Details for: SERPINE2

Gene ID: 5270

Symbol: SERPINE2

Ensembl ID: ENSG00000135919

Description: serpin family E member 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 225.4007
    Cell Significance Index: -35.0600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 117.9609
    Cell Significance Index: -29.9200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 90.1814
    Cell Significance Index: -37.1500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 80.6358
    Cell Significance Index: -38.0700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 80.2447
    Cell Significance Index: -32.6000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 33.9987
    Cell Significance Index: -32.4600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 29.2549
    Cell Significance Index: -36.0700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 14.6144
    Cell Significance Index: -39.1500
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 10.3551
    Cell Significance Index: 132.6200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.2827
    Cell Significance Index: -36.6300
  • Cell Name: theca cell (CL0000503)
    Fold Change: 9.1098
    Cell Significance Index: 53.5200
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 6.6227
    Cell Significance Index: 41.1500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 5.6013
    Cell Significance Index: 147.2900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.6921
    Cell Significance Index: 77.1700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.2422
    Cell Significance Index: 59.8700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.7409
    Cell Significance Index: 345.4800
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 1.7378
    Cell Significance Index: 24.3000
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.5226
    Cell Significance Index: 9.4200
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: 1.4090
    Cell Significance Index: 6.7400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.9346
    Cell Significance Index: 26.1200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.8839
    Cell Significance Index: 46.0400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5645
    Cell Significance Index: 509.6700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5217
    Cell Significance Index: 104.6500
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.5119
    Cell Significance Index: 7.1800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3478
    Cell Significance Index: 34.4100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.3108
    Cell Significance Index: 4.2400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3068
    Cell Significance Index: 58.3900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2873
    Cell Significance Index: 46.7300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.2116
    Cell Significance Index: 4.4300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2112
    Cell Significance Index: 93.3800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1808
    Cell Significance Index: 24.8300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1699
    Cell Significance Index: 18.4800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1063
    Cell Significance Index: 58.0400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0550
    Cell Significance Index: 0.9200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0477
    Cell Significance Index: 33.0000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0387
    Cell Significance Index: 1.8200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0190
    Cell Significance Index: 1.1400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.0091
    Cell Significance Index: 0.2600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0024
    Cell Significance Index: 0.1600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0014
    Cell Significance Index: 0.0500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0012
    Cell Significance Index: -2.2400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0024
    Cell Significance Index: -0.0600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0060
    Cell Significance Index: -0.1500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0097
    Cell Significance Index: -7.1600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0181
    Cell Significance Index: -11.3200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0248
    Cell Significance Index: -8.8800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0258
    Cell Significance Index: -47.6500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0308
    Cell Significance Index: -47.4400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0353
    Cell Significance Index: -48.0100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0396
    Cell Significance Index: -29.0500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0439
    Cell Significance Index: -24.7800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0509
    Cell Significance Index: -38.5500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0540
    Cell Significance Index: -3.3200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0541
    Cell Significance Index: -34.3400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0596
    Cell Significance Index: -0.3600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0613
    Cell Significance Index: -2.1300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0630
    Cell Significance Index: -1.0900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0649
    Cell Significance Index: -7.9800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0710
    Cell Significance Index: -32.2100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0762
    Cell Significance Index: -1.6500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0823
    Cell Significance Index: -14.8400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0842
    Cell Significance Index: -17.7400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0920
    Cell Significance Index: -15.7100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0973
    Cell Significance Index: -27.9900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1251
    Cell Significance Index: -14.5800
  • Cell Name: reticulocyte (CL0000558)
    Fold Change: -0.1388
    Cell Significance Index: -0.7300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1543
    Cell Significance Index: -15.7700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1598
    Cell Significance Index: -7.2500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1681
    Cell Significance Index: -24.4300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1745
    Cell Significance Index: -22.3700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1814
    Cell Significance Index: -23.4300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1895
    Cell Significance Index: -5.4600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2341
    Cell Significance Index: -16.5600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2488
    Cell Significance Index: -28.5100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2657
    Cell Significance Index: -14.9100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2708
    Cell Significance Index: -16.6000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3045
    Cell Significance Index: -31.7100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3097
    Cell Significance Index: -35.3500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.3127
    Cell Significance Index: -2.5500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3278
    Cell Significance Index: -6.8000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3302
    Cell Significance Index: -38.9500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3377
    Cell Significance Index: -25.9200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4308
    Cell Significance Index: -9.1800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4504
    Cell Significance Index: -35.6800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.4951
    Cell Significance Index: -7.6600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4993
    Cell Significance Index: -37.2100
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.5261
    Cell Significance Index: -5.4800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5289
    Cell Significance Index: -27.7700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.5446
    Cell Significance Index: -36.6200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.5659
    Cell Significance Index: -36.5100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5696
    Cell Significance Index: -25.2000
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.5723
    Cell Significance Index: -6.5500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5736
    Cell Significance Index: -18.3700
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.5822
    Cell Significance Index: -8.3600
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.5955
    Cell Significance Index: -4.9200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.6230
    Cell Significance Index: -23.5900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.6381
    Cell Significance Index: -5.1000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.6447
    Cell Significance Index: -16.4700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.7046
    Cell Significance Index: -23.0700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.7143
    Cell Significance Index: -22.7500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Serpin Family Member**: SERPINE2 is a member of the serpin family, which is characterized by their ability to inhibit proteolytic enzymes. 2. **Glia-derived Nexin (GDNA)**: The encoded protein is also known as Glia-derived Nexin, which suggests its role in regulating proteolytic processes in the central nervous system. 3. **Negative Regulation of Proteolytic Processes**: SERPINE2 regulates various proteolytic processes, including blood coagulation, cell growth, cell migration, and proteolysis, by inhibiting proteolytic enzymes. 4. **Multiple Cellular Localizations**: The protein is expressed in various cell types, including interstitial cells of the ovary, astrocytes of the cerebral cortex, and fibroblasts of connective tissue in different organs. **Pathways and Functions** 1. **Blood Coagulation**: SERPINE2 regulates blood coagulation by inhibiting proteolytic enzymes involved in the clotting cascade. 2. **Cell Growth and Migration**: The protein regulates cell growth and migration by inhibiting proteolytic enzymes involved in these processes. 3. **Proteolysis**: SERPINE2 regulates proteolysis by inhibiting proteolytic enzymes involved in protein processing and degradation. 4. **Neuroprotection**: The protein has neuroprotective effects by regulating proteolytic processes involved in neuronal damage and death. 5. **Hemostasis**: SERPINE2 regulates hemostasis by inhibiting proteolytic enzymes involved in the formation of fibrin clots. **Clinical Significance** 1. **Thrombosis**: SERPINE2 has been implicated in thrombosis, a condition characterized by the formation of blood clots in blood vessels. 2. **Neurological Disorders**: The protein's role in regulating proteolytic processes suggests its involvement in neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Cancer**: SERPINE2 has been implicated in cancer, where it regulates proteolytic processes involved in cell growth and migration. 4. **Reproductive Disorders**: The protein's expression in interstitial cells of the ovary suggests its involvement in reproductive disorders, such as polycystic ovary syndrome (PCOS). 5. **Inflammatory Disorders**: SERPINE2's role in regulating proteolytic processes involved in inflammation suggests its involvement in inflammatory disorders, such as rheumatoid arthritis. In conclusion, SERPINE2 is a multifunctional protein that regulates proteolytic processes involved in various physiological and pathological processes. Its dysregulation has been implicated in several diseases, highlighting the importance of this gene in human health and disease.

Genular Protein ID: 1034071556

Symbol: GDN_HUMAN

Name: Glia-derived nexin

UniProtKB Accession Codes:

P07093 B2R6A4 B4DIF2 Q53S15 Q5D0C4

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 CarbonylDB 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 37 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 3 RefSeq 7 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3427015

Title: cDNA sequence coding for a rat glia-derived nexin and its homology to members of the serpin superfamily.

PubMed ID: 3427015

DOI: 10.1021/bi00394a016

PubMed ID: 2877744

Title: A glia-derived neurite promoting factor with protease inhibitory activity belongs to the protease nexins.

PubMed ID: 2877744

DOI: 10.1016/0092-8674(86)90511-8

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3997857

Title: Protease nexin. Properties and a modified purification procedure.

PubMed ID: 3997857

DOI: 10.1016/s0021-9258(18)88883-4

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 398
  • Mass: 44002
  • Checksum: 2A165604E2CBE6B8
  • Sequence:
    • MNWHLPLFLL ASVTLPSICS HFNPLSLEEL GSNTGIQVFN QIVKSRPHDN IVISPHGIAS 
VLGMLQLGAD GRTKKQLAMV MRYGVNGVGK ILKKINKAIV SKKNKDIVTV ANAVFVKNAS 
EIEVPFVTRN KDVFQCEVRN VNFEDPASAC DSINAWVKNE TRDMIDNLLS PDLIDGVLTR 
LVLVNAVYFK GLWKSRFQPE NTKKRTFVAA DGKSYQVPML AQLSVFRCGS TSAPNDLWYN 
FIELPYHGES ISMLIALPTE SSTPLSAIIP HISTKTIDSW MSIMVPKRVQ VILPKFTAVA 
QTDLKEPLKV LGITDMFDSS KANFAKITTG SENLHVSHIL QKAKIEVSED GTKASAATTA 
ILIARSSPPW FIVDRPFLFF IRHNPTGAVL FMGQINKP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.