Details for: WNT16

Gene ID: 51384

Symbol: WNT16

Ensembl ID: ENSG00000002745

Description: Wnt family member 16

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 2.6543
    Cell Significance Index: 58.1200
  • Cell Name: chandelier cell (CL4023083)
    Fold Change: 0.4273
    Cell Significance Index: 3.4500
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.2757
    Cell Significance Index: 0.8200
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.1994
    Cell Significance Index: 0.9700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1798
    Cell Significance Index: 79.5100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.1782
    Cell Significance Index: 3.8100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1110
    Cell Significance Index: 209.0000
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.1005
    Cell Significance Index: 1.2700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.0650
    Cell Significance Index: 1.3800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0480
    Cell Significance Index: 6.5900
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.0240
    Cell Significance Index: 0.5000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0142
    Cell Significance Index: 9.7900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0086
    Cell Significance Index: 0.4800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0080
    Cell Significance Index: 1.1700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0070
    Cell Significance Index: 1.2700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0021
    Cell Significance Index: 0.0300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0013
    Cell Significance Index: 0.6900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0007
    Cell Significance Index: 0.0300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0005
    Cell Significance Index: 0.0300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0010
    Cell Significance Index: -1.9400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0012
    Cell Significance Index: -1.9100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0015
    Cell Significance Index: -2.0600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0019
    Cell Significance Index: -0.3800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0025
    Cell Significance Index: -1.6100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0034
    Cell Significance Index: -0.6800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0034
    Cell Significance Index: -1.2300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0036
    Cell Significance Index: -2.7000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0038
    Cell Significance Index: -2.1300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0039
    Cell Significance Index: -1.7700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0052
    Cell Significance Index: -1.4900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0075
    Cell Significance Index: -0.7800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0103
    Cell Significance Index: -2.1600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0104
    Cell Significance Index: -0.2500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0115
    Cell Significance Index: -1.4100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0121
    Cell Significance Index: -2.0700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0134
    Cell Significance Index: -0.9500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0138
    Cell Significance Index: -1.4100
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0176
    Cell Significance Index: -0.2800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0181
    Cell Significance Index: -2.1300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0183
    Cell Significance Index: -2.1000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0196
    Cell Significance Index: -0.8500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0197
    Cell Significance Index: -0.9200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0206
    Cell Significance Index: -0.7800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0211
    Cell Significance Index: -1.1100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0229
    Cell Significance Index: -0.4800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0242
    Cell Significance Index: -1.8600
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0254
    Cell Significance Index: -0.3700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0256
    Cell Significance Index: -1.7200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0318
    Cell Significance Index: -0.7700
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0333
    Cell Significance Index: -0.4200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0335
    Cell Significance Index: -2.1600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0340
    Cell Significance Index: -1.6000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0374
    Cell Significance Index: -1.3100
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0376
    Cell Significance Index: -0.5200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0381
    Cell Significance Index: -1.9800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0384
    Cell Significance Index: -0.7600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0396
    Cell Significance Index: -1.1100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0428
    Cell Significance Index: -1.5700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0432
    Cell Significance Index: -1.0800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0449
    Cell Significance Index: -1.4300
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0454
    Cell Significance Index: -0.4300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0498
    Cell Significance Index: -1.7500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0499
    Cell Significance Index: -0.8600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0502
    Cell Significance Index: -1.2900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0510
    Cell Significance Index: -1.6700
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0514
    Cell Significance Index: -0.6000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0516
    Cell Significance Index: -1.2600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0524
    Cell Significance Index: -0.8400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0594
    Cell Significance Index: -1.7100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0599
    Cell Significance Index: -1.7100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0603
    Cell Significance Index: -1.6400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0627
    Cell Significance Index: -1.6800
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0629
    Cell Significance Index: -1.9900
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0656
    Cell Significance Index: -0.7900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0658
    Cell Significance Index: -1.7300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0663
    Cell Significance Index: -1.6600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0677
    Cell Significance Index: -2.0000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0688
    Cell Significance Index: -1.8400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0691
    Cell Significance Index: -1.9800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0702
    Cell Significance Index: -1.4100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0730
    Cell Significance Index: -1.8200
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0730
    Cell Significance Index: -1.0600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0731
    Cell Significance Index: -1.5800
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0732
    Cell Significance Index: -1.4400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0742
    Cell Significance Index: -1.9800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0749
    Cell Significance Index: -1.7300
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0757
    Cell Significance Index: -1.5400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0757
    Cell Significance Index: -1.5700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0789
    Cell Significance Index: -2.0100
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0809
    Cell Significance Index: -0.8000
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.0817
    Cell Significance Index: -1.0600
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: -0.0818
    Cell Significance Index: -0.8300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0840
    Cell Significance Index: -1.6400
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.0866
    Cell Significance Index: -1.3000
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0878
    Cell Significance Index: -1.7500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0897
    Cell Significance Index: -4.5300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0914
    Cell Significance Index: -1.5300
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0925
    Cell Significance Index: -1.3300
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.0930
    Cell Significance Index: -1.5000
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0934
    Cell Significance Index: -1.1000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Genetic Location**: The Wnt16 gene is located on chromosome 1q32.3, and its Ensembl ID is ENSG00000002745. 2. **Protein Structure**: The Wnt16 protein is a secreted glycoprotein, which interacts with Frizzled receptors to activate the Wnt signaling pathway. 3. **Cellular Expression**: Wnt16 is expressed in various cell types, including Purkinje cells, stem cells, epithelial cells, and thymocytes, suggesting its involvement in different cellular processes. 4. **Signaling Pathway**: Wnt16 activates the canonical Wnt signaling pathway, which regulates cell fate determination, cell proliferation, and differentiation. **Pathways and Functions** 1. **Canonical Wnt Signaling Pathway**: Wnt16 activates the canonical Wnt signaling pathway, which regulates cell fate determination, cell proliferation, and differentiation. This pathway is crucial for development, tissue homeostasis, and disease progression. 2. **Bone Remodeling**: Wnt16 is involved in bone remodeling, a process that involves the coordinated action of osteoblasts and osteoclasts to maintain bone density and structure. 3. **Cardiac Epithelial to Mesenchymal Transition**: Wnt16 regulates the cardiac epithelial to mesenchymal transition, a process that involves the conversion of cardiac epithelial cells into mesenchymal cells. 4. **Keratinocyte Differentiation**: Wnt16 is involved in keratinocyte differentiation, a process that regulates the development and maintenance of skin epithelial cells. 5. **Cell Fate Commitment**: Wnt16 regulates cell fate commitment, a process that determines the fate of cells during development and tissue repair. **Clinical Significance** 1. **Bone Diseases**: Wnt16 dysregulation has been implicated in bone diseases, such as osteoporosis and bone cancer. 2. **Cardiovascular Diseases**: Wnt16 dysregulation has been implicated in cardiovascular diseases, such as atherosclerosis and cardiac arrhythmias. 3. **Cancer**: Wnt16 dysregulation has been implicated in various cancers, including colorectal, breast, and ovarian cancer. 4. **Neurological Disorders**: Wnt16 dysregulation has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease. 5. **Developmental Disorders**: Wnt16 dysregulation has been implicated in developmental disorders, such as congenital heart defects and cleft palate. In conclusion, Wnt16 is a critical regulator of various cellular processes, including cell fate determination, cell proliferation, and differentiation. Its dysregulation has been implicated in various diseases, including bone diseases, cardiovascular diseases, cancer, neurological disorders, and developmental disorders. Further research is needed to fully understand the role of Wnt16 in human health and disease.

Genular Protein ID: 385434197

Symbol: WNT16_HUMAN

Name: Protein Wnt-16

UniProtKB Accession Codes:

Q9UBV4 Q2M3G1 Q9Y5C0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 20 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10500199

Title: Oncogenic homeodomain transcription factor E2A-Pbx1 activates a novel WNT gene in pre-B acute lymphoblastoid leukemia.

PubMed ID: 10500199

DOI: 10.1073/pnas.96.20.11464

PubMed ID: 11095990

Title: Wnt-16a, a novel Wnt-16 isoform, which shows differential expression in adult human tissues.

PubMed ID: 11095990

DOI: 10.1006/bbrc.2000.3852

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 365
  • Mass: 40690
  • Checksum: 313A26D8FFBCC56F
  • Sequence:
    • MDRAALLGLA RLCALWAALL VLFPYGAQGN WMWLGIASFG VPEKLGCANL PLNSRQKELC 
KRKPYLLPSI REGARLGIQE CGSQFRHERW NCMITAAATT APMGASPLFG YELSSGTKET 
AFIYAVMAAG LVHSVTRSCS AGNMTECSCD TTLQNGGSAS EGWHWGGCSD DVQYGMWFSR 
KFLDFPIGNT TGKENKVLLA MNLHNNEAGR QAVAKLMSVD CRCHGVSGSC AVKTCWKTMS 
SFEKIGHLLK DKYENSIQIS DKTKRKMRRR EKDQRKIPIH KDDLLYVNKS PNYCVEDKKL 
GIPGTQGREC NRTSEGADGC NLLCCGRGYN THVVRHVERC ECKFIWCCYV RCRRCESMTD 
VHTCK

Genular Protein ID: 3771469106

Symbol: E9PH60_HUMAN

Name: N/A

UniProtKB Accession Codes:

E9PH60

Database IDs:

ARBA 9 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 1 GeneTree 1 HGNC 1 InterPro 4 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 1 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 RuleBase 1 SMART 1 SMR 1 SwissPalm 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 355
  • Mass: 39700
  • Checksum: D61118B3FBB4FD4D
  • Sequence:
    • MQLTTCLRET LFTGASQKTS LWWLGIASFG VPEKLGCANL PLNSRQKELC KRKPYLLPSI 
REGARLGIQE CGSQFRHERW NCMITAAATT APMGASPLFG YELSSGTKET AFIYAVMAAG 
LVHSVTRSCS AGNMTECSCD TTLQNGGSAS EGWHWGGCSD DVQYGMWFSR KFLDFPIGNT 
TGKENKVLLA MNLHNNEAGR QAVAKLMSVD CRCHGVSGSC AVKTCWKTMS SFEKIGHLLK 
DKYENSIQIS DKTKRKMRRR EKDQRKIPIH KDDLLYVNKS PNYCVEDKKL GIPGTQGREC 
NRTSEGADGC NLLCCGRGYN THVVRHVERC ECKFIWCCYV RCRRCESMTD VHTCK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.