Details for: SSUH2

Gene ID: 51066

Symbol: SSUH2

Ensembl ID: ENSG00000125046

Description: ssu-2 homolog

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 9.1713
    Cell Significance Index: -4.3300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 1.8590
    Cell Significance Index: -4.9800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7891
    Cell Significance Index: 22.7400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5966
    Cell Significance Index: 113.5400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.5553
    Cell Significance Index: 12.1600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4902
    Cell Significance Index: 97.2800
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 0.3818
    Cell Significance Index: 6.1600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.3629
    Cell Significance Index: 8.7900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2898
    Cell Significance Index: 261.6900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.2570
    Cell Significance Index: 6.2700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.2416
    Cell Significance Index: 9.1500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.2335
    Cell Significance Index: 10.3300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2273
    Cell Significance Index: 22.4900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1695
    Cell Significance Index: 34.0100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.1607
    Cell Significance Index: 4.5900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1241
    Cell Significance Index: 20.1900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1232
    Cell Significance Index: 13.4000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1218
    Cell Significance Index: 7.3100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1049
    Cell Significance Index: 7.2600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0838
    Cell Significance Index: 6.4300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0604
    Cell Significance Index: 21.6800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0538
    Cell Significance Index: 1.8900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0501
    Cell Significance Index: 2.2700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0300
    Cell Significance Index: 0.6500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0284
    Cell Significance Index: 1.9100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.0212
    Cell Significance Index: 0.3200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0200
    Cell Significance Index: 1.0400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0132
    Cell Significance Index: 0.3300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0114
    Cell Significance Index: 7.2400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0025
    Cell Significance Index: 4.7200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0018
    Cell Significance Index: 3.3200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0006
    Cell Significance Index: -0.9900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0007
    Cell Significance Index: -0.9200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0024
    Cell Significance Index: -0.7000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0039
    Cell Significance Index: -1.7600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0043
    Cell Significance Index: -0.0500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0049
    Cell Significance Index: -0.0700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0050
    Cell Significance Index: -2.7400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0058
    Cell Significance Index: -4.3100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0058
    Cell Significance Index: -4.4000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0065
    Cell Significance Index: -0.1000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0070
    Cell Significance Index: -5.1400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0076
    Cell Significance Index: -4.3100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0082
    Cell Significance Index: -0.9500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0138
    Cell Significance Index: -2.0000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0171
    Cell Significance Index: -1.0500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0173
    Cell Significance Index: -3.1100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0212
    Cell Significance Index: -4.4600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0249
    Cell Significance Index: -4.2600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0303
    Cell Significance Index: -4.1700
  • Cell Name: colonocyte (CL1000347)
    Fold Change: -0.0307
    Cell Significance Index: -0.1900
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0307
    Cell Significance Index: -0.4100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0317
    Cell Significance Index: -4.1000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0332
    Cell Significance Index: -4.0800
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0334
    Cell Significance Index: -0.4500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0395
    Cell Significance Index: -4.0400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0395
    Cell Significance Index: -4.5300
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -0.0399
    Cell Significance Index: -0.4400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0403
    Cell Significance Index: -2.2600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0409
    Cell Significance Index: -4.2600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0447
    Cell Significance Index: -5.2700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0460
    Cell Significance Index: -3.4300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0469
    Cell Significance Index: -1.3100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0519
    Cell Significance Index: -3.2700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0524
    Cell Significance Index: -2.7200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0562
    Cell Significance Index: -1.7900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0573
    Cell Significance Index: -3.5200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0634
    Cell Significance Index: -1.7000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0638
    Cell Significance Index: -1.6400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0666
    Cell Significance Index: -2.1800
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0720
    Cell Significance Index: -0.9600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0737
    Cell Significance Index: -3.8700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0738
    Cell Significance Index: -1.2700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0739
    Cell Significance Index: -3.4500
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0759
    Cell Significance Index: -1.2500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0815
    Cell Significance Index: -3.8300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0820
    Cell Significance Index: -1.2100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0824
    Cell Significance Index: -1.6300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0828
    Cell Significance Index: -2.9000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0857
    Cell Significance Index: -5.5300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0862
    Cell Significance Index: -1.4500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0937
    Cell Significance Index: -2.0000
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: -0.0990
    Cell Significance Index: -0.6800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.1013
    Cell Significance Index: -1.7900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1033
    Cell Significance Index: -1.4100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1079
    Cell Significance Index: -2.2900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1082
    Cell Significance Index: -2.7000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1085
    Cell Significance Index: -4.7200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1166
    Cell Significance Index: -4.2800
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1185
    Cell Significance Index: -1.8800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1259
    Cell Significance Index: -2.7200
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.1263
    Cell Significance Index: -1.6200
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1293
    Cell Significance Index: -4.0900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1296
    Cell Significance Index: -3.4600
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.1328
    Cell Significance Index: -1.9100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1392
    Cell Significance Index: -3.6600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1497
    Cell Significance Index: -3.8200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1508
    Cell Significance Index: -4.8300
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1508
    Cell Significance Index: -1.8700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1519
    Cell Significance Index: -5.2800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SSUH2 is a protein-coding gene that belongs to the ssu-2 homolog family. It is primarily expressed in cells of the immune system, including smooth muscle fibers of the ileum, CD8-alpha-beta-positive alpha-beta intraepithelial T cells, enterocytes of the small intestine, and enteroendocrine cells of the colon. Additionally, SSUH2 is also expressed in cells involved in muscle development, such as type II muscle cells and type I muscle cells. Notably, SSUH2 is also expressed in neoplastic cells, suggesting its potential role in cancer progression. **Pathways and Functions:** The expression patterns of SSUH2 suggest that it is involved in various cellular processes, including heat shock response, protein binding, and unfolded protein binding. These pathways are critical for maintaining cellular homeostasis and responding to stress stimuli. SSUH2 may play a role in regulating the expression of heat shock proteins, which are essential for protecting cells against protein misfolding and aggregation. Furthermore, SSUH2 may interact with other proteins involved in immune responses, such as CD14 and CD16, to modulate the activity of monocytes and macrophages. **Clinical Significance:** The clinical significance of SSUH2 is an area of active research. Given its expression in neoplastic cells, SSUH2 may serve as a potential biomarker for cancer diagnosis and prognosis. Additionally, SSUH2's involvement in immune responses suggests that it may play a role in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Further studies are needed to fully elucidate the functional role of SSUH2 in these conditions. **Conclusion:** In conclusion, SSUH2 is a gene with a complex expression profile that suggests a multifaceted role in cellular homeostasis and immune responses. Further research is necessary to fully understand the functional significance of SSUH2 and its potential applications in the diagnosis and treatment of immune-related disorders. As our understanding of this gene continues to evolve, it is likely that SSUH2 will emerge as a key player in the regulation of cellular responses to stress and immune stimuli. **Recommendations for Future Research:** 1. Investigate the role of SSUH2 in cancer progression and diagnosis. 2. Examine the interaction between SSUH2 and other proteins involved in immune responses. 3. Explore the potential therapeutic applications of SSUH2 in autoimmune diseases. 4. Elucidate the mechanisms by which SSUH2 regulates heat shock response and protein binding. By addressing these research gaps, we can gain a deeper understanding of the enigmatic role of SSUH2 and unlock its full potential as a therapeutic target.

Genular Protein ID: 960267631

Symbol: SSUH2_HUMAN

Name: Protein ssu-2 homolog

UniProtKB Accession Codes:

Q9Y2M2 A6NFA9 B3KS84 B7Z6E3 F5H2S5 Q7Z7K4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 5 ExpressionAtlas 1 GO 5 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 8 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 20205943

Title: Small intestinal mucosa expression of putative chaperone fls485.

PubMed ID: 20205943

DOI: 10.1186/1471-230x-10-27

PubMed ID: 27680507

Title: Mutation in SSUH2 causes autosomal-dominant dentin dysplasia type I.

PubMed ID: 27680507

DOI: 10.1002/humu.23130

Sequence Information:

  • Length: 375
  • Mass: 42732
  • Checksum: D5B84353A89786CC
  • Sequence:
    • MDRDLNEDDS VVDLSFEAES PLAPPTELLE RLPSYDWLLQ GGRGQIFFPP LEAPGRPQEQ 
RSWPSFLEHR VPAMTEEVAR EALLSFVDSK CCYSSTVAGD LVIQELKRQT LCRYRLETFS 
ESRISEWTFQ PFTNHSVDGP QRGASPRLWD IKVQGPPMFQ EDTRKFQVPH SSLVKECHKC 
HGRGRYKCSG CHGAGTVRCP SCCGAKRKAK QSRRCQLCAG SGRRRCSTCS GRGNKTCATC 
KGEKKLLHFI QLVIMWKNSL FEFVSEHRLN CPRELLAKAK GENLFKDENS VVYPIVDFPL 
RDISLASQRG IAEHSAALAS RARVLQQRQT IELIPLTEVH YWYQGKTYVY YIYGTDHQVY 
AVDYPERYCC GCTIV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.