Details for: CYP39A1

Gene ID: 51302

Symbol: CYP39A1

Ensembl ID: ENSG00000146233

Description: cytochrome P450 family 39 subfamily A member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.5567
    Cell Significance Index: 33.2800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.9883
    Cell Significance Index: 188.0900
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.8333
    Cell Significance Index: 13.2200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.8287
    Cell Significance Index: 22.2100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6272
    Cell Significance Index: 124.4700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.5654
    Cell Significance Index: 31.7300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.5237
    Cell Significance Index: 40.1900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4637
    Cell Significance Index: 418.7100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.4132
    Cell Significance Index: 6.9600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4098
    Cell Significance Index: 24.6000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3856
    Cell Significance Index: 17.4800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3800
    Cell Significance Index: 41.3400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3796
    Cell Significance Index: 17.7000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3098
    Cell Significance Index: 50.3900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1924
    Cell Significance Index: 6.7600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1867
    Cell Significance Index: 12.9100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1622
    Cell Significance Index: 16.0500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1407
    Cell Significance Index: 7.3100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1282
    Cell Significance Index: 69.9900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1227
    Cell Significance Index: 24.6200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1154
    Cell Significance Index: 2.5000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.1148
    Cell Significance Index: 1.4700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1131
    Cell Significance Index: 3.2600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1050
    Cell Significance Index: 18.9200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1041
    Cell Significance Index: 72.0200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1034
    Cell Significance Index: 46.9400
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.1028
    Cell Significance Index: 0.6100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0944
    Cell Significance Index: 33.8800
  • Cell Name: glioblast (CL0000030)
    Fold Change: 0.0892
    Cell Significance Index: 0.5600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0831
    Cell Significance Index: 36.7400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0479
    Cell Significance Index: 3.0200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0450
    Cell Significance Index: 82.9600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0433
    Cell Significance Index: 5.3300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0393
    Cell Significance Index: 24.9900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0366
    Cell Significance Index: 56.3500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0347
    Cell Significance Index: 65.4200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0254
    Cell Significance Index: 34.4800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0189
    Cell Significance Index: 0.9500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.0176
    Cell Significance Index: 0.2600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0166
    Cell Significance Index: 1.9300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0077
    Cell Significance Index: -5.6100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0132
    Cell Significance Index: -9.9600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0140
    Cell Significance Index: -0.3900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0157
    Cell Significance Index: -11.6500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0173
    Cell Significance Index: -2.3700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0197
    Cell Significance Index: -0.4200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0206
    Cell Significance Index: -12.8400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0217
    Cell Significance Index: -12.2100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0241
    Cell Significance Index: -0.6200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0244
    Cell Significance Index: -0.4200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0252
    Cell Significance Index: -4.3100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0286
    Cell Significance Index: -0.3900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0291
    Cell Significance Index: -3.7300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0292
    Cell Significance Index: -4.2500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0304
    Cell Significance Index: -8.7400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0331
    Cell Significance Index: -3.8000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0395
    Cell Significance Index: -4.6600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0436
    Cell Significance Index: -5.6300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0507
    Cell Significance Index: -3.1100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0614
    Cell Significance Index: -1.6700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0639
    Cell Significance Index: -13.4600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0664
    Cell Significance Index: -0.9800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0670
    Cell Significance Index: -6.8500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0708
    Cell Significance Index: -4.3500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0770
    Cell Significance Index: -8.0200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0818
    Cell Significance Index: -2.1500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0830
    Cell Significance Index: -1.6200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0845
    Cell Significance Index: -3.9700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0969
    Cell Significance Index: -3.1100
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: -0.1018
    Cell Significance Index: -0.6300
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.1169
    Cell Significance Index: -1.2100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1250
    Cell Significance Index: -3.1300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1338
    Cell Significance Index: -10.6000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1359
    Cell Significance Index: -10.1300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1366
    Cell Significance Index: -9.1900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1428
    Cell Significance Index: -10.1000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1550
    Cell Significance Index: -6.7400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1766
    Cell Significance Index: -7.8100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1833
    Cell Significance Index: -2.1900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1924
    Cell Significance Index: -2.7600
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.2094
    Cell Significance Index: -3.0400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2094
    Cell Significance Index: -11.0000
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.2223
    Cell Significance Index: -2.8500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2229
    Cell Significance Index: -8.4400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2422
    Cell Significance Index: -3.6500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.2517
    Cell Significance Index: -7.9600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2618
    Cell Significance Index: -5.4800
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.2619
    Cell Significance Index: -4.4100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2626
    Cell Significance Index: -4.4000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2651
    Cell Significance Index: -9.7300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2656
    Cell Significance Index: -3.9800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2670
    Cell Significance Index: -8.5100
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.2701
    Cell Significance Index: -2.8700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2772
    Cell Significance Index: -9.7100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2783
    Cell Significance Index: -9.1100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2815
    Cell Significance Index: -7.0300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2932
    Cell Significance Index: -10.1900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2952
    Cell Significance Index: -7.1500
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: -0.2999
    Cell Significance Index: -1.8500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3014
    Cell Significance Index: -8.6000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Substrate specificity**: CYP39A1 exhibits specificity towards 24-hydroxycholesterol, a cholesterol derivative involved in bile acid biosynthesis. 2. **Bile acid synthesis**: CYP39A1 is essential for the synthesis of bile acids from cholesterol derivatives, such as 24-hydroxycholesterol. 3. **Cytochrome P450 enzyme**: CYP39A1 belongs to the cytochrome P450 enzyme family, which plays a crucial role in the metabolism of various xenobiotics and endogenous compounds. 4. **Tissue distribution**: CYP39A1 is expressed in various cell types, including those involved in the immune system, such as leptomeningeal cells and retinal progenitor cells. **Pathways and Functions:** 1. **Bile acid biosynthesis**: CYP39A1 is involved in the hydroxylation of cholesterol derivatives, such as 24-hydroxycholesterol, to produce bile acids. 2. **Bile acid metabolism**: CYP39A1 plays a crucial role in the metabolism of bile acids, regulating their levels and activity in the body. 3. **Cholesterol homeostasis**: CYP39A1 is involved in maintaining the delicate balance of cholesterol homeostasis by regulating the synthesis and metabolism of bile acids. 4. **Immune system function**: CYP39A1 expression is observed in various cell types involved in the immune system, suggesting its role in modulating immune responses. **Clinical Significance:** 1. **Metabolic disorders**: Dysregulation of CYP39A1 has been implicated in various metabolic disorders, such as liver disease and cholesterol-related disorders. 2. **Immunological disorders**: CYP39A1 expression in immune cells suggests its role in modulating immune responses and the development of immunological disorders. 3. **Cancer**: CYP39A1 has been linked to the development and progression of certain types of cancer, such as liver cancer. 4. **Pharmacological applications**: Understanding the role of CYP39A1 in bile acid metabolism and homeostasis has implications for the development of new therapeutic strategies for metabolic and immunological disorders. In conclusion, the CYP39A1 gene plays a critical role in the biosynthesis and metabolism of bile acids, maintaining the delicate balance of cholesterol homeostasis and immune system function. Further research on CYP39A1 is essential to elucidate its role in various metabolic and immunological disorders and to develop new therapeutic strategies for the treatment of these diseases.

Genular Protein ID: 277895290

Symbol: CP39A_HUMAN

Name: Cytochrome P450 39A1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10748047

Title: Expression cloning of an oxysterol 7alpha-hydroxylase selective for 24-hydroxycholesterol.

PubMed ID: 10748047

DOI: 10.1074/jbc.m001810200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 25201972

Title: Genetic, anatomic, and clinical determinants of human serum sterol and vitamin D levels.

PubMed ID: 25201972

DOI: 10.1073/pnas.1413561111

Sequence Information:

  • Length: 469
  • Mass: 54116
  • Checksum: 74B013055257275C
  • Sequence:
  • MELISPTVII ILGCLALFLL LQRKNLRRPP CIKGWIPWIG VGFEFGKAPL EFIEKARIKY 
    GPIFTVFAMG NRMTFVTEEE GINVFLKSKK VDFELAVQNI VYRTASIPKN VFLALHEKLY 
    IMLKGKMGTV NLHQFTGQLT EELHEQLENL GTHGTMDLNN LVRHLLYPVT VNMLFNKSLF 
    STNKKKIKEF HQYFQVYDED FEYGSQLPEC LLRNWSKSKK WFLELFEKNI PDIKACKSAK 
    DNSMTLLQAT LDIVETETSK ENSPNYGLLL LWASLSNAVP VAFWTLAYVL SHPDIHKAIM 
    EGISSVFGKA GKDKIKVSED DLENLLLIKW CVLETIRLKA PGVITRKVVK PVEILNYIIP 
    SGDLLMLSPF WLHRNPKYFP EPELFKPERW KKANLEKHSF LDCFMAFGSG KFQCPARWFA 
    LLEVQMCIIL ILYKYDCSLL DPLPKQSYLH LVGVPQPEGQ CRIEYKQRI

Genular Protein ID: 836256427

Symbol: A0A087WTD2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 297
  • Mass: 34492
  • Checksum: 95427853FC52F924
  • Sequence:
  • MLFNKSLFST NKKKIKEFHQ YFQVYDEDFE YGSQLPECLL RNWSKSKKWF LELFEKNIPD 
    IKACKSAKDN SMTLLQATLD IVETETSKEN SPNYGLLLLW ASLSNAVPVA FWTLAYVLSH 
    PDIHKAIMEG ISSVFGKAGK DKIKVSEDDL ENLLLIKWCV LETIRLKAPG VITRKVVKPV 
    EILNYIIPSG DLLMLSPFWL HRNPKYFPEP ELFKPERWKK ANLEKHSFLD CFMAFGSGKF 
    QCPARWFALL EVQMCIILIL YKYDCSLLDP LPKQSYLHLV GVPQPEGQCR IEYKQRI

Genular Protein ID: 1980568841

Symbol: B7Z786_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 449
  • Mass: 51833
  • Checksum: 1EA140EAA57413E3
  • Sequence:
  • MELISPTVII ILGCLALFLL LQRKNLRRPP CIKGWIPWIG VGFEFGKAPL EFIEKARIKY 
    GPIFTVFAMG NRMTFVTEEE GINVFLKSKK VDFELAVQNI VYRTGKMGTV NLHQFTGQLT 
    EELHEQLENL GTHGTMDLNN LVRHLLYPVT VNMLFNKSLF STNKKKIKEF HQYFQVYDED 
    FEYGSQLPEC LLRNWSKSKK WFLELFEKNI PDIKACKSAR DNSMTLLQAT LDIVETETSK 
    ENSPNYGLLL LWASLSNAVP VAFWTLAYVL SHPDIHKAIM EGISSVFGKA GKDKIKVSED 
    DLENLLLIKW CVLETIRLKA PGVITRKVVK PVEILNYIIP SGDLLMLSPF WLHRNPKYFP 
    EPELFKPERW KKANLEKHSF LDCFMAFGSG KFQCPARWFA LLEVQMCIIL ILYKYDCSLL 
    DPLPKQSYLH LVGVPQPEGQ CRIEYKQRI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.