Details for: TLR7

Gene ID: 51284

Symbol: TLR7

Ensembl ID: ENSG00000196664

Description: toll like receptor 7

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 29.7020
    Cell Significance Index: -4.6200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 18.1751
    Cell Significance Index: -4.6100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 9.1566
    Cell Significance Index: -4.7100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 4.1857
    Cell Significance Index: 64.7600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 3.7471
    Cell Significance Index: -4.6200
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.9355
    Cell Significance Index: 9.2300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.3787
    Cell Significance Index: 7.0000
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.1582
    Cell Significance Index: 1.2900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0065
    Cell Significance Index: 1.2900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0045
    Cell Significance Index: 1.3000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0022
    Cell Significance Index: -4.1200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0041
    Cell Significance Index: -7.5700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0048
    Cell Significance Index: -7.4300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0049
    Cell Significance Index: -1.7600
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0049
    Cell Significance Index: -0.0600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0057
    Cell Significance Index: -7.7900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0059
    Cell Significance Index: -4.4500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0061
    Cell Significance Index: -4.5400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0066
    Cell Significance Index: -4.2100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0070
    Cell Significance Index: -0.7100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0078
    Cell Significance Index: -4.2500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0081
    Cell Significance Index: -4.5900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0108
    Cell Significance Index: -4.9200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0110
    Cell Significance Index: -2.2100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0136
    Cell Significance Index: -0.5900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0155
    Cell Significance Index: -2.8000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0200
    Cell Significance Index: -2.5700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0211
    Cell Significance Index: -1.0700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0218
    Cell Significance Index: -4.6000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0227
    Cell Significance Index: -3.8800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0270
    Cell Significance Index: -3.1800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0278
    Cell Significance Index: -3.4200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0283
    Cell Significance Index: -4.1200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0305
    Cell Significance Index: -4.1900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0349
    Cell Significance Index: -4.0700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0356
    Cell Significance Index: -2.3000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0360
    Cell Significance Index: -4.6500
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.0395
    Cell Significance Index: -0.3200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0403
    Cell Significance Index: -4.6200
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0410
    Cell Significance Index: -0.6000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0462
    Cell Significance Index: -1.8900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0467
    Cell Significance Index: -1.2000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0520
    Cell Significance Index: -2.7000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0547
    Cell Significance Index: -2.5500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0573
    Cell Significance Index: -1.6000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0574
    Cell Significance Index: -2.7000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0627
    Cell Significance Index: -4.6800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0640
    Cell Significance Index: -4.9100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0647
    Cell Significance Index: -1.7300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0679
    Cell Significance Index: -4.5700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0755
    Cell Significance Index: -4.6400
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0760
    Cell Significance Index: -1.2900
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0764
    Cell Significance Index: -1.0200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0789
    Cell Significance Index: -4.8400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0806
    Cell Significance Index: -4.2000
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -0.0849
    Cell Significance Index: -1.0200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0956
    Cell Significance Index: -5.0200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0966
    Cell Significance Index: -5.4200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1033
    Cell Significance Index: -4.6800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1056
    Cell Significance Index: -3.7000
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.1183
    Cell Significance Index: -1.0000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1183
    Cell Significance Index: -4.1100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1214
    Cell Significance Index: -5.3700
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.1229
    Cell Significance Index: -1.4500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1237
    Cell Significance Index: -3.9400
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1276
    Cell Significance Index: -1.8600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1280
    Cell Significance Index: -3.7700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1301
    Cell Significance Index: -4.2600
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1309
    Cell Significance Index: -1.9000
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.1415
    Cell Significance Index: -1.4500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1418
    Cell Significance Index: -2.4300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1424
    Cell Significance Index: -2.9800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1434
    Cell Significance Index: -5.4300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1491
    Cell Significance Index: -3.8100
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.1504
    Cell Significance Index: -1.3600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1523
    Cell Significance Index: -4.0800
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1550
    Cell Significance Index: -3.0300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1591
    Cell Significance Index: -5.8400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1600
    Cell Significance Index: -3.9900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1620
    Cell Significance Index: -4.0400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1620
    Cell Significance Index: -4.6500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1622
    Cell Significance Index: -4.6300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1627
    Cell Significance Index: -2.7400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1641
    Cell Significance Index: -3.9800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1668
    Cell Significance Index: -5.8600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1674
    Cell Significance Index: -4.4700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1761
    Cell Significance Index: -4.6300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1830
    Cell Significance Index: -2.6200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1841
    Cell Significance Index: -4.6900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1844
    Cell Significance Index: -5.0200
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.1961
    Cell Significance Index: -2.7900
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.2000
    Cell Significance Index: -4.0700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.2013
    Cell Significance Index: -5.8000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2055
    Cell Significance Index: -4.5000
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.2075
    Cell Significance Index: -4.3300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2092
    Cell Significance Index: -4.5200
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.2103
    Cell Significance Index: -2.8600
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.2116
    Cell Significance Index: -2.4900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2153
    Cell Significance Index: -4.5700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2160
    Cell Significance Index: -5.1800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Specificity**: TLR7 is highly specific for ssRNA, making it an ideal receptor for recognizing viral infections. 2. **Expression**: TLR7 is expressed on various cell types, including hematopoietic cells, epithelial cells, and immune cells, such as monocytes and dendritic cells. 3. **Signaling**: TLR7 activates the MyD88-dependent and -independent signaling pathways, leading to the production of pro-inflammatory cytokines and type I interferons. 4. **Regulation**: TLR7 is regulated by endogenous ligands, such as ssRNA, and by negative regulators, such as TLR7-interacting protein (TIRAP). **Pathways and Functions** 1. **Canonical NF-κB Signaling**: TLR7 activates the MyD88-dependent pathway, leading to the activation of NF-κB, a transcription factor that regulates the expression of pro-inflammatory genes. 2. **Non-Canonical NF-κB Signaling**: TLR7 also activates the non-canonical NF-κB pathway, which leads to the activation of NF-κB-inducing kinase (NIK) and the subsequent production of interleukin-6 (IL-6). 3. **Type I Interferon Production**: TLR7 triggers the production of type I interferons, such as interferon-alpha (IFN-α) and interferon-beta (IFN-β), which play a crucial role in antiviral defense. 4. **Immune Cell Activation**: TLR7 activates immune cells, such as monocytes and dendritic cells, leading to the production of pro-inflammatory cytokines and chemokines. **Clinical Significance** 1. **Viral Infections**: TLR7 plays a critical role in recognizing viral infections, such as respiratory syncytial virus (RSV), influenza, and SARS-CoV-2. 2. **Autoimmune Diseases**: Dysregulation of TLR7 has been implicated in autoimmune diseases, such as rheumatoid arthritis and lupus. 3. **Cancer**: TLR7 has been shown to play a role in cancer immunology, with potential applications in cancer vaccination and immunotherapy. 4. **Infectious Disease Treatment**: TLR7 has been identified as a potential target for the development of therapeutic strategies against viral infections, such as SARS-CoV-2. In conclusion, TLR7 is a vital component of the innate immune system, playing a crucial role in recognizing viral infections and modulating the immune response. Understanding the mechanisms of TLR7 activation and regulation has significant implications for the development of therapeutic strategies against viral infections and autoimmune diseases.

Genular Protein ID: 1241334867

Symbol: TLR7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9NYK1 D1CS69 Q9NR98

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 8 DrugCentral 1 EMBL 5 EMDB 1 Ensembl 1 ExpressionAtlas 1 GO 38 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 5 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 11 RefSeq 1 SIGNOR 1 SMART 4 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11022119

Title: Three novel mammalian Toll-like receptors: gene structure, expression, and evolution.

PubMed ID: 11022119

PubMed ID: 11022120

Title: Cloning and characterization of a sub-family of human Toll-like receptors: hTLR7, hTLR8 and hTLR9.

PubMed ID: 11022120

PubMed ID: 19924287

Title: The heterogeneous allelic repertoire of human Toll-Like receptor (TLR) genes.

PubMed ID: 19924287

DOI: 10.1371/journal.pone.0007803

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12738885

Title: Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7.

PubMed ID: 12738885

DOI: 10.1073/pnas.0631696100

PubMed ID: 14976261

Title: Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA.

PubMed ID: 14976261

DOI: 10.1126/science.1093616

PubMed ID: 18250417

Title: TLR7 is involved in sequence-specific sensing of single-stranded RNAs in human macrophages.

PubMed ID: 18250417

DOI: 10.4049/jimmunol.180.4.2117

PubMed ID: 27742543

Title: Structural Analysis Reveals that Toll-like Receptor 7 Is a Dual Receptor for Guanosine and Single-Stranded RNA.

PubMed ID: 27742543

DOI: 10.1016/j.immuni.2016.09.011

PubMed ID: 31608988

Title: Deoxyguanosine is a TLR7 agonist.

PubMed ID: 31608988

DOI: 10.1002/eji.201948151

PubMed ID: 32433612

Title: TASL is the SLC15A4-associated adaptor for IRF5 activation by TLR7-9.

PubMed ID: 32433612

DOI: 10.1038/s41586-020-2282-0

PubMed ID: 32706371

Title: Presence of Genetic Variants Among Young Men With Severe COVID-19.

PubMed ID: 32706371

DOI: 10.1001/jama.2020.13719

PubMed ID: 35477763

Title: TLR7 gain-of-function genetic variation causes human lupus.

PubMed ID: 35477763

DOI: 10.1038/s41586-022-04642-z

PubMed ID: 33432245

Title: Cryo-EM structures of Toll-like receptors in complex with UNC93B1.

PubMed ID: 33432245

DOI: 10.1038/s41594-020-00542-w

Sequence Information:

  • Length: 1049
  • Mass: 120922
  • Checksum: 8C701E9E437F2721
  • Sequence:
    • MVFPMWTLKR QILILFNIIL ISKLLGARWF PKTLPCDVTL DVPKNHVIVD CTDKHLTEIP 
GGIPTNTTNL TLTINHIPDI SPASFHRLDH LVEIDFRCNC VPIPLGSKNN MCIKRLQIKP 
RSFSGLTYLK SLYLDGNQLL EIPQGLPPSL QLLSLEANNI FSIRKENLTE LANIEILYLG 
QNCYYRNPCY VSYSIEKDAF LNLTKLKVLS LKDNNVTAVP TVLPSTLTEL YLYNNMIAKI 
QEDDFNNLNQ LQILDLSGNC PRCYNAPFPC APCKNNSPLQ IPVNAFDALT ELKVLRLHSN 
SLQHVPPRWF KNINKLQELD LSQNFLAKEI GDAKFLHFLP SLIQLDLSFN FELQVYRASM 
NLSQAFSSLK SLKILRIRGY VFKELKSFNL SPLHNLQNLE VLDLGTNFIK IANLSMFKQF 
KRLKVIDLSV NKISPSGDSS EVGFCSNART SVESYEPQVL EQLHYFRYDK YARSCRFKNK 
EASFMSVNES CYKYGQTLDL SKNSIFFVKS SDFQHLSFLK CLNLSGNLIS QTLNGSEFQP 
LAELRYLDFS NNRLDLLHST AFEELHKLEV LDISSNSHYF QSEGITHMLN FTKNLKVLQK 
LMMNDNDISS STSRTMESES LRTLEFRGNH LDVLWREGDN RYLQLFKNLL KLEELDISKN 
SLSFLPSGVF DGMPPNLKNL SLAKNGLKSF SWKKLQCLKN LETLDLSHNQ LTTVPERLSN 
CSRSLKNLIL KNNQIRSLTK YFLQDAFQLR YLDLSSNKIQ MIQKTSFPEN VLNNLKMLLL 
HHNRFLCTCD AVWFVWWVNH TEVTIPYLAT DVTCVGPGAH KGQSVISLDL YTCELDLTNL 
ILFSLSISVS LFLMVMMTAS HLYFWDVWYI YHFCKAKIKG YQRLISPDCC YDAFIVYDTK 
DPAVTEWVLA ELVAKLEDPR EKHFNLCLEE RDWLPGQPVL ENLSQSIQLS KKTVFVMTDK 
YAKTENFKIA FYLSHQRLMD EKVDVIILIF LEKPFQKSKF LQLRKRLCGS SVLEWPTNPQ 
AHPYFWQCLK NALATDNHVA YSQVFKETV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.