Details for: RAPGEFL1

Gene ID: 51195

Symbol: RAPGEFL1

Ensembl ID: ENSG00000108352

Description: Rap guanine nucleotide exchange factor like 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 89.6202
    Cell Significance Index: -13.9400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 55.5504
    Cell Significance Index: -14.0900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 11.3386
    Cell Significance Index: -13.9800
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 8.2635
    Cell Significance Index: 18.6300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 6.5202
    Cell Significance Index: 88.9600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.5744
    Cell Significance Index: -12.2000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.3680
    Cell Significance Index: -14.3800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.5871
    Cell Significance Index: -14.1600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 3.4866
    Cell Significance Index: 100.4600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 3.1328
    Cell Significance Index: 87.5500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 3.1037
    Cell Significance Index: 140.6800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.7168
    Cell Significance Index: 141.1300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 2.5437
    Cell Significance Index: 38.1200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.2133
    Cell Significance Index: 47.9500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.8145
    Cell Significance Index: 363.9900
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.7230
    Cell Significance Index: 10.6300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.6265
    Cell Significance Index: 1468.6200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.5916
    Cell Significance Index: 107.0200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.5236
    Cell Significance Index: 43.4800
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.2785
    Cell Significance Index: 18.2000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.2412
    Cell Significance Index: 135.0100
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.2249
    Cell Significance Index: 9.4000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.9455
    Cell Significance Index: 41.8200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.9264
    Cell Significance Index: 11.4900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.9098
    Cell Significance Index: 34.4500
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.8841
    Cell Significance Index: 5.9900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.7325
    Cell Significance Index: 15.6000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7123
    Cell Significance Index: 49.2600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6516
    Cell Significance Index: 117.4600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6499
    Cell Significance Index: 64.2900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5584
    Cell Significance Index: 200.3000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5089
    Cell Significance Index: 351.9600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4975
    Cell Significance Index: 61.1800
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.4878
    Cell Significance Index: 4.3300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.4445
    Cell Significance Index: 15.6200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4391
    Cell Significance Index: 71.4100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.3794
    Cell Significance Index: 7.8700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3004
    Cell Significance Index: 59.6100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2962
    Cell Significance Index: 130.9700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.2710
    Cell Significance Index: 4.6500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.2599
    Cell Significance Index: 5.6900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1784
    Cell Significance Index: 4.4600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.1466
    Cell Significance Index: 1.3500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1278
    Cell Significance Index: 9.0400
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 0.1141
    Cell Significance Index: 1.4800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1134
    Cell Significance Index: 21.5900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0908
    Cell Significance Index: 5.5800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0662
    Cell Significance Index: 36.1500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0415
    Cell Significance Index: 6.0300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0231
    Cell Significance Index: 35.5700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0170
    Cell Significance Index: 31.9400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0150
    Cell Significance Index: 27.7300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0100
    Cell Significance Index: 13.5600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0053
    Cell Significance Index: 0.4100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0074
    Cell Significance Index: -4.6900
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0142
    Cell Significance Index: -0.1900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0145
    Cell Significance Index: -6.5800
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.0158
    Cell Significance Index: -0.1500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0170
    Cell Significance Index: -12.4600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0173
    Cell Significance Index: -12.8300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0178
    Cell Significance Index: -13.5100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0179
    Cell Significance Index: -0.4300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0229
    Cell Significance Index: -14.3300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0242
    Cell Significance Index: -13.6700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0358
    Cell Significance Index: -0.7600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0400
    Cell Significance Index: -11.5200
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: -0.0436
    Cell Significance Index: -0.1900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0440
    Cell Significance Index: -1.4100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0490
    Cell Significance Index: -8.3700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0503
    Cell Significance Index: -5.8600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0530
    Cell Significance Index: -3.3400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0545
    Cell Significance Index: -2.8600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0575
    Cell Significance Index: -7.8900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0697
    Cell Significance Index: -14.6800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0836
    Cell Significance Index: -2.2800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0879
    Cell Significance Index: -2.2600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0965
    Cell Significance Index: -12.3700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0976
    Cell Significance Index: -1.9600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0980
    Cell Significance Index: -5.5000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0987
    Cell Significance Index: -12.7500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1014
    Cell Significance Index: -11.6200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1061
    Cell Significance Index: -12.5100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1092
    Cell Significance Index: -11.1500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1093
    Cell Significance Index: -6.7000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1203
    Cell Significance Index: -2.6000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1268
    Cell Significance Index: -4.0400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1277
    Cell Significance Index: -4.1800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1296
    Cell Significance Index: -13.4900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1472
    Cell Significance Index: -2.9100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1634
    Cell Significance Index: -12.9400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1728
    Cell Significance Index: -12.8800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1830
    Cell Significance Index: -2.6200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1937
    Cell Significance Index: -9.0300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1970
    Cell Significance Index: -12.7100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1976
    Cell Significance Index: -4.9300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2140
    Cell Significance Index: -11.1500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2209
    Cell Significance Index: -7.7400
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.2244
    Cell Significance Index: -2.3200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2275
    Cell Significance Index: -10.6900
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.2388
    Cell Significance Index: -4.9900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RAPGEFL1 is a member of the Rap guanine nucleotide exchange factor (GEF) family, which is characterized by their ability to stimulate the exchange of GDP for GTP on small GTPases, such as Ras. The RAPGEFL1 protein is specifically involved in regulating the activity of these small GTPases, which in turn modulate various cellular processes, including cell proliferation, differentiation, and survival. The gene is also known to interact with other signaling molecules, including G protein-coupled receptors, to regulate immune responses and inflammation. **Pathways and Functions:** RAPGEFL1 is involved in several key signaling pathways, including: 1. **G protein-coupled receptor signaling pathway:** RAPGEFL1 regulates the activity of G protein-coupled receptors, which are essential for transmitting signals from the cell surface to the interior of the cell. 2. **Guanyl-nucleotide exchange factor activity:** RAPGEFL1 stimulates the exchange of GDP for GTP on small GTPases, such as Ras, which in turn modulate various cellular processes. 3. **Ras protein signal transduction:** RAPGEFL1 regulates the activity of Ras proteins, which are involved in cell proliferation, differentiation, and survival. 4. **Membrane trafficking:** RAPGEFL1 is involved in regulating membrane trafficking, including endocytosis and exocytosis, which are essential for maintaining tissue homeostasis and immune function. **Clinical Significance:** RAPGEFL1 has been implicated in various diseases, including: 1. **Immunodeficiency disorders:** RAPGEFL1 mutations have been associated with immunodeficiency disorders, such as severe combined immunodeficiency (SCID). 2. **Cancer:** RAPGEFL1 is involved in regulating cell proliferation and differentiation, and its dysregulation has been implicated in various types of cancer. 3. **Neurological disorders:** RAPGEFL1 is involved in regulating neuronal function and development, and its dysregulation has been implicated in neurological disorders, such as autism spectrum disorder. In conclusion, RAPGEFL1 is a complex gene that plays a multifaceted role in regulating immune response, cell signaling, and development. Further research is necessary to fully understand the mechanisms of RAPGEFL1 and its clinical significance in various diseases.

Genular Protein ID: 2216743549

Symbol: RPGFL_HUMAN

Name: Rap guanine nucleotide exchange factor-like 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 662
  • Mass: 73265
  • Checksum: C6724336938D5769
  • Sequence:
  • MKPLEKFLKK QTSQLAGRTV AGGPGGGLGS CGGPGGGGGP GGGGGPAGGQ RSLQRRQSVS 
    RLLLPAFLRE PPAEPGLEPP VPEEGGEPAG VAEEPGSGGP CWLQLEEVPG PGPLGGGGPL 
    RSPSSYSSDE LSPGEPLTSP PWAPLGAPER PEHLLNRVLE RLAGGATRDS AASDILLDDI 
    VLTHSLFLPT EKFLQELHQY FVRAGGMEGP EGLGRKQACL AMLLHFLDTY QGLLQEEEGA 
    GHIIKDLYLL IMKDESLYQG LREDTLRLHQ LVETVELKIP EENQPPSKQV KPLFRHFRRI 
    DSCLQTRVAF RGSDEIFCRV YMPDHSYVTI RSRLSASVQD ILGSVTEKLQ YSEEPAGRED 
    SLILVAVSSS GEKVLLQPTE DCVFTALGIN SHLFACTRDS YEALVPLPEE IQVSPGDTEI 
    HRVEPEDVAN HLTAFHWELF RCVHELEFVD YVFHGERGRR ETANLELLLQ RCSEVTHWVA 
    TEVLLCEAPG KRAQLLKKFI KIAALCKQNQ DLLSFYAVVM GLDNAAVSRL RLTWEKLPGK 
    FKNLFRKFEN LTDPCRNHKS YREVISKMKP PVIPFVPLIL KDLTFLHEGS KTLVDGLVNI 
    EKLHSVAEKV RTIRKYRSRP LCLDMEASPN HLQTKAYVRQ FQVIDNQNLL FELSYKLEAN 
    SQ

Genular Protein ID: 2146728076

Symbol: F5H2D5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

Sequence Information:

  • Length: 505
  • Mass: 58003
  • Checksum: E5950019660C4D41
  • Sequence:
  • MMLRPGYPLS QESFPIDILL DDIVLTHSLF LPTEKFLQEL HQYFVRAGGM EGPEGLGRKQ 
    ACLAMLLHFL DTYQGLLQEE EGAGHIIKDL YLLIMKDESL YQGLREDTLR LHQLVETVEL 
    KIPEENQPPS KQVKPLFRHF RRIDSCLQTR VAFRGSDEIF CRVYMPDHSY VTIRSRLSAS 
    VQDILGSVTE KLQYSEEPAG REDSLILVAV SSSGEKVLLQ PTEDCVFTAL GINSHLFACT 
    RDSYEALVPL PEEIQVSPGD TEIHRVEPED VANHLTAFHW ELFRCVHELE FVDYVFHGER 
    GRRETANLEL LLQRCSEVTH WVATEVLLCE APGKRAQLLK KFIKIAALCK QNQDLLSFYA 
    VVMGLDNAAV SRLRLTWEKL PGKFKNLFRK FENLTDPCRN HKSYREVISK MKPPVIPFVP 
    LILKDLTFLH EGSKTLVDGL VNIEKLHSVA EKVRTIRKYR SRPLCLDMEA SPNHLQTKAY 
    VRQFQVIDNQ NLLFELSYKL EANSQ

Genular Protein ID: 220985018

Symbol: B4DGK9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 392
  • Mass: 44988
  • Checksum: 0A8C3F46C3B5AF45
  • Sequence:
  • MPSCVHARIP EENQPPSKQV KPLFRHFRRI DSCLQTRVAF RGSDEIFCRV YMPDHSYVTI 
    RSRLSASVQD ILGSVTEKLQ YSEEPAGRED SLILVAVSSS GEKVLLQPTE DCVFTALGIN 
    SHLFACTRDS YEALVPLPEE IQVSPGDTEI HRVEPEDVAN HLTAFHWELF RCVHELEFVD 
    YVFHGERGRR ETANLELLLQ RCSEVTHWVA TEVLLCEAPG KRAQLLKKFI KIAALCKQNQ 
    DLLSFYAVVM GLDNAAVSRL RLTWEKLPGK FKNLFRKFEN LTDPCRNHKS YREVISKMKP 
    PVIPFVPLIL KDLTFLHEGS KTLVDGLVNI EKLHSVAEKV RTIRKYRSRP LCLDMEASPN 
    HLQTKAYVRQ FQVIDNQNLL FELSYKLEAN SQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.