Details for: PABPC3

Gene ID: 5042

Symbol: PABPC3

Ensembl ID: ENSG00000151846

Description: poly(A) binding protein cytoplasmic 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 15.8153
    Cell Significance Index: -2.4600
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 3.2348
    Cell Significance Index: 20.6500
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 2.5610
    Cell Significance Index: 16.9900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 2.0844
    Cell Significance Index: -2.5700
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.9057
    Cell Significance Index: 14.5300
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.7983
    Cell Significance Index: 4.6900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 0.7097
    Cell Significance Index: -0.1800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.6675
    Cell Significance Index: 76.1900
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.6165
    Cell Significance Index: 7.9700
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.5806
    Cell Significance Index: 8.3200
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.5500
    Cell Significance Index: 1.2400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4833
    Cell Significance Index: 91.9800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 0.4330
    Cell Significance Index: -1.1600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.4308
    Cell Significance Index: 269.0100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.3983
    Cell Significance Index: 3.1800
  • Cell Name: pancreatic epsilon cell (CL0005019)
    Fold Change: 0.3529
    Cell Significance Index: 3.2700
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: 0.3401
    Cell Significance Index: 2.4500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3290
    Cell Significance Index: 19.7500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2866
    Cell Significance Index: 56.8800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2642
    Cell Significance Index: 26.1400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2210
    Cell Significance Index: 24.0400
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.2067
    Cell Significance Index: 3.2800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1863
    Cell Significance Index: 168.2400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1471
    Cell Significance Index: 4.1100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1355
    Cell Significance Index: 22.0500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1134
    Cell Significance Index: 5.8900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1043
    Cell Significance Index: 7.2200
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0835
    Cell Significance Index: 1.0600
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.0809
    Cell Significance Index: 0.8600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0659
    Cell Significance Index: 2.2900
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.0533
    Cell Significance Index: 0.5700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0465
    Cell Significance Index: 2.9300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0460
    Cell Significance Index: 2.0900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0458
    Cell Significance Index: 0.9800
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.0428
    Cell Significance Index: 0.3800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0403
    Cell Significance Index: 1.1600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0378
    Cell Significance Index: 0.8200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0343
    Cell Significance Index: 0.9200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.0322
    Cell Significance Index: 0.4800
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.0284
    Cell Significance Index: 0.3600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0185
    Cell Significance Index: 0.2700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0180
    Cell Significance Index: 1.2100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0153
    Cell Significance Index: 1.7800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0069
    Cell Significance Index: 0.3200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0047
    Cell Significance Index: 0.6400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0028
    Cell Significance Index: 0.0900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0021
    Cell Significance Index: 0.9200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0017
    Cell Significance Index: 0.4800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0015
    Cell Significance Index: 0.1900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0001
    Cell Significance Index: 0.0100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0001
    Cell Significance Index: 0.0800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0004
    Cell Significance Index: -0.0100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0009
    Cell Significance Index: -0.3100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0013
    Cell Significance Index: -0.9900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0013
    Cell Significance Index: -2.4300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0018
    Cell Significance Index: -1.0300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0019
    Cell Significance Index: -1.4500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0019
    Cell Significance Index: -3.4400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0021
    Cell Significance Index: -3.1600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0024
    Cell Significance Index: -3.3000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0030
    Cell Significance Index: -0.6400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0030
    Cell Significance Index: -0.6100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0037
    Cell Significance Index: -2.7000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0040
    Cell Significance Index: -0.7300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0040
    Cell Significance Index: -2.5500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0043
    Cell Significance Index: -0.1500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0069
    Cell Significance Index: -3.1100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0080
    Cell Significance Index: -0.2000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0087
    Cell Significance Index: -1.1300
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0093
    Cell Significance Index: -0.1600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0096
    Cell Significance Index: -0.2000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0106
    Cell Significance Index: -0.1600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0122
    Cell Significance Index: -0.2100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0125
    Cell Significance Index: -1.2800
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0148
    Cell Significance Index: -0.1000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0153
    Cell Significance Index: -1.7500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0171
    Cell Significance Index: -2.4900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0188
    Cell Significance Index: -1.3300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0195
    Cell Significance Index: -0.3800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0230
    Cell Significance Index: -2.7200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0253
    Cell Significance Index: -1.5500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0280
    Cell Significance Index: -0.8000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0331
    Cell Significance Index: -0.8500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0349
    Cell Significance Index: -2.2500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0354
    Cell Significance Index: -1.8600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0364
    Cell Significance Index: -2.7100
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.0387
    Cell Significance Index: -0.4500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0394
    Cell Significance Index: -0.6600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0401
    Cell Significance Index: -1.1800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0425
    Cell Significance Index: -1.5600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0426
    Cell Significance Index: -1.1600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0464
    Cell Significance Index: -2.8500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0466
    Cell Significance Index: -1.1900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0470
    Cell Significance Index: -2.6400
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0477
    Cell Significance Index: -0.6700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0486
    Cell Significance Index: -2.5300
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0488
    Cell Significance Index: -0.7300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0506
    Cell Significance Index: -1.6100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0511
    Cell Significance Index: -1.7900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0531
    Cell Significance Index: -2.5000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PABPC3 is a cytoplasmic protein that belongs to the poly(A) binding protein family. It is characterized by its ability to bind to poly(A) RNA, thereby regulating mRNA stability and translation. The gene is highly expressed in specific cell types, including retinal bipolar neurons, intestinal crypt stem cells, and cerebral cortex GABAergic interneurons. PABPC3 is also involved in the formation of stress granules, which are cytoplasmic structures that regulate mRNA translation during stress conditions. **Pathways and Functions:** PABPC3 is involved in several cellular pathways, including: 1. **mRNA Metabolic Process:** PABPC3 regulates mRNA stability and translation by binding to poly(A) RNA, thereby controlling the degradation and translation of mRNAs. 2. **Poly(A) Binding:** PABPC3 interacts with poly(A) RNA, facilitating the assembly of ribonucleoprotein complexes and regulating mRNA translation. 3. **Cytoplasmic Stress Granule Formation:** PABPC3 is involved in the formation of stress granules, which regulate mRNA translation during stress conditions. 4. **Extracellular Exosome:** PABPC3 is also involved in the regulation of extracellular exosome formation and function. **Functions:** The functions of PABPC3 include: 1. **Regulation of mRNA Stability:** PABPC3 regulates mRNA stability by binding to poly(A) RNA, thereby controlling the degradation of mRNAs. 2. **Translation Regulation:** PABPC3 regulates translation by interacting with ribosomes and regulating the assembly of ribonucleoprotein complexes. 3. **Stress Granule Formation:** PABPC3 is involved in the formation of stress granules, which regulate mRNA translation during stress conditions. 4. **Exosome Formation:** PABPC3 is involved in the regulation of extracellular exosome formation and function. **Clinical Significance:** PABPC3 has been implicated in various diseases, including: 1. **Neurological Disorders:** PABPC3 has been linked to neurological disorders, such as Alzheimer's disease and Parkinson's disease, due to its role in regulating mRNA stability and translation. 2. **Cancer:** PABPC3 has been implicated in cancer, including colorectal cancer, due to its role in regulating mRNA stability and translation. 3. **Neurodevelopmental Disorders:** PABPC3 has been linked to neurodevelopmental disorders, such as autism spectrum disorder, due to its role in regulating mRNA stability and translation. In conclusion, PABPC3 is a critical gene involved in various cellular processes, including mRNA metabolism, translation, and stress granule formation. Its clinical significance in various diseases highlights the importance of further research into the functions and regulation of PABPC3.

Genular Protein ID: 200616593

Symbol: PABP3_HUMAN

Name: Polyadenylate-binding protein 3

UniProtKB Accession Codes:

Q9H361 Q8NHV0 Q9H086

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 4 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 10 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11328870

Title: Human testis expresses a specific poly(A)-binding protein.

PubMed ID: 11328870

DOI: 10.1093/nar/29.9.1872

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 631
  • Mass: 70031
  • Checksum: 2F8C5BF6F508AAEF
  • Sequence:
    • MNPSTPSYPT ASLYVGDLHP DVTEAMLYEK FSPAGPILSI RICRDLITSG SSNYAYVNFQ 
HTKDAEHALD TMNFDVIKGK PVRIMWSQRD PSLRKSGVGN IFVKNLDKSI NNKALYDTVS 
AFGNILSCNV VCDENGSKGY GFVHFETHEA AERAIKKMNG MLLNGRKVFV GQFKSRKERE 
AELGARAKEF PNVYIKNFGE DMDDERLKDL FGKFGPALSV KVMTDESGKS KGFGFVSFER 
HEDAQKAVDE MNGKELNGKQ IYVGRAQKKV ERQTELKRTF EQMKQDRITR YQVVNLYVKN 
LDDGIDDERL RKAFSPFGTI TSAKVMMEGG RSKGFGFVCF SSPEEATKAV TEMNGRIVAT 
KPLYVALAQR KEERQAYLTN EYMQRMASVR AVPNQRAPPS GYFMTAVPQT QNHAAYYPPS 
QIARLRPSPR WTAQGARPHP FQNKPSAIRP GAPRVPFSTM RPASSQVPRV MSTQRVANTS 
TQTVGPRPAA AAAAAATPAV RTVPRYKYAA GVRNPQQHRN AQPQVTMQQL AVHVQGQETL 
TASRLASAPP QKQKQMLGER LFPLIQAMHP TLAGKITGML LEIDNSELLY MLESPESLRS 
KVDEAVAVLQ AHQAKEATQK AVNSATGVPT V

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.