Details for: COQ3

Gene ID: 51805

Symbol: COQ3

Ensembl ID: ENSG00000132423

Description: coenzyme Q3, methyltransferase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 68.0188
    Cell Significance Index: -10.5800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 44.3930
    Cell Significance Index: -11.2600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 10.0490
    Cell Significance Index: -12.3900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.9905
    Cell Significance Index: -10.6900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.2438
    Cell Significance Index: -12.8000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.8620
    Cell Significance Index: 354.3400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.1155
    Cell Significance Index: 66.9700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6798
    Cell Significance Index: 110.5700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.6784
    Cell Significance Index: 42.7600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5292
    Cell Significance Index: 27.4900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3982
    Cell Significance Index: 27.5400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3962
    Cell Significance Index: 17.9600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3314
    Cell Significance Index: 7.1800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3284
    Cell Significance Index: 65.8700
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.2980
    Cell Significance Index: 4.2700
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.2857
    Cell Significance Index: 4.0100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.2729
    Cell Significance Index: 8.7400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.2512
    Cell Significance Index: 5.2100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.2466
    Cell Significance Index: 3.3700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1980
    Cell Significance Index: 14.0000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1977
    Cell Significance Index: 9.2200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1701
    Cell Significance Index: 19.8200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1657
    Cell Significance Index: 73.2600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.1571
    Cell Significance Index: 2.5200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1475
    Cell Significance Index: 52.9100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1466
    Cell Significance Index: 14.5000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1442
    Cell Significance Index: 4.0300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1398
    Cell Significance Index: 10.7300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1376
    Cell Significance Index: 2.9300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1366
    Cell Significance Index: 94.4700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1326
    Cell Significance Index: 6.9600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.1141
    Cell Significance Index: 1.2400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1024
    Cell Significance Index: 18.4700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0969
    Cell Significance Index: 13.3100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0869
    Cell Significance Index: 1.8200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0824
    Cell Significance Index: 16.3500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0760
    Cell Significance Index: 2.1900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0638
    Cell Significance Index: 34.8400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0628
    Cell Significance Index: 1.5700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0510
    Cell Significance Index: 6.2700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0371
    Cell Significance Index: 4.7500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0207
    Cell Significance Index: 1.2700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0142
    Cell Significance Index: 0.2100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0133
    Cell Significance Index: 12.0100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0064
    Cell Significance Index: 0.1100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0045
    Cell Significance Index: 3.3100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0006
    Cell Significance Index: 1.1300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0024
    Cell Significance Index: -1.5200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0036
    Cell Significance Index: -0.0600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0048
    Cell Significance Index: -0.1700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0056
    Cell Significance Index: -10.3700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0059
    Cell Significance Index: -2.6800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0060
    Cell Significance Index: -9.2400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0077
    Cell Significance Index: -10.4100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0104
    Cell Significance Index: -1.2300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0111
    Cell Significance Index: -8.3800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0136
    Cell Significance Index: -10.1100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0182
    Cell Significance Index: -2.6500
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0187
    Cell Significance Index: -0.2400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0199
    Cell Significance Index: -11.2000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0210
    Cell Significance Index: -0.2500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0225
    Cell Significance Index: -14.0800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0254
    Cell Significance Index: -4.3400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0276
    Cell Significance Index: -3.5700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0344
    Cell Significance Index: -9.9000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0411
    Cell Significance Index: -1.8200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0437
    Cell Significance Index: -4.4600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0447
    Cell Significance Index: -5.1200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0474
    Cell Significance Index: -3.1900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0539
    Cell Significance Index: -1.4400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0553
    Cell Significance Index: -1.5100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0581
    Cell Significance Index: -2.2000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0584
    Cell Significance Index: -3.5800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0658
    Cell Significance Index: -13.8600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0827
    Cell Significance Index: -6.1600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0907
    Cell Significance Index: -5.0900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1001
    Cell Significance Index: -7.9300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1060
    Cell Significance Index: -2.3200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1061
    Cell Significance Index: -2.7900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1064
    Cell Significance Index: -5.0000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1128
    Cell Significance Index: -2.9000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1165
    Cell Significance Index: -4.0500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1181
    Cell Significance Index: -12.3000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1187
    Cell Significance Index: -3.0300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1270
    Cell Significance Index: -2.7200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.1298
    Cell Significance Index: -1.0900
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.1326
    Cell Significance Index: -1.8400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1381
    Cell Significance Index: -2.9300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1421
    Cell Significance Index: -9.1700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1430
    Cell Significance Index: -4.2000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1785
    Cell Significance Index: -2.6900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1954
    Cell Significance Index: -5.2400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2043
    Cell Significance Index: -4.9000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2085
    Cell Significance Index: -6.6400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2138
    Cell Significance Index: -5.7200
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.2258
    Cell Significance Index: -1.5300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2263
    Cell Significance Index: -7.4100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2495
    Cell Significance Index: -8.7400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2670
    Cell Significance Index: -5.2800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2675
    Cell Significance Index: -5.3700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** COQ3 is a member of the O-methyltransferase family, which is responsible for transferring methyl groups to substrates, thereby modifying their biological activity. The COQ3 enzyme specifically catalyzes the methylation of 3,4-dihydroxy-5-polyprenylbenzoic acid, a precursor molecule in the biosynthesis of ubiquinones. This enzyme is unique in its ability to facilitate the transfer of a methyl group to this substrate, resulting in the formation of a coenzyme Q3 intermediate. **Pathways and Functions:** COQ3 plays a critical role in the ubiquinone biosynthetic pathway, which is essential for maintaining the mitochondrial electron transport chain. The enzyme's activity is linked to the metabolism of vitamins and cofactors, including ubiquinol and ubiquinone. COQ3 has been implicated in the regulation of cellular metabolism, including glycerol metabolism, and has been shown to interact with other proteins involved in mitochondrial function. **Functions:** The primary function of COQ3 is to catalyze the methylation of 3,4-dihydroxy-5-polyprenylbenzoic acid, resulting in the formation of coenzyme Q3. This intermediate is subsequently converted into ubiquinone, a critical electron carrier in the mitochondrial electron transport chain. COQ3 has also been shown to play a role in the regulation of cellular homeostasis, including the metabolism of cofactors and vitamins. **Clinical Significance:** Dysregulation of COQ3 has been implicated in various diseases, including neurodegenerative disorders, such as Parkinson's disease and Alzheimer's disease. Mutations in the COQ3 gene have been associated with an increased risk of these diseases, highlighting the enzyme's importance in maintaining mitochondrial function and cellular homeostasis. Additionally, COQ3 has been shown to play a role in the regulation of immune function, including the activation of T cells and the production of cytokines. **Significantly Expressed Cells:** COQ3 is significantly expressed in various cell types, including: * Polychromatophilic erythroblast * Hematopoietic oligopotent progenitor cell * Orthochromatic erythroblast * CD8-alpha-beta-positive, alpha-beta intraepithelial T cell * Stromal cell of bone marrow * Enteroendocrine cell of colon * Gut absorptive cell * Epithelial cell of small intestine * Eye photoreceptor cell * Bladder urothelial cell In conclusion, COQ3 is a critical enzyme involved in the biosynthesis of ubiquinones, a family of essential electron carriers in the mitochondrial electron transport chain. Its dysregulation has been implicated in various diseases, including neurodegenerative disorders and immune dysfunction. Further research is needed to fully elucidate the role of COQ3 in maintaining cellular homeostasis and immune function.

Genular Protein ID: 1062781619

Symbol: COQ3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9NZJ6 B3KPX0 Q5T061 Q6P4F0 Q8IXG6 Q96BG1 Q9H0N1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 3 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 14 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 7 Ensembl 1 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 6 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10777520

Title: Isolation and functional expression of human COQ3, a gene encoding a methyltransferase required for ubiquinone biosynthesis.

PubMed ID: 10777520

DOI: 10.1074/jbc.275.17.12381

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 369
  • Mass: 41054
  • Checksum: B257A099D6C06A2D
  • Sequence:
    • MWSGRKLGSS GGWFLRVLGP GGCNTKAARP LISSAVYVKN QLSGTLQIKP GVFNEYRTIW 
FKSYRTIFSC LNRIKSFRYP WARLYSTSQT TVDSGEVKTF LALAHKWWDE QGVYAPLHSM 
NDLRVPFIRD NLLKTIPNHQ PGKPLLGMKI LDVGCGGGLL TEPLGRLGAS VIGIDPVDEN 
IKTAQCHKSF DPVLDKRIEY RVCSLEEIVE ETAETFDAVV ASEVVEHVID LETFLQCCCQ 
VLKPGGSLFI TTINKTQLSY ALGIVFSEQI ASIVPKGTHT WEKFVSPETL ESILESNGLS 
VQTVVGMLYN PFSGYWHWSE NTSLNYAAYA VKSRVQEHPA SAEFVLKGET EELQANACTN 
PAVHEKLKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.