Details for: KCNK9

Gene ID: 51305

Symbol: KCNK9

Ensembl ID: ENSG00000169427

Description: potassium two pore domain channel subfamily K member 9

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 2.5374
    Cell Significance Index: 81.2700
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 2.4379
    Cell Significance Index: 27.6900
  • Cell Name: granule cell (CL0000120)
    Fold Change: 2.4019
    Cell Significance Index: 27.3500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 2.3586
    Cell Significance Index: 40.4200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.2600
    Cell Significance Index: 77.2500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.7749
    Cell Significance Index: 18.7700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6268
    Cell Significance Index: 125.7300
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 0.6116
    Cell Significance Index: 6.7900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4944
    Cell Significance Index: 177.3300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4131
    Cell Significance Index: 78.6100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.3757
    Cell Significance Index: 4.6600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.2736
    Cell Significance Index: 5.9900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1877
    Cell Significance Index: 11.2700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1855
    Cell Significance Index: 18.3500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1752
    Cell Significance Index: 158.2100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1633
    Cell Significance Index: 17.7700
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: 0.1604
    Cell Significance Index: 1.7700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.1535
    Cell Significance Index: 4.3800
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.1484
    Cell Significance Index: 1.9800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1320
    Cell Significance Index: 91.3300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1199
    Cell Significance Index: 19.5100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0861
    Cell Significance Index: 17.0800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0718
    Cell Significance Index: 2.0700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0672
    Cell Significance Index: 4.6500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0444
    Cell Significance Index: 0.9200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0441
    Cell Significance Index: 0.9400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.0170
    Cell Significance Index: 0.5400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.0115
    Cell Significance Index: 0.3800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0114
    Cell Significance Index: 0.4000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0112
    Cell Significance Index: 0.2800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0023
    Cell Significance Index: 0.0500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0014
    Cell Significance Index: -2.5300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0016
    Cell Significance Index: -2.5300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0018
    Cell Significance Index: -3.3600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0019
    Cell Significance Index: -2.5300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0052
    Cell Significance Index: -3.8600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0061
    Cell Significance Index: -3.7900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0069
    Cell Significance Index: -4.3700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0072
    Cell Significance Index: -4.0600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0077
    Cell Significance Index: -4.2100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0084
    Cell Significance Index: -6.1400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0097
    Cell Significance Index: -4.4200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0104
    Cell Significance Index: -0.4700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0105
    Cell Significance Index: -0.1500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0121
    Cell Significance Index: -1.7600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0124
    Cell Significance Index: -3.5700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0132
    Cell Significance Index: -0.8900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0143
    Cell Significance Index: -0.8800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0203
    Cell Significance Index: -3.4600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0212
    Cell Significance Index: -4.4600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0220
    Cell Significance Index: -3.9600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0311
    Cell Significance Index: -0.6600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0328
    Cell Significance Index: -3.7600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0365
    Cell Significance Index: -0.5500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0371
    Cell Significance Index: -3.7900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0383
    Cell Significance Index: -4.4600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0395
    Cell Significance Index: -5.4300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0403
    Cell Significance Index: -0.8700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0419
    Cell Significance Index: -5.1500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0443
    Cell Significance Index: -0.8900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0490
    Cell Significance Index: -3.1600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0524
    Cell Significance Index: -6.1800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0525
    Cell Significance Index: -5.4700
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0538
    Cell Significance Index: -0.5100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0568
    Cell Significance Index: -1.9900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0582
    Cell Significance Index: -1.1500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0600
    Cell Significance Index: -1.4400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0636
    Cell Significance Index: -4.8800
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0670
    Cell Significance Index: -0.7300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0676
    Cell Significance Index: -3.1500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0681
    Cell Significance Index: -3.5800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0698
    Cell Significance Index: -1.9500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0722
    Cell Significance Index: -4.0500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0778
    Cell Significance Index: -2.4600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0795
    Cell Significance Index: -2.1300
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0840
    Cell Significance Index: -0.9800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0849
    Cell Significance Index: -4.4100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0860
    Cell Significance Index: -4.0400
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0882
    Cell Significance Index: -1.1000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0938
    Cell Significance Index: -4.1500
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0945
    Cell Significance Index: -0.7800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0975
    Cell Significance Index: -1.3300
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.1078
    Cell Significance Index: -1.3600
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.1080
    Cell Significance Index: -2.1300
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.1093
    Cell Significance Index: -1.0400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1106
    Cell Significance Index: -4.1900
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1178
    Cell Significance Index: -2.3500
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.1184
    Cell Significance Index: -1.5300
  • Cell Name: intratelencephalic-projecting glutamatergic cortical neuron (CL4023008)
    Fold Change: -0.1245
    Cell Significance Index: -1.2800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1284
    Cell Significance Index: -3.6800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1301
    Cell Significance Index: -3.4800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1343
    Cell Significance Index: -3.3500
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.1358
    Cell Significance Index: -1.8100
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.1442
    Cell Significance Index: -1.8200
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1454
    Cell Significance Index: -3.0400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1486
    Cell Significance Index: -3.8200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1510
    Cell Significance Index: -3.6900
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1543
    Cell Significance Index: -2.2400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1554
    Cell Significance Index: -3.5900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1587
    Cell Significance Index: -4.3200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The KCNK9 channel is a tandem pore domain potassium channel, which is characterized by its unique structure and function. It is composed of two pore domains that are connected by a linker region. This channel is sensitive to changes in the extracellular pH, which allows it to regulate potassium ion transport and modulate cellular excitability. The KCNK9 channel is also involved in maintaining the resting membrane potential and regulating muscle contraction. **Pathways and Functions:** KCNK9 channels are involved in various cellular processes, including: 1. **Cardiac Conduction:** KCNK9 channels play a crucial role in regulating cardiac conduction by controlling the flow of potassium ions across the cardiac cell membrane. This helps to maintain the proper rhythm and timing of heartbeats. 2. **Muscle Contraction:** KCNK9 channels are involved in regulating muscle contraction by controlling the flow of potassium ions across the muscle cell membrane. This helps to modulate muscle excitability and contraction force. 3. **Neuronal Function:** KCNK9 channels are involved in regulating neuronal function by controlling the flow of potassium ions across the neuronal cell membrane. This helps to modulate neuronal excitability and synaptic transmission. 4. **Ion Transport:** KCNK9 channels are involved in regulating potassium ion transport across the plasma membrane. This helps to maintain the proper balance of potassium ions and regulate cellular excitability. **Clinical Significance:** Dysregulation of KCNK9 channels has been implicated in various diseases, including: 1. **Cardiac Arrhythmias:** Abnormal KCNK9 channel function has been linked to cardiac arrhythmias, such as atrial fibrillation and ventricular tachycardia. 2. **Muscle Disorders:** KCNK9 channel dysfunction has been implicated in muscle disorders, such as muscular dystrophy and myasthenia gravis. 3. **Neurological Disorders:** KCNK9 channel dysfunction has been linked to neurological disorders, such as epilepsy and Parkinson's disease. 4. **Gastrointestinal Disorders:** KCNK9 channel dysfunction has been implicated in gastrointestinal disorders, such as irritable bowel syndrome and inflammatory bowel disease. In conclusion, the KCNK9 gene plays a critical role in regulating various cellular processes, including cardiac conduction, muscle contraction, neuronal function, and ion transport. Dysregulation of KCNK9 channels has been implicated in various diseases, highlighting the importance of this gene in maintaining proper cellular function and overall health.

Genular Protein ID: 1198028833

Symbol: KCNK9_HUMAN

Name: Potassium channel subfamily K member 9

UniProtKB Accession Codes:

Q9NPC2 Q2M290 Q540F2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 DrugCentral 1 EMBL 9 EMDB 4 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 20 PDBsum 20 PIRSF 1 PRINTS 3 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10747866

Title: TASK-3, a novel tandem pore domain acid-sensitive K+ channel. An extracellular histidine as pH sensor.

PubMed ID: 10747866

DOI: 10.1074/jbc.m000030200

PubMed ID: 11042359

Title: Cloning, localisation and functional expression of a novel human, cerebellum specific, two pore domain potassium channel.

PubMed ID: 11042359

DOI: 10.1016/s0169-328x(00)00183-2

PubMed ID: 11431495

Title: KT3.2 and KT3.3, two novel human two-pore K(+) channels closely related to TASK-1.

PubMed ID: 11431495

DOI: 10.1152/jn.2001.86.1.130

PubMed ID: 12676587

Title: Genomic amplification and oncogenic properties of the KCNK9 potassium channel gene.

PubMed ID: 12676587

DOI: 10.1016/s1535-6108(03)00054-0

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 23169818

Title: SUMOylation silences heterodimeric TASK potassium channels containing K2P1 subunits in cerebellar granule neurons.

PubMed ID: 23169818

DOI: 10.1126/scisignal.2003431

PubMed ID: 18678320

Title: Maternally inherited Birk Barel mental retardation dysmorphism syndrome caused by a mutation in the genomically imprinted potassium channel KCNK9.

PubMed ID: 18678320

DOI: 10.1016/j.ajhg.2008.07.010

PubMed ID: 27151206

Title: KCNK9 imprinting syndrome-further delineation of a possible treatable disorder.

PubMed ID: 27151206

DOI: 10.1002/ajmg.a.37740

PubMed ID: 30690205

Title: Novel variant in the KCNK9 gene in a girl with Birk Barel syndrome.

PubMed ID: 30690205

DOI: 10.1016/j.ejmg.2019.01.009

Sequence Information:

  • Length: 374
  • Mass: 42264
  • Checksum: 8A19EAEE5A4D7F38
  • Sequence:
    • MKRQNVRTLS LIVCTFTYLL VGAAVFDALE SDHEMREEEK LKAEEIRIKG KYNISSEDYR 
QLELVILQSE PHRAGVQWKF AGSFYFAITV ITTIGYGHAA PGTDAGKAFC MFYAVLGIPL 
TLVMFQSLGE RMNTFVRYLL KRIKKCCGMR NTDVSMENMV TVGFFSCMGT LCIGAAAFSQ 
CEEWSFFHAY YYCFITLTTI GFGDYVALQT KGALQKKPLY VAFSFMYILV GLTVIGAFLN 
LVVLRFLTMN SEDERRDAEE RASLAGNRNS MVIHIPEEPR PSRPRYKADV PDLQSVCSCT 
CYRSQDYGGR SVAPQNSFSA KLAPHYFHSI SYKIEEISPS TLKNSLFPSP ISSISPGLHS 
FTDHQRLMKR RKSV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.