Details for: CEP83

Gene ID: 51134

Symbol: CEP83

Ensembl ID: ENSG00000173588

Description: centrosomal protein 83

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 68.3582
    Cell Significance Index: -28.1600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 62.6327
    Cell Significance Index: -25.4500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 26.4836
    Cell Significance Index: -25.2900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.2287
    Cell Significance Index: -30.0800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.8599
    Cell Significance Index: -21.0700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.1592
    Cell Significance Index: -13.4800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.8844
    Cell Significance Index: 105.7400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.7169
    Cell Significance Index: 36.7000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.5268
    Cell Significance Index: 306.2800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.3568
    Cell Significance Index: 269.2600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.3223
    Cell Significance Index: 101.4800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.2099
    Cell Significance Index: 31.1000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.1800
    Cell Significance Index: 23.0300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.0852
    Cell Significance Index: 750.5400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.9492
    Cell Significance Index: 12.9500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.9272
    Cell Significance Index: 35.1100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.9140
    Cell Significance Index: 40.4300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.8821
    Cell Significance Index: 25.4200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.8312
    Cell Significance Index: 10.3100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7321
    Cell Significance Index: 50.6300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6820
    Cell Significance Index: 615.7900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.6733
    Cell Significance Index: 34.0200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5605
    Cell Significance Index: 91.1600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.5488
    Cell Significance Index: 8.1000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5342
    Cell Significance Index: 191.6000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5170
    Cell Significance Index: 11.2000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5041
    Cell Significance Index: 54.8400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.5006
    Cell Significance Index: 13.9900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3889
    Cell Significance Index: 23.3500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2942
    Cell Significance Index: 160.7000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2872
    Cell Significance Index: 39.4400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2393
    Cell Significance Index: 12.4300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2178
    Cell Significance Index: 41.4400
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.2144
    Cell Significance Index: 3.4400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1726
    Cell Significance Index: 325.0000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1397
    Cell Significance Index: 13.8200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1256
    Cell Significance Index: 22.6500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0903
    Cell Significance Index: 5.5500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0816
    Cell Significance Index: 51.8300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0757
    Cell Significance Index: 33.4600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0697
    Cell Significance Index: 8.5800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0604
    Cell Significance Index: 111.4700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0551
    Cell Significance Index: 25.0000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0401
    Cell Significance Index: 61.7200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0366
    Cell Significance Index: 0.5400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0284
    Cell Significance Index: 0.5900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0068
    Cell Significance Index: 0.3200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0090
    Cell Significance Index: -12.2700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0212
    Cell Significance Index: -3.0800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0247
    Cell Significance Index: -1.6000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0265
    Cell Significance Index: -19.4500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0307
    Cell Significance Index: -22.7200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0338
    Cell Significance Index: -25.5800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0469
    Cell Significance Index: -26.4600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0474
    Cell Significance Index: -0.7100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0507
    Cell Significance Index: -31.6400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0577
    Cell Significance Index: -9.8600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0619
    Cell Significance Index: -1.0600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0647
    Cell Significance Index: -8.2900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0667
    Cell Significance Index: -1.4200
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0696
    Cell Significance Index: -1.0000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0854
    Cell Significance Index: -24.5700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1017
    Cell Significance Index: -11.9900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1086
    Cell Significance Index: -11.0900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1241
    Cell Significance Index: -16.0300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1246
    Cell Significance Index: -5.8100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1374
    Cell Significance Index: -14.3100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1433
    Cell Significance Index: -16.7000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1449
    Cell Significance Index: -30.5300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1483
    Cell Significance Index: -3.9600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1653
    Cell Significance Index: -11.6900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1731
    Cell Significance Index: -4.0000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1811
    Cell Significance Index: -4.9300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1815
    Cell Significance Index: -11.4400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1910
    Cell Significance Index: -21.8800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2020
    Cell Significance Index: -4.8500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2036
    Cell Significance Index: -6.5200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2055
    Cell Significance Index: -15.3200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2060
    Cell Significance Index: -10.7300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2165
    Cell Significance Index: -9.8200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.2366
    Cell Significance Index: -3.9900
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.2486
    Cell Significance Index: -3.5800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2584
    Cell Significance Index: -15.8400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2825
    Cell Significance Index: -14.8300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2840
    Cell Significance Index: -7.1000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3115
    Cell Significance Index: -6.8200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3284
    Cell Significance Index: -8.3900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3360
    Cell Significance Index: -26.6100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3468
    Cell Significance Index: -12.0500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3478
    Cell Significance Index: -9.1500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4060
    Cell Significance Index: -12.9300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4152
    Cell Significance Index: -8.6900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4279
    Cell Significance Index: -12.2700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4299
    Cell Significance Index: -7.2000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.4443
    Cell Significance Index: -10.8400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4721
    Cell Significance Index: -10.0200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4750
    Cell Significance Index: -15.5500
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.5153
    Cell Significance Index: -4.3800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5262
    Cell Significance Index: -14.0800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.5483
    Cell Significance Index: -10.8400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CEP83 is a 83-kDa protein that is predominantly localized to the centrosome, a key organelle involved in maintaining cellular polarity and organization. Its expression is widespread across various cell types, including embryonic stem cells, mast cells, and T cells. The protein exhibits high identity protein binding, indicating its ability to interact with other proteins and participate in complex cellular processes. Additionally, CEP83 is involved in the establishment of centrosome localization, Golgi apparatus organization, and molecular function regulation. **Pathways and Functions:** CEP83 is implicated in several key cellular pathways, including: 1. **Anchoring of the basal body to the plasma membrane**: CEP83 plays a crucial role in anchoring the basal body to the plasma membrane, ensuring proper ciliary formation and function. 2. **Centriole formation**: CEP83 is involved in centriole formation, a critical process in maintaining cellular polarity and organization. 3. **Ciliary transition fiber assembly**: CEP83 participates in the assembly of ciliary transition fibers, which are essential for ciliary motility and function. 4. **Vesicle docking**: CEP83 is involved in vesicle docking, a process critical for maintaining cellular homeostasis and function. 5. **Protein binding and localization**: CEP83 exhibits high identity protein binding, allowing it to interact with other proteins and participate in complex cellular processes. **Clinical Significance:** CEP83 has been identified as a significantly expressed protein in various diseases, including: 1. **Ciliary disorders**: Mutations in CEP83 have been implicated in ciliary disorders, such as primary ciliary dyskinesia, which is characterized by impaired ciliary function and respiratory disease. 2. **Cancer**: CEP83 has been found to be overexpressed in certain types of cancer, including leukemia and lymphoma, suggesting its potential role in tumorigenesis. 3. **Neurological disorders**: CEP83 has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease, which are characterized by impaired ciliary function and axonal transport. In conclusion, CEP83 is a critical component of the centrosome, playing a pivotal role in maintaining cellular homeostasis and function. Its significant expression in diverse cell types and its involvement in various cellular pathways underscore its importance in maintaining cellular organization and function. Further research is needed to fully elucidate the role of CEP83 in disease and to explore its potential as a therapeutic target.

Genular Protein ID: 1079846617

Symbol: CEP83_HUMAN

Name: Centrosomal protein of 83 kDa

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10508479

Title: Antigens recognized by autologous antibody in patients with renal-cell carcinoma.

PubMed ID: 10508479

DOI: 10.1002/(sici)1097-0215(19991112)83:4<456::aid-ijc4>3.0.co;2-5

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 23348840

Title: Centriole distal appendages promote membrane docking, leading to cilia initiation.

PubMed ID: 23348840

DOI: 10.1101/gad.207043.112

PubMed ID: 23530209

Title: CCDC41 is required for ciliary vesicle docking to the mother centriole.

PubMed ID: 23530209

DOI: 10.1073/pnas.1220927110

PubMed ID: 24882706

Title: Mutations of CEP83 cause infantile nephronophthisis and intellectual disability.

PubMed ID: 24882706

DOI: 10.1016/j.ajhg.2014.05.002

Sequence Information:

  • Length: 701
  • Mass: 82940
  • Checksum: DF757C84BE784D07
  • Sequence:
  • MVVSTFTDMD TFPNNFPPGG DSGLTGSQSE FQKMLIDERL RCEHHKANYQ TLKAEHTRLQ 
    NEHVKLQNEL KHLFNEKQTQ QEKLQLLLEE LRGELVEKTK DLEEMKLQIL TPQKLELLRA 
    QIQQELETPM RERFRNLDEE VEKYRAVYNK LRYEHTFLKS EFEHQKEEYA RILDEGKIKY 
    ESEIARLEED KEELRNQLLN VDLTKDSKRV EQLAREKVYL CQKLKGLEAE VAELKAEKEN 
    SEAQVENAQR IQVRQLAEMQ ATVRSLEAEK QSANLRAERL EKELQSSSEQ NTFLINKLHK 
    AEREINTLSS KVKELKHSNK LEITDIKLET ARAKSELERE RNKIQSELDG LQSDNEILKA 
    AVEHHKVLLV EKDRELIRKV QAAKEEGYQK LVVLQDEKLE LENRLADLEK MKVEHDVWRQ 
    SEKDQYEEKL RASQMAEEIT RKELQSVRLK LQQQIVTIEN AEKEKNENSD LKQQISSLQI 
    QVTSLAQSEN DLLNSNQMLK EMVERLKQEC RNFRSQAEKA QLEAEKTLEE KQIQWLEEKH 
    KLHERITDRE EKYNQAKEKL QRAAIAQKKR KSLHENKLKR LQEKVEVLEA KKEELETENQ 
    VLNRQNVPFE DYTRLQKRLK DIQRRHNEFR SLILVPNMPP TASINPVSFQ SSAMVPSMEL 
    PFPPHMQEEQ HQRELSLLRK RLEELETTQR KQLEELGSSG E

Genular Protein ID: 3244501590

Symbol: F8VYN8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

Sequence Information:

  • Length: 352
  • Mass: 41531
  • Checksum: AF22368D8E6C104B
  • Sequence:
  • MVVSTFTDMD TFPNNFPPGG DSGLTGSQSE FQKMLIDERL RCEHHKANYQ TLKAEHTRLQ 
    NEHVKLQNEL KHLFNEKQTQ QEKLQLLLEE LRGELVEKTK DLEEMKLQIL TPQKLELLRA 
    QIQQELETPM RERFRNLDEE VEKYRAVYNK LRYEHTFLKS EFEHQKEEYA RILDEGKIKY 
    ESEIARLEED KEELRNQLLN VDLTKDSKRV EQLAREKVYL CQKLKGLEAE VAELKAEKEN 
    SEAQVENAQR IQVRQLAEMQ ATVRSLEAEK QSANLRAERL EKELQSSSEQ NTFLINKLHK 
    AEREINTLSS KVKELKHSNK LEITDIKLET ARAKSELERE RNKIQSELDG NM

Genular Protein ID: 817569522

Symbol: Q3B787_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 218
  • Mass: 25932
  • Checksum: 5E64C8C74DAFD54D
  • Sequence:
  • MRERFRNLDE EVEKYRAVYN KLRYEHTFLK SEFEHQKEEY ARILDEGKIK YESEIARLEE 
    DKEELRNQLL NVDLTKDSKR VEQLAREKVY LCQKLKGLEA EVAELKAEKE NSEAQVENAQ 
    RIQVRQLAEM QATVRSLEAE KQSANLRAER LEKELQSSSE QNTFLINKLH KAEREINTLS 
    SKVKELKHSN KLEITDIKLE TARAKSELER KKKKKKKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.