Details for: HSPA14

Gene ID: 51182

Symbol: HSPA14

Ensembl ID: ENSG00000187522

Description: heat shock protein family A (Hsp70) member 14

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 93.8634
    Cell Significance Index: -14.6000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 71.4783
    Cell Significance Index: -18.1300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 44.0881
    Cell Significance Index: -20.8200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 44.0115
    Cell Significance Index: -17.8800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 31.1093
    Cell Significance Index: -20.8800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 18.9580
    Cell Significance Index: -18.1000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 16.1990
    Cell Significance Index: 404.9300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 15.7670
    Cell Significance Index: -19.4400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.9461
    Cell Significance Index: -18.6100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.1571
    Cell Significance Index: -20.3500
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 2.8158
    Cell Significance Index: 46.4000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 2.2783
    Cell Significance Index: 433.5700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.8189
    Cell Significance Index: 22.5600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.4229
    Cell Significance Index: 231.4200
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.2678
    Cell Significance Index: 20.3400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.1750
    Cell Significance Index: 70.5400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0848
    Cell Significance Index: 979.4900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9950
    Cell Significance Index: 108.2300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5445
    Cell Significance Index: 109.2200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.4255
    Cell Significance Index: 49.5900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4164
    Cell Significance Index: 21.6300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.3704
    Cell Significance Index: 9.8900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3451
    Cell Significance Index: 188.4700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3092
    Cell Significance Index: 21.3800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2954
    Cell Significance Index: 8.0400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2816
    Cell Significance Index: 6.1000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2237
    Cell Significance Index: 10.4300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2220
    Cell Significance Index: 79.6400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2092
    Cell Significance Index: 41.5200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2010
    Cell Significance Index: 10.4700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1794
    Cell Significance Index: 8.1300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1577
    Cell Significance Index: 15.6000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1362
    Cell Significance Index: 3.6500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1335
    Cell Significance Index: 4.2800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1289
    Cell Significance Index: 17.7000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1229
    Cell Significance Index: 3.5400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1124
    Cell Significance Index: 77.7600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1039
    Cell Significance Index: 3.6100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0930
    Cell Significance Index: 5.8600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0800
    Cell Significance Index: 2.3500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0794
    Cell Significance Index: 1.3600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0512
    Cell Significance Index: 1.4300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0225
    Cell Significance Index: 0.4800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0153
    Cell Significance Index: 28.8900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0143
    Cell Significance Index: 21.9400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0079
    Cell Significance Index: 14.6400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0070
    Cell Significance Index: 4.4400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0008
    Cell Significance Index: -1.1500
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.0023
    Cell Significance Index: -0.0200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0063
    Cell Significance Index: -0.9200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0134
    Cell Significance Index: -10.1800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0214
    Cell Significance Index: -9.7000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0313
    Cell Significance Index: -23.1900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0326
    Cell Significance Index: -18.3700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0343
    Cell Significance Index: -3.5000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0391
    Cell Significance Index: -24.4400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0514
    Cell Significance Index: -2.7000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0567
    Cell Significance Index: -16.3100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0646
    Cell Significance Index: -11.0300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0697
    Cell Significance Index: -1.7800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0845
    Cell Significance Index: -2.9700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0914
    Cell Significance Index: -1.5300
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1021
    Cell Significance Index: -1.5500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1150
    Cell Significance Index: -24.2300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1312
    Cell Significance Index: -1.7900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1342
    Cell Significance Index: -15.3700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1428
    Cell Significance Index: -10.9600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1533
    Cell Significance Index: -7.2100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1830
    Cell Significance Index: -19.0500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1984
    Cell Significance Index: -5.1000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2182
    Cell Significance Index: -3.1300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2423
    Cell Significance Index: -14.8600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2502
    Cell Significance Index: -3.7700
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: -0.2502
    Cell Significance Index: -2.6900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2583
    Cell Significance Index: -3.8700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2675
    Cell Significance Index: -5.2200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3010
    Cell Significance Index: -6.5900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3210
    Cell Significance Index: -8.4400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3224
    Cell Significance Index: -21.6800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3529
    Cell Significance Index: -21.6900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.3641
    Cell Significance Index: -2.2000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.3943
    Cell Significance Index: -4.7000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3949
    Cell Significance Index: -8.2700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4032
    Cell Significance Index: -13.2000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4085
    Cell Significance Index: -14.3100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4165
    Cell Significance Index: -11.1400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4227
    Cell Significance Index: -12.4500
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.4245
    Cell Significance Index: -7.3400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4254
    Cell Significance Index: -13.5500
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.4513
    Cell Significance Index: -9.4200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4514
    Cell Significance Index: -12.9400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4665
    Cell Significance Index: -9.9000
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.4680
    Cell Significance Index: -6.5600
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.4711
    Cell Significance Index: -5.9700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4779
    Cell Significance Index: -17.5500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.4910
    Cell Significance Index: -10.5000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.5155
    Cell Significance Index: -12.8600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.5187
    Cell Significance Index: -4.2300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.5270
    Cell Significance Index: -9.7400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.5318
    Cell Significance Index: -11.4900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** HSPA14 is a small heat shock protein (sHSP) with a molecular weight of approximately 70 kDa. It belongs to the Hsp70 family, which is characterized by its ability to bind ATP and facilitate protein folding, refolding, and degradation. HSPA14 is predominantly expressed in cells that require rapid protein synthesis, such as hematopoietic cells, smooth muscle fibers, and epithelial cells. Its expression is also upregulated in response to cellular stress, including heat shock, oxidative stress, and inflammation. **Pathways and Functions:** HSPA14 is involved in various cellular pathways, including: 1. **De novo protein folding**: HSPA14 assists in the correct folding of newly synthesized proteins, preventing the aggregation of misfolded proteins. 2. **ATP-dependent protein folding chaperone**: HSPA14 uses ATP hydrolysis to drive protein folding and refolding reactions. 3. **Chaperone cofactor-dependent protein refolding**: HSPA14 interacts with other chaperone proteins, such as HSP70, to facilitate protein refolding. 4. **Regulation of HSF1-mediated heat shock response**: HSPA14 modulates the activity of heat shock transcription factor 1 (HSF1), a key regulator of the heat shock response. **Functions:** HSPA14 performs several critical functions, including: 1. **Protein folding and refolding**: HSPA14 assists in the correct folding of newly synthesized proteins and the refolding of misfolded proteins. 2. **Cellular stress response**: HSPA14 is upregulated in response to cellular stress, including heat shock, oxidative stress, and inflammation. 3. **Protein degradation**: HSPA14 interacts with protein degradation pathways, such as the ubiquitin-proteasome system, to facilitate the degradation of misfolded proteins. **Clinical Significance:** HSPA14 plays a critical role in various disease states, including: 1. **Neurodegenerative disorders**: HSPA14 has been implicated in the pathogenesis of neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. 2. **Cancer**: HSPA14 is overexpressed in various types of cancer, including breast cancer and lung cancer, and is associated with poor prognosis. 3. **Cardiovascular disease**: HSPA14 has been linked to cardiovascular disease, including atherosclerosis and cardiac hypertrophy. 4. **Inflammatory disorders**: HSPA14 is upregulated in response to inflammation and has been implicated in the pathogenesis of inflammatory disorders, such as rheumatoid arthritis and multiple sclerosis. In conclusion, HSPA14 is a multifaceted protein that plays a critical role in maintaining protein homeostasis and protecting cells against various forms of stress. Its dysregulation has been implicated in various disease states, highlighting the importance of HSPA14 in human health and disease. Further research is needed to fully elucidate the mechanisms of HSPA14 and its potential therapeutic applications.

Genular Protein ID: 3306443934

Symbol: HSP7E_HUMAN

Name: Heat shock 70 kDa protein 14

UniProtKB Accession Codes:

Q0VDF9 A8K8F8 B0YIY9 Q9P0X2 Q9UI07

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 1 ExpressionAtlas 1 GO 11 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14592822

Title: Novel heat shock protein Hsp70L1 activates dendritic cells and acts as a Th1 polarizing adjuvant.

PubMed ID: 14592822

DOI: 10.1182/blood-2003-08-2828

PubMed ID: 10931946

Title: Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.

PubMed ID: 10931946

DOI: 10.1073/pnas.160270997

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15930317

Title: Hsp70-like protein 1 fusion protein enhances induction of carcinoembryonic antigen-specific CD8+ CTL response by dendritic cell vaccine.

PubMed ID: 15930317

DOI: 10.1158/0008-5472.can-04-3912

PubMed ID: 16002468

Title: The chaperones MPP11 and Hsp70L1 form the mammalian ribosome-associated complex.

PubMed ID: 16002468

DOI: 10.1073/pnas.0504400102

PubMed ID: 15802566

Title: Human Mpp11 J protein: ribosome-tethered molecular chaperones are ubiquitous.

PubMed ID: 15802566

DOI: 10.1126/science.1109247

PubMed ID: 18851947

Title: Protective effect of a RSV subunit vaccine candidate G1F/M2 was enhanced by a HSP70-Like protein in mice.

PubMed ID: 18851947

DOI: 10.1016/j.bbrc.2008.10.002

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 509
  • Mass: 54794
  • Checksum: C3B685C7192B95C3
  • Sequence:
    • MAAIGVHLGC TSACVAVYKD GRAGVVANDA GDRVTPAVVA YSENEEIVGL AAKQSRIRNI 
SNTVMKVKQI LGRSSSDPQA QKYIAESKCL VIEKNGKLRY EIDTGEETKF VNPEDVARLI 
FSKMKETAHS VLGSDANDVV ITVPFDFGEK QKNALGEAAR AAGFNVLRLI HEPSAALLAY 
GIGQDSPTGK SNILVFKLGG TSLSLSVMEV NSGIYRVLST NTDDNIGGAH FTETLAQYLA 
SEFQRSFKHD VRGNARAMMK LTNSAEVAKH SLSTLGSANC FLDSLYEGQD FDCNVSRARF 
ELLCSPLFNK CIEAIRGLLD QNGFTADDIN KVVLCGGSSR IPKLQQLIKD LFPAVELLNS 
IPPDEVIPIG AAIEAGILIG KENLLVEDSL MIECSARDIL VKGVDESGAS RFTVLFPSGT 
PLPARRQHTL QAPGSISSVC LELYESDGKN SAKEETKFAQ VVLQDLDKKE NGLRDILAVL 
TMKRDGSLHV TCTDQETGKC EAISIEIAS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.