Details for: PRKN
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
-
CSI 61.87rCSI 76.97%PRS 59.75
-
CSI 60.03rCSI 71.7%PRS 61.93
-
CSI 56.53rCSI 72.88%PRS 62.93
-
CSI 55.83rCSI 71.69%PRS 70.06
-
CSI 54.68rCSI 74.82%PRS 71.53
-
CSI 51.44rCSI 73.81%PRS 69.61
-
CSI 45.79rCSI 73.64%PRS 63.46
-
CSI 42.33rCSI 74.75%PRS 61.12
-
CSI 41.33rCSI 69.38%PRS 61.8
-
CSI 38.93rCSI 70.73%PRS 71.26
-
CSI 32.92rCSI 52.98%PRS 69.79
-
CSI 32.4rCSI 72.64%PRS 62.57
-
CSI 31.57rCSI 67.27%PRS 54.55
-
CSI 31.02rCSI 35.83%PRS 71.89
-
CSI 30.49rCSI 24.1%PRS 68.45
-
CSI 30.29rCSI 66.66%PRS 62.8
-
CSI 28.89rCSI 46.09%PRS 71.41
-
CSI 28.27rCSI 68.7%PRS 59.82
-
CSI 27.74rCSI 29.73%PRS 80.95
-
CSI 25.28rCSI 18.72%PRS 73.29
-
CSI 25.08rCSI 55.41%PRS 65.58
-
CSI 23.19rCSI 21.58%PRS 80.57
-
CSI 23.19rCSI 32.87%PRS 76.41
-
CSI 23.03rCSI 72.03%PRS 65.84
-
CSI 23.03rCSI 45.72%PRS 75.55
-
CSI 22.8rCSI 73.37%PRS 76.66
-
CSI 22.68rCSI 60.4%PRS 67.67
-
CSI 22.33rCSI 69.78%PRS 63.46
-
CSI 22.11rCSI 57.15%PRS 75.14
-
CSI 20.22rCSI 41.96%PRS 76.52
-
CSI 19.76rCSI 57.26%PRS 69.37
-
CSI 19.35rCSI 49.09%PRS 70.14
-
CSI 19.34rCSI 38.83%PRS 69.98
-
CSI 19.08rCSI 49.58%PRS 80.62
-
CSI 19.08rCSI 41.39%PRS 67.56
-
CSI 18.98rCSI 97.19%PRS 83.03
-
CSI 18.96rCSI 68.24%PRS 59.71
-
CSI 18.5rCSI 69.92%PRS 62.3
-
CSI 18.31rCSI 42.26%PRS 67.8
-
CSI 18.12rCSI 44.25%PRS 72.21
-
CSI 18.07rCSI 31.68%PRS 73.6
-
CSI 17.97rCSI 90.43%PRS 77.15
-
CSI 17.97rCSI 61.54%PRS 66.23
-
CSI 17.85rCSI 94.88%PRS 69.92
-
CSI 17.84rCSI 72.67%PRS 71.95
-
CSI 17.76rCSI 50.47%PRS 75.86
-
CSI 17.61rCSI 32.99%PRS 68.23
-
CSI 17.46rCSI 71.92%PRS 86.74
-
CSI 17.33rCSI 30.55%PRS 75.35
-
CSI 17.3rCSI 35.1%PRS 58.34
-
CSI 17.06rCSI 44.48%PRS 80.85
-
CSI 16.94rCSI 55.68%PRS 66.08
-
CSI 16.9rCSI 57.26%PRS 75.45
-
CSI 16.72rCSI 27.38%PRS 69.29
-
CSI 16.43rCSI 37.5%PRS 71.32
-
CSI 16.31rCSI 72.86%PRS 64.09
-
CSI 15.83rCSI 27.39%PRS 71.36
-
CSI 15.76rCSI 69.25%PRS 74.99
-
CSI 15.54rCSI 60.76%PRS 58.44
-
CSI 15.27rCSI 37.8%PRS 79.36
-
CSI 14.9rCSI 39.83%PRS 71.58
-
CSI 14.71rCSI 26.43%PRS 73.14
-
CSI 13.89rCSI 21.55%PRS 83.88
-
CSI 13.61rCSI 34.99%PRS 76.64
-
CSI 13.54rCSI 50.72%PRS 72.24
-
CSI 13.54rCSI 21.53%PRS 72.76
-
CSI 13.33rCSI 16.58%PRS 80.75
-
CSI 13.1rCSI 34.12%PRS 74.76
-
CSI 12.51rCSI 36.92%PRS 78.86
-
CSI 12.51rCSI 13.7%PRS 81.61
-
CSI 12.38rCSI 36.59%PRS 71.6
-
CSI 12.38rCSI 28.31%PRS 80.48
-
CSI 12.36rCSI 32.61%PRS 86.2
-
CSI 12.21rCSI 40.48%PRS 84.36
-
CSI 12.07rCSI 28.8%PRS 76.55
-
CSI 12.01rCSI 51.05%PRS 72.26
-
CSI 11.97rCSI 33%PRS 74.96
-
CSI 11.91rCSI 15.61%PRS 89.81
-
CSI 11.8rCSI 69.49%PRS 62.56
-
CSI 11.57rCSI 65.4%PRS 65.81
-
CSI 11.46rCSI 25.22%PRS 83.39
-
CSI 11.35rCSI 70.87%PRS 71.31
-
CSI 11.29rCSI 56.13%PRS 74.73
-
CSI 11.14rCSI 44.84%PRS 81.38
-
CSI 11.03rCSI 44.48%PRS 79.4
-
CSI 10.95rCSI 78.19%PRS 78.09
-
CSI 10.74rCSI 34.93%PRS 77.55
-
CSI 10.66rCSI 18.8%PRS 84.83
-
CSI 10.54rCSI 14.6%PRS 77.07
-
CSI 10.52rCSI 33.65%PRS 77.08
-
CSI 9.9rCSI 41.13%PRS 80.41
-
CSI 9.89rCSI 20.33%PRS 67.34
-
CSI 9.64rCSI 22.98%PRS 80
-
CSI 9.52rCSI 14.54%PRS 79.98
-
CSI 9.47rCSI 7.69%PRS 79.11
-
CSI 9.45rCSI 23.91%PRS 84.9
-
CSI 9.43rCSI 13.86%PRS 72.78
-
CSI 9.39rCSI 69.03%PRS 67.24
-
CSI 9.02rCSI 21.56%PRS 66.82
-
CSI 8.85rCSI 14.57%PRS 83.49
-
CSI 1.4rCSI 1.1%PRS 82.4%
-
CSI 1.6rCSI 3.6%PRS 85.3%
-
CSI 1.8rCSI 5.1%PRS 86.5%
-
CSI 2.1rCSI 4.6%PRS 86.5%
-
CSI 2.1rCSI 4.0%PRS 87.5%
-
CSI 2.6rCSI 7.3%PRS 86.8%
-
CSI 2.6rCSI 27.9%PRS 76.2%
-
CSI 2.7rCSI 30.6%PRS 68.9%
-
CSI 2.8rCSI 66.9%PRS 60.7%
-
CSI 2.8rCSI 67.1%PRS 60.2%
-
CSI 3.0rCSI 18.9%PRS 85.1%
-
CSI 3.0rCSI 25.0%PRS 67.8%
-
CSI 3.0rCSI 17.7%PRS 71.7%
-
CSI 3.2rCSI 25.7%PRS 73.9%
-
CSI 3.3rCSI 8.8%PRS 84.5%
-
CSI 3.4rCSI 68.3%PRS 71.0%
-
CSI 3.4rCSI 68.8%PRS 69.8%
-
CSI 3.4rCSI 3.9%PRS 72.0%
-
CSI 3.4rCSI 25.7%PRS 70.6%
-
CSI 3.4rCSI 8.2%PRS 83.9%
-
CSI 3.7rCSI 10.4%PRS 74.9%
-
CSI 3.7rCSI 19.5%PRS 81.2%
-
CSI 4.0rCSI 17.4%PRS 68.3%
-
CSI 4.0rCSI 5.2%PRS 83.0%
-
CSI 4.1rCSI 6.4%PRS 81.3%
-
CSI 4.1rCSI 22.8%PRS 83.1%
-
CSI 4.1rCSI 19.1%PRS 90.5%
-
CSI 4.2rCSI 30.0%PRS 71.0%
-
CSI 4.5rCSI 23.5%PRS 71.3%
-
CSI 4.6rCSI 5.7%PRS 88.4%
-
CSI 4.6rCSI 21.6%PRS 71.5%
-
CSI 4.7rCSI 31.8%PRS 72.8%
-
CSI 4.7rCSI 33.3%PRS 73.1%
-
CSI 4.9rCSI 68.9%PRS 70.9%
-
CSI 4.9rCSI 6.6%PRS 85.8%
-
CSI 5.2rCSI 45.1%PRS 74.8%
-
CSI 5.4rCSI 9.6%PRS 78.9%
-
CSI 5.4rCSI 16.7%PRS 84.0%
-
CSI 5.5rCSI 4.3%PRS 92.5%
-
CSI 5.7rCSI 8.5%PRS 83.6%
-
CSI 5.9rCSI 36.9%PRS 60.5%
-
CSI 6.2rCSI 23.4%PRS 70.9%
-
CSI 6.2rCSI 29.8%PRS 76.4%
-
CSI 6.3rCSI 13.8%PRS 87.3%
-
CSI 6.5rCSI 50.5%PRS 74.2%
-
CSI 6.9rCSI 30.5%PRS 80.3%
-
CSI 6.9rCSI 59.7%PRS 68.0%
-
CSI 6.9rCSI 27.5%PRS 75.6%
-
CSI 7.0rCSI 46.3%PRS 74.8%
-
CSI 7.3rCSI 17.5%PRS 83.0%
-
CSI 7.4rCSI 11.8%PRS 83.4%
-
CSI 7.5rCSI 15.8%PRS 90.5%
-
CSI 7.9rCSI 45.3%PRS 76.6%
-
CSI 7.9rCSI 43.0%PRS 76.5%
-
CSI 7.9rCSI 26.4%PRS 63.8%
-
CSI 8.0rCSI 8.2%PRS 83.9%
-
CSI 8.0rCSI 70.0%PRS 68.1%
-
CSI 8.3rCSI 11.0%PRS 78.3%
-
CSI 8.3rCSI 39.5%PRS 79.7%
-
CSI 8.3rCSI 85.8%PRS 73.6%
-
CSI 8.4rCSI 12.8%PRS 76.6%
-
CSI 8.9rCSI 14.6%PRS 83.5%
-
CSI 9.0rCSI 21.6%PRS 66.8%
-
CSI 9.4rCSI 69.0%PRS 67.2%
-
CSI 9.4rCSI 13.9%PRS 72.8%
-
CSI 9.5rCSI 23.9%PRS 84.9%
-
CSI 9.5rCSI 7.7%PRS 79.1%
-
CSI 9.5rCSI 14.5%PRS 80.0%
-
CSI 9.6rCSI 23.0%PRS 80.0%
-
CSI 9.9rCSI 20.3%PRS 67.3%
-
CSI 9.9rCSI 41.1%PRS 80.4%
-
CSI 10.5rCSI 33.7%PRS 77.1%
-
CSI 10.5rCSI 14.6%PRS 77.1%
-
CSI 10.7rCSI 18.8%PRS 84.8%
-
CSI 10.7rCSI 34.9%PRS 77.6%
-
CSI 11.0rCSI 78.2%PRS 78.1%
-
CSI 11.0rCSI 44.5%PRS 79.4%
-
CSI 11.1rCSI 44.8%PRS 81.4%
-
CSI 11.3rCSI 56.1%PRS 74.7%
-
CSI 11.4rCSI 70.9%PRS 71.3%
-
CSI 11.5rCSI 25.2%PRS 83.4%
-
CSI 11.6rCSI 65.4%PRS 65.8%
-
CSI 11.8rCSI 69.5%PRS 62.6%
-
CSI 11.9rCSI 15.6%PRS 89.8%
-
CSI 12.0rCSI 33.0%PRS 75.0%
-
CSI 12.0rCSI 51.1%PRS 72.3%
-
CSI 12.1rCSI 28.8%PRS 76.6%
-
CSI 12.2rCSI 40.5%PRS 84.4%
-
CSI 12.4rCSI 32.6%PRS 86.2%
-
CSI 12.4rCSI 28.3%PRS 80.5%
-
CSI 12.4rCSI 36.6%PRS 71.6%
-
CSI 12.5rCSI 13.7%PRS 81.6%
-
CSI 12.5rCSI 36.9%PRS 78.9%
-
CSI 13.1rCSI 34.1%PRS 74.8%
-
CSI 13.3rCSI 16.6%PRS 80.8%
-
CSI 13.5rCSI 21.5%PRS 72.8%
-
CSI 13.5rCSI 50.7%PRS 72.2%
-
CSI 13.6rCSI 35.0%PRS 76.6%
-
CSI 13.9rCSI 21.6%PRS 83.9%
-
CSI 14.7rCSI 26.4%PRS 73.1%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 1055890305
Symbol: PRKN_HUMAN
Name: Parkinson juvenile disease protein 2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9560156
Title: Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism.
PubMed ID: 9560156
DOI: 10.1038/33416
PubMed ID: 19501131
Title: Evidence for the presence of full-length PARK2 mRNA and Parkin protein in human blood.
PubMed ID: 19501131
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 14574404
Title: The DNA sequence and analysis of human chromosome 6.
PubMed ID: 14574404
DOI: 10.1038/nature02055
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 10319893
Title: Immunohistochemical and subcellular localization of Parkin protein: absence of protein in autosomal recessive juvenile parkinsonism patients.
PubMed ID: 10319893
DOI: 10.1002/1531-8249(199905)45:5<668::aid-ana19>3.0.co;2-z
PubMed ID: 10973942
Title: Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity.
PubMed ID: 10973942
PubMed ID: 10888878
Title: Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase.
PubMed ID: 10888878
DOI: 10.1038/77060
PubMed ID: 11078524
Title: Parkin functions as an E2-dependent ubiquitin-protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1.
PubMed ID: 11078524
PubMed ID: 11439185
Title: An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin.
PubMed ID: 11439185
PubMed ID: 11590439
Title: Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease.
PubMed ID: 11590439
DOI: 10.1038/nm1001-1144
PubMed ID: 11431533
Title: Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease.
PubMed ID: 11431533
PubMed ID: 12446796
Title: Comparative genomics of the RBR family, including the Parkinson's disease-related gene parkin and the genes of the ariadne subfamily.
PubMed ID: 12446796
PubMed ID: 12150907
Title: CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity.
PubMed ID: 12150907
PubMed ID: 12925569
Title: The autosomal recessive juvenile Parkinson disease gene product, parkin, interacts with and ubiquitinates synaptotagmin XI.
PubMed ID: 12925569
DOI: 10.1093/hmg/ddg269
PubMed ID: 14532270
Title: A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death.
PubMed ID: 14532270
PubMed ID: 12628165
Title: Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity.
PubMed ID: 12628165
PubMed ID: 14614460
Title: Alterations in the common fragile site gene Parkin in ovarian and other cancers.
PubMed ID: 14614460
PubMed ID: 12719539
Title: Parkin, a gene implicated in autosomal recessive juvenile parkinsonism, is a candidate tumor suppressor gene on chromosome 6q25-q27.
PubMed ID: 12719539
PubMed ID: 15229644
Title: How does parkin ligate ubiquitin to Parkinson's disease?
PubMed ID: 15229644
PubMed ID: 15105460
Title: S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function.
PubMed ID: 15105460
PubMed ID: 15987638
Title: Parkin interacts with the proteasome subunit alpha4.
PubMed ID: 15987638
PubMed ID: 15728840
Title: Parkin mediates nonclassical, proteasomal-independent ubiquitination of synphilin-1: implications for Lewy body formation.
PubMed ID: 15728840
PubMed ID: 16135753
Title: Accumulation of the authentic parkin substrate aminoacyl-tRNA synthetase cofactor, p38/JTV-1, leads to catecholaminergic cell death.
PubMed ID: 16135753
PubMed ID: 16352719
Title: Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin and mutant LRRK2 induces neuronal degeneration.
PubMed ID: 16352719
PubMed ID: 16332688
Title: Parkin ubiquitinates and promotes the degradation of RanBP2.
PubMed ID: 16332688
PubMed ID: 16955485
Title: Functional modulation of parkin through physical interaction with SUMO-1.
PubMed ID: 16955485
DOI: 10.1002/jnr.21041
PubMed ID: 17846173
Title: Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6.
PubMed ID: 17846173
PubMed ID: 18957282
Title: PINK1 controls mitochondrial localization of Parkin through direct phosphorylation.
PubMed ID: 18957282
PubMed ID: 19029340
Title: Parkin is recruited selectively to impaired mitochondria and promotes their autophagy.
PubMed ID: 19029340
PubMed ID: 18541373
Title: Parkin is ubiquitinated by Nrdp1 and abrogates Nrdp1-induced oxidative stress.
PubMed ID: 18541373
PubMed ID: 19229105
Title: Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation.
PubMed ID: 19229105
DOI: 10.1172/jci37617
PubMed ID: 19801972
Title: Transcriptional repression of p53 by parkin and impairment by mutations associated with autosomal recessive juvenile Parkinson's disease.
PubMed ID: 19801972
DOI: 10.1038/ncb1981
PubMed ID: 20798600
Title: The PINK1/Parkin-mediated mitophagy is compromised by PD-associated mutations.
PubMed ID: 20798600
PubMed ID: 20889974
Title: Parkin mono-ubiquitinates Bcl-2 and regulates autophagy.
PubMed ID: 20889974
PubMed ID: 19966284
Title: PINK1-dependent recruitment of Parkin to mitochondria in mitophagy.
PubMed ID: 19966284
PubMed ID: 21376232
Title: PARIS (ZNF746) repression of PGC-1alpha contributes to neurodegeneration in Parkinson's disease.
PubMed ID: 21376232
PubMed ID: 20889486
Title: Molecular chaperone-mediated rescue of mitophagy by a Parkin RING1 domain mutant.
PubMed ID: 20889486
DOI: 10.1093/hmg/ddq428
PubMed ID: 21753002
Title: Parkin interacts with Ambra1 to induce mitophagy.
PubMed ID: 21753002
PubMed ID: 21532592
Title: UBCH7 reactivity profile reveals parkin and HHARI to be RING/HECT hybrids.
PubMed ID: 21532592
DOI: 10.1038/nature09966
PubMed ID: 22082830
Title: Parkin interacts with Klokin1 for mitochondrial import and maintenance of membrane potential.
PubMed ID: 22082830
DOI: 10.1093/hmg/ddr530
PubMed ID: 22396657
Title: Parkinson's disease-associated kinase PINK1 regulates Miro protein level and axonal transport of mitochondria.
PubMed ID: 22396657
PubMed ID: 23754282
Title: Parkin-catalyzed ubiquitin-ester transfer is triggered by PINK1-dependent phosphorylation.
PubMed ID: 23754282
PubMed ID: 23685073
Title: Mutations in the intellectual disability gene Ube2a cause neuronal dysfunction and impair parkin-dependent mitophagy.
PubMed ID: 23685073
PubMed ID: 23933751
Title: The Parkinson's disease-linked proteins Fbxo7 and Parkin interact to mediate mitophagy.
PubMed ID: 23933751
DOI: 10.1038/nn.3489
PubMed ID: 24270810
Title: High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy.
PubMed ID: 24270810
DOI: 10.1038/nature12748
PubMed ID: 23770917
Title: A molecular explanation for the recessive nature of parkin-linked Parkinson's disease.
PubMed ID: 23770917
DOI: 10.1038/ncomms2983
PubMed ID: 23620051
Title: PINK1-phosphorylated mitofusin 2 is a Parkin receptor for culling damaged mitochondria.
PubMed ID: 23620051
PubMed ID: 24660806
Title: Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65.
PubMed ID: 24660806
DOI: 10.1042/bj20140334
PubMed ID: 24898855
Title: MUL1 acts in parallel to the PINK1/parkin pathway in regulating mitofusin and compensates for loss of PINK1/parkin.
PubMed ID: 24898855
DOI: 10.7554/elife.01958
PubMed ID: 25474007
Title: Phosphorylation of mitochondrial polyubiquitin by PINK1 promotes Parkin mitochondrial tethering.
PubMed ID: 25474007
PubMed ID: 24751536
Title: PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity.
PubMed ID: 24751536
PubMed ID: 24784582
Title: Ubiquitin is phosphorylated by PINK1 to activate parkin.
PubMed ID: 24784582
DOI: 10.1038/nature13392
PubMed ID: 24896179
Title: The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy.
PubMed ID: 24896179
DOI: 10.1038/nature13418
PubMed ID: 25527291
Title: Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis.
PubMed ID: 25527291
PubMed ID: 25621951
Title: USP30 and parkin homeostatically regulate atypical ubiquitin chains on mitochondria.
PubMed ID: 25621951
DOI: 10.1038/ncb3097
PubMed ID: 27534820
Title: Covalent ISG15 conjugation positively regulates the ubiquitin E3 ligase activity of parkin.
PubMed ID: 27534820
DOI: 10.1098/rsob.160193
PubMed ID: 32047033
Title: Decision between mitophagy and apoptosis by Parkin via VDAC1 ubiquitination.
PubMed ID: 32047033
PubMed ID: 33499712
Title: Mammalian BCAS3 and C16orf70 associate with the phagophore assembly site in response to selective and non-selective autophagy.
PubMed ID: 33499712
PubMed ID: 12634850
Title: Parkin binds the Rpn10 subunit of 26S proteasomes through its ubiquitin-like domain.
PubMed ID: 12634850
PubMed ID: 17360614
Title: Structure of the Parkin in-between-ring domain provides insights for E3-ligase dysfunction in autosomal recessive Parkinson's disease.
PubMed ID: 17360614
PubMed ID: 23727886
Title: Structure of the human Parkin ligase domain in an autoinhibited state.
PubMed ID: 23727886
PubMed ID: 23770887
Title: Structure and function of Parkin E3 ubiquitin ligase reveals aspects of RING and HECT ligases.
PubMed ID: 23770887
DOI: 10.1038/ncomms2982
PubMed ID: 14976155
Title: Parkin genetics: one model for Parkinson's disease.
PubMed ID: 14976155
DOI: 10.1093/hmg/ddh089
PubMed ID: 9731209
Title: Point mutations (Thr240Arg and Gln311Stop) in the Parkin gene.
PubMed ID: 9731209
PubMed ID: 10072423
Title: A wide variety of mutations in the parkin gene are responsible for autosomal recessive parkinsonism in Europe.
PubMed ID: 10072423
DOI: 10.1093/hmg/8.4.567
PubMed ID: 10511432
Title: Association of codon 167 Ser/Asn heterozygosity in the parkin gene with sporadic Parkinson's disease.
PubMed ID: 10511432
PubMed ID: 10939576
Title: Novel mutations, pseudo-dominant inheritance, and possible familial affects in patients with autosomal recessive juvenile parkinsonism.
PubMed ID: 10939576
DOI: 10.1002/1531-8249(200008)48:2<245::aid-ana15>3.3.co;2-u
PubMed ID: 10965160
Title: Polymorphisms of the parkin gene in sporadic Parkinson's disease among Chinese in Taiwan.
PubMed ID: 10965160
DOI: 10.1159/000008203
PubMed ID: 10824074
Title: Association between early-onset Parkinson's disease and mutations in the parkin gene.
PubMed ID: 10824074
PubMed ID: 11179010
Title: Origin of the mutations in the parkin gene in Europe: exon rearrangements are independent recurrent events, whereas point mutations may result from founder effects.
PubMed ID: 11179010
DOI: 10.1086/318791
PubMed ID: 11487568
Title: The importance of gene dosage studies: mutational analysis of the parkin gene in early-onset parkinsonism.
PubMed ID: 11487568
PubMed ID: 11163284
Title: A novel Cys212Tyr founder mutation in parkin and allelic heterogeneity of juvenile parkinsonism in a population from North West Colombia.
PubMed ID: 11163284
PubMed ID: 12116199
Title: Complex relationship between parkin mutations and Parkinson disease.
PubMed ID: 12116199
DOI: 10.1002/ajmg.10525
PubMed ID: 12112109
Title: Role of parkin mutations in 111 community-based patients with early-onset parkinsonism.
PubMed ID: 12112109
DOI: 10.1002/ana.10179
PubMed ID: 12056932
Title: Molecular findings in familial Parkinson disease in Spain.
PubMed ID: 12056932
PubMed ID: 12114481
Title: Linkage stratification and mutation analysis at the parkin locus identifies mutation positive Parkinson's disease families.
PubMed ID: 12114481
DOI: 10.1136/jmg.39.7.489
PubMed ID: 12397156
Title: Relative high frequency of the c.255delA parkin gene mutation in Spanish patients with autosomal recessive parkinsonism.
PubMed ID: 12397156
PubMed ID: 11971093
Title: Evaluation of 50 probands with early-onset Parkinson's disease for parkin mutations.
PubMed ID: 11971093
PubMed ID: 12362318
Title: A new point mutation on exon 2 of parkin gene in Parkinson's disease.
PubMed ID: 12362318
PubMed ID: 12730996
Title: Parkin mutations and susceptibility alleles in late-onset Parkinson's disease.
PubMed ID: 12730996
DOI: 10.1002/ana.10524
PubMed ID: 12629236
Title: Heterozygosity for a mutation in the parkin gene leads to later onset Parkinson disease.
PubMed ID: 12629236
PubMed ID: 12781599
Title: Parkin mutations are rare in patients with young-onset parkinsonism in a US population.
PubMed ID: 12781599
PubMed ID: 15584030
Title: Novel parkin mutations detected in patients with early-onset Parkinson's disease.
PubMed ID: 15584030
DOI: 10.1002/mds.20343
PubMed ID: 20404107
Title: PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy.
PubMed ID: 20404107
PubMed ID: 22956510
Title: Systematic review and UK-based study of PARK2 (parkin), PINK1, PARK7 (DJ-1) and LRRK2 in early-onset Parkinson's disease.
PubMed ID: 22956510
DOI: 10.1002/mds.25132
PubMed ID: 27535533
Title: Analysis of protein-coding genetic variation in 60,706 humans.
PubMed ID: 27535533
DOI: 10.1038/nature19057
PubMed ID: 29311685
Title: Synaptotagmin-11 is a critical mediator of parkin-linked neurotoxicity and Parkinson's disease-like pathology.
PubMed ID: 29311685
Sequence Information:
- Length: 465
- Mass: 51641
- Checksum: 9A8BB802A3FC84C3
- Sequence:
MIVFVRFNSS HGFPVEVDSD TSIFQLKEVV AKRQGVPADQ LRVIFAGKEL RNDWTVQNCD LDQQSIVHIV QRPWRKGQEM NATGGDDPRN AAGGCEREPQ SLTRVDLSSS VLPGDSVGLA VILHTDSRKD SPPAGSPAGR SIYNSFYVYC KGPCQRVQPG KLRVQCSTCR QATLTLTQGP SCWDDVLIPN RMSGECQSPH CPGTSAEFFF KCGAHPTSDK ETSVALHLIA TNSRNITCIT CTDVRSPVLV FQCNSRHVIC LDCFHLYCVT RLNDRQFVHD PQLGYSLPCV AGCPNSLIKE LHHFRILGEE QYNRYQQYGA EECVLQMGGV LCPRPGCGAG LLPEPDQRKV TCEGGNGLGC GFAFCRECKE AYHEGECSAV FEASGTTTQA YRVDERAAEQ ARWEAASKET IKKTTKPCPR CHVPVEKNGG CMHMKCPQPQ CRLEWCWNCG CEWNRVCMGD HWFDV