
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.3891
    Cell Significance Index: 4.0300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.3740
    Cell Significance Index: 6.3000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2909
    Cell Significance Index: 31.6400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.2664
    Cell Significance Index: 16.3300
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.2466
    Cell Significance Index: 2.9800
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.2251
    Cell Significance Index: 2.7900
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.1434
    Cell Significance Index: 0.9400
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.1409
    Cell Significance Index: 1.3900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1330
    Cell Significance Index: 6.0300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1299
    Cell Significance Index: 8.9900
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.1001
    Cell Significance Index: 1.2700
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.0569
    Cell Significance Index: 0.4700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0499
    Cell Significance Index: 37.7700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0137
    Cell Significance Index: 1.7600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0118
    Cell Significance Index: 1.3800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0023
    Cell Significance Index: 0.1000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0009
    Cell Significance Index: -0.0200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0017
    Cell Significance Index: -1.2700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0039
    Cell Significance Index: -0.6300
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0039
    Cell Significance Index: -0.0500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0039
    Cell Significance Index: -2.1300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0048
    Cell Significance Index: -0.1700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0057
    Cell Significance Index: -3.1900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0058
    Cell Significance Index: -0.6600
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0061
    Cell Significance Index: -0.0900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0069
    Cell Significance Index: -0.2000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0104
    Cell Significance Index: -2.0900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0119
    Cell Significance Index: -0.6000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0122
    Cell Significance Index: -1.5800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0146
    Cell Significance Index: -2.0100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0179
    Cell Significance Index: -3.0600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0252
    Cell Significance Index: -1.8800
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.0289
    Cell Significance Index: -0.2800
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0314
    Cell Significance Index: -0.3800
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: -0.0417
    Cell Significance Index: -0.1100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0421
    Cell Significance Index: -6.1300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0533
    Cell Significance Index: -2.9900
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0580
    Cell Significance Index: -0.6000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0628
    Cell Significance Index: -2.9500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0635
    Cell Significance Index: -2.8100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0643
    Cell Significance Index: -3.3400
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0663
    Cell Significance Index: -0.9300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0669
    Cell Significance Index: -1.4000
  • Cell Name: metallothionein-positive alveolar macrophage (CL4033042)
    Fold Change: -0.0689
    Cell Significance Index: -0.4200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0695
    Cell Significance Index: -3.2400
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0702
    Cell Significance Index: -0.7400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0709
    Cell Significance Index: -1.9300
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0717
    Cell Significance Index: -1.4300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0727
    Cell Significance Index: -2.0900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0727
    Cell Significance Index: -1.5700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0782
    Cell Significance Index: -1.1200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0829
    Cell Significance Index: -2.2200
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0905
    Cell Significance Index: -1.0700
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0974
    Cell Significance Index: -0.8300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1015
    Cell Significance Index: -2.6700
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.1027
    Cell Significance Index: -1.3400
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: -0.1039
    Cell Significance Index: -0.9800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1047
    Cell Significance Index: -2.0700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1088
    Cell Significance Index: -2.3100
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1092
    Cell Significance Index: -1.5700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1149
    Cell Significance Index: -2.8700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1161
    Cell Significance Index: -3.1000
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.1200
    Cell Significance Index: -1.4600
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.1207
    Cell Significance Index: -1.4200
  • Cell Name: peptic cell (CL0000155)
    Fold Change: -0.1238
    Cell Significance Index: -1.1000
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.1242
    Cell Significance Index: -1.6900
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: -0.1251
    Cell Significance Index: -0.3400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1256
    Cell Significance Index: -3.2000
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1266
    Cell Significance Index: -2.0500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1285
    Cell Significance Index: -1.4000
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: -0.1288
    Cell Significance Index: -1.2000
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.1320
    Cell Significance Index: -1.0500
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.1335
    Cell Significance Index: -1.5700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1343
    Cell Significance Index: -1.4600
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.1344
    Cell Significance Index: -1.2300
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: -0.1348
    Cell Significance Index: -1.3400
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.1365
    Cell Significance Index: -1.4900
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.1419
    Cell Significance Index: -1.1200
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.1464
    Cell Significance Index: -1.5700
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.1479
    Cell Significance Index: -1.9000
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.1495
    Cell Significance Index: -1.4500
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1506
    Cell Significance Index: -2.0700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ORM2 is a member of the orosomucoid family, which is involved in the acute-phase response. This family of proteins is characterized by their ability to bind to lipopolysaccharides (LPS) and other ligands, triggering the activation of immune cells and the production of pro-inflammatory cytokines. ORM2 shares similarities with its orosomucoid counterparts, such as alpha-1-acid glycoprotein (AAG), in terms of its structure and function. **Pathways and Functions:** ORM2 is involved in several key pathways and processes, including: 1. **Acute-phase response**: ORM2 is upregulated in response to inflammatory stimuli, leading to the activation of immune cells and the production of pro-inflammatory cytokines. 2. **Immune system regulation**: ORM2 modulates the immune response by regulating the production of cytokines, such as interleukin-1 beta, interleukin-1, and tumor necrosis factor. 3. **Neutrophil degranulation**: ORM2 is involved in the regulation of neutrophil degranulation, a process crucial for the elimination of pathogens. 4. **Platelet activation**: ORM2 is also involved in platelet activation, which is essential for hemostasis and wound healing. **Clinical Significance:** The clinical significance of ORM2 is multifaceted: 1. **Inflammatory disorders**: ORM2's role in the acute-phase response makes it a potential target for the treatment of inflammatory disorders, such as rheumatoid arthritis and asthma. 2. **Infectious diseases**: ORM2's involvement in the regulation of immune responses makes it a potential biomarker for infectious diseases, such as sepsis and tuberculosis. 3. **Cancer**: ORM2's expression in various cell types, including glutamatergic neurons and microglial cells, suggests its potential role in cancer development and progression. 4. **Neurological disorders**: ORM2's expression in glutamatergic neurons and oligodendrocyte precursor cells makes it a potential target for the treatment of neurological disorders, such as multiple sclerosis and Alzheimer's disease. In conclusion, ORM2 is a multifunctional protein that plays a critical role in the immune system's response to inflammation and infection. Further research is necessary to fully elucidate its mechanisms of action and to explore its potential therapeutic applications.

Genular Protein ID: 4020344761

Symbol: A1AG2_HUMAN

Name: Alpha-1-acid glycoprotein 2

UniProtKB Accession Codes:

P19652 B2R5L2 Q16571 Q5T538 Q6IB74

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 57 EMBL 16 Ensembl 1 EvolutionaryTrace 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 PANTHER 2 PDB 5 PDBsum 5 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2822385

Title: Structure and expression of the genes coding for human alpha 1-acid glycoprotein.

PubMed ID: 2822385

DOI: 10.1002/j.1460-2075.1987.tb02503.x

PubMed ID: 2970990

Title: Structure and characterisation of a duplicated human alpha 1 acid glycoprotein gene.

PubMed ID: 2970990

DOI: 10.1016/0378-1119(88)90228-4

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 4603214

Title: The disulfide bonds of alpha1-acid glycoprotein.

PubMed ID: 4603214

DOI: 10.1021/bi00710a006

PubMed ID: 1567356

Title: Analysis of the five glycosylation sites of human alpha 1-acid glycoprotein.

PubMed ID: 1567356

DOI: 10.1042/bj2830105

PubMed ID: 15253437

Title: A new strategy for identification of N-glycosylated proteins and unambiguous assignment of their glycosylation sites using HILIC enrichment and partial deglycosylation.

PubMed ID: 15253437

DOI: 10.1021/pr034112b

PubMed ID: 15084671

Title: A proteomic analysis of human bile.

PubMed ID: 15084671

DOI: 10.1074/mcp.m400015-mcp200

PubMed ID: 14760718

Title: Screening for N-glycosylated proteins by liquid chromatography mass spectrometry.

PubMed ID: 14760718

DOI: 10.1002/pmic.200300556

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19838169

Title: Enrichment of glycopeptides for glycan structure and attachment site identification.

PubMed ID: 19838169

DOI: 10.1038/nmeth.1392

PubMed ID: 22171320

Title: Human urinary glycoproteomics; attachment site specific analysis of N- and O-linked glycosylations by CID and ECD.

PubMed ID: 22171320

DOI: 10.1074/mcp.m111.013649

PubMed ID: 21349832

Title: Structural insights into differences in drug-binding selectivity between two forms of human {alpha}1-acid glycoprotein genetic variants, the A and F1*S forms.

PubMed ID: 21349832

DOI: 10.1074/jbc.m110.208926

Sequence Information:

  • Length: 201
  • Mass: 23603
  • Checksum: 49167ABCC22933B9
  • Sequence:
    • MALSWVLTVL SLLPLLEAQI PLCANLVPVP ITNATLDRIT GKWFYIASAF RNEEYNKSVQ 
EIQATFFYFT PNKTEDTIFL REYQTRQNQC FYNSSYLNVQ RENGTVSRYE GGREHVAHLL 
FLRDTKTLMF GSYLDDEKNW GLSFYADKPE TTKEQLGEFY EALDCLCIPR SDVMYTDWKK 
DKCEPLEKQH EKERKQEEGE S

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.