Details for: DHH

Gene ID: 50846

Symbol: DHH

Ensembl ID: ENSG00000139549

Description: desert hedgehog signaling molecule

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 2.6499
    Cell Significance Index: -2.5300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.2872
    Cell Significance Index: 31.1800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.1067
    Cell Significance Index: 29.6600
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.5212
    Cell Significance Index: 7.3100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.5115
    Cell Significance Index: 13.4500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.2660
    Cell Significance Index: 3.8100
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.1660
    Cell Significance Index: 0.9800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1227
    Cell Significance Index: 6.3900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0797
    Cell Significance Index: 4.1400
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.0551
    Cell Significance Index: 0.8000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0531
    Cell Significance Index: 2.4100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0360
    Cell Significance Index: 24.9200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0189
    Cell Significance Index: 2.4200
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.0104
    Cell Significance Index: 0.1700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0054
    Cell Significance Index: 0.6600
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.0015
    Cell Significance Index: 0.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0013
    Cell Significance Index: -2.4600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0026
    Cell Significance Index: -4.7700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0032
    Cell Significance Index: -4.8500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0033
    Cell Significance Index: -0.4800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0036
    Cell Significance Index: -4.9200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0039
    Cell Significance Index: -2.8600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0040
    Cell Significance Index: -2.5300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0045
    Cell Significance Index: -1.6100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0047
    Cell Significance Index: -0.8500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0051
    Cell Significance Index: -2.8800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0051
    Cell Significance Index: -2.8100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0056
    Cell Significance Index: -0.2400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0073
    Cell Significance Index: -1.4700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0076
    Cell Significance Index: -2.1800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0103
    Cell Significance Index: -4.6800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0124
    Cell Significance Index: -2.4700
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0137
    Cell Significance Index: -0.1900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0145
    Cell Significance Index: -1.6700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0165
    Cell Significance Index: -2.8200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0222
    Cell Significance Index: -2.5900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0234
    Cell Significance Index: -3.2100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0258
    Cell Significance Index: -0.6900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0269
    Cell Significance Index: -2.7500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0312
    Cell Significance Index: -1.5800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0332
    Cell Significance Index: -1.5500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0347
    Cell Significance Index: -0.3200
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0348
    Cell Significance Index: -0.4100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0360
    Cell Significance Index: -4.6500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0367
    Cell Significance Index: -2.4700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0412
    Cell Significance Index: -3.1600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0456
    Cell Significance Index: -2.9400
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0495
    Cell Significance Index: -0.6400
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0512
    Cell Significance Index: -0.6700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0526
    Cell Significance Index: -3.2300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0528
    Cell Significance Index: -0.7200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0530
    Cell Significance Index: -1.1600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0549
    Cell Significance Index: -2.8800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0582
    Cell Significance Index: -2.0400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0593
    Cell Significance Index: -3.3300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0598
    Cell Significance Index: -2.4500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0624
    Cell Significance Index: -4.6500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0625
    Cell Significance Index: -0.7100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0633
    Cell Significance Index: -2.9800
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.0662
    Cell Significance Index: -0.9000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0667
    Cell Significance Index: -2.9500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0708
    Cell Significance Index: -2.0400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0766
    Cell Significance Index: -2.9000
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0772
    Cell Significance Index: -1.2500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0795
    Cell Significance Index: -2.5500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0805
    Cell Significance Index: -2.1900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0813
    Cell Significance Index: -2.8300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0828
    Cell Significance Index: -2.7100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0857
    Cell Significance Index: -2.7300
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.0869
    Cell Significance Index: -1.1900
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0872
    Cell Significance Index: -1.4900
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0898
    Cell Significance Index: -1.2600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0922
    Cell Significance Index: -2.6300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0942
    Cell Significance Index: -2.3500
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.0977
    Cell Significance Index: -1.0300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0979
    Cell Significance Index: -2.8900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0982
    Cell Significance Index: -3.4500
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1007
    Cell Significance Index: -2.0500
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.1016
    Cell Significance Index: -1.6300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1022
    Cell Significance Index: -2.7300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1026
    Cell Significance Index: -2.5600
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.1052
    Cell Significance Index: -1.0000
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1094
    Cell Significance Index: -1.5000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1109
    Cell Significance Index: -3.1000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1135
    Cell Significance Index: -2.9000
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1137
    Cell Significance Index: -1.9600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1154
    Cell Significance Index: -2.9400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1167
    Cell Significance Index: -3.0000
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.1171
    Cell Significance Index: -1.9300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1181
    Cell Significance Index: -2.4500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1190
    Cell Significance Index: -2.4900
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1203
    Cell Significance Index: -2.5100
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.1209
    Cell Significance Index: -1.6600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1260
    Cell Significance Index: -2.5300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1277
    Cell Significance Index: -2.7300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1302
    Cell Significance Index: -4.7800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1308
    Cell Significance Index: -3.7500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1323
    Cell Significance Index: -1.9800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1333
    Cell Significance Index: -2.8800
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1345
    Cell Significance Index: -2.6300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** DHH is a secreted signaling molecule that belongs to the hedgehog family, which consists of a group of cysteine-rich proteins. The DHH protein is characterized by its ability to interact with the Smo receptor, activating the Smo signaling pathway. This pathway is crucial for regulating various cellular processes, including cell fate specification, differentiation, and survival. DHH is also known to be involved in the regulation of steroid biosynthesis and has been implicated in the development of male sex determination. **Pathways and Functions:** DHH's signaling pathway involves the interaction with the Smo receptor, leading to the activation of the Smo signaling pathway. This pathway is crucial for regulating various cellular processes, including: 1. **Cell fate specification:** DHH regulates cell fate specification by activating the Smo signaling pathway, which in turn controls the expression of genes involved in cell differentiation and survival. 2. **Differentiation:** DHH has been implicated in the regulation of differentiation processes, including Leydig cell differentiation and osteoblast differentiation. 3. **Signal transduction:** DHH interacts with its receptors to activate the Smo signaling pathway, regulating signal transduction and response to estradiol and estrogen. 4. **Gene expression regulation:** DHH regulates gene expression by activating the Smo signaling pathway, which in turn controls the expression of genes involved in cell differentiation and survival. **Clinical Significance:** DHH's signaling pathway has been implicated in various diseases, including: 1. **Immunological disorders:** DHH has been implicated in immunological disorders, such as autoimmune diseases and allergies, due to its role in regulating immune cell function and response. 2. **Cancer:** DHH has been implicated in the development and progression of various cancers, including lung cancer and prostate cancer, due to its role in regulating cell growth and differentiation. 3. **Neurological disorders:** DHH has been implicated in neurological disorders, such as multiple sclerosis and Parkinson's disease, due to its role in regulating neural development and function. In conclusion, the desert hedgehog signaling molecule, encoded by the DHH gene, plays a crucial role in regulating various cellular processes, including cell fate specification, differentiation, and signal transduction. Its significance extends beyond immunology, with implications in cancer, neurological disorders, and other diseases. Further research is needed to fully elucidate the DHH gene's role in human disease and to develop novel therapeutic strategies targeting this signaling pathway. **Significantly expressed cells:** * Ciliated cell of the bronchus * CD14-low, CD16-positive monocyte * Cortical cell of adrenal gland * Sertoli cell * Granulosa cell * Medial ganglionic eminence derived interneuron * Endocardial cell * Lung endothelial cell * Bladder urothelial cell * Early T lineage precursor **Proteins:** * DHH_HUMAN (HHG-3)

Genular Protein ID: 2113973843

Symbol: DHH_HUMAN

Name: HHG-3

UniProtKB Accession Codes:

O43323 Q15794

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 17 DIP 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 1 EvolutionaryTrace 1 GO 24 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MEROPS 1 MIM 5 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 8 RefSeq 1 Rhea 5 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11017805

Title: A novel mutation of desert hedgehog in a patient with 46,XY partial gonadal dysgenesis accompanied by minifascicular neuropathy.

PubMed ID: 11017805

DOI: 10.1016/s0002-9297(07)62958-9

PubMed ID: 11472839

Title: Comparative biological responses to human Sonic, Indian, and Desert hedgehog.

PubMed ID: 11472839

DOI: 10.1016/s0925-4773(01)00427-0

PubMed ID: 24342078

Title: A new role for Hedgehogs in juxtacrine signaling.

PubMed ID: 24342078

DOI: 10.1016/j.mod.2013.12.002

PubMed ID: 24784881

Title: Loss of function mutation in the palmitoyl-transferase HHAT leads to syndromic 46,XY disorder of sex development by impeding Hedgehog protein palmitoylation and signaling.

PubMed ID: 24784881

DOI: 10.1371/journal.pgen.1004340

PubMed ID: 19561611

Title: Structural insights into hedgehog ligand sequestration by the human hedgehog-interacting protein HHIP.

PubMed ID: 19561611

DOI: 10.1038/nsmb.1607

PubMed ID: 20519495

Title: All mammalian Hedgehog proteins interact with cell adhesion molecule, down-regulated by oncogenes (CDO) and brother of CDO (BOC) in a conserved manner.

PubMed ID: 20519495

DOI: 10.1074/jbc.m110.131680

PubMed ID: 15356051

Title: Mutations in the desert hedgehog (DHH) gene in patients with 46,XY complete pure gonadal dysgenesis.

PubMed ID: 15356051

DOI: 10.1210/jc.2004-0863

PubMed ID: 30298535

Title: In vitro functional characterization of the novel DHH mutations p.(Asn337Lysfs*24) and p.(Glu212Lys) associated with gonadal dysgenesis.

PubMed ID: 30298535

DOI: 10.1002/humu.23664

PubMed ID: 33063110

Title: Full-length Dhh and N-terminal Shh act as competitive antagonists to regulate angiogenesis and vascular permeability.

PubMed ID: 33063110

DOI: 10.1093/cvr/cvaa285

Sequence Information:

  • Length: 396
  • Mass: 43577
  • Checksum: FCE4FB21972C3AD5
  • Sequence:
    • MALLTNLLPL CCLALLALPA QSCGPGRGPV GRRRYARKQL VPLLYKQFVP GVPERTLGAS 
GPAEGRVARG SERFRDLVPN YNPDIIFKDE ENSGADRLMT ERCKERVNAL AIAVMNMWPG 
VRLRVTEGWD EDGHHAQDSL HYEGRALDIT TSDRDRNKYG LLARLAVEAG FDWVYYESRN 
HVHVSVKADN SLAVRAGGCF PGNATVRLWS GERKGLRELH RGDWVLAADA SGRVVPTPVL 
LFLDRDLQRR ASFVAVETEW PPRKLLLTPW HLVFAARGPA PAPGDFAPVF ARRLRAGDSV 
LAPGGDALRP ARVARVAREE AVGVFAPLTA HGTLLVNDVL ASCYAVLESH QWAHRAFAPL 
RLLHALGALL PGGAVQPTGM HWYSRLLYRL AEELLG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.