Details for: ORM2

Gene ID: 5005

Symbol: ORM2

Ensembl ID: ENSG00000228278

Description: orosomucoid 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 15.99
    Marker Score: 162077
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 3.76
    Marker Score: 4649
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 3.75
    Marker Score: 6837
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2
    Marker Score: 1996
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 2
    Marker Score: 10739
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1172
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.46
    Marker Score: 6320
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 857
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4813
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.12
    Marker Score: 7208
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 1.06
    Marker Score: 329.5
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.05
    Marker Score: 799
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.04
    Marker Score: 432
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.04
    Marker Score: 660.5
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.02
    Marker Score: 224
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71825
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48051
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 511
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 465
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.98
    Marker Score: 670
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.95
    Marker Score: 437
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.94
    Marker Score: 1008
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 377
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5348
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 329
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.88
    Marker Score: 2004
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5295
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.79
    Marker Score: 5281
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.79
    Marker Score: 331
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1267
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 709
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.71
    Marker Score: 181
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.65
    Marker Score: 430
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.64
    Marker Score: 1330
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.64
    Marker Score: 411
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.62
    Marker Score: 1004
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.6
    Marker Score: 228
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.57
    Marker Score: 3624
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.57
    Marker Score: 451
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.56
    Marker Score: 176
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.55
    Marker Score: 151
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.54
    Marker Score: 143
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.52
    Marker Score: 219
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.5
    Marker Score: 805
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.48
    Marker Score: 208
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 280
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.46
    Marker Score: 172
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.45
    Marker Score: 340
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.44
    Marker Score: 420
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.4
    Marker Score: 403
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.35
    Marker Score: 393
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.35
    Marker Score: 204
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.34
    Marker Score: 339
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.33
    Marker Score: 204
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.33
    Marker Score: 2148
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.32
    Marker Score: 321
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.3
    Marker Score: 289
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.3
    Marker Score: 172
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.26
    Marker Score: 802
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.23
    Marker Score: 137
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.23
    Marker Score: 208
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 66
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.23
    Marker Score: 157
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.23
    Marker Score: 265
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 76
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.22
    Marker Score: 133
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.22
    Marker Score: 147
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.2
    Marker Score: 311
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.18
    Marker Score: 54
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.18
    Marker Score: 44
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.17
    Marker Score: 224
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.16
    Marker Score: 64
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.16
    Marker Score: 94
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.15
    Marker Score: 99
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.15
    Marker Score: 357
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.14
    Marker Score: 243
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.14
    Marker Score: 280
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.13
    Marker Score: 61
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.13
    Marker Score: 133
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.12
    Marker Score: 298
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.12
    Marker Score: 130.5
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.12
    Marker Score: 219
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.12
    Marker Score: 64
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.1
    Marker Score: 26.5
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.1
    Marker Score: 36
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.1
    Marker Score: 161
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.1
    Marker Score: 506
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.1
    Marker Score: 43
  • Cell Name: immature neutrophil (CL0000776)
    Fold Change: 0.09
    Marker Score: 32
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.09
    Marker Score: 21
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.09
    Marker Score: 33
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.09
    Marker Score: 80
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.09
    Marker Score: 25
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.08
    Marker Score: 1313
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.08
    Marker Score: 25
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.08
    Marker Score: 44

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Other Information

**Key Characteristics:** ORM2 is a member of the orosomucoid family, which is involved in the acute-phase response. This family of proteins is characterized by their ability to bind to lipopolysaccharides (LPS) and other ligands, triggering the activation of immune cells and the production of pro-inflammatory cytokines. ORM2 shares similarities with its orosomucoid counterparts, such as alpha-1-acid glycoprotein (AAG), in terms of its structure and function. **Pathways and Functions:** ORM2 is involved in several key pathways and processes, including: 1. **Acute-phase response**: ORM2 is upregulated in response to inflammatory stimuli, leading to the activation of immune cells and the production of pro-inflammatory cytokines. 2. **Immune system regulation**: ORM2 modulates the immune response by regulating the production of cytokines, such as interleukin-1 beta, interleukin-1, and tumor necrosis factor. 3. **Neutrophil degranulation**: ORM2 is involved in the regulation of neutrophil degranulation, a process crucial for the elimination of pathogens. 4. **Platelet activation**: ORM2 is also involved in platelet activation, which is essential for hemostasis and wound healing. **Clinical Significance:** The clinical significance of ORM2 is multifaceted: 1. **Inflammatory disorders**: ORM2's role in the acute-phase response makes it a potential target for the treatment of inflammatory disorders, such as rheumatoid arthritis and asthma. 2. **Infectious diseases**: ORM2's involvement in the regulation of immune responses makes it a potential biomarker for infectious diseases, such as sepsis and tuberculosis. 3. **Cancer**: ORM2's expression in various cell types, including glutamatergic neurons and microglial cells, suggests its potential role in cancer development and progression. 4. **Neurological disorders**: ORM2's expression in glutamatergic neurons and oligodendrocyte precursor cells makes it a potential target for the treatment of neurological disorders, such as multiple sclerosis and Alzheimer's disease. In conclusion, ORM2 is a multifunctional protein that plays a critical role in the immune system's response to inflammation and infection. Further research is necessary to fully elucidate its mechanisms of action and to explore its potential therapeutic applications.

Genular Protein ID: 4020344761

Symbol: A1AG2_HUMAN

Name: Alpha-1-acid glycoprotein 2

UniProtKB Accession Codes:

P19652 B2R5L2 Q16571 Q5T538 Q6IB74

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DOSAC-COBS-2DPAGE 1 DisGeNET 1 DrugBank 54 EMBL 16 Ensembl 1 EvolutionaryTrace 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 PANTHER 2 PDB 8 PDBsum 5 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SWISS-2DPAGE 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2822385

Title: Structure and expression of the genes coding for human alpha 1-acid glycoprotein.

PubMed ID: 2822385

DOI: 10.1002/j.1460-2075.1987.tb02503.x

PubMed ID: 2970990

Title: Structure and characterisation of a duplicated human alpha 1 acid glycoprotein gene.

PubMed ID: 2970990

DOI: 10.1016/0378-1119(88)90228-4

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 4603214

Title: The disulfide bonds of alpha1-acid glycoprotein.

PubMed ID: 4603214

DOI: 10.1021/bi00710a006

PubMed ID: 1567356

Title: Analysis of the five glycosylation sites of human alpha 1-acid glycoprotein.

PubMed ID: 1567356

DOI: 10.1042/bj2830105

PubMed ID: 15253437

Title: A new strategy for identification of N-glycosylated proteins and unambiguous assignment of their glycosylation sites using HILIC enrichment and partial deglycosylation.

PubMed ID: 15253437

DOI: 10.1021/pr034112b

PubMed ID: 15084671

Title: A proteomic analysis of human bile.

PubMed ID: 15084671

DOI: 10.1074/mcp.m400015-mcp200

PubMed ID: 14760718

Title: Screening for N-glycosylated proteins by liquid chromatography mass spectrometry.

PubMed ID: 14760718

DOI: 10.1002/pmic.200300556

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19838169

Title: Enrichment of glycopeptides for glycan structure and attachment site identification.

PubMed ID: 19838169

DOI: 10.1038/nmeth.1392

PubMed ID: 22171320

Title: Human urinary glycoproteomics; attachment site specific analysis of N- and O-linked glycosylations by CID and ECD.

PubMed ID: 22171320

DOI: 10.1074/mcp.m111.013649

PubMed ID: 21349832

Title: Structural insights into differences in drug-binding selectivity between two forms of human {alpha}1-acid glycoprotein genetic variants, the A and F1*S forms.

PubMed ID: 21349832

DOI: 10.1074/jbc.m110.208926

Sequence Information:

  • Length: 201
  • Mass: 23603
  • Checksum: 49167ABCC22933B9
  • Sequence:
    • MALSWVLTVL SLLPLLEAQI PLCANLVPVP ITNATLDRIT GKWFYIASAF RNEEYNKSVQ 
EIQATFFYFT PNKTEDTIFL REYQTRQNQC FYNSSYLNVQ RENGTVSRYE GGREHVAHLL 
FLRDTKTLMF GSYLDDEKNW GLSFYADKPE TTKEQLGEFY EALDCLCIPR SDVMYTDWKK 
DKCEPLEKQH EKERKQEEGE S

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.