Details for: MRPS17

Gene ID: 51373

Symbol: MRPS17

Ensembl ID: ENSG00000239789

Description: mitochondrial ribosomal protein S17

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 30.9748
    Cell Significance Index: -12.7600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 26.4588
    Cell Significance Index: -13.6100
  • Cell Name: colon endothelial cell (CL1001572)
    Fold Change: 4.1666
    Cell Significance Index: 3.1800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.0838
    Cell Significance Index: -10.9400
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 2.1762
    Cell Significance Index: 18.7000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.7522
    Cell Significance Index: 105.1900
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.6462
    Cell Significance Index: 26.4100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.2329
    Cell Significance Index: 121.9700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.1678
    Cell Significance Index: 127.0300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8948
    Cell Significance Index: 807.9300
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.7791
    Cell Significance Index: 18.0000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.7552
    Cell Significance Index: 11.1500
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.6920
    Cell Significance Index: 5.5300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6816
    Cell Significance Index: 110.8500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.6220
    Cell Significance Index: 16.9300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5720
    Cell Significance Index: 39.5600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5490
    Cell Significance Index: 67.5100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.5483
    Cell Significance Index: 34.5600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4912
    Cell Significance Index: 88.5600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.4896
    Cell Significance Index: 14.3800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.4315
    Cell Significance Index: 12.3700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.4083
    Cell Significance Index: 3.7600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.4004
    Cell Significance Index: 10.2300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3456
    Cell Significance Index: 25.7600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3431
    Cell Significance Index: 9.8900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3363
    Cell Significance Index: 17.4700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.3321
    Cell Significance Index: 3.6100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2967
    Cell Significance Index: 13.4500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2858
    Cell Significance Index: 9.9300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2730
    Cell Significance Index: 35.2800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2696
    Cell Significance Index: 19.0700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2610
    Cell Significance Index: 142.5500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2315
    Cell Significance Index: 102.3600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2266
    Cell Significance Index: 31.1200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2147
    Cell Significance Index: 5.6500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1916
    Cell Significance Index: 4.0100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1869
    Cell Significance Index: 4.0500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1519
    Cell Significance Index: 30.4800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1449
    Cell Significance Index: 6.8100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.1391
    Cell Significance Index: 1.5800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1355
    Cell Significance Index: 4.3400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.1343
    Cell Significance Index: 3.5900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1280
    Cell Significance Index: 16.4100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1105
    Cell Significance Index: 5.1500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1065
    Cell Significance Index: 20.2700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1018
    Cell Significance Index: 12.0000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.0906
    Cell Significance Index: 2.6700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0566
    Cell Significance Index: 3.6500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0478
    Cell Significance Index: 17.1600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0364
    Cell Significance Index: 2.2400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0296
    Cell Significance Index: 1.0400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0272
    Cell Significance Index: 1.4300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0268
    Cell Significance Index: 0.5700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0070
    Cell Significance Index: 5.2900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0030
    Cell Significance Index: 0.0500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0041
    Cell Significance Index: -3.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0067
    Cell Significance Index: -12.6800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0086
    Cell Significance Index: -15.8000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0102
    Cell Significance Index: -15.6500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0116
    Cell Significance Index: -15.7400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0120
    Cell Significance Index: -8.8600
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.0167
    Cell Significance Index: -0.1200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0175
    Cell Significance Index: -9.9000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0196
    Cell Significance Index: -3.3600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0196
    Cell Significance Index: -2.2500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0199
    Cell Significance Index: -12.6300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0237
    Cell Significance Index: -14.8100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0307
    Cell Significance Index: -13.9600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0332
    Cell Significance Index: -3.3900
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.0420
    Cell Significance Index: -0.2600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0432
    Cell Significance Index: -5.0400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0641
    Cell Significance Index: -13.5000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.0778
    Cell Significance Index: -1.3800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0903
    Cell Significance Index: -13.1300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0929
    Cell Significance Index: -2.4800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0999
    Cell Significance Index: -7.6700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1053
    Cell Significance Index: -5.9100
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: -0.1092
    Cell Significance Index: -0.6500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1231
    Cell Significance Index: -9.7500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1312
    Cell Significance Index: -3.2800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1322
    Cell Significance Index: -8.1000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1420
    Cell Significance Index: -1.4700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1466
    Cell Significance Index: -2.0000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1545
    Cell Significance Index: -2.3200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2110
    Cell Significance Index: -7.3900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2422
    Cell Significance Index: -7.9300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2430
    Cell Significance Index: -8.9200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2532
    Cell Significance Index: -8.0700
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.2643
    Cell Significance Index: -2.6500
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.3069
    Cell Significance Index: -6.2500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3120
    Cell Significance Index: -6.7400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3138
    Cell Significance Index: -5.8000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3220
    Cell Significance Index: -6.8400
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.3227
    Cell Significance Index: -5.1200
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.3411
    Cell Significance Index: -7.1200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3444
    Cell Significance Index: -8.5900
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.3586
    Cell Significance Index: -5.0300
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.3615
    Cell Significance Index: -5.1800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3719
    Cell Significance Index: -18.7900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3878
    Cell Significance Index: -9.3000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Location**: MRPS17 is primarily localized to the mitochondrial inner membrane, where it is integral to the mitochondrial ribosomal subunit. 2. **Expression**: MRPS17 is expressed in a wide range of cell types, including embryonic stem cells, peripheral blood mononuclear cells, colon endothelial cells, and various immune cells. 3. **Protein structure**: MRPS17 is a 28-kDa protein that forms part of the large subunit of the mitochondrial ribosomal subunit, interacting with other ribosomal proteins to facilitate translation. **Pathways and Functions:** MRPS17 is involved in several critical mitochondrial translation processes, including: 1. **Mitochondrial translation elongation**: MRPS17 interacts with other ribosomal proteins to facilitate the elongation of mitochondrial mRNAs into polypeptides. 2. **Mitochondrial translation initiation**: MRPS17 is essential for the initiation of mitochondrial translation, ensuring the accurate translation of mitochondrial mRNAs. 3. **Mitochondrial translation termination**: MRPS17 plays a role in the termination of mitochondrial translation, regulating the release of completed polypeptides from the ribosome. **Clinical Significance:** Dysregulation of MRPS17 has been implicated in various diseases, including: 1. **Mitochondrial disorders**: Mutations in MRPS17 have been associated with mitochondrial disorders, such as MELAS syndrome and Kearns-Sayre syndrome. 2. **Metabolic disorders**: Alterations in MRPS17 expression have been linked to metabolic disorders, including insulin resistance and type 2 diabetes. 3. **Cancer**: MRPS17 has been identified as a tumor suppressor gene, with altered expression levels observed in various types of cancer. In conclusion, MRPS17 is a crucial protein that plays a vital role in mitochondrial translation and cellular homeostasis. Its dysregulation has significant implications for various diseases, highlighting the importance of further research into the molecular mechanisms underlying MRPS17 function and its clinical significance.

Genular Protein ID: 4161982098

Symbol: RT17_HUMAN

Name: 28S ribosomal protein S17, mitochondrial

UniProtKB Accession Codes:

Q9Y2R5 Q86X15

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 EMDB 41 Ensembl 1 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 42 PDBsum 42 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9653160

Title: Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning.

PubMed ID: 9653160

DOI: 10.1073/pnas.95.14.8175

PubMed ID: 11402041

Title: Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28S small subunit.

PubMed ID: 11402041

DOI: 10.1074/jbc.m103236200

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11279123

Title: The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present.

PubMed ID: 11279123

DOI: 10.1074/jbc.m100727200

PubMed ID: 25838379

Title: Ribosome. The structure of the human mitochondrial ribosome.

PubMed ID: 25838379

DOI: 10.1126/science.aaa1193

Sequence Information:

  • Length: 130
  • Mass: 14502
  • Checksum: 5346917E78F7C6C3
  • Sequence:
    • MSVVRSSVHA RWIVGKVIGT KMQKTAKVRV TRLVLDPYLL KYFNKRKTYF AHDALQQCTV 
GDIVLLRALP VPRAKHVKHE LAEIVFKVGK VIDPVTGKPC AGTTYLESPL SSETTQLSKN 
LEELNISSAQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.