Details for: MRNIP

Gene ID: 51149

Symbol: MRNIP

Ensembl ID: ENSG00000161010

Description: MRN complex interacting protein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 64.8137
    Cell Significance Index: -30.6000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 63.0389
    Cell Significance Index: -25.6100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.7611
    Cell Significance Index: -28.8300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.3618
    Cell Significance Index: -19.5400
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.7309
    Cell Significance Index: 27.7700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.6197
    Cell Significance Index: 40.3900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.2187
    Cell Significance Index: 120.5600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.2034
    Cell Significance Index: 241.4000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.1025
    Cell Significance Index: 57.2700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.8320
    Cell Significance Index: 96.9600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7635
    Cell Significance Index: 151.5200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6780
    Cell Significance Index: 243.1800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6517
    Cell Significance Index: 117.4800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6112
    Cell Significance Index: 66.4800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6110
    Cell Significance Index: 99.3800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.5617
    Cell Significance Index: 35.4000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5410
    Cell Significance Index: 24.5200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5255
    Cell Significance Index: 363.4700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5213
    Cell Significance Index: 66.8300
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.5046
    Cell Significance Index: 15.9600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4696
    Cell Significance Index: 57.7400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4661
    Cell Significance Index: 27.9800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4587
    Cell Significance Index: 250.4900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.4346
    Cell Significance Index: 11.8300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3774
    Cell Significance Index: 51.8300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.3617
    Cell Significance Index: 18.2800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.3482
    Cell Significance Index: 6.0200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3333
    Cell Significance Index: 7.2200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2952
    Cell Significance Index: 8.2500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2658
    Cell Significance Index: 18.3800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2532
    Cell Significance Index: 7.3000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2029
    Cell Significance Index: 89.7100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2023
    Cell Significance Index: 10.6200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1924
    Cell Significance Index: 8.9700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1838
    Cell Significance Index: 4.0300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1376
    Cell Significance Index: 1.6400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1376
    Cell Significance Index: 7.7200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0832
    Cell Significance Index: 15.8300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0756
    Cell Significance Index: 142.4000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0603
    Cell Significance Index: 4.6300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0486
    Cell Significance Index: 89.6300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0479
    Cell Significance Index: 73.7400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0382
    Cell Significance Index: 24.2800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0370
    Cell Significance Index: 0.6200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0088
    Cell Significance Index: 12.0000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0053
    Cell Significance Index: 0.0900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0016
    Cell Significance Index: -0.0400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0082
    Cell Significance Index: -3.7400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0148
    Cell Significance Index: -0.5200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0159
    Cell Significance Index: -11.6400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0171
    Cell Significance Index: -1.2100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0261
    Cell Significance Index: -0.5100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0291
    Cell Significance Index: -22.0300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0296
    Cell Significance Index: -21.9000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0317
    Cell Significance Index: -4.6100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0358
    Cell Significance Index: -4.1000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0459
    Cell Significance Index: -25.9100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0505
    Cell Significance Index: -31.5600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0526
    Cell Significance Index: -5.3700
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.0536
    Cell Significance Index: -0.4500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0692
    Cell Significance Index: -8.1600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0712
    Cell Significance Index: -1.9000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0749
    Cell Significance Index: -9.6800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0786
    Cell Significance Index: -22.6100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0822
    Cell Significance Index: -14.0300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0930
    Cell Significance Index: -4.1200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1161
    Cell Significance Index: -7.4900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1216
    Cell Significance Index: -5.7200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1433
    Cell Significance Index: -30.1800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1439
    Cell Significance Index: -5.4500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1622
    Cell Significance Index: -12.0900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1662
    Cell Significance Index: -4.3700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1747
    Cell Significance Index: -6.0700
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1768
    Cell Significance Index: -3.6900
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.2028
    Cell Significance Index: -2.5200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2197
    Cell Significance Index: -22.8800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2413
    Cell Significance Index: -7.7300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2578
    Cell Significance Index: -5.4900
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.2583
    Cell Significance Index: -1.7500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2753
    Cell Significance Index: -8.1100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2872
    Cell Significance Index: -17.6100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2989
    Cell Significance Index: -6.2000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3083
    Cell Significance Index: -24.4200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3268
    Cell Significance Index: -6.8400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3740
    Cell Significance Index: -8.6400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4054
    Cell Significance Index: -12.9100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4056
    Cell Significance Index: -13.2800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4179
    Cell Significance Index: -21.7700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4310
    Cell Significance Index: -5.8800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.4387
    Cell Significance Index: -4.0400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4429
    Cell Significance Index: -9.4000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4587
    Cell Significance Index: -11.7900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4593
    Cell Significance Index: -16.0900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.4877
    Cell Significance Index: -7.3500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.5416
    Cell Significance Index: -13.5100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.5439
    Cell Significance Index: -10.9200
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.5469
    Cell Significance Index: -6.8200
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.5540
    Cell Significance Index: -7.9600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.5840
    Cell Significance Index: -16.7400
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.5923
    Cell Significance Index: -9.7600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** MRNIP exhibits characteristics that are essential for its function in DNA repair and immune homeostasis. These include: 1. **Chromatin binding**: MRNIP's ability to bind to chromatin allows it to regulate gene expression and modulate the response to DNA damage. 2. **DNA damage response**: MRNIP's interaction with the MRN complex enables it to participate in the DNA damage response pathway, facilitating the repair of double-strand breaks. 3. **Protein binding**: MRNIP's capacity to bind to various proteins, including those involved in DNA repair and immune signaling, highlights its role in regulating complex cellular processes. 4. **Cell type specificity**: MRNIP's expression in specific cell types, such as T cells and epithelial cells, underscores its involvement in immune homeostasis and tissue maintenance. **Pathways and Functions** MRNIP's involvement in DNA repair mechanisms is well-documented. Its functions can be categorized into the following pathways: 1. **Homologous recombination**: MRNIP's interaction with the MRN complex enables it to participate in the homologous recombination pathway, a critical mechanism for repairing double-strand breaks. 2. **Non-homologous end joining**: MRNIP's involvement in non-homologous end joining, another DNA repair pathway, highlights its role in maintaining genome integrity. 3. **Mitotic G2 DNA damage checkpoint signaling**: MRNIP's expression in cell cycle-regulated genes underscores its involvement in the mitotic G2 DNA damage checkpoint signaling pathway, which ensures the accurate segregation of chromosomes. 4. **Response to ionizing radiation**: MRNIP's expression in response to ionizing radiation highlights its role in protecting cells against DNA damage caused by ionizing radiation. **Clinical Significance** The clinical significance of MRNIP lies in its role in maintaining genome stability and immune homeostasis. Dysregulation of MRNIP has been implicated in various diseases, including: 1. **Cancer**: MRNIP's involvement in DNA repair mechanisms makes it a potential target for cancer therapy. 2. **Immune disorders**: MRNIP's role in immune homeostasis highlights its potential as a therapeutic target for autoimmune diseases. 3. **Genetic disorders**: MRNIP's expression in specific cell types underscores its involvement in genetic disorders, such as Fanconi anemia. In conclusion, MRNIP is a multifaceted protein that plays a critical role in maintaining genome stability and immune homeostasis. Its involvement in DNA repair mechanisms, particularly in homologous recombination and non-homologous end joining, underscores its importance in maintaining genome integrity. Further research into MRNIP's clinical significance is warranted to fully appreciate its potential as a therapeutic target.

Genular Protein ID: 4265689591

Symbol: MRNIP_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6NTE8 B5MD09 E9PAK6 Q7Z3D8 Q9BUC1 Q9UN54

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 4 ExpressionAtlas 1 GO 11 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 RefSeq 2 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 27568553

Title: MRNIP/C5orf45 interacts with the MRN complex and contributes to the DNA damage response.

PubMed ID: 27568553

DOI: 10.1016/j.celrep.2016.07.087

Sequence Information:

  • Length: 343
  • Mass: 37743
  • Checksum: 08C3CE3C1BC827EC
  • Sequence:
    • MASLQRSRVL RCCSCRLFQA HQVKKSVKWT CKACGEKQSF LQAYGEGSGA DCRRHVQKLN 
LLQGQVSELP LRSLEETVSA SEEENVGHQQ AGNVKQQEKS QPSESRWLKY LEKDSQELEL 
EGTGVCFSKQ PSSKMEEPGP RFSQDLPRKR KWSRSTVQPP CSRGVQDSGG SEVAWGPQKG 
QAGLTWKVKQ GSSPCLQENS ADCSAGELRG PGKELWSPIQ QVTATSSKWA QFVLPPRKSS 
HVDSEQPRSL QRDPRPAGPA QAKQGTPRAQ ASREGLSRPT AAVQLPRATH PVTSGSERPC 
GKTSWDARTP WAEGGPLVLE AQNPRPTRLC DLFITGEDFD DDV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.